| abstract |
The invention relates to a novel class of substituted spirocyclic compounds, represented by formula (II), the compounds can restrain histone deacetylation enzymes and are suitable for inducing terminal differentiation optionally, as well as prevent cell growth and/or programmed cell death of neoplastic cells, thus restraining proliferation of the cells. Therefore, the compounds of the invention are used for treating the sufferers of tumor which is characterized in proliferation of neoplastic cells. The compounds of the invention also can be used for preventing and treating the TRX-mediated diseases, such as autoimmune diseases, allergic diseases and inflammatory diseases, and used for preventing and/or treating central nervous system (CNS) diseases, such as nervous degenerative diseases. The invention also provides a medicament composition which contains the compounds of the invention, and a safe dosage regimen of the medicament composition which is easy to follow and generate curative effective dose of the compounds in the body. |