| abstract |
Compounds of formula (I) effective in ameliorating diseases characterized by undesired sodium and/or calcium channel activity, especially undesired Nav 1.7, Nav 1.8 or Cav 3.2 channel activity are disclosed. Specifically, a series of compounds containing piperidine or piperazine attached to an aromatic ring via an amide or isoxazole or similar linker are described and shown to be useful in the treatment of pain and/or epilepsy. A is selected from formula (i) or (ii). |