http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_f5784c937e35472e145b85db24debf3a
Outgoing Links
Predicate | Object |
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family-name | Liu Jun Liu |
name | Jun Liu J.u.n. Liu |
given-name | Jun J.u.n. |
organization-name | College of Physics and Technology; Guangxi Normal University; Guilin 541004; P. R. China Department of Urology, Wuhan Hankou Hospital, Wuhan, Hubei, China Ethics Committee, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China Department of Epidemiology, Beijing Anzhen Hospital, Capital University of Medical Science, Beijing 100029, China. Medical School of Chinese PLA, Beijing 100853, China, General Hospital of PLA, Beijing 100853, China.E-mail: gzzyyljun@sina.com. From the Division of Plastic Surgery, Baylor College of Medicine; and the Department of Plastic Surgery, The University of Texas M. D. Anderson Cancer Center. Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials; Beijing University of Chemical Technology; People's Republic of China; Beijing Engineering Research Center of Advanced Elastomers; Beijing University of Chemical Technology Department of Cardiology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, P.R. China Ultrasonography Department, Sichuan Academy of Medical Sciences (Sichuan Provincial People's Hospital), Chinese Academy of Sciences, Chengdu, Sichuan, China Enzon Pharmaceuticals, 20 Kingsbridge Road, Piscataway, New Jersey 08854-3969 Sichuan Drug Rehabilitation Administration , No. 90 Shu Tong Jie, Jinniu District, Chengdu , China Department of Nephrology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China. Chinese Academy of Sciences; University of Chinese Academy of Sciences ‡ Pharmaceutical Research and Development, Chemical Engineering Research Center; School of Chemical Engineering and Technology; Tianjin University; Tianjin 300350; PR China College of Information Engineering, Zhejiang University of Technology Department of Plastic Surgery University of Texas, MD Anderson Cancer Center, Houston Tex. Department of HIV/AIDS Control and Prevention, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China. State Key Laboratory of Medicinal Chemical Biology Tianjin Key Laboratory of Biosensing and Molecular Recognition Research Center for Analytical Science Frontiers Science Center for New Organic Matter College of Chemistry Nankai University Tianjin 300071 China Department of Pathology and Laboratory Medicine University of British Columbia Vancouver British Columbia Canada Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, U.S.A. College of Agro-Grassland Science, Nanjing Agricultural University, Nanjing 210095, China Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, 7500AE, University of Twente, Enschede, The Netherlands; Hengyang City CDC, Hunan Province, Hengyang, China. Department of Cardiology The First Affiliated Hospital Sun Yat‐Sen University, Key Laboratory on Assisted Circulation, Ministry of Health Guangzhou P.R. China Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials; State Key Laboratory of Organic–Inorganic Composites; Beijing University of Chemical Technology; 100029 Beijing; China Tianjin Medical University, Tianjin, China. dr_liujun@126.com Department of Orthopaedics, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China Department of Joint, Tianjin Hospital, Tianjin, China §Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People’s Republic of China; Department of Infectious Diseases, State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China Authors' Affiliations: 1Novartis Institutes for BioMedical Research (China), Shanghai, P.R. China; 2Genomics Institute of the Novartis Research Foundation, San Diego, California; and 3Novartis Institutes for BioMedical Research, Cambridge, Massachusetts *Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;; ‡National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China; and Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China; Guangzhou Key Laboratory of Inflammatory and Immune Diseases, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China Xiaoshan Hospital of Zhejiang, Hangzhou 311201, China. xiaoshanry@sina.com Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China The University of Texas MD Anderson Cancer Center, USA Department of Urology Guangzhou General Hospital of Guangzhou Military Command Guangzhou China Department of Orthopaedic Surgery, Tianjin Hospital, Tianjin 300211, China Department of Joint Surgery, Tianjin Hospital, Tianjin Medical University, Tianjin 300211, P.R. China Department of Hematology‐Oncology Chongqing University Cancer Hospital Chongqing China Department of Otology Henan Provincial People's Hospital Zhengzhou China State Key Laboratory of Dynamic Measurement Technology, Shanxi Province Key Laboratory of Quantum Sensing and Precision Measurement, North University of China, Taiyuan 030051, China State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Plant Resources and Conservation of Guangdong Higher Education Institutes, College of Ecology and Evolution, Sun Yat-sen University , Guangzhou, People’s Republic of China Laboratory of Plant Molecular Biology, The Rockefeller University, New York, New York 10065 State Key Laboratory of Agricultural Microbiology, College of Resources and Environment, Huazhong Agricultural University, Wuhan, People’s Republic of China Department of Oncology, Taixing People's Hospital Taixing 225400, Jiangsu, China. Cardiology; and Department of Biochemistry and Molecular MedicineCancer CenterGeorge Washington University Washington District of Columbia USA Key Laboratory of Animal Biotechnology of the Ministry of Agriculture, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, People’s Republic of China Brigham and Women’s Hospital and Harvard Medical School Boston Massachusetts Department of Joint Surgery, Tianjin Hospital, Tianjin 300211, P.R. China Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New Energy iChEM (Collaborative Innovation Center of Chemistry for Energy Materials) Fudan University Shanghai 200433 China Department of HIV/AIDS Third People's Hospital of Kunming Kunming China Department of Radiation Oncology Xiamen Cancer Center The First Affiliated Hospital School of Medicine Xiamen University Teaching Hospital of Fujian Medical University Xiamen China National Drug Screening Center, China Pharmaceutical University R&D Division Shenzhen Ritzcon Biological Technology Co., Ltd. Shenzhen People's Republic of China Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials and ‡State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, P. R. China State Key Laboratory of Agrobiotechnology and MOA Key Laboratory for Monitoring and Green Management of Crop Pests, China Agricultural University , Beijing 100193 , China State Key Laboratory of Biocontrol and Collaborative Innovation Center of Genetics and Development, Guangdong Provincial Key Laboratory of Plant Resources, School of Life Sciences Sun Yat‐sen University Guangzhou 510275 China 2Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China School of Electrical and Computer Engineering, and Birck Nanotechnology Center, Purdue University, West Lafayette, Indiana 47907, Department of Electrical Engineering, University of Southern California, Los Angeles, California 90089, and Department of Chemistry and the Materials Research Center, and the Institute for Nanoelectronics and Computing, Northwestern University, Evanston, Illinois 60208-3113 Institute for Interfacial Catalysis, Pacific Northwest National Laboratory, Richland, Washington 99352, United States Section of Pediatric Gastroenterology-Hepatology, Department of Pediatrics, Yale School of Medicine, New Haven, CT; Institute of Hydrogeology and Environmental Geology, Chinese Academy of Geological Sciences, Shijiazhuang 050061, China. huilingjun69@163.com College of Veterinary Medicine Northwest A&F University Yangling Shaanxi China; Key Laboratory of Animal Biotechnology Ministry of Agriculture Northwest A&F University Yangling Shaanxi China Key Laboratory of Mesoscopic Chemistry, MOE, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, China CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101; Graduate University, Chinese Academy of Sciences, Beijing 100049; China-Japan Joint Laboratory of Molecular Immunology and Molecular Microbiology, Institute of Microbiology Technical Institute of Physics and Chemistry; Chinese Academy of Sciences; Beijing 100190; China Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China Department of Chemistry and the Materials Research Center, Northwestern University, Evanston, Illinois 60208, and Department of Physics and Astronomy and the Materials Research Center, Northwestern University, Evanston, Illinois 60208 Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Science, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, China Max Planck Institute for Solid State Research Heisenbergstr. 1 Stuttgart 70569 Germany China Academy of Chinese Medical Sciences Institute of Basic Research in Clinical Medicine, , Beijing 100700 , China Department of Otolaryngology, Henan Province People's Hospital, Zhengzhou 450003. Department of Urology, Second Xiangya Hospital, Central South University, Changsha 410011, China. Monash Institute of Medical Research, Monash University, Clayton VIC, 3168, Australia. Department of Epidemiology, Institute of Beijing Heart, Lung and Blood Vessel Diseases, Beijing 100029, China. Department of Breast-Thyroid-Vascular Surgery, Shanghai General Hospital, Shanghai, China Department of Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China. Department of Epidemiology and Biostatistics School of Public Health Jilin University Changchun Jilin China Department of Nephrology, University of South China affiliated Changsha Central Hospital School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 211198 Nanjing, Jiang Su, China; Department of Otolaryngology, Head and Neck Surgery, West China Hospital Sichuan University Chengdu People's Republic of China Department of Thoracic Oncology, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China The Second People’s Hospital of Huaihua, Huaihua 418000, China College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, China. Department of Breast-Thyroid-Vascular Surgery, Shanghai General Hospital, Shanghai JiaoTong University, School of Medicine, Shanghai, China Department of Hepatobiliary, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250000, Shandong, China Departments of Epidemiology and Cardiology, Beijing Anzhen Hospital, Capital Medical University, the Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases, No.2 Anzhen Road, Chaoyang District, Beijing 100029, China Department of Thoracic Surgery, Shengjing Hospital, China Medical University, Shenyang 110004, China 1Section of Genetics and Development; 2Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853-2703 The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi, Jiangsu Province 214002, China College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China Suncor AgroScience, 2489 North Sheridan Way, Mississauga, ON L5K 1A8, Canada Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences, Key Laboratory of Biology and Genetic Improvement of Oil Crops, Ministry of Agriculture and Rural Affairs , Wuhan, Hubei , People’s Republic of China From the *Departments of Cell Systems and Anatomy, University of Texas Health Science Center at San Antonio, San Antonio, TX; †Department of Cancer Biology, Mayo Clinic, Jacksonville, FL; and ‡Surgery Department, University of Pennsylvania School of Medicine, Philadelphia, PA. Department of Chemistry, Division of Mathematical and Physical Sciences, and Department of Electrical Engineering, School of Engineering, University of California, Davis, Davis, California 95616 Department of Biochemistry and Biophysics, Institute for Plant Genomics and Biotechnology, Texas A&M University, College Station, Texas 77843 Laboratory of Pathogenic Biology, Guangdong Medical University, Zhanjiang 524023, PR China Pharmacology and Systems Therapeutics Mount‐Sinai‐School of Medicine 1468 Madison Avenue New York NY 10029 USA Beijing National Laboratory for Molecular Sciences, Synthetic and Functional Biomolecules Center, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; From the Department of Plastic Surgery, University of Texas MD Anderson Cancer Center. Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China Department of Orthopedics, Jining No. 2 People’s Hospital, Jining, Shandong Province, China Shenyang Pharmaceutical University Shenyang, China. Guangdong Academy of Traditional Chinese Medicine, Research Team on Bone and Joint Degeneration and Injury, Guangzhou, People’s Republic of China.; The Second Affiliated Hospital, Guangzhou University of Chinese Medicine (Guangdong Province Hospital of Traditional Chinese Medicine), Guangzhou, People’s Republic of China.; Guangdong Second Traditional Chinese Medicine Hospital (Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine), Guangzhou, People’s Republic of China. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China Department of Orthopedics, Tianjin Hospital, Tianjin, People’s Republic of China Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China. Department of Pathogenic Organism, Fourth Military Medical University, Xi'an 710033, Shaanxi Province, China. etiology@fmmu.edu.cn Laboratory of Plant Molecular Biology The Rockefeller University 1230 York Avenue New York NY 10065 USA Guangdong Qifang Pharmaceutical Co., Ltd., Guangzhou 510075, China Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials; People's Republic of China; Beijing Engineering Research Center of Advanced Elastomers; People's Republic of China; Engineering Research Center of Elastomer Materials on Energy Conservation and Resources Division of Pharmacoepidemiology and Pharmacoeconomics Brigham and Women’s Hospital and Harvard Medical School Boston MA Key Laboratory of Biomedical Photonics of Ministry of Education, Huazhong University of Science and Technology, 430074, Peopleʼs Repiblic of China Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People’s Republic of China Physical Education College, China University of Geosciences, Wuhan, Hubei, China Department of Thoracic Surgery, People's Hospital, Peking University, Beijing 100044, China. State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China;; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China; and Department of Neurology & Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200025 China, State Key Laboratory of Medical Genomics, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200025 China, and Institute of Health Science, Shanghai Institutes of Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) & Shanghai Jiaotong University School of Medicine, Shanghai, 200025 China The University of Texas—Houston Medical School, Department of Pathology & Laboratory Medicine, 6431 Fannin, MSB 2.228, Houston, Texas 77030 Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029; and Computer and Information Science and Engineering, University of Florida, Gainesville, FL 32611, USA College of Veterinary Medicine Northwest A&F University Yangling Shaanxi PR China; Key Laboratory of Animal Biotechnology of the Ministry of Agriculture Northwest A&F University Yangling Shaanxi PR China Institute of Military Veterinary, AMMS, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, China Department of Pathology, Luzhou Medical College Luzhou, Sichuan 646000, China. The University of Texas–Houston Medical School, Department of Pathology and Laboratory Medicine, Houston, Texas 77030; State Key Laboratory of High Field Laser Physics, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800, People’s Republic of China Department of Social Medicine and Public Health, School of Basic Medicine, Jiujiang University, Jiujiang, Jiangxi 332005, P.R. China College of Plant Protection and Key Laboratory of Integrated Management of Crop Diseases and Pests Nanjing Agricultural University Nanjing 210095 P. R. China; Department of Crop Sciences University of Illinois at Urbana‐Champaign Urbana IL 61801 USA Department of Plastic Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas Key Laboratory of Synthetic Chemistry of Natural Substances Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 P. R. China Departments of 1Pediatrics and Department of Intensive Care Unit, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215001, Jiangsu, China. Department of Mechanical Engineering, University of Colorado, Boulder, Colorado, 80309, United States Key Laboratory of Potato Biology and Biotechnology, Ministry of Agriculture Huazhong Agricultural University Wuhan 430070 People's Republic of China; Huazhong Agricultural University Wuhan 430070 People's Republic of China; National Center for Vegetable Improvement (Central China) Wuhan 430070 People's Republic of China State Key Laboratory of Biocontrol and Collaborative Innovation Center of Genetics and Development, Guangdong Provincial Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, 510275 Guangzhou, People's Republic of China Department of Rehabilitation, School of Acupuncture-Moxibustion and Tuina, Hebei University of Chinese Medicine, Shijiazhuang 050200, China; Hebei International Joint Research Center for Dominant Diseases in Chinese Medicine and Acupuncture, Shijiazhuang 050091, China Department of Gynaecology and Obstetrics, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhongshan 2nd Road, Yuexiu District, Guangzhou, China College of Chemistry and Chemical Engineering; Yang Zhou University; Yangzhou; China Department of Pathology and Laboratory Medicine, The University of Texas Medical School at Houston, Houston, TX 77030; Department of Medical Genetics and Microbiology, University of Toronto, Ontario M5S-1A8, Canada Department of Laboratory Medicine The Fifth