http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102329268-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_078cb8366425c7f7bb46338421d23406 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D223-16 |
| filingDate | 2011-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9f532c8d47c36bd12fa7945a4337453 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a9c7d47622bbcb4e49a2e72a81fab5c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf318d3090d6ffdbbdc46e067c8ca671 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab17765e0a67fc1d09bd370779f2055d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b0ed8688b1febdee564700ded77b48e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e069914601b8151de5f0eb58911f6a7c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5fa6203fe476364a10912ca81044462a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_18eeaf2e6be8ed1443beb595e21ded98 |
| publicationDate | 2014-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102329268-B |
| titleOfInvention | Preparation method for 7-chlorine-5-oxo-2,3,4,5-tetrahydro-1H-1-benzoazepine |
| abstract | The invention relates to a preparation method for 7-chlorine-5-oxo-2,3,4,5-tetrahydro-1H-1-benzoazepine. The 7-chlorine-5-oxo-2,3,4,5-tetrahydro-1H-1-benzoazepine is an important intermediate for preparing arginine pitressin V2 receptor antagonist Tolvaptan. In the preparation method, the target product 7-chlorine-5-oxo-2,3,4,5-tetrahydro-1H-1-benzoazepine is prepared by removing tosyl and carbalkoxy from 7-chlorine-5-oxo-4-carbalkoxy-1-tosyl-2,3,4,5-tetrahydro-1-benzoazepine serving as a raw material under the action of sulfuric acid and by a 'one-pot method'. The sulfuric acid is used for performing 'one-pot method' reaction, so reaction steps are reduced and reaction time is greatly shortened. The preparation method has the advantages of simpleness and convenience for operation, equipment and cost saving, simpleness and practicability in separation and purification, short reaction time, high yield and high product purity and is applicable to industrialized production. |
| priorityDate | 2011-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 66.