http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102093293-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_44ecb18a0e845e46fda71225c5f6d26c |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D223-16 |
| filingDate | 2011-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d39c7069ac25b3fcf67bebd356d1f03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32d22ada2b07a3f9b0a6113a7abaff15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f06325734c8d580a646ba917badd31fd |
| publicationDate | 2011-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102093293-A |
| titleOfInvention | Method for preparing 7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepino-5-ketone |
| abstract | The invention relates to a preparation method of benzazepine compounds, particularly a preparation method of 7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepino-5-ketone. The 7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepino-5-ketone can be used as an intermediate for preparing a pitressin antagonist medicament Tolvaptan. The method comprises the following steps: by using parachloroaniline as a raw material, reacting with paratoluensulfonyl chloride in a condensation mode under the alkaline condition to firstly protect amino groups; under the alkaline condition, coupling with ethyl 4-bromobutyrate to obtain a compound; in the presence of alkali, hydrolyzing the obtained compound, and acidifying; in dichloromethane, preparing acyl chloride from the acidified compound under the action of thionyl chloride; under the action of Lewis acid, carrying out Friedel-Crafts acylation reaction to perform intramolecular cyclization; and finally, removing tosyl groups to obtain the target product. The invention has the advantages of simple technique and low cost, and is convenient for industrial large-scale production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102329268-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102329268-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103012266-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105753735-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103012265-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109400533-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103012266-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103204810-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103204810-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104829533-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105753735-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112661759-A |
| priorityDate | 2011-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.