| abstract |
The present invention relates to the method for preparing inhibitors of dipeptidyl IV and the intermediate for this preparation method, be specifically related to provide a kind of method preparing the inhibitor based on cyclopropyl-anellated tetramethyleneimine of DPP IV, it adopts the amine through BOC-protection with structure 3, this amine through BOC-protection is prepared as follows: use ammonium formiate, Reduced nicotinamide-adenine dinucleotide, the enzyme enriched material (PDH/FDH) of dithiothreitol (DTT) and partially purified Phenylalanine dehydrogenase/hydrogenlyase processes the acid of structure 1, this acid is made to carry out reductive amination process, and the amine of the structure 2 using tert-Butyl dicarbonate process to generate when not emanating, to form the amine through BOC-protection. |