People’s Hospital of Wuxi Wuxi China Department of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China %dongdw663@nenu.edu.cn Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom Department of Breast‑Thyroid Surgery, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai 201620, P.R. China Shanghai Key Laboratory of Functional Materials Chemistry and Institute of Fine Chemicals East China University of Science and Technology Meilong Road 130 Shanghai China College of Animal Science and Technology Nanjing Agricultural University Nanjing 210095 China Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 Energy and Environmental Directorate, ‡Fundamental and Computational Science Directorate, and §Environmental Molecular Science Laboratory, Pacific Northwest National Laboratory, 902 Battelle Boulevard, Richland, Washington 99352, United States Department of Pathology and Laboratory Medicine McGovern Medical School at UT Health Science Center Houston TX 77030 USA College of Resources and Environment, Huazhong Agricultural University, Wuhan430070, China; State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan430070, China Beijing National Laboratory for Molecular Sciences, Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China Jiangsu Institute of Hematology, The First Affiliated Hospital and Collaborative Innovation Center of Hematology, State Key Laboraotry of Radiation Medicine and Protection, Soochow University, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Suzhou, Jiangsu 215006, China; Department of Pathology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate University of Chinese Academy of Sciences; Shanghai China Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences , Tianjin 300308 , P. R. China; Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences , Tianjin 300308 , P. R. China School of Basic Medical Sciences,Anhui Medical University,Hefei,China; Biopharmaceutical Research Institute,Anhui Medical University,Hefei,China National Clinical Research Center of Kidney Disease, Nanfang Hospital, Southern Medical University, Guangzhou, China School of New Energy Science and Engineering, Xinyu University, Xinyu 338004, China; Jiangxi Lithium Battery New Material Industrial Technology Institute, Xinyu 338004, China Harvard University, Cambridge, MA, USA; Department of Chemistry, Northeast Normal University, Changchun, 130024, China, and State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, 116012, China Department of Plastic and Reconstructive Surgery (Hassan, Asaad, Liu, Offodile, Butler), University of Texas MD Anderson Cancer Center, Houston, TX. Guangdong Provincial Key Laboratory for Crop Germplasm Resources Preservation and Utilization, Agro-biological Gene Research Center, Guangdong Academy of Agricultural Sciences, Guangzhou, 510640, China Department of Biomedical Engineering, Department of Ophthalmology, Ohio State University, 1080 Carmack Road, Columbus, OH 43210 Chinese PLA No.291 Hospital, Baotou 014040 Inner Mongolia, China. Department of Plastic Surgery The University of Texas MD Anderson Cancer Center Houston TX Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Houston, TX 77030, USA. Department of Microbial Pathogenesis & Microbial Sciences Institute Yale University School of Medicine New Haven CT 06516 USA Beijing Advanced Innovation Center for Food Nutrition and Human HealthCollege of Food Science and Nutritional EngineeringBeijingChina Department of Developmental Genetics, School of Basic Medical Sciences, Nanjing Medical University, 140 Hanzhong Road, Nanjing, Jiangsu 210029, China Department of Hematology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, People's Republic of China Department of Hepatobiliary Pancreatic Surgery, Hainan General Hospital, Hainan Affiliated of Hainan Medical University, Haikou, Hainan, China CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101; Graduate University, Chinese Academy of Sciences, Beijing 100049 Department of Physics, University of Virginia, Charlottesville, VA 22904, USA. Department of Pediatric Critical Care Medicine Beijing Children's Hospital Capital Medical University National Center for Children's Health China Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Texas 77030 Department of Neurology and Institute of Neurology Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine Shanghai China Department of Neurosurgery, Xinqiao Hospital, Army Medical University, Chongqing 400037, China Key Laboratory of Instrument Science and Dynamic Testing Ministry of Education, North University of China, Taiyuan 030051, China; Key Laboratory of Quantum Sensing and Precision Measurement, Taiyuan 030051, China; Institute of Instrument and Electronics, North University of China, Taiyuan 030051, China Department of Otolaryngology Head and Neck Surgery, West China Hospital Sichuan University Chengdu China Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China Department of Cardiothoracic Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China Department of Radiology The Third Xiangya Hospital, Central South University Changsha China National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China School of Electronic Information, Hangzhou Dianzi University, Hangzhou 310018, China; Key Laboratory of Large Scale Integrated Design, Hangzhou 310018, China School of Basic Medical Sciences Anhui Medical University Hefei China; Biopharmaceutical Institute Anhui Medical University Hefei China College of Pharmacy Jinan University Guangzhou People's Republic of China Second School of Clinic Medicine, Guangzhou University of Chinese Medicine, Guanzhou 510120, China Beijing Synchrotron Radiation Facility, Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China Department of Preventive Medicine, School of Public Health, Zunyi Medical University, Guizhou, Zunyi, China. Email: liujun_zmc@sina.com. Department of Cardiology, The 1st Hospital of Hebei Medical University Key Laboratory of Jiangxi Province for Image Processing and Pattern Recognition, Nanchang Hangkong University, Nanchang, Jiangxi, China Department of Thoracic Surgery, The First People’sHospital of Yunnan Province, Yunnan Province, China State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China; Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China Department of Anesthesiology, The First Affiliated Hospital of Xinxiang Medical University Weihui 453100, Xinxiang, Henan, People's Republic of China. Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.; Department of Gene Regulation and Drug Discovery, City of Hope Beckman Research Institute, 1500 East Duarte, Duarte, CA 91010, USA. Department of General Surgery and Institute of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen, China; Department of Epidemiology, Dalian Medical University, Dalian, China Department of Oncology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China Cell Reprogramming and Stem Cells, Monash Institute of Medical Research, Monash University, Clayton, VIC, Australia; Current address: Department of Biological Engineering, Monash University, Clayton, VIC, Australia The Comprehensive Cancer Centre of Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing China Department of Plastic and Reconstructive Surgery The University of Texas MD Anderson Cancer Center Houston Texas Department of research, Air Force Medical Center, PLA, Beijing, China Renmin Hospital of Wuhan University, Wuhan, Hubei, P. R. China International Institute for Earth System Science, Nanjing University, Nanjing 210093, China. 8886355@163.com Department of Orthopedics, General Hospital of Shenyang Military Area Command of Chinese PLA Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai 200032, China College of Chemistry and Chemical Engineering, College of Life Science, Jiangxi Normal University, Nanchang, Jiangxi 330022, China Wuhan Huaxia University of Technology, Wuhan 430223, China Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research Center Frontiers Science Center for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science and Technology 130 Meilong Road Shanghai 200237 China Department of Tissue Regeneration, MIRA Research Institute, University of Twente, Enschede, The Netherlands. National Center for Drug Screening and State Key Laboratory of Natural Medicines China Pharmaceutical University Nanjing China Department of Pathology and Laboratory Medicine University of Texas Health Science Center Houston TX USA Department of Gastroenterology, Endoscopic center, People’s Hospital of Ningxia Hui Autonomous Region, Yinchuan, China Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853 Department of Medicine, Yale University School of Medicine, New Haven, Connecticut. Department of Biology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China Jiangsu Key Laboratory of Pediatric TCM and Specialty Preparations, Jichuan Pharmaceutical Group Co., Ltd. Taixing 225400, China. Department of Physical Education, School of Civil Engineering, Dalian University of Technology, Dalian 116024, China Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA †CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; Energy and Environment Directorate Pacific Northwest National Laboratory Richland WA 99354 USA Department of Gastroenterology Renmin Hospital of Wuhan University Wuhan China Department of Plastic and Reconstructive Surgery, The University of Texas MD Anderson Cancer Center, Houston, Tex. College of Chemistry State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing 100029 China State Key Joint Laboratory of Environment Simulation and Pollution Control Research Center for Eco-environmental Sciences Chinese Academy of Sciences Beijing 100085 China Department of Otolaryngology,Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine. Department of Clinical Laboratory, First People's Hospital of Xiaoshan, Hangzhou, Zhejiang 311201, P.R.China. Faculty of Environmental Science and Engineering, Kunming University of Science and Technology Kunming China Late Stage Pharmaceutical Development, Genentech, 1 DNA Way, South San Francisco, California 94080, United States Department of Pediatric Intensive Care Unit Beijing Children's Hospital Capital Medical University; National Center for Children's Health Beijing 100045 China College of Life Sciences, China Jiliang University Pacific Northwest National Laboratory, Richland, Washington 99352 and Department of Pathology, Harborview Medical Center, University of Washington, Seattle, Washington 98104 Department of Epidemiology, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, China (Y. Hao, Jing Liu, Jun Liu, N.Y., M.Z, Y.X., D.Z.). Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio 5Department of Ophthalmology, The Ohio State University, Columbus, Ohio Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control, National Demonstration Center for Experimental Mechanical and Electrical Engineering Education, Tianjin University of Technology, Tianjin, China (mainland) Endoscopy Center, Northern Jiangsu People’s Hospital, Clinical Medical College of Yangzhou University, Yangzhou, China Department of Integrative Medicine, Affiliated Zhongshan Hospital, Fudan University, Shanghai 200032, China. College of Agro‐Grassland Science Nanjing Agricultural University Nanjing China From the Departments of Biomedical Engineering and 3Ophthalmology, and Key Laboratory of Potato Biology and Biotechnology Ministry of Agriculture and Countryside Huazhong Agricultural University Wuhan Hubei 430070 China; College of Life Science and Technology Huazhong Agricultural University Wuhan Hubei 430070 China; National Center for Vegetable Improvement (Central China) Wuhan Hubei 430070 China Department of Biomedical Engineering, Key Laboratory of Biomedical Engineering of Ministry of Education of China, Zhejiang University, Hangzhou, Zhejiang 310027, China Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China. Department of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China Department of Neurology & Collaborative Innovation Center for Brain Science Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine Shanghai China Department of Biology, Indiana University, Bloomington, IN, 47405, USA Department of Thoracic Surgery, the Second Affiliated Hospital of China Medical University, Shenyang Liaoning, 110004, P.R. China. School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China Jiangsu Key Laboratory of Pediatric Chinese Medicine and Characteristic Preparations, Jumpcan Pharmaceutical Co., Ltd. Taixing 225400, China. Department of Cariology, Restorative Sciences and Endodontics, Dental School, University of Michigan, Ann Arbor, Michigan. Department of Chemistry, University of Jyväskylä, FI-40014 JYU, Finland State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou City, China Department of Hematology/Hematological Lab, The Second Hospital of Anhui Medical University, Hefei, Anhui, Peoples Republic of China Department of Orthopaedics The Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine Guangzhou China Shenzhen Ritzcon Biological Technology Co., Ltd. Shenzhen Guangdong China Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, China Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, China Computer and Information Science and Engineering, University of Florida Gainesville 1 1 FL, 32611 USA Department of Immunology & Rheumatology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China Department of Plastic Surgery The University of Texas M. D. Anderson Cancer Center Houston Texas USA Department of Orthodontics, College of Stomatology, Hebei Medical University & Key Laboratory of Stomatology, Hebei Province, Shijiazhuang 050017, China. From the Department of Cardiothoracic and Vascular Surgery, University Hospital Ulm, Ulm, Germany. Pacific Northwest National Laboratory, Richland, Washington 99354, United States Department of Orthopedic Trauma, Weifang People’s Hospital, Weifang 261041, Shandong, China College of Chemistry, Taiyuan University of Technology, Taiyuan 030024, Shanxi, P. R. China Department of Pathology, Harvard Medical School, Beth Israel Hospital, Boston, MA 02215, USA. Department of Radiation Oncology, The First Affiliated Hospital of Xiamen University, Xiamen, China Key Laboratory of Standardization of Chinese Medicines of Ministry of Education, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Department of Pharmaceutical Sciences, The University of Michigan, Ann Arbor, MI 48109, USA Genomics Institute of Novartis Research Foundation, San Diego, CA 92121 Department of Materials Science and Engineering, University of California Los Angeles, Los Angeles, California 90095, United States National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Sciences Chinese Academy of Agricultural Sciences (CAAS) Beijing China Agro‐biological Gene Research Center Guangdong Academy of Agricultural Sciences Guangzhou 510640 China Fundamental Science on Radioactive Geology and Exploration Technology Laboratory, East China University of Technology, Nanchang 330013, China; School of Geophysics and Measure Control Technology, East China University of Technology, Nanchang 330013, China Psychosomatic Ward, Wuhan Mental Health Center, Wuhan Hospital for Psychotherapy, 430000 Wuhan, Hubei, China. Department of Neurology Sun Yat‐Sen Memorial Hospital Sun Yat‐Sen University Guangzhou China Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China. TripleSAI Technology, Shenzhen, China State Key Laboratory of Fine Chemicals, Department of Materials Science and Chemical Engineering, School of Chemical Engineering, Dalian University of Technology, 158 Zhongshan Road, Dalian 116012, P. R. China, and Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Singapore State Key Laboratory of Microbial Technology Shandong University 27 Binhai Road 266237 Qingdao China University of Illinois 2 Department of Materials Science and Engineering, and Frederick-Seitz Materials Research Laboratory, , Urbana, Illinois 61801, USA School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, Liaoning 110016, P. R. China Department of Orthopaedics, People's Hospital of Tianjin, P.R. China. Department of Laboratory Medicine, Wuxi Fifth People's Hospital, Wuxi City, 214000 Jiangsu Province, China Naoki Niikura, Jun Liu, Naoki Hayashi, Elizabeth A. Mittendorf, Yun Gong, Shana L. Palla, Ana M. Gonzalez-Angulo, Gabriel N. Hortobagyi, and Naoto T. Ueno, The University of Texas MD Anderson Cancer Center, Houston, TX; and Naoki Niikura and Yutaka Tokuda, Tokai University School of Medicine, Kanagawa, Japan. Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China. Department of Neuro Surgery, Jining No.1 People’s Hospital of Jining City Shandong Province, Jining City 272000, Shandong Province, China Department of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guanzhou, Guangdong, China Key Lab of Advanced Energy Materials Chemistry (Ministry of Education) Renewable Energy Conversion and Storage Center College of Chemistry Nankai University Weijin Rd. 94 Tianjin 300071 China Department of Orthopedics, General Hospital of Northern Theater Command of Chinese PLA College of Resources and Environments, Southwest University, Chongqing 400715, China. liulove_jun@126.com Department of Cardiothoracic Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530000, China Jiangsu Center for Drug Screening China Pharmaceutical University Nanjing 21009 China Departments of Nephrology The Third Xiangya Hospital Central South University Changsha Hunan Province China MC 136-93, Department of Chemical Engineering, California Institute of Technology, Pasadena, California 91125, and Division of Immunology, Beckman Research Institute of the City of Hope, 1500 East Duarte Road, Duarte, California 91010 Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Houston, Texas, USA. Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China National Key Laboratory for Electronic Measurement Technology, North University of China, Taiyuan 030051, China; Key Laboratory of Instrumentation Science and Dynamic Measurement, North University of China, Ministry of Education, Taiyuan 030051, China Institute of Life Science and Biotechnology, College of Chemistry & Chemical Engineering, Hunan University, 410082, Changsha, China Department of Medical Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China Department of Medical Oncology, Fujian Medical University Cancer Hospital and Fujian Cancer Hospital, Fuzhou, Fujian Province, China Department of Cardiac Surgery People's Hospital of Xinjiang Uygur Autonomous Region Urumqi Xinjiang China Department of Thoracic Surgery The First Affiliated Hospital of Guangzhou Medical University Guangzhou China; State Key Lab of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou China Pacific Northwest National Laboratory, Richland, Washington 99352, United States Institute of Ageing Research Hangzhou Normal University School of Medicine Hangzhou China Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, China d Departments of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston Texas, USA; Department of Orthopaedics Center, Lanzhou General Hospital of PLA, Lanzhou 730050, China. Department of Otolaryngology-Head & Neck Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 Zhejiang Province P. R. China Clinical Research Center for Medical Imaging in Hunan Province, Department of Radiology Quality Control Center in Hunan Province, Department of Radiology The Second Xiangya Hospital of Central South University Changsha Hunan China School of Materials Science and Engineering Guangdong Provincial Key Laboratory of Advanced Energy Storage Materials South China University of Technology Guangzhou 510640 China State Key Laboratory of Dynamic Measurement Technology, Shanxi Province Key Laboratory of Quantum Sensing and Precision Measurement, North University of China , Taiyuan 030051, China Department of Plastic Surgery, MD Anderson Cancer Center, University of Texas, Houston, Tex. Institute of Human Virology Zhongshan School of Medicine Sun Yat‐sen University Guangzhou Guangdong China; Key Laboratory of Tropical Disease Control of Ministry of Education Zhongshan School of Medicine Sun Yat‐sen University Guangzhou Guangdong China International Center for Bamboo and Rattan, Key Laboratory of Bamboo and Rattan Science and Technology, State Forestry and Grassland Administration, Beijing 100102, China Xiangya Hospital Central South University Changsha China; Molecular Science and Biomedicine Laboratory Hunan University Changsha China; State Key Laboratory for Chemo/Bio‐Sensing and Chemometrics Hunan University Changsha China; College of Chemistry and Chemical Engineering Hunan University Changsha China; College of Biology Hunan University Changsha China Department of Cardiovascular Ultrasound and Non‐invasive Cardiology Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital Chengdu Sichuan China CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, MA, USA Suncor AgroScience, 2489 North Sheridan Way, Mississauga, Ontario, CanadaL5K 1A8 Department of Hematology Oncology Chongqing University Cancer Hospital, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Chongqing China Department of Medical Genetics and Microbiology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada Department of Spine and Spinal Cord Surgery, Orthopaedics Hospital of Wendeng, Weihai 264400, Shandong, China. State Key Laboratory of Genetic EngineeringSchool of Life Science, Fudan University 200438 Shanghai China; Department of Molecular GeneticsFaculty of Medicine, University of Toronto M5G 1M1 Toronto ON Canada Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Medical Oncology, Changzheng Hospital, Shanghai, People's Republic of China National Engineering Lab for TFT-LCD Materials and Technologies, and Department of Electronic Engineering, Shanghai Jiao Tong University, Shanghai 200240, People’s Republic of China Institute of Functional Nano and Soft Materials (FUNSOM) Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Soochow University 199 Ren'ai Road Suzhou Jiangsu 215123 P. R. China Institute of Nuclear Physics and Chemistry, CAEP, Mianyang, Sichuan 621900, China State Key Laboratory of Environmental Chemistry and Eco-toxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China Department of Biochemistry and Molecular Biology Mayo Clinic College of Medicine and Science Rochester Minnesota USA; Division of Endocrinology Mayo Clinic College of Medicine and Science Rochester Minnesota USA Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta T6G 2 V4, Canada Department of Chemotherapy Affiliated Hospital of Nantong University China Institute of Fluid Physics Laboratory for Shock Waves and Detonation Physics Research, , P.O. Box 919-109, Mianyang, Sichuan 621900, People’s Republic of China School of Materials and Energy Guangdong University of Technology Guangzhou 510006 P. R. China Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL, 60637, USA. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences Beijing 100700, China. State Key Laboratory of Plant Genomics, Institute of Microbiology Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences; Zhangjiang Laboratory Guangdong Provincial Key Laboratory of Advanced Energy Storage Materials School of Materials Science and Engineering South China University of Technology Guangzhou 510641 P. R. China; SUNWODA-SCUT Joint Laboratory for Advanced Energy Storage Technology South China University of Technology Guangzhou 510641 P. R. China Department of Otolaryngology-Head and Neck Surgery, Central Hospital of Enshi Prefecture, Enshi 445000, China. dalia00589@163.com International Ocular Surface Research Center, Institute of Ophthalmology, and Jinan University Medical School, Guangzhou, China Department of Radiology, Second Xiangya Hosipital, Central South University, Changsha 410011, Hunan Province, China ; School of Public Administration, Central South University, Changsha 410083, Hunan Province, China. State Key Laboratory of Intense Pulsed Radiation Simulation and Effect; Northwest Institute of Nuclear Technology; Xi'an 710024; China Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas. Energy and Environment Directorate Pacific Northwest National Laboratory 902 Battelle Boulevard Richland WA 99352 USA Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea; Center for Medical Innovation, Seoul National University Hospital, Seoul, Republic of Korea Department of Orthopaedics, Tianjin Medical University General Hospital, Tianjin, P. R. China Department of Neurosurgery, The Second Affiliated Hospital of Wannan Medical College, Wuhu 241000, Anhui, China Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin 300350, China Department of General Surgery, Sichuan Mianyang 404 Hospital Mianyang 621000, Sichuan Province, China. Department of Orthopedics, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China (mainland) Department of orthopaedics, People's Hospital of Tianjin, PR China. Pacific Northwest National Laboratory Richland, Washington 99352 Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Department of Hematology/Hematological Lab The Second Hospital of Anhui Medical University Hefei China b Departments of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Department of Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China (mainland) Key Laboratory of Forest Ecology and Management Institute of Applied Ecology Chinese Academy of Sciences Shenyang 110016 China; University of Chinese Academy of Sciences Beijing 100049 China Department of Epidemiology Dalian Medical University Dalian China Zhejiang Provincial Key Laboratory of Laser Processing Robotics, College of Mechanical & Electrical Engineering, Wenzhou University, Wenzhou 325035, China Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials; Beijing University of Chemical Technology; Beijing 100029, P. R. China China Jiliang University, Zhejiang Provincial Key Laboratory of Biometrology and Inspection & Quarantine; College of Innovation, Hangzhou, China Assistant Professor, Department of Radiation, The Second Xiangya Hospital, Central South University Changsha, Hunan, China Department of HIV/AIDS, The Third People’s Hospital of Kunming, Kunming, China Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China, 510080; Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou, Guangdong, China, 510080 Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China Department of Orthopaedics The Second Affiliated Hospital of Nanjing Medical University Nanjing China Department of Traditional Chinese Medicine, Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai China University of California, San Francisco Department of Pharmaceutical Chemistry San Francisco CA 94158 USA Key Laboratory of Microsystems and Microstructures Manufacturing (Ministry of Education), School of Medicine and Health, Harbin Institute of Technology, No. 92 XiDaZhi Street, Harbin, 150001, China Department of Neurosurgery, Jiujiang First People's Hospital, Jiujiang Jiangxi 332000, China. MOE Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China The Key State Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Diseases, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, Guangdong Province, China Advanced Ultrafast Laser Research Center, University of Electro-Communications, Chofugaoka 1-5-1, Chofu, Tokyo 182-8585 Japan; State Key Laboratory of High Field Laser Physics, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800, China; Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan National Key Laboratory for Electronic Measurement Technology, School of Instrument and Electronics, North University of China , Taiyuan 030051, People’s Republic of China Department of Physiology, Pharmacology, Metabolism and Cardiovascular Sciences, University of Toledo College of Medicine, Toledo, Ohio 43614 Department of Hematology/Hematological Lab School of Basic Medicine and Clinical Pharmacy, State Key Laboratory of Natural Medicines China Pharmaceutical University Nanjing China Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China; Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, People's Republic of China. Cardio-Cerebrovascular Control and Research Center, Shandong Academy of Medical Sciences, Jinan 250062, China. Department of Cell Biology, Southern Medical University, Guangzhou 510515, China. Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI 53226. Department of Orthopedic Surgery, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, People’s Republic of China CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing 100101, People's Republic of China; China-Japan Joint Laboratory of Molecular Immunology and Molecular Microbiology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China; College of Life Sciences, Graduate University, Chinese Academy of Sciences, Beijing 100049, People's Republic of China Department of Joint Surgery, Tianjin Hospital, Tianjin, 300211, PR China Department of Otolaryngology Head & Neck Surgery, Otorhinolaryngological Institute, Genetic Testing Center for Deafness, General Hospital of Chinese People's Liberation Army, Beijing 100853, China. Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada M5S 3G8 Department of Thoracic Surgery, The First People's Hospital of Yunnan Province, Kunming, Yunnan 650032, P.R. China School of Materials Science and Engineering and Guangdong Provincial Key Laboratory of Advanced Energy Storage Materials, South China University of Technology, Guangzhou, 510641, P. R. China; China-Australia Joint Laboratory for Energy & Environmental Materials, South China University of Technology, Guangzhou, 510641, P. R. China Key Laboratory of Animal Biotechnology of the Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine Northwest A&F University Yangling China aDepartment of Biochemistry, University of Missouri-Columbia, Columbia, Missouri 65212 Military Joint Teaching and Research Office, the 32684 Troop of Chinese PLA, Shenyang, China. Department of Plastic and Reconstructive Surgery, University of Texas M. D. Anderson Cancer Center School of Biological Sciences, Nanyang Technological University, Singapore *State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, People's Republic of China; Department of Cardiology, Tianjin Beichen Hospital, Tianjin, China Department of Orthopedic, Shaanxi Provincial People's Hospital Department of Neurology & Institute of Neurology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Neonatology, General Hospital of Northern Theater Command, Shenyang, P.R. China; Post-graduate College, China Medical University, Shenyang, P.R. China Department of Urology, The Second Affiliated Hospital of University of South China, Hengyang, Hunan 421001, P.R. China Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, 1 Gustave Levy Place, New York, New York 10029, United States Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Hongkou, Shanghai 200080, P.R. China Key Laboratory of Instrumentation Science and Dynamic Measurement, School of Instrument and Electronics, North University of China 1 , Taiyuan 030051, China Orthopedics, The Fifth Clinical Medical College of Henan University of Chinese Medicine (Zhengzhou People's Hospital), Zhengzhou, Henan, China. Department of General Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, China Navigation College, Dalian Maritime University, Dalian, China Department of Critical Care Medicine The Fifth Affiliated Hospital (Zhuhai) of Zunyi Medical University Zhuhai People's Republic of China; Department of Emergency The Fifth Affiliated Hospital (Zhuhai) of Zunyi Medical University Zhuhai People's Republic of China Fujian Provincial Key Laboratory for Coastal Ecology and Environmental Studies, Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, College of the Environment and Ecology, Xiamen University, Xiamen 361005, China Department of Biochemistry and Molecular Biology, State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China. Institute of Military Veterinary Science, The Academy of Military Medical Science of PLA, Changchun, China. Energy and Environmental Directorate, Pacific Northwest National Laboratory, 902 Battelle Boulevard, Richland, Washington 99354, United States Department of Laboratory Animal Science, School of Basic Medical Sciences, Xi’an Jiaotong University, Xi’an, People’s Republic of China; Cardiometabolic Innovation Center, Ministry of Education, Xi'an, People’s Republic of China College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China. mailtoliujun@yahoo.com.cn Department of Biochemistry and Molecular Biology, State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College Department of General Surgery, Wuhan Third Hospital, Wuhan, Hubei, China Radiology, Guangdong Provincial Key Laboratory of Advanced Energy Storage Materials School of Materials Science and Engineering South China University of Technology Guangzhou 510641 P. R. China; Guangdong Provincial Key Laboratory of Functional Soft Condensed Matter Smart Energy Research Centre School of Materials and Energy Guangdong University of Technology Guangzhou 510000 P. R. China Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853 Center for Drug Discovery, College of Pharmacy, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, People’s Republic of China, and Jiangsu Center for Drug Screening, China Pharmaceutical University, 1 Shennonglu, Nanjing 210038, People’s Republic of China Department of Radiology, the Second Xiangya Hosipital, Central South University, Changsha 410011, Hunan Province, China ; School of Public Administration, Central South University, Changsha 410011, Hunan Province, China. Key Laboratory of Potato Biology and Biotechnology Ministry of Agriculture and Rural Affairs Huazhong Agricultural University Wuhan Hubei 430070 China; Potato Engineering and Technology Research Center of Hubei Province Huazhong Agricultural University Wuhan Hubei 430070 China Harvard Medical School Boston MA USA Department of Neurosurgery Yale School of Medicine New Haven CT 06520 USA Department of Civil, Construction and Environmental Engineering, The University of Alabama, Tuscaloosa, AL, USA Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang Junhong Pharmaceutical Technology Co., Ltd, Shenyang, China Department of Molecular Biology and Genetics, 439 Biotechnology Building, Cornell University, Ithaca, NY 14853; Department of Cell Biology, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205; and Department of Genetics, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel Department of Stomatology Medical Center, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China. State Key Laboratory of Organ Failure Research Guangdong Provincial Key Laboratory of Gastroenterology Department of Gastroenterology Nanfang Hospital Southern Medical University Guangzhou Guangdong China; Department of Gastroenterology Liuzhou Worker's Hospital Liuzhou China Institute of Human Virology Key Laboratory of Tropical Disease Control of Ministry Education Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology Zhongshan School of Medicine Sun Yat‐sen University Guangzhou China Department of Plant Sciences, University of Saskatchewan , Saskatoon, SK , Canada Institute of Military Veterinary Science the Academy of Military Medical Science of PLA Changchun China Department of Laboratory Medicine, The Fifth People's Hospital of Wuxi, Wuxi, Jiangsu 214005, P.R. China Department of Radiology The Second Xiangya Hospital of Central South University Changsha China; Department of Radiology Quality Control Center Changsha China; Clinical Research Center for Medical Imaging in Hunan Province Changsha China Guangzhou Institute of Respiratory Diseases, Guangzhou Medical College, Guangzhou 510120, China. liujun9707@tom.com Pacific Northwest National Laboratory, 902 Battelle Boulevard P.O. Box 999, Richland, Washington 