http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103373986-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 |
| filingDate | 2012-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103373986-B |
| titleOfInvention | (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine prodrug and preparation method thereof and purposes |
| abstract | The present invention relates to (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine prodrug and preparation method thereof and purposes, the present invention provides the compound shown in a kind of logical formula (II) or its stereoisomer or its pharmaceutically acceptable salt, solvate or hydrate: Wherein, X is O or CH 2 ；M is 0 or 1；R 1 、R 2 It selected from identical or different group, is hydrogen, halogen, nitro, cyano group, hydroxyl, amino, C independently of one another 1 ‑C 6 Saturated or undersaturated chain alkylene, C 1 ‑C 6 Saturated or undersaturated cyclic hydrocarbon radical；R 1 With R 2 Also being present in same ring, collectively forming 36 rings, this 36 ring can be substituted or unsubstituted cycloalkane, aromatic ring or hetero-aromatic ring, and the substituent on ring is selected from halogen, nitro, cyano group, hydroxyl, amino, C 1 ‑C 6 Alkyl, C 1 ‑C 6 Alkoxyl；R 3 Selected from hydrogen, replacement or unsubstituted C 1 ‑C 12 Saturated or undersaturated alkyl, substituted or unsubstituted phenyl or heteroaryl, substituted or unsubstituted alkanoyloxy, substituted or unsubstituted phosphinylidyne epoxide, substituted or unsubstituted aryl acyloxy or heteroaryl acyloxy, above-mentioned substituent is selected from halogen, nitro, cyano group, hydroxyl, amino, phenyl or heteroaryl, C 1 ‑C 6 Alkyl, C 1 ‑C 6 Alkoxyl, C 1 ‑C 6 Thiazolinyl, C 1 ‑C 6 Alkynyl. |
| priorityDate | 2012-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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