http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101623503-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fbf7f6130e324577618e08783c303919 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-54 |
| filingDate | 2009-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ce42abe701e96915afc347832d53265 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17a340d05192c59cb5d9bd4478a26288 |
| publicationDate | 2010-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101623503-A |
| titleOfInvention | Composite of survivin and sialylLewis and preparation method and application thereof |
| abstract | The invention discloses a composite of survivin and sialylLewis and a preparation method and an application thereof, wherein the composite is prepared from survivin and sialylLewis-x with non-covalent bonds, and the surviving has an amino acid sequence presented by SEQ ID No.2; in the preparation method, a cross-linking agent of survivin and streptavidin is firstly prepared and then combined with (sialylLewis-x)-polyacrylate sodium-biotin with high affinity of the streptavidin and biotin so that the composite of the survivin and the sialylLewis is prepared; the composite in the invention can successfully target dendritic cell surface specificity C-type agglutinin-intercellular adhesion molecule 3 to combine non-integrin molecules (DC-SIGN) with guide effect of sialylLewis-x, thereby promoting immune response of survivin specificity T cells and efficiently inducing tumor cell apoptosis and inhibiting tumor angiogenesis; and the invention can be used for preparing tumor vaccines, and has good development and application prospects in the field of tumor immunotherapy. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105194666-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108379567-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105194666-A |
| priorityDate | 2009-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 123.