99352 Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, 388 Lumo Road, Wuhan 430074, China Department of Respiratory Diseases I Beijing Children's Hospital, Capital Medical University, National Clinical Research Center for Respiratory Diseases, National Center for Children's Health Beijing China Department of Laboratory Medicine, The Fifth People's Hospital of Wuxi Affiliated to Jiangnan University, Wuxi, Jiangsu 214005, P.R. China Department of Gastroenterology, Longgang People's Hospital, Shenzhen, Guangdong 518172, P.R. China School of Materials Science and Engineering, Central South University, Changsha, Hunan 410083, China Division of Pharmacoepidemiology and Pharmacoeconomics Brigham and Women's Hospital Boston MA USA Pacific Northwest National Laboratory Richland WA 99352 USA Department of Neurology and Institute of Neurology Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China; Clinical Neuroscience Center Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China Energy Processes and Materials Division; Energy and Environment Directorate Pacific Northwest National Laboratory; Richland; USA Institute of Vegetable Crops, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China; Laboratory for Horticultural Crop Genetic Improvement, Nanjing 210014, China Department of Pediatrics the People Hospital of Bozhou Anhui China Department of Patholoy, Kennedy University Hospital, Cherry Hill, NJ, USA. School of Tourism, Sichuan University, 610064 Chengdu, China State Key Laboratory of Advanced Electromagnetic Engineering and Technology, Huazhong University of Science and Technology , Wuhan, Hubei 430074, China Pacific Northwest National Laboratory, 902 Battelle Boulevard P.O. Box 999, Richland, Washington 99352, United States Columbia College of Physicians and Surgeons and New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032; and Department of Molecular and Cellular Biochemistry and the Lucille Markey Cancer Center University of Kentucky College of Medicine 741 S. Limestone Lexington KY 40536 USA Division of Pharmacoepidemiology and PharmacoeconomicsBrigham and Women's HospitalBostonMAUSA State Key Laboratory of Agricultural Microbiology, State Environmental Protection Key Laboratory of Soil Health and Green Remediation, College of Resources and Environment, Huazhong Agricultural University, Wuhan, People’s Republic of China Institute of Molecular Biophysics, Florida State University, Chieftain Way, Tallahassee, FL 32306; Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, USA Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China State Key Laboratory of Environmental Chemistry and Eco-toxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China State Key Laboratory of Biocontrol and Key Laboratory of Biodiversity Dynamics and Conservation of Guangdong Higher Education Institutes, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, PR China Department of Chemistry; Tongji University; Shanghai, P. R. China Department of Neurosurgery, The First Affiliated Hospital of Wannan Medical College, Wuhu 241001, Anhui, People’s Republic of China *Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China; Department of Orthopaedics, Daping Hospital, Army Medical University, Chongqing, China. Institute of Batteries, School of Materials and Energy, Guangdong University of Technology, Guangzhou 510006, China Department of Plastic Surgery The University of Texas MD Anderson Cancer Center Houston Texas USA Department of Orthopedic Shaanxi Provincial People's Hospital Xi'an China; Xi'an Medical University Xi'an China University of Leicester Department of Chemistry, , University Road, Leicester LE1 7RH, United Kingdom From the Department of Surgery, Division of Plastic Surgery, Pennsylvania State University, College of Medicine; and the Departments of Plastic Surgery and Diagnostic Radiology, M. D. Anderson Cancer Center, University of Texas. Department of Internal Medicine and Physiology, Life Science Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109 Department of Immunology, School of Basic Medical Sciences, Fudan University , Shanghai , China Key Laboratory of Food Bioengineering (China National Light Industry), College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China State Key Laboratory of Optoelectronic Materials and Technologies; School of Physics & Engineering; Sun Yat-sen University; Guangzhou 510275, P. R. China College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, P. R. China Institute of Deep‐Sea Science and Engineering Chinese Academy of Sciences Sanya China Department of Plastic & Reconstructive Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Department of Epidemiology, Beijing An Zhen Hospital, Capital Medical University; Beijing Institute of Heart, Lung and Blood Vessel Diseases; The Key Laboratory of Remodeling-related Cardiovascular Diseases, Ministry of Education; Beijing Municipal Key Laboratory of Clinical Epidemiology Department of Radiation Oncology Shanghai Chest Hospital, Shanghai Jiaotong University Shanghai People's Republic of China Department of Center for Clinical and Epidemiologic Research, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases. The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing Municipal Key Laboratory of Clinical Epidemiology, China. Centre of Liver Transplantation, Guangzhou General Hospital of Chinese PLA, Guangzhou, China Longhua Affiliated Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China; Department of Gastroenterology, China–Canada Center of Research for Digestive Diseases, Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials; Beijing University of Chemical Technology; Beijing 100029; P. R. China Stem Cells and Genome Editing, Genomics and Cellular Sciences, Agriculture Victoria Research, Bundoora, VIC, Australia. jun.liu@agriculture.vic.gov.au. Institute of Military Veterinary, AMMS, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, China; Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai 200032, China. Department of Orthopaedics, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China From the Departments of Plastic Surgery and Breast Surgical Oncology, Division of Surgery, the Department of Radiation Oncology, Division of Radiation Oncology, the Department of Breast Medical Oncology, and the Health Services Research Department, University of Texas M. D. Anderson Cancer Center. Urology and Lithotripsy Center, Peking University People's Hospital, Beijing, China.; Peking University Applied Lithotripsy Institute, Beijing, China. Department of Integrative Medicine, Zhongshan Hospital, Fudan University, Shanghai, China Department of Biochemistry and Molecular Biology,; HEALth Program, and; Division of Endocrinology, Mayo Clinic in Arizona, Scottsdale, Arizona; and Department of Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, U.S.A. Department of Chemistry, Northeast Normal University, Changchun Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China Department of Cardiac Surgery, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, Guangdong, China Department of Otorhinolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University Chengdu, Sichuan, PR China. Department of General Surgery, The Jiang Bei People's Hospital of Nanjing, Nanjing 210048, China State Key Laboratory of Biocontrol and Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, 510275 Guangzhou, People’s Republic of China Section of Digestive Diseases, Department of Medicine, Yale University School of Medicine, New Haven, CT; Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, North Carolina 27695, United States Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials Beijing University of Chemical Technology Beijing 100029 China Department of Mathematics and Statistics, Southern Illinois University Edwardsville, Edwardsville, IL 62026, USA Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Dongzhimennei, Beijing 100700, China Department of Preventive Medicine Laboratory, School of Public Health, Zunyi Medical University, Zunyi, China Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario M5S 1A8 College of Health Science, Hubei Provincial Collaborative Innovation Center for Exercise and Health Promotion Wuhan Sports University Wuhan China Center for Arrhythmia Diagnosis and Treatment, Fu Wai Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China. Department of Liver Transplantation and Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong, China; Department of Liver Transplantation and Hepatobiliary Surgery, Shandong Provincial Hospital, Shandong University, Shandong, China The Central Hospital of Wuhan, Wuhan, China From the Department of Medicine (H.J., W.Z., X.W., J.L., C.M.E., K.S.) and Center for the Study of Sex Differences in Health, Aging, and Disease (H.J., W.Z., X.W., J.L., C.M.E., K.S.), Georgetown University, Washington, DC; Department of Physiological Science and Laboratory of Neuroendocrinology (R.W., A.P.A.), Brain Research Institute, University of California, Los Angeles, Calif. Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA. Department of Radiation Oncology, Cancer Center, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Houston, Texas, USA Department of Critical Care Medicine, Nanjing Zhong-Da Hospital, Southeast University School of Medicine, Nanjing 210009, PR China. Cryobiology Research Institute, Wells Research Center, Indiana University Medical School, Indianapolis, IN 46202 Real-World Solutions, IQVIA China, Shanghai 200041, China Department of Hepatobiliary Surgery, Zhujiang Hospital; Southern Medical University; Guangzhou 510282 Guangdong People's Republic of China Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, China; State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, Guangzhou, China Key Laboratory of Instrumentation and Science and Dynamic Measurement, Ministry of Education, School of Instrument and Electronics, North University of China , Taiyuan 030051, People’s Republic of China Center of Electron Microscopy, State Key Laboratory of Silicon Materials, Department of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China Departments of Pediatrics Nuerosury & Neurodegenerative Diseases and Aging Sun Yat‐Sen Memorial Hospital Sun Yat‐Sen University Guangdong China State Key Laboratory of Food Science and Technology, Key Laboratory of Industrial Biotechnology, Ministry of Education, Wuxi, Jiangsu, China; Synergetic Innovation Center of Food Safety and Nutrition, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China From the Departments of Anesthesiology and Plastic Surgery, University of Texas M. D. Anderson Cancer Center. College of Chemistry and Materials Engineering; Hunan University of Arts and Science; Changde 415000; P. R. China 1Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA Hebei Academy of Forestry and Grassland Sciences, Shijiazhuang 050061, China State Key Laboratory of Plant Genomics, Institute of Microbiology Chinese Academy of Sciences Beijing 100101 China; CAS Center for Excellence in Biotic Interactions University of Chinese Academy of Sciences Beijing 100049 China School of Biology and Pharmaceutical Engineering Wuhan Polytechnic University Wuhan 430023 China Department of Biochemistry, Molecular and Cellular Biology, Georgetown University Medical Center, Washington, D.C. 20007 b Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Key Laboratory of Bio‐Inspired Smart Interfacial Science and Technology of Ministry of Education School of Chemistry Beihang University Beijing 100191 P. R. China The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease, Guangzhou, China Laboratory of Molecular Biology Disease Control and Prevention Center of PLA’s Southern Theatre Command Guangzhou China; Biotechnology Center, School of Pharmacy Air Force Medical University Xi’an China Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, P. R. China; Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, P. R. China Emergency Medicine, Putuo Hospital Affiliated to Shanghai Traditional Chinese Medicine University, Shanghai 200333, P.R. China Department of Geriatrics, Xiangya Hospital, Central South University, Changsha 410008, P.R. China Department of Liver Transplantation and Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China Division of Hormone ResearchDepartments of Cell Biology, Pharmacology and NeuroscienceGeorgetown University Medical CenterWashingtonDC20057 From the Departments of Epidemiology, Pathology, Thoracic and Cardiovascular Surgery, Radiation Oncology, Experimental Radiation Oncology, Experimental Therapeutics, GI Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX Nuffield Department of Population Health, University of Oxford, Oxford, UK; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands. Wuhan University of Science and Technology, College of Computer Science and Technology, Wuhan, ChinabHubei Province Key Laboratory of Intelligent Information Processing and Real-time Industrial System, Wuhan, China Department of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200025, China Center of Electron Microscopy and State Key Laboratory of Silicon Materials; School of Materials Science and Engineering; Zhejiang University; Hangzhou 310027; China Key Laboratory of Cancer, Prevention and Therapy National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute & Hospital Tianjin China; Key Laboratory of Breast Cancer Prevention and Therapy Tianjin's Clinical Research Center for Cancer, Tianjin Medical University, Ministry of Education Tianjin China; Second Department of Breast Cancer Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Houston, TX 77030; Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials, State Key Laboratory of Organic−Inorganic Composites, Beijing University of Chemical Technology, Beijing, 100029, China Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China Department of Histology and Embryology, Southern Medical University, Guangzhou 510515, China. Department of Medicinal Chemistry UF Health Science Center UF Health Cancer Center University of Florida 1345 Center Dr. Gainesville FL 32610 USA; Department of Chemistry and Chemical Biology UNM Comprehensive Cancer Center University of New Mexico 300 Terrace St. NE Albuquerque NM 87131 USA Department of Epidemiology, Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China Department of Anesthesiology , The Third Affiliated Hospital , Sun Yat-sen University , Guangzhou , China Late Stage Pharamaceutical and Processing Development, Genentech. Department of Cardiology, Guangdong Second Provincial General Hospital, Guangzhou 510317, China From the Singapore Eye Research Institute, Singapore, Rep. of Singapore; Department of Critical Care Medicine, Nanjing Zhongda Hospital and School of Medicine, Southeast University, Nanjing 210009, China. Department of Medicinal Chemistry, College of Pharmacy, UF Health Science Center, UF Health Cancer Center, University of Florida, Gainesville, Florida 32610, United States Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease , Guangzhou, China Center of Electron Microscopy, State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, 38 Zhe Da Road, Hangzhou, Zhejiang 310027, China Department of Gastroenterology Clinical Medical College, Yangzhou University, Northern Jiangsu People's Hospital Yangzhou China Department of Health Sciences National Natural Science Foundation of China Beijing 100085 P. R. China; Department of Thoracic Surgery Zhongnan Hospital of Wuhan University Wuhan Hubei 430000 P. R. China Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated with Shanghai Jiaotong University School of Medicine , Shanghai , China Department of Endocrinology Shanghai Fifth People's Hospital Fudan University Shanghai China Genentech, Inc., 1 DNA Way, MS 56-2A, South San Francisco, California 94080, United States Department of Epidemiology, Beijing Anzhen Hospital affiliated to the Capital University of Medical Science, Beijing, China. Department of Thoracic and Cardiovascular Diseases First Affiliated Hospital of Guangxi Medical University Nanning China Department of Ultrasound in Medicine Sichuan Provincial People's Hospital Chengdu China Department of Spine Surgery, Affiliated Hospital of Yan’an University, Yan’an, China. Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, Jilin, China Pacific Northwest National Laboratory; Richland, USA Department of Obstetrics and Gynecology, Beijing Chaoyang Hospital, Capital University of Medical Sciences, Beijing 100020, China. Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha, Hunan Province, China Liverna Therapeutics Inc., Zhuhai 519000, China Department of Cardiology, Peking University People's Hospital Beijing, China. Beijing Key Laboratory of Early Prediction and Intervention of Acute Myocardial Infarction, Peking University People's Hospital Beijing, China. Center for Cardiovascular Translational Research, Peking University People's Hospital Beijing, China. College of Chemistry and Chemical Engineering Central South University 410083 Changsha China 1 Laboratory of Plant Molecular Biology, Rockefeller University, New York, NY 10065, USA and 2School of Computing, National University of Singapore, 117417 Singapore Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan 523808, China Departments of Pathology and Materials Science & Engineering, University of Washington School of Medicine, Seattle, Washington 98104 Department of Plastic Surgery, Division of Surgery, University of Texas M. D. Anderson Cancer Center, Houston, Texas Department of Epidemiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, People’s Republic of China; Graduate School of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China *Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;; ‖Chinese Center for Disease Control and Prevention, Beijing 102206, China Department of Radiation Oncology Shanghai Chest Hospital, Shanghai Jiaotong University Shanghai China Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S 1A8 Department of Cardiothoracic Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China People’s Hospital of NanJiang, Bazhong, China Department of Microbial Pathogenesis, Yale University, School of Medicine, New Haven, Connecticut, USA; Microbial Sciences Institute, Yale University, School of Medicine, New Haven, Connecticut, USA Department of Clinical Laboratory, Dongguan Hospital of Guangzhou University of Chinese Medicine, Dongguan 523005, China; Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, Shantou 515000, China Center for Drug Discovery, College of Pharmacy, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, People's Republic of China, Jiangsu Center for Drug Screening, China Pharmaceutical University, 1 Shennonglu, Nanjing 210038, People's Republic of China, and Laboratoire de Photophysique et Photochimie Supramoléculaires et Macromoléculaires, CNRS UMR 8531, Ecole Normale Supérieure de Cachan, 61 Avenue du Pt Wilson, F-94235 Cachan, France Department of Infectious Disease, Tianjin First Center Hospital, Tianjin, China State Key Laboratory of Freshwater Ecology and Biotechnology, Wuhan Center for Developmental Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China. Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, China; College of Earth and Planetary Sciences, University of Chinese Academy of Sciences, Beijing, China; CAS Center for Excellence in Life and Paleoenvironment, Beijing, China Department of Ophthalmology, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, China The Fifth People's Hospital of Datong Datong 037056, Shanxi, China. Department of Radiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China. Department of Polymer Material Science, Dalian University of Technology, Dalian 116024, People’s Republic of China College of Pharmacy, Jinan University, Guangzhou 510632, P. R. China From the Division of Pharmacoepidemiology and Pharmacoeconomics (J.J.J., H.K., L.A.W., C.-Y.C., J.L., J.D.S., A.T.R., S.S.), Division of Cardiovascular Medicine (M.D.G.-H.), and Division of Vascular and Endovascular Surgery (L.L.N.), Brigham and Women’s Hospital, Harvard Medical School, Boston, MA; Division of Consulting and Analytics, LASER Analytica, New York, NY (J.J.J.); Division of Cardiovascular Medicine, Massachusetts General Hospital, Boston (M.R.J.); Division of Vascular and Endovascular... State Key Laboratory of Oral Diseases, West China College of Stomatology, West China Hospital of Stomatology, Sichuan University, Chengdu, China Department of Chemical Engineering, ‡Department of Civil and Environmental Engineering, University of Virginia, Charlottesville, Virginia 22904, United States Institute of Animal Science, The Academy of Military Medical Science, Changchun 130062, China. Department of Cardiac Surgery, Shanghai East Hospital Tongji University Shanghai China Urology Department Tianjin Hospital Tianjin People's Republic of China Biomaterials and Tissue Engineering Division, Department of Endodontics, Prosthodontics and Operative Dentistry, University of Maryland Dental School, Baltimore, Maryland.; State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, China. Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China College of Information Engineering Zhejiang University of Technology Hangzhou China Department of Pathology, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China. Center for Cell Signaling, University of Virginia School of Medicine, P.O. Box 800577, Charlottesville, VA 22908-0577; and Telethon Institute of Genetics and Medicine (TIGEM), Via P. Castellino 111, 80131 Naples, Italy 6Oncology Center, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China. Department of Cardiothoracic Surgery, The First Affiliated Hospital of Guangxi Medical University, No. 6, Shuangyong Road, Nanning, Guangxi Zhuang Autonomous Region, China 6 School of Computing and Mathematics, Faculty of Computing and Engineering, Ulster University, Jordanstown campus, Northern Ireland, UK Department of Gynecology, Jiangxi Provincial Maternal and Child Health Hospital, Nanchang, Jiangxi 330006, P.R. China Department of Orthopedics, Second Affiliated Hospital of the Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine; Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China. Department of Neurosurgery, Yale University, New Haven, Connecticut 06510, United States Department of Orthopedics, Municipal Peoples' Hospital, Tianjin 300121, China. Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China; Laboratory of RNA and Major Diseases of Brain and Heart, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China People's Hospital of Ningxia Hui Autonomous Region (Ningxia Medical University Affiliated People's Hospital of Autonomous Region) Yinchuan China Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, P.O. Box 603, Beijing 100190, China, Academy of Fundamental and Interdisciplinary Sciences, Harbin Institute of Technology, Harbin 150080, China, and Department of Physics, Xinjiang University, Urumchi 830046, China Energy and Environment Directorate Pacific Northwest National Laboratory 902 Battelle Boulevard. Richland Washington 99354 USA Department of Orthopaedics, the Second Affiliated Hospital of Nanjing Medical University, Nanjing 210000, Jiangsu, China. Institute of Chemical Biology and Pharmaceutical Chemistry, Zhejiang University, Hangzhou 310028, China Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands College of Veterinary Medicine, Northwest A&F University, Key Laboratory of Animal Reproductive Physiology & Embryo Technology, Ministry of Agriculture, Yangling, Shaanxi, People's Republic of China. †Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China; Department of Chemistry, Hebei University, Baoding 071002, China. State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China Department of General Surgery Affiliated People's Hospital of Jiangsu University Zhenjiang China Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong; Laboratory of RNA and Major Diseases of Brain and Heart, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong; Guangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong , China From the Department of Medicine and Center for the Study of Sex Differences in Health, Aging, and Disease (H.J., W.Z., X.L., J.L., X.W., J.G.U., K.S.) and Department of Pharmacology and Physiology and Center for Development of Radioligands (R.C.S.), Georgetown University, Washington, DC; Department of Experimental Pharmacology and Toxicology, School of Pharmaceutical Science, Jilin University, Changchun, Jilin, People’s Republic of China (X.L.); Biorepository and Biochemistry Laboratory, MedStar... Department of Digestive Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Liujun_99@126.com. Department of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Zhongshan Second Road 58, Guangzhou 510080, Guangdong, P. R. China National Engineering Lab for TFT-LCD Materials and Technologies, and Department of Electronic Engineering, and ‡School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, People’s Republic of China State Key Laboratory of Biocontrol, and School of Life Sciences, Sun Yat-sen University, Guangzhou, People’s Republic of China; Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, P. R. China Robley Rex VA Medical Center, Louisville, Kentucky; and Pulmonary Medicine, University of Louisville, Louisville, Kentucky Key Laboratory of Agro‐Microbial Resource and Development (Ministry of Agriculture) Huazhong Agricultural University Wuhan Hubei Province P.R. China; Institute of Applied Mycology Huazhong Agricultural University Wuhan Hubei Province P.R. China From Division of Cardiovascular Medicine, Saha Cardiovascular Research Center (B.X., G.Z., S.Y., R.Z., S.S.S., Z.L.), Department of Molecular and Cellular Biochemistry (S.Y., S.W.W.), and Markey Cancer Center (C.H.), University of Kentucky, Lexington; Department of Biochemistry and Molecular Biology, Mayo Clinic in Arizona, Scottsdale (J.L.); Department of Oncology (M.T.) and Jiangsu Institute of Hematology, Department of Hematology (C.R.), First Affiliated Hospital of Soochow University, Suzhou,... Department of Etiology, Fourth Military Medical University, Xi'an 710033, Shaanxi Province, China. etiology@fmmu.edu.cn Department of Rheumatology and Immunology The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China Changsha China Department of Oto-Rhino-Laryngology, West China Hospital, Sichuan University, Chengdu, China Department of Endocrinology Central South University Changsha China Tongji University; Chinese Academy of Sciences; University of Chinese Academy of Sciences a Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture , Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences , Haikou, 571101, China Department of Biochemistry and Harold C. Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038 Pathology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA. The Second Affiliated Hospital of Guangzhou University of TCM. liujun.tcm@163.com Department of Thoracic Oncology and Surgery China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease the First Affiliated Hospital of Guangzhou Medical University Guangzhou China Department of Cardiology, Zhengzhou University People’s Hospital, Zhengzhou, China State Key Laboratory of Precision Measurement Technology and Instruments, School of Precision Instruments and Opto-electronics Engineering, Tianjin University, No. 92 Weijin Road, Tianjin 300072, China School of Science; Chongqing University of Posts and Telecommunications; Chongqing 400065; China Biomedical Engineering Center, The Ohio State University, Columbus, OH 43210, USA Environmental Energy Technologies Division; Lawrence Berkeley National Laboratory; Berkeley; USA Department of Pediatric Surgery Jiaxing Maternal and Child Health Care Hospital, Affiliated Hospital of Jiaxing University Jiaxing China Department of Gastroenterology, Liuzhou Worker’s Hospital, Liuzhou 545005, China Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Orthopedics, General Hospital of Shenyang Military Area Command of Chinese PLA, Shenyang 110016, Liaoning Province, China. Department of Breast-Thyroid-Vascular Surgery, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine , Shanghai 201620, China Department of Environmental Science and Engineering, Tsinghua University, Beijing 100084, China. Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China (Y.Y., Y.L., L.S., A.D., T.H., J.Z., J.L., M.C., S.X., M.L., J.J., J.H.) The Second Affiliated Hospital University of South China Hengyang China High Magnetic Field Laboratory, Chinese Academy of Sciences, 230031 Hefei, Anhui, China; The National Key Facility for Crop Gene Resources and Genetic Improvement (NFCRI), Institute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing 100081, China Department of General Surgery, Qilu Hospital, Shandong University, Jinan 250012, China. dr_liujun@hotmail.com Laboratory of Plant Molecular Biology The Rockefeller University New York NY USA Department of Otolaryngology, Hospital of Traditional Chinese Medicine of Zhejiang Province, Hangzhou, 310006, China. Center of Advanced Elastomer Materials, Beijing University of Chemical Technology, Beijing 100029, China Department of Cardiothoracic and Vascular Surgery, University Hospital, Ulm, Germany Center for Drug Discovery, College of Pharmacy, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, China, Jiangsu Center for Drug Screening, China Pharmaceutical University, 1 Shennonglu, Nanjing 210038, China, Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, Athens 11635, Greece, and Organic Chemistry Laboratory, Department of Chemistry, University of Athens, Panepistimiopolis, Athens 15771, Greece Department of Materials Science and Engineering, University of California, Los Angeles, CA 90095, USA Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China Department of Gastroenterology, the Tenth Hospital, Tongji University Department of Plastic and Reconstructive Surgery, The University of Texas MD Anderson Cancer Center, Houston School of Biological Science and Medical Engineering, Beihang University, Beijing; and Agro‐biological Gene Research Center Guangdong Academy of Agricultural Sciences 510640 Guangzhou China School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, 212013, China Department of Medical Record Management, Shenzhen Maternal and Child HealthCare Hospital, Shenzhen, China Department of Chemistry, Northeast Normal University, Changchun, 130024, People's Republic of China Department of Ultrasound Ruijin Hospital, School of Medicine, Shanghai Jiaotong University Shanghai China Department of General Surgery, The First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China. liujum@yahoo.com.cn Microbial Sciences Institute, Yale University, West Haven, Connecticut, USA; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P.R. China Department of Chemistry and Biochemistry, University of Delaware, 136 Brown Laboratory, Newark, DE, 19716, USA. Hubei Key Lab of Novel Reactor & Green Chemical Technology, Wuhan Institute of Technology, Wuhan 430073, China. From the Department of Anesthesiology, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (K.S.L., B.T.B.); Department of Anesthesia, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada (K.S.L.; and) Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital, Har Shandong Yuwang Ecological Food Industry Co. Ltd Yucheng China Beijing Advanced Innovation Center for Food Nutrition and Human Health College of Food Science and Nutritional Engineering China Agricultural University Beijing 100083 China College of Forestry, Sichuan Agricultural University, Chengdu 611130, China Department of Orthopedics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shanxi 710061, P.R. China Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA; Microbial Sciences Institute, Yale University, West Haven, Connecticut, USA Energy Processes & Materials Division; Energy and Environmental Directorate; Richland; USA East China University of Science and Technology 2 Shanghai Key Laboratory of Functional Materials Chemistry and Institute of Fine Chemicals, , Meilong Road 130, Shanghai, China Department of Biomedical Engineering, Ohio State University, 140 W 19th Ave, Columbus, OH 43210 Biological Products Division, Bayer HealthCare LLC, Berkeley, CA 94701; State Key Laboratory of Pollution Control and Resources Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China Second Xiangya Hospital, Central South University, Quality Control Center, Changsha, China Guangzhou KingCreate Biotechnology Co., Ltd., Guangzhou, Guangdong, 510005, PR China Key Laboratory of Low Dimensional Materials & Application Technology, Ministry of Education, School of Materials Science and Engineering, Xiangtan University, Xiangtan 411105, China; Key Laboratory of Advanced Energy Storage Materials of Guangdong Province, School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China State Key Laboratory of Microbial Technology, Shandong University, Binhai Road 72, Qingdao 266237, China Preventive Medicine Experimental Teaching Center, Zunyi Medical University, Zunyi, Guizhou, China Neuroscience Program, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, Georgia.; Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia. Department of Pediatrics, Section of Gastroenterology and Hepatology Yale University School of Medicine New Haven CT USA Department of Medicine, Yale School of Medicine, New Haven, CT 06520; Department of Otorhinolaryngology Head and Neck Surgery, Central Hospital of Enshi, Enshi, 445000, China. dalia00589@163.com Department of Endocrinology, Shanghai Fifth People’s Hospital Affiliated to Fudan University, Shanghai, China (mainland) Beijing University of Chemical Technology 1 Division of Molecular and Materials Simulation, Key Laboratory for Nanomaterials, Ministry of Education, , Beijing 100029, People’s Republic of China; Beijing University of Chemical Technology 2 Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials, , Beijing 100029, People’s Republic of China The First Affiliated Hospital of Fujian Medical University, Fuzhou, China. The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou, Guangdong, People’s Republic of China National Key Facility for Crop Resources and Genetic Improvement; Institute of Crop Science, Chinese Academy of Agricultural Sciences; Beijing 100081 People's Republic of China Department of Pathology, North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China. Inner Mongolia Center for Endemic Disease Control and Research, Huhehot 010031, People's Republic of China Department of Otorhinolaryngology, Head and Neck Surgery West China Hospital, Sichuan University Chengdu China Department of Otorhinolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China Key Laboratory of Microsystems and Microstructures Manufacturing (Ministry of Education) School of Medicine and Health Harbin Institute of Technology No. 92 XiDaZhi Street Harbin 150001 P. R. China College of Plant Protection China Agricultural University Beijing China Department of Clinical Laboratory, Zhejiang Xiaoshan Hospital Hangzhou, Zhejiang 311201, China. From the Departments of Neurology (J.C.) and Department of Gastroenterology and Hepatology (D.S.), Zhongshan Hospital, Fudan University, Shanghai; Department of Gastroenterology and Hepatology (D.S.), Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen; Departments of Neurology (J.C., S.Z., Y.S., C.R.), Rehabilitation (F.Q., Y.Z.), and Radiology (J.L.), Shanghai Fifth People's Hospital, Fudan University; and Department of Neurology (C.R.), Shanghai East Hospital, Tongji University, China. Hubei Academy of Agricultural Sciences, 117996, Nanhu Road 18, Wuhan, Wuhan, Hubei , China, 430064; Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital Harvard Medical School Boston Massachusetts USA