http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103288790-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_048f16c527f4c5abde2048c4436c331b |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-366 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 |
| filingDate | 2013-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b554234f09e69d2ca922cfa1f1bc775 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_602335407447fc5ec63dcc43e1bf6de7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a7d137772c3fa4374baf54c8ace3f49 |
| publicationDate | 2013-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103288790-A |
| titleOfInvention | Preparation method and application of triterpenoid with effect of resisting rheumatoid arthritis |
| abstract | The invention relates to a preparation method of isomalabaricane triterpenes (isomalabaricane triterpenes) jaspolide B with strong proliferation activity of inhibiting a human fibroblast-like synovial cell, and application thereof in the treatment aspect of rheumatoid arthritis. The compound is shown in a structural formula 1; the fibroblast-like synovial cell (FLS) of a sufferer with the rheumatoid arthritis (RA) is utilized as a model for evaluating the activity of resisting the rheumatoid arthritis, so as to find out that the jaspolide B has strong proliferation activity of inhibiting the human fibroblast-like synovial cell; the IC50 value is 10 muM. By adopting the preparation method, a lead compound is provided for development of a new drug for resisting the rheumatoid arthritis; development and utilization of the medicinal value of marine sponge are facilitated. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111620809-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10933044-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108463230-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108463230-A |
| priorityDate | 2013-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 59.