| abstract |
The present invention relates to the effective combined utilization of monobactams antibiotic and beta-lactamase inhibitor.More specifically, the open medicinal compositions of the present invention, this medicinal compositions comprises formula (I) compound with antibiotic activity and formula (II) beta-lactamase inhibitor to one of formula (XIII), said composition has activity to Gram-negative bacteria, particularly microbiotic such as aztreonam, carumonam and tigemonam is produced to this bacterioid of resistance.Said composition optionally comprises the beta-lactamase inhibitor of another kind of formula (II) to formula (XIII), particularly one of formula (V) or formula (VI). |