Shanghai Key Laboratory of Functional Materials Chemistry and Institute of Fine Chemicals, East China University of Science and Technology, Meilong Road 130, Shanghai 200237, China College of Life Sciences, China Jiliang University, Hangzhou, China. Pharmaceutical Sciences Division, School of Pharmacy University of Wisconsin, Madison (UW‐Madison) Madison WI 53705 USA; Wisconsin Center for NanoBioSystems University of Wisconsin, Madison (UW‐Madison) Madison WI 53705 USA; Carbone Cancer Center, School of Medicine and Public Health University of Wisconsin, Madison (UW‐Madison) Madison WI 53705 USA School of Computer Science and Technology, Wuhan University of Science and Technology, Wuhan 430065, China; Hubei Province Key Laboratory of Intelligent Information Processing and Real-Time Industrial System, Wuhan 430065, China National Engineering Laboratory for Deep Process of Rice and Byproducts, Hunan Key Laboratory of Grain-Oil Deep Process and Quality Control, Hunan Key Laboratory of Processed Food for Special Medical Purpose, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, Hunan 410004, China Department of Immunology and Rheumatology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China (mainland) College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, China. Advanced Micro and Nanosystems Laboratory, University of Toronto, Toronto, ON, Canada State Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University Nanjing 210096 China Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu Province, China. College of Agro-Grassland Science, Nanjing Agricultural University, Nanjing 210095, P.R. China Ningbo Hygeia Medical Technology Co., Ltd., No. 6 Jingyuan Road, High-Tech Zone, Ningbo 315040, China Traditional Chinese Medicine Department, The Fourth Hospital of Changsha, Changsha, Hunan, China Department of Genetics; Yale Stem Cell Center; Yale Cancer Center and Yale Center for RNA Science and Medicine; New Haven CT USA Shenzhen Maternity & Child Health HospitalShenzhen 518052, China; The Center of Allergy & Immunology, School of Medicine, Shenzhen UniversityShenzhen 518060, China. Department of Hepato-Pancreato-Biliary Surgery, Shandong Provincial Hospital, Shandong, 250000, China. Institute of Military Veterinary, Academy of Military Medical Sciences, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, China. Department of Orthopaedics, General Hospital of Lanzhou Command, Lanzhou 730050, China. Department of Magnetic Resonance Tianjin Union Medicine Centre People's Republic of China Department of Orthopaedics, Wuxi No.9 People’s Hospital Affiliated to Soochow University, Wuxi 214062, Jiangsu, China Authors' Affiliation: Department of Cell and Molecular Biology, Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People's Republic of China Department of Molecular Biology and Genetics, 439 Biotechnology Building, Cornell University, Ithaca, NY 14853, USA Nanchang University College of Civil and Architectural Engineering, Heilongjiang Institute of Technology, Harbin, Heilongjiang 150001, China Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China *CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, The People’s Republic of China;; ¶Graduate University of Chinese Academy of Sciences, Beijing 100049, The People’s Republic of China; Center for Metabolic and Vascular Biology, Mayo Clinic Arizona, Scottsdale, Arizona; and Genomics Institute of Novartis Research Foundation, San Diego, California, USA. Department of Cardiology, Renmin Hospital, Wuhan University School of Medicine, Wuhan, People's Republic of China. State Key Laboratory of Dynamic Measurement Technology, North University of China, Taiyuan 030051, China; School of Instrument and Electronics, North University of China, Taiyuan 030051, China Medical College of Qinghai University, Xining 810016, China. State Key Laboratory of Crop Gene Resources and Breeding, Institute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing 100081, China Department of Biochemistry and Molecular Biology, State Key Laboratory of Medical Molecular Biology, School of Basic Medicine, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing, China Department of Nephrology, Daping Hospital, Third Military Medical University, Chongqing, China; and; State Key Laboratory of Kidney Disease, Kidney Center of the People's Liberation Army, Chinese PLA General Hospital and Military Medical Postgraduate College, Beijing, China College of Pharmacy and Life Science University of South China Hengyang China Guangzhou University of Chinese Medicine Guangdong Provincial Academy of Chinese Medical Sciences Guangzhou China Shanghai Key Laboratory of Materials Protection and Advanced Materials in Electric Power, College of Environmental and Chemical Engineering, Shanghai University of Electric Power, Shanghai 200090, China; Interdisciplinary Research Centre, School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China Northwest Institute of Nuclear Technology Xi'an 710024 China First Affiliated Hospital of Fujian Medical University, Fuzhou, China.; Fujian Key Laboratory of Individualized Active Immunotherapy and Key Laboratory of Radiation Biology of Fujian Province Universities, Fuzhou, China. The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangzhou Institute of Respiratory Health (GIRH), Guangzhou, China; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Diseases, Guangzhou, China Department of Radiology, The Second XiangYa Hospital of Central South University, Changsha, Hunan 410011, P.R. China Clinical Laboratory, Yuebei People's Hospital Affiliated to Shantou University Medical College, Shaoguan, Guangdong Province, China MOEKLINNS Lab, Department of Computer Science and Technology, Xi'an Jiaotong University, 710049, China Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China. South China University of Technology School of Materials Science and Engineering No. 381, five mountain road, Tianhe District, Guangzhou 510641 Guangzhou CHINA Department of Radiology, Second Xiangya Hospital, Central South University, Changsha 410011, China. Department of Rheumatology and Immunology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China Department of Breast surgery, Sichuan Mianyang 404 Hospital, Mianyang, Sichuan Province, China Department of Microbial Pathogenesis, Microbial Sciences Institute, Yale University, West Haven, Connecticut, USA Department of Pathology Peking University Shenzhen Hospital Shenzhen Guangdong China Department of Neurosurgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; Ningbo Hygeia Medical Technology Co., Ltd., No. 6 Jinyuan Road, High-Tech Zone, Ningbo 315201, China Key Laboratory of Vegetation Ecology of Ministry of Education, Institute of Grassland Science, School of Environment, Northeast Normal University, Changchun, 130024 Jilin, China; Third Military Medical University, China From the Departments of Plastic Surgery, Hematopathology, and Lymphoma, University of Texas MD Anderson Cancer Center; and Hospital Santa Helena. Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai 200032, China. Department of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510700, P.R. China Cell Biology Program, the Hospital for Sick Children, Toronto, Ontario, Canada; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States Department of Chemistry, University of California, Berkeley, California 94720, Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, California 94720, Biological Products Division, Bayer HealthCare LLC, Berkeley, California 94701, Departments of Chemical Engineering and Bioengineering, University of California, Berkeley, California 94720, Physical Bioscience Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, Molecular... Qianyang Biomedical Research Institute, Guangzhou, Guangdong, China Massachusetts General Hospital, Harvard Medical School, Boston National Engineering Research Center for Biomaterials; Sichuan University; Chengdu 610064; China; State Key Laboratory of Bioelectronics Department of Medicine, University of Toronto, Toronto, Ontario, Canada School of Basic Sciences, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China Department of Biomedical Engineering, Ohio State University, 1080 Carmack Road, Columbus, OH 43210 Department of Nephrology, The Third Xiangya Hospital Central South University Changsha Hunan China Department of Otolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu 610064, China; Head and Neck Surgical Center, West China Hospital, Sichuan University, Chengdu 610064, China Department of Biology, Indiana University, Bloomington, Indiana, USA Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China Laboratory of RNA and Major Diseases of Brain and Heart, Sun Yat-sen Memorial Hospital, Sun Yat-sen University Guangzhou 510120, Guangdong, China. Guangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University Guangzhou 510120, Guangdong, China. Department of Radiology, The Third Xiangya Hospital Central South University Changsha China Department of Biochemistry, Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China. Development and Stem Cell Program and Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia Department of Radiology Taian Maternal and Child Health Hospital Taian China College of Animal Science, South China Agricultural University, Tianhe District, Wushan Road, Guangzhou, Guangdong, People's Republic of China Department of Otolaryngology, Head and Neck Surgery West China Hospital, Sichuan University Chengdu China College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, China.; Key Laboratory of Animal Biotechnology of the Ministry of Agriculture, Yangling, Shaanxi 712100, China. Department of Urology, The Fifth Affiliated Hospital of Xinjiang Medical University, Wulumuqi, Xinjiang 830011, P.R. China Plastic Surgery The University of Texas MD Anderson Cancer Center Houston TX USA Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China. Sichuan Mental Health Center, Third Hospital of Mianyang, Mianyang, China Department of Radiology, Second Xiangya Hospital, Central South University, Changsha 410011, China. junliu123@csu.edu.cn. Department of Endocrinology Fifth People's Hospital of Shanghai Shanghai China State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China, and Departments of Chemistry, Biology, and Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180 duyuguo@rcees.ac.cn State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology Interdisciplinary Research Center for Artificial Intelligence, Beijing University of Chemical Technology Beijing 100029, P. R. China Department of Chemistry and Innovation Center of Pesticide Research, China Agricultural University, Beijing 100193, P. R. China State Key Laboratory of Chemical Biology and Drug Discovery and Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Hung Hom Kowloon Hong Kong SAR China School of Materials Science and Engineering Guangdong Provincial Key Laboratory of Advanced Energy Storage Materials South China University of Technology Guangzhou Guangdong 510641 China Shenzhen Maternity & Child Health Hospital Shenzhen 518052, Shanxi, China. College of Chemistry Taiyuan University of Technology Taiyuan 030024 P. R. China; National Engineering Laboratory for Multi Flue Gas Pollution Control Technology and Equipment School of Environment Tsinghua University Beijing 100084 P. R. China Department of Macromolecular Science and Engineering Case School of Engineering Case Western Reserve University 10900 Euclid Avenue Cleveland Ohio 44106 USA Departments of aPathology and Laboratory Medicine and Department of Pathology Ankang Central Hospital Ankang China Department of Plastic Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX Nuffield Department of Population Health, University of Oxford, Oxford, UK. Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. lj0371@163.com National Engineering Laboratory for Deep Process of Rice and Byproducts, Hunan Province Key Laboratory of Edible forestry Resources Safety and Processing Utilization, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, China State Key Laboratory of Plant Genomics Institute of Microbiology Chinese Academy of Sciences Beijing 100101 China Jiangsu Key Laboratory of Crop Genetics and Physiology/Key Laboratory of the Ministry of Education for Plant Functional Genomics , Yangzhou University, Yangzhou 225009, Jiangsu Province, People's Republic of China Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou 225009, China; Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou 225009, China Department of Laboratory Medicine, The Fifth People’s Hospital of Wuxi, Affiliated to Jiangnan University, Wuxi, China Department of Breast-Thyroid Surgery, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, China Department of Cardiac Surgery, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine Guangdong Academy of Agricultural Sciences Guangzhou Guangdong China Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China Key Laboratory of Animal Biotechnology of the Ministry of Agriculture College of Veterinary Medicine Northwest A&F University Yangling PR China Department of Epidemiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China. Science and Technology on Electronic Test and Measurement Laboratory, North University of China 1 , Taiyuan, Shanxi 030051, China; Key Laboratory of Instrumentation Science and Dynamic Measurement, North University of China, Ministry of Education 2 , Shanxi 030051, China Department of Cardiology The First Affiliated Hospital of Sun Yat‐Sen University NO. 58 Zhongshan Road 2 Guangzhou 510080 China Center for Clinical and Epidemiological Research, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing Municipal Key Laboratory of Clinical Epidemiology Department of Imaging, Tianjin Union Medicine Centre, Tianjin 300121, China Columbia College of Physicians and Surgeons, and New York State Psychiatric Institute, New York Institute of Functional Nano & Soft Materials (FUNSOM) Joint International Research Laboratory of Carbon-Based Functional Materials and Devices Soochow University 199 Ren'ai Road Suzhou 215123 Jiangsu P. R. China 1Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China Dezhou National Hi‐Tech Industrial Development Zone Shandong Yuwang Ecogical Food Industry Co. Ltd. Yucheng China State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China. (e-mail: junliu@scu.edu.cn) State Key Laboratory of High Field Laser Physics; Shanghai Institute of Optics and Fine Mechanics; Chinese Academy of Sciences; Shanghai 201800; People's Republic of China Ohio State University Department of Biomedical Engineering, , Columbus, Ohio 43210 State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, P. R. China; Graduate University of Chinese Academy of Sciences, Beijing 100029, P. R. China Cancer Bio-immunotherapy Center; Fujian Medical University Cancer Hospital; Fujian Cancer Hospital; Fuzhou 350014; China Energy Processes & Materials Division; Pacific Northwest National Laboratory; Richland WA, USA Department of Thoracic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China (mainland) From Shanghai Jiao Tong University School of Medicine (M.-s.Y.); and Department of Neurology (S.C., J.L.), Shanghai Ruijin Hospital, Affiliated Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai, China. Institute of Deep-Sea Science and Engineering, Chinese Academy of Sciences, Sanya, China School of Chemistry and Chemical Engineering and Department of Electronic Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China, and Max-Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany College of Agro‐grassland Science Nanjing Agricultural University Nanjing China Department of Oto‐Rhino‐Laryngology, National Clinical Research Center for Geriatrics, West China Hospital Sichuan University Chengdu China Department of Endocrinology, The Fifth People’s Hospital of Shanghai, Fudan University, Shanghai 200240, China Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430016, China School of Data Science and Information Engineering, Guizhou Minzu University, Guiyang 550025, China North University of China Key Laboratory of Instrumentation Science and Dynamic Measurement, Ministry of Education, , Taiyuan 030051, People’s Republic of China and National Key Laboratory for Electronic Measurement Technology, School of Instrument and Electronics, , Taiyuan 030051, People’s Republic of China; North University of China Key Laboratory of Instrumentation Science and Dynamic Measurement, Ministry of Education, , Taiyuan 030051, People’s Republic of China and National Key Laboratory for Electronic Measurement Technology, School of Instrument and Electronics, , Taiyuan 030051, People’s Republic of China Key Laboratory of Agricultural Measurement and Control Technology and Equipment for Mechanical Industrial Facilities, School of Electrical and Information Engineering, Jiangsu University, Zhenjiang 212013, China School of Life Sciences, Guangdong Provincial Key Laboratory of Plant Resources Sun Yat‐sen University Guangzhou 510275 People's Republic of China Department of Tissue Regeneration, Institute for BioMedical Technology, University of Twente, Enschede, The Netherlands. Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated with the Shanghai Jiao Tong University School of Medicine, Shanghai, China; CAS Center for Excellence in Brain Science and Intelligence Technology, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China Department of Pathology and Laboratory Medicine, The University of Texas Medical School at Houston, Houston, Texas, USA Jiangsu Key Lab of Drug Screening China Pharmaceutical University Nanjing China Department of Radiology, The Second Xiangya Hospital of Central South University, The School of Public Administration of Central South University Changsha 410011, China. State Key Joint Laboratory of Environment Simulation and Pollution Control, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China Department of Hand and Foot Surgery and Reparative and Reconstructive Surgery, Orthopedic Hospital of The Second Hospital of Jilin University, Changchun, Jilin 130000, P.R. China Department of Microbial Pathogenesis Yale University School of Medicine New Haven CT USA; Department of Cell Biology Yale University School of Medicine New Haven CT USA College of Food Science and Engineering Yangzhou University Yangzhou 225127 Jiangsu China State Key Laboratory of Magnetism; Institute of Physics; Chinese Academy of Sciences; Beijing 100190; P. R. China National Key Lab of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation; State Key Laboratory of Physical Chemistry of Solid Surfaces; Department of Chemistry; College of Chemistry and Chemical Engineering; Xiamen University Singapore Eye Research Institute, Singapore Division of Dyslipidemia, Cardiovascular Medicine, Fu Wai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China. Department of Otolaryngology Renji Hospital, Shanghai Jiao Tong University Shanghai China Research Center for Marine Ecology, First Institute of Oceanography, State Oceanic Administration, Qingdao 266061, China. Key Laboratory of Marine Sedimentology and Environmental Geology, First Institute of Oceanography, State Oceanic Administration, Qingdao 266061, China. Laboratory for Marine Geology, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China. State Key Laboratory of Biocontrol and Key Laboratory of Biodiversity Dynamics and Conservation of Guangdong Higher Education Institutes, School of Life Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China Department of Hand Surgery, The Second Hospital of Jilin University, Changchun, Jilin Province, China Institute of Deep‐sea Science and Engineering Chinese Academy of Sciences Sanya China Postgraduate Training Base of Hubei University of Medicine, Jinzhou Medical University, Shiyan, Hubei, PRC; Tongren Hospital of Wuhan University, Hongshan District, Wuhan City, Hubei, PRC Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University; Institute of Infection and Immunity, Nanchang University, Nanchang, Jiangxi 330006, China State Key Laboratory of Biocontrol and Guangdong Key Laboratory of Plant Resources School of Life Sciences Sun Yat–sen University 510275 Guangzhou China Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA School of Energy and Environmental Engineering, University of Science and Technology Beijing , China College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu Province 215009, People's Republic of China National Engineering Lab for Big Data Analytics and School of Computer Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China Department of Clinical Laboratory, Yue Bei People’s Hospital, Shantou University Medical College, Shaoguan, Guangdong, China Department of Orthopedics, General Hospital of Shenyang Military Area Command of Chinese PLA, Shenyang, Liaoning School of Safety Science and Engineering, Henan Polytechnic University, Jiaozuo, Henan454000, China; State key Laboratory Cultivation Base for Gas Geology and Gas Control, Jiaozuo, Henan454000, China; The Collaborative Innovation Center of Coal Safety Production of Henan, Jiaozuo, Henan454000, China Department of Chemistry and School of Medicine, Biological Chemistry, and Department of Animal Science, University of California, Davis, California 95616 Department of Gastroenterology Shandong University Qilu Hospital Jinan China Department of Joint Tianjin Hospital Tianjin China Fundamental and Computational Science Directorate; Pacific Northwest National Laboratory; Richland; USA College of Basic Medical, Jining Medical UniversityJining 272067Shandong ProvincePeople's Republic of China The Joint Laboratory of Chinese Pharmaceutical University and Taian City Central Hospital; Taian City Central Hospital; Taian; China From the Department of Plastic and Reconstructive Surgery, The University of Texas M. D. Anderson Cancer Center, and The University of Texas, McGovern Medical School. State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P.R. China Advanced Micro and Nanosystems Laboratory, University of Toronto, Toronto, Ontario, Canada; and Department of Microbial Pathogenesis, Microbial Sciences Institute Yale University School of Medicine New Haven CT USA Department of Neonatology, The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, China. Department of Liver Transplantation and Hepatobiliary Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China; Department of Liver Transplantation and Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province, China Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada Laboratory of Molecular Engineering and Laboratory of Natural Product Synthesis, Guangzhou Institute of Biomedicine and Health, The Chinese Academy of Sciences, Guangzhou 510663, China, and Department of Chemistry, Wuhan University of Science and Technology, Wuhan 430070, China Seed Science Center Institute of Crop Science College of Agriculture and Biotechnology Zhejiang University Hangzhou China Ministry of Education Key Laboratory for Earth System Modeling; Department of Earth System Science; Tsinghua University; Beijing; China Department of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Capital Medical University, Beijing Anzhen Hospital, Beijing, China State Key Laboratory of Applied Organic Chemistry (SKLAOC), College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu, 730000, China College of Veterinary Medicine and; Key Laboratory of Animal Biotechnology, Ministry of Agriculture, Northwest A&F University, Yangling 712100, Shaanxi, China CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China; China-Japan Joint Laboratory of Molecular Immunology and Molecular Microbiology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China Energy Process and Materials Division; Pacific Northwest National Laboratory (PNNL); Richland; USA Center for Reproduction and Development, Monash Institute of Medical Research, Monash University, Clayton, Australia. Department of Orthopedics, General Hospital of Shenyang Military Command Area of Chinese PLA, Shenyang, Liaoning Province, China. Department of Limbs (Foot and Hand) Microsurgery, Affiliated Chenzhou No.1 People’s Hospital, Southern Medical University, Chenzhou, 423000, China Department of Mechanical Engineering and Aerospace Engineering, North Carolina State University, Raleigh, North Carolina 27695, United States Department of Chemistry, University of California, Santa Cruz, California 95064, Lawrence Livermore National Laboratories, P.O. BOX 808, L-370, Livermore, California 94551, Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, Sandia National Laboratories, Biomolecular Materials and Interfaces Department 1140, Mail Stop 1413, P.O. Box 5800, Albuquerque, New Mexico 87185, Department of Physics, University of California, Santa Cruz,... Department of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China Singapore University of Technology and Design (SUTD), Singapore Pacific Northwest National Laboratory, P.O. Box 999, Richland, Washington 99352, United States Department of Microbial Pathogenesis, School of Medicine, Yale University, New Haven, United States Changzheng Hospital, Naval Medical University, Shanghai, People’s Republic of China Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, China. Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands; Nuffield Department of Population Health, University of Oxford, Oxford, UK Carnegie Institution of Washington, Department of Embryology, 115 West University Parkway, Baltimore, MD 21210, USA Department of Medical Genetics and Microbiology, University of Toronto, Medical Sciences Building, Room 4382, One King's College Circle, Toronto, Ontario M5S 1A8, Canada Department of Hand Surgery The Second Hospital of Jilin University Changchun China Shandong Yuwang Ecological Food Industry Co. Ltd. Yucheng China Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China College of Life Science and Technology, Xinjiang University, Urumqi, Xinjiang 830002, China Hunan Province YinFeng New Energy Co., Ltd., Changsha 410000, China; School of Chemistry and Materials Science, Hunan Agricultural University, Changsha 410128, China Brain and Behavior Discovery Institute and Department of Neurology, Medical College of Georgia at Augusta University, Augusta, GA, USA Department of Orthopedic Surgery, Jingzhou Central Hospital, Jingzhou, Hubei 434020, P.R. China Beijing Advanced Innovation Center for Food Nutrition and Human Health College of Food Science and Nutritional Engineering China Agricultural University Beijing China; Department of Plant Sciences University of Saskatchewan Saskatoon SK Canada State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China Department of Orthopedics, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China; Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China Institute for Biomedical Sciences of Pain, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China. Email:tutuhe@163.com. Department of Laboratory Medicine, The Fifth People's Hospital of Wuxi, Affiliated to Jiangnan University, Wuxi Department of Radiology, Second Xiangya Hospital, Central South University, Hunan Province, China.; Department of Biomedical Engineering, Wayne State University School of Medicine, Detroit, Michigan. Department of Medicinal Chemistry, College of Pharmacy, UF Health Science Center, University of Florida, Gainesville, Florida 32610, United States; Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico 87131, United States The Research Team on Bone and Joint Degeneration and Injury of Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510120, China; Guangdong Second Traditional Chinese Medicine Hospital (Guangdong Province Enginering Technology Research Institute of Traditional Chinese Medicine), Guangzhou 510095, China; Guangdong Second Traditional Chinese Medicine Hospital (Guangdong Province Enginering Technology Research Institute of Traditional Chinese Medicine), Guangzhou 510095, China Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China College of Forestry, Northwest A & F University, Yangling 712100 Shaanxi, PR China; Hunan Research Center of Engineering Technology for Utilization of Environmental and Resources Plant, Central South University of Forestry and Technology, Changsha 410004 Hunan, PR China Medical Research Centre, Changzhou Second People’s Hospital Affiliated to Nanjing Medical University, Changzhou, China Department of Nephrology, Third Xiangya Hospital Central South University Changsha Hunan China Department of Hematology, Xinqiao Hospital, Army Medical University; State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing School of Materials and Energy, Guangzhou Key Laboratory of Low-dimensional Materials and Energy Storage Devices, Guangdong University of Technology, Guangzhou 510006, China School of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing, China *Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada; Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121; Guangdong Provincial Key Laboratory of Advanced Energy Storage Materials, School of Chemistry and Chemical Engineering and School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China; School of Physics and Electronics, Gannan Normal University, Ganzhou 341000, PR China Department of Orthopedics, Jintan Hospital Affiliated to Jiangsu University, Jintan, Jiangsu, People’s Republic of China Beijing Anding Hospital Department of Gastroenterology, Songgang People’s Hospital, Shenzhen, Guangdong, China; Department of Obstetrics and Gynecology, Beijing Chao‐yang Hospital Capital Medical University Beijing China School of Materials Science and Engineering, Central South University, Changsha 410083, China Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Department of Cardiology, Heart Center of Henan Provincial People's Hospital, Central China Fuwai Hospital, Zhengzhou University, Zhengzhou 450003, China d Hunan Key Laboratory of Biomedical Nanomaterials and Devices, School of Life Science and Chemistry, Hunan University of Technology, Zhuzhou 412007, China Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou 510028, China. State Key Laboratory of Tree Genetics and Breeding, Chinese Academy of Forestry, Beijing 100091, China; Key Laboratory of Tree Breeding of Zhejiang Province, Research Institute of Subtropical Forestry, Chinese Academy of Forestry, Hangzhou 311400, China Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, People's Republic of China Department of Plastic Surgery The University of Texas MD Anderson Cancer Center Houston Texas Department of Pathology, Brigham & Women's Hospital Division of Nephrology and Hypertension, Department of Medicine, Georgetown University Medical Center, Washington, District of Columbia Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China Department of Immunology, School of Basic Medical Sciences, Fudan University, 200032 Shanghai, China; Department of Radiology, Clinical Research Center for Medical Imaging in Hunan Province, The Second Xiangya Hospital, Central South University , Changsha, Hunan, China National Renewable Energy Laboratory 15013 Denver West Parkway Golden CO 80401 USA Radiology Department, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, China Department of Cardiology, Peking University People's Hospital, Beijing, China; Beijing Key Laboratory of Early Prediction and Intervention of Acute Myocardial Infarction, Peking University People's Hospital, Beijing, China; Center for Cardiovascular Translational Research, Peking University People's Hospital, Beijing, China National Glycoengineering Research Center, the State Key Laboratory of Microbial Technology and School of Life Science, Shandong University, Jinan, Shandong 250100, China CAS Key Laboratory of Forest Ecology and Management Institute of Applied Ecology Shenyang China; Forest Ecology – Stable Isotope Research Center College of Forestry Fujian Agriculture and Forestry University Fuzhou China Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, China. Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA From the Department of Pathology, Brigham and Women’s Hospital (Y.-C.L., C. Gao, Jun Liu, J.Y., L. Chai), Harvard Stem Cell Institute, Harvard Medical School (A.I.J., M.A.B., D.G.T.), and the Department of Medical Oncology, Dana–Farber Cancer Institute (R.P.) — all in Boston; the Division of Hematology, Department of Medicine, Taipei Veterans General Hospital (Y.-C.L.), and the Faculty of Medicine and the Program in Molecular Medicine, Institute of Biopharmaceutical Sciences, School of Life Science,... Tianjin Union Medical Center; Tianjin; China Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China Department of Health Science, Xi’an Sport University, Xi’an 817006, China Department of Neurosurgery, Jiujiang First People’s Hospital The Second Xiangya Hospital, Central South University, Quality Control Center, Changsha, China College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, People’s Republic of China; Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Science, Hangzhou, People’s Republic of China School of Computer Science and Engineering, Northeastern University, 169 Chuangxin Road, Shenyang 110169, China Department of Nursing Management, Northern Huashan Hospital, Fudan University, Shanghai, China (mainland) Department of Orthopaedics, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Fudan University Shanghai 200438 P. R. China Department of Environmental Engineering School of the Environment and Safety Engineering Jiangsu University Zhenjiang 212013 P. R. China Department of gastroenterology The Affiliated Clinical College ShenZhen Second People Hospital Shenzhen China School of Environmental and Municipal Engineering, Qingdao University of Technology, Qingdao, People’s Republic of China Department of Radiology The Second Xiangya Hospital of Central South University Changsha Hunan Province China Siemens Corporate Research, Princeton, NJ, USA Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada Department of Nephrology, The Third Xiangya Hospital, Central South University, Changsha 410013, China Guangdong Provincial Key Laboratory on Functional Soft Condensed Matter, Materials and Energy School, Guangdong University of Technology Panyu District, Guangzhou, 510006, China Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi’an, Shaanxi 710126, P. R. China Department of Ultrasonic Imaging, Tai'an Central Hospital People's Republic of China. Engineering Research Center of Molecular and Neuro Imaging; Ministry of Education; School of Life Science and Technology; Xidian University; Xi'an University of Michigan 3 Department of Chemical Engineering, , Ann Arbor, Michigan 48109, USA Department of Otorhinolaryngology Head and Neck Surgery, Henan Provincial People's Hospital, Zhengzhou 450000, China; Email: lj0371ent@sina.com. Departments of Internal Medicine and Physiology, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109 Department of Biomedical Engineering, Ohio State University, Columbus, Ohio, United States; Biophysics Interdisciplinary Group, Ohio State University, Columbus, Ohio, United States; Department of Ophthalmology and Visual Science, Ohio State University, Columbus, Ohio, United States Department of Radiology Second Xiangya Hospital, Central South University Changsha China Department of Pathology, Medical School, Sun Yat-Sen University, Guangzhou 510080, China. houjunran2003@tom.com Department of Plastic Surgery, The University of Texas, MD Anderson Cancer Center, Houston, Texas School of Chemistry and Chemical Engineering, Xianyang Normal University, Xianyang City, China Department of Chemistry, Northeast Normal University, Changchun 130024, P. R. China College of Earth And Environmental Sciences, Lanzhou University, Lanzhou 730030, Gansu, China. Department of Urology, General Hospital of Guangzhou Command of