| abstract |
The invention relates to a preparation method of a high-purity contrast medium raw material iopromide, wherein byproducts generated in the preparation process can be removed by introducing a compound shown in a formula (19): 5-methoxyl acetamido-2, 4, 6-triiodo isophthalic acid [(2, 3-diacetoxyl-N-methyl propyl)-(2, 3-diacetoxyl propyl)] diamide serving as an intermediate. The invention provides the preparation method of iopromide with high purity. |