http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101456858-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_56d9856858f491640008656f9086efaa |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2008-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5d22fabae44c72e998aa66ecfbdf9d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_951bc8e25936fe845cabf5d414c8d681 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af78d3a55fec649bbc24bb9ebd4cc720 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c3f7c3a0e91e8a0c4fb2db5dcc30c2c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0332f41dcd42571bd39f8083ca3fb2a8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66d3b8e17cff6223d99f92b95511aac8 |
| publicationDate | 2009-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-101456858-A |
| titleOfInvention | Cyano-containing fused heterocyclic ketene aminals with chiral centre and synthetic method thereof |
| abstract | The invention discloses a cyclo-heterocyclic ketene aminal compound containing cyano-group and having a chiral center, and a synthetic method thereof. The structure of the cyclo-heterocyclic ketene aminal compound containing the cyano-group and having the chiral center is as formula I, wherein in the formula I, Z is NH, NR', O or S; n is 1, 2 or 3; R is aroyl, heterocyclic aroyl, fused ring aroyl, alkanoyl, ester group, nitryl or cyano-group; R' is aryl, heterocyclic aryl, fused ring aryl, alkyl, substituted alkyl, naphthenic group or substituted naphthenic group; and R' is alkyl, substituted alkyl, aryl or substituted aryl. The method uses simple and easily obtained heterocyclic ketene aminal or analog thereof and alpha-beta-unsaturated compounds with chiral assistants to carry out 1, 4 Michael addition, and carry out intramolecular amide aminolysis at the same time to form a cycle shape, so as to obtain a target compound (formula I) through further reaction. The compound can be used as an intermediate compound for synthesizing other heterocyclic compounds. The method has the advantages of simple synthesis technology, high yield and stable product. The method achieves parallel and efficient synthesis of the cyclo-heterocyclic ketene aminal compound containing the cyano-group and having the chiral center, and has the characteristics of high yield, simple courses, quickness and the like. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10689309-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020010494-A1 |
| priorityDate | 2008-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 72.