PLA/Urology Institute of Guangzhou Command of PLA, Guangzhou, Guangdong, 510010, PR China. Department of Cardiology The First Affiliated Hospital, Sun Yat‐Sen University and Key Laboratory on Assisted Circulation, NHC Guangzhou China State Key Laboratory of Optoelectronic Materials and Technologies, Sun Yat-sen University, 135 Xingang Xi Road, Guangzhou 510275, P.R. China; State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng Dong Road, Guangzhou 510060, P.R. China Department of Critical Care Medicine, Suzhou Hospital, Nanjing Medical University, Suzhou 215001, China. Laboratory of Cytophysiology, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen 518055, China Department of Thoracic Surgery, Guangzhou Institute of Respiratory, Guangzhou 510120, China. *Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China;; †Key Laboratory of Tropical Disease Control, Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China; and Real World Solutions, IQVIA, Shanghai, 200124, China Key Laboratory of Nutrition and Metabolism, Chinese Academy of Sciences Center for Excellence in Molecular Cell Sciences, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences (J.L., B.Z., M.Y., R.H., Yu.W., Z.H., Y.Y., C.D., Yi.W., F.Z., Q.Z.), 200031 Shanghai, China; Institute of Human Virology and Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China. United States Army Medical Research Institute of Infectious Diseases, Fort Detrick 21702 Frederick MD USA Murad Research Center for Modernization Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China Guangxi Medical University Nanning China Department of Pathogenic Microbiology and Immunology School of Basic Medical Sciences; Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of Stomatology Xi'an Jiaotong University Xi'an China; Institute of Infection and Immunity Translational Medicine Institute Xi'an Jiaotong University Health Science Center Xi'an China Guangdong Academy of Agricultural Sciences Guangzhou China Jiangsu Key Laboratory of Drug Screening China Pharmaceutical University 24 Tongjia Xiang Nanjing 210009 China College of Bioresources Chemical and Materials Engineering, Key Laboratory of Auxiliary Chemistry and Technology for Chemical Industry, Ministry of Education, Shaanxi Collaborative Innovation Center of Industrial Auxiliary Chemistry and Technology, Shaanxi University of Science and Technology, Xi’an 710021, China State Key Laboratory of Virology/Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei 430071, China Museum of Science and Technology of Shandong Province 3 , Jinan, Shandong 250012, China Department of Chemical & Biomolecular Engineering, University of South Florida, Tampa, Florida 33620-5350, United States Breast Center, China-Japan Friendship Hospital, Beijing, China Department of Medical Genetics and Microbiology, University of Toronto, Ontario M5S 1A8, Canada Division of Pharmacoepidemiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts Department of Plastic and Reconstructive Surgery, The University of Texas MD Anderson Cancer Center Department of Oto-Rhino-Laryngology, and National Clinical Research Center for Geriatrics, West China Hospital, West China Medical School, Sichuan University Department of Brain and Cognitive Sciences and McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts; No. 2 Hospital of Jilin University, Jilin University, Changchun 130025, China Department of Ophthalmology, The First People's Hospital of Yunnan Province Kunming 650100, Yunnan, P. R. China. Department of Ophthalmology, Affiliated Hospital of Kunming University of Technology Kunming 650032, Yunnan, P. R. China. Guangdong Provincial Key Laboratory of Advanced Energy Storage Materials School of Materials Science and Engineering South China University of Technology Guangzhou 510640 China State Key Laboratory of Biocontrol and Guangdong Key Laboratory of Plant Resources School of Life Sciences Sun Yat‐sen University 510275 Guangzhou China Department of Endocrinology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China Jun Liu is a programmer at Brigham and Women’s Hospital. Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China; Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China School of Medicine, Wuhan University, Wuhan, China; and Department of Medical and Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University , Shanghai , China Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan Vollum Institute, Oregon Health and Science University, Portland, United States; Howard Hughes Medical Institute, Chevy Chase, United States School of Basic Medical Sciences, Anhui Medical University, Hefei, China; School of Pharmacy, Anhui Medical University, Hefei, China; Biopharmaceutical Research Institute, Anhui Medical University, Hefei, China From the Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center. Department of Nephrology, The Third Xiangya Hospital of Central South University, Changsha, China; Department of Pathology Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts USA Department of Medical Oncology, Fujian Cancer Hospital Fujian Medical University Cancer Hospital Fuzhou Fujian China National Engineering Research Center for Biomaterials; Sichuan University; Chengdu 610064, China Radiology, Huashan Hospital, Fudan University; and Hunan Research Center of Engineering Technology for Utilization of Environmental and Resources Plant, Central South University of Forestry and Technology, Changsha 410004 Hunan, PR China State Key Laboratory of Cardiovascular Disease, Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China. a State Key Laboratory of Genetic Engineering, School of Life Sciences , Fudan University , Shanghai , P. R. China Department of Urology, Second Affiliated Hospital of The University of South China, Hengyang, Hunan 421001, P.R. China Guangdong Second Traditional Chinese Medicine Hospital, Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine, Guangzhou, China. Fifth Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China. Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States Department of Plastic Surgery University of Texas MD Anderson Cancer Center Houston Texas NHC Key Laboratory of Birth Defects and Reproductive Health (Chongqing Population and Family Planning Science and Technology Research Institute) Chongqing China Langfang Academy of Agriculture and Forestry, Langfang, China Division of Nephrology Shanghai No. 1 People's Hospital, Shanghai Jiao Tong University Shanghai China Max Planck Institute for Solid State Research, Heisenbergstr. 1, Stuttgart 70569, Germany Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Department of Biochemistry and Molecular Biology, Mayo Clinic, Scottsdale, AZ, USA Hunan University of Arts and Science; Changde; China Beijing Synchrotron Radiation Facility, Institute of High Energy Physics,Chinese Academy of Sciences, Beijing, China Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853; and Department of Genetics, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem 91904, Israel Department of Urology Huxi Affiliated Hospital of Jining Medical College (Shanxian Central Hospital) Shanxian China §School of Basic Medical Sciences, Fudan University, Shanghai 200032, China; Department of Chemistry The University of Hong Kong Hong Kong 999077 China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences Beijing China ‡National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China; and The First School of Clinical Medicine, Southern Medical University, Guangzhou, China; Department of Hand and Foot Microsurgery, Chenzhou No.1 People’s Hospital, Chenzhou, China; Department of Hand Microsurgery, Nanhua Hospital Affiliated to University of South China, Hengyang, China Department of Immunology, School of Basic Medical Sciences, Shanghai Huashen Institute of Microbes and Infections, Fudan University, Shanghai 200032, China. Department of Gastroenterology, Clinical Medical College of Yangzhou University, Subei People's Hospital of Jiangsu Province, Yangzhou, Jiangsu 225001, P.R. China Department of Liver Transplantation and Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong University State Key Laboratory of Silicon Materials and Center of Electron Microscopy School of Materials Science and Engineering Zhejiang University Hangzhou 310027 P. R. China Department of Orthopaedics, Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou 510120, China Department of Physiology, Medical College Jinan University Guangzhou 510632 People's Republic of China University of California, San Francisco Department of Pharmaceutical Chemistry and the Cardiovascular Research Institute 555 Mission Bay Blvd. South San Francisco CA 94158 USA Department of Mechanical and Industrial Engineering, University of Toronto, 5 King's College Road, Toronto, ON, Canada, M5S3G8. Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University, 510080, Guangzhou, Guangdong, China; College of Chemsitry and Materials Engineering, Hunan University of Arts and Science, Changde 415000, P. R. China; Hunan Provincial Key Laboratory of Water Treatment Functional Materials, Hunan University of Arts and Science, Changde 415000, P. R. China; Hunan Province Engineering Research Center of Electroplating Wastewater Reuse Technology, Hunan University of Arts and Science, Changde 415000, P. R. China Department of Oncology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, China. State Key Laboratory of Oncogenes and Related Genes, Department of Oncology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, China Biomaterials and Tissue Engineering Division, Department of Endodontics, Prosthodontics and Operative Dentistry, University of Maryland Dental School, Baltimore, Maryland.; State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, China. Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA. State Key Laboratory of Organometallic Chemistry; Shanghai Institute of Organic Chemistry; Chinese Academy of Sciences; Shanghai 200032; P. R. China Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226;; Jiangsu Center for Drug Screening, China Pharmaceutical University, Nanjing 210009, People's Republic of China; for the H-REPLACE Investigators Department of Neurology and Institute of Neurology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Radiology, The Second Xiangya Hospital, Central South University, No.139 Middle Renmin Road, Changsha, Hunan, P. R. China; Department of Radiology Quality Control Center, Changsha, Hunan Province, China Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Singapore. Engineering Research Center of Freshwater Fish High‐value Utilization of Jiangxi Province National Research and Development Center of Freshwater Fish Processing Nanchang China Department of Biochemistry and Molecular Biology Michigan State University East Lansing MI 48824 USA Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Hangzhou, Zhejiang, China; Research Institute of Zhejiang University-Taizhou, Taizhou, Zhejiang, China Hunan Provincial Key Laboratory of Environmental Catalysis & Waste Regeneration College of Materials and Chemical Engineering Hunan Institute of Engineering Xiangtan China Rutgers Robert Wood Johnson Medical School Institute for Neurological Therapeutics, Piscataway, NJ 08854; Department of Neurology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ 08854 Hand & Foot Surgery and Reparative & Reconstructive Surgery Center, No. 2 Hospital of Jilin University, Changchun, P.R. China Nanjing Agricultural University, 70578, College of Agro-grassland Science, Nanjing, Jiangsu, China; School of Pharmaceutical Sciences, Nanchang University Pacific Northwest National Laboratory 902 Battelle Boulevard Richland WA 99354 USA Jun Liu is a programmer in the Division of Pharmacoepidemiology and Pharmacoeconomics. Guangdong Provincial Key Laboratory for Crop Germplasm Resources Preservation and Utilization, Agro-Biological Gene Research Center, Guangdong Academy of Agricultural Sciences, 510640 Guangzhou, China Pediatric Surgery Department Women and Children's Hospital of Jiaxing University Jiaxing China Department of Neurology, Institute of Neurology, Ruijin Hospital affiliated to School of Medicine, Shanghai Jiaotong University, Shanghai, China. Electronic address: jly0520@hotmail.com. School of Materials Science and Engineering, Guangdong Provincial Key Laboratory of Advanced Energy Storage Materials, South China University of Technology, Guangzhou 510641, People’s Republic of China Department of Otolaryngology – Head and Neck Surgery West China Hospital, Sichuan University Chengdu China; Head and Neck Surgical Center West China Hospital Chengdu China Department of Epidemiology, Capital Medical University Beijing Anzhen Hospital–Beijing Institute of Heart, Lung & Blood Vessel Diseases, Beijing, China Department of Plant Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8, Canada Institute of Oncology, Tianjin Union Medical Center, Tianjin 300121, China Key Laboratory of State Forestry Administration on Forest Ecosystem Protection and Restoration of Poyang Lake Watershed (JXAU), Nanchang 330045, China State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China Tianjin Medical University Cancer Hospital & Institute, Tianjin, China. Key Laboratory of Deep Underground Science and Engineering (Ministry of Education), Institute of New Energy and Low-Carbon Technology, Sichuan University, Chengdu 610065, China National Key Facility for Crop Gene Resources and Genetic Improvement (NFCRI) Institute of Crop Sciences, Chinese Academy of Agricultural Sciences (CAAS) Beijing 100081 China Department of Orthopaedics, the Second Affiliated Hospital of Nanjing Medical University, Nanjing 210000, Jiangsu, China; 13776698080@139.com. National Engineering Research Center for Biomaterials, Sichuan University, 29 Wangjiang Road, Chengdu 610064, China From the Department of Neurology and Institute of Neurology (Y.L., W.K., Q.Y., Linyuan Zhang, F.D., S.C., J.L.), Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine; Department of Neurology (W.K.), Ruijin Hospital North affiliated to Shanghai Jiaotong University School of Medicine; and Department of Biostatistics (Lina Zhang), Shanghai Jiaotong University School of Medicine, Shanghai, China. State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing 100871, China; Langfang Academy of Agriculture and Forestry, Langfang, 065000, China Department of Tissue Regeneration, Mira Institute for Biomedical Technology, University of Twente, Enschede, The Netherlands. Chongqing Yunkang Zhilian Technology Co., LTD, Chongqing 401331, China National University of Defense Technology 1 College of Mechatronics Engineering and Automation, , Changsha 410073, China; Northwest Institute of Nuclear Technology 2 , Xi’an 710024, China Department of NeurologyDepartment of Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China Department of Radiology, University of Michigan Medical School, Ann Arbor, MI; State Key Laboratory of Cardiovascular Disease, Cardiac Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Department of Chemical Engineering, Princeton University, Princeton, New Jersey 08544, and Pacific Northwest National Laboratory, Richland, Washington 99352 Department of Epidemiology, Beijing An Zhen Hospital, Capital Medical University, Beijing 100029, China; Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing 100029, China; The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing 100029, China; The Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing 100029, China. Department of Emergency Medicine, Affiliated Hospital of Jiangnan University, Wuxi 214122, Jiangsu, China. Department of Infectious Disease, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine Zhejiang University Hangzhou Zhejiang China School of Power and Mechanical Engineering; Wuhan University; Wuhan 430071; P. R. China Department of Neurology and Collaborative Innovation Center for Brain Science, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200020 Shanghai, People’s Republic of China; Department of Physics, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China, Institut de Chimie, Université Louis Pasteur-CNRS/UMR 7177, 4, rue Blaise Pascal, 67070 Strasbourg, France, and Key Lab for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Meilong Road 130, Shanghai, China Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware. Department of Pharmaceutical Chemistry and the Cardiovascular Research Institute University of California, San Francisco 555 Mission Bay Blvd. South San Francisco CA, 94158 USA Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, People’s Republic of China; Hubei Provincial Clinical Research Center for Digestive Disease Minimally Invasive Incision, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, People’s Republic of China; Nursing Department of Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, People’s Republic of China Department of Digestive Endoscopy, The First Affiliated Hospital of Shenzhen University, Shenzhen 518023, PR China Department of Emergency Intensive Care Unit, Affiliated Hospital of Jiangnan University, Wuxi 214122, Jiangsu, China. Department of Critical Care Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China. Corresponding author: Zuo Xiangrong, Email: 13913979197@139.com. College of Information Engineering, Zhejiang University of Technology, Hangzhou, China Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093, United States National Key Facility for Crop Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, China Shenzhen Maternity & Child Health Hospital, Shenzhen, China Key Laboratory of Mesoscopic Chemistry; MOE; School of Chemistry and Chemical Engineering; Nanjing University; Nanjing 210023 Department of Traumatic Orthopedics Wuxi Ninth People's Hospital affiliated to Soochow University Wuxi People's Republic of China The Second Department of Cardiology, Guangdong Second Provincial General Hospital & Guