http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102321010-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_95cebe3906e865030e31cc99cd12fa34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-42 |
| filingDate | 2011-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_836859846d7f6e95e88e4b94e92d1c05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_540cba28703bd2348925d7f8e1fdf7c9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a93e3915adc301406c0962c60d85689b |
| publicationDate | 2012-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102321010-A |
| titleOfInvention | The preparation method of (2S, 3aR, 7aS)-benzyl octahydroindole-2-carboxylate |
| abstract | The invention relates to a preparation method of a pharmaceutical intermediate, and the purpose is to provide a preparation method of (2S, 3aR, 7aS)-octahydroindole-2-carboxylic acid benzyl ester with improved yield and fewer steps. The invention comprises: cyclohexene and chloramine-T are added in cis under the condition of adding catalyst I 2 ; diethyl malonate and cis addition product are heated and refluxed to undergo a ring-closing reaction, and the ring-closing reaction product is hydrolyzed; the hydrolyzed product Heating decarboxylation reaction; the decarboxylation product undergoes sodium borohydride reductive chlorination reaction; the reduced chlorination product is added to trimethylsilyl cyanide to undergo a substitution reaction; concentrated hydrochloric acid and acetic acid are used as catalysts to acidolyze the substituted product under the condition of heating and reflux; The acid hydrolysis product and benzyl alcohol undergo an esterification reaction under the action of a strong acid catalyst by reflux and water separation; the esterification product is further purified with a resolving agent. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103044241-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103360299-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103288710-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103360299-B |
| priorityDate | 2011-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID466441533 |
Total number of triples: 17.