http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103243130-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ac31afbea1cbbb03498644721ffb4a62 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-07 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-14 |
| filingDate | 2013-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7fd5985d8fd9b66320610a9160c4dde9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6f488fc99248dc0a5aa157ebb145170f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5115dd3ffa740b7b12fbfa6564e06632 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d77c80faf855fd34c29f58feff21c49f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a118291f139066ad3aa4533e0e4549b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2322a5d1188965c8b151db9f0c728f0c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fdac48a4078169b5371233aae6d71ec3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_930718a058808174aa75e591d225cfb1 |
| publicationDate | 2013-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103243130-A |
| titleOfInvention | A kind of one pot method prepares the method for γ-glutamine compound |
| abstract | The invention discloses a method for preparing γ-glutamine compounds in one pot. The method comprises the following steps: using 5-carboxyethyl hydantoin and amine compounds for amidation reaction in water phase to form 5-carboxyethyl hydantoin amide compounds; The bacterium with carbamylase is used as a catalyst to carry out enzymatic hydrolysis and acyclic reaction to obtain γ-glutamine compounds. In the present invention, hydantoin rings are used to co-protect the α-amino and α-carboxyl groups of glutamic acid, and only the γ-carboxyl groups are exposed, which ensures the site specificity of the amidation reaction; the intermediate product does not need to be extracted and separated directly Carry out the next step of enzymatic reaction, the "one pot" reaction process can effectively improve the total yield of the reaction, and at the same time, the aqueous phase reaction also avoids the environmental pollution caused by organic solvents; the use of enzymatic hydrolysis and ring opening avoids most of the chemical synthesis. Repeated protection and deprotection steps reduce the occurrence of side reactions. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106916858-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113278660-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113278660-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106916858-B |
| priorityDate | 2013-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID466460908 |
Total number of triples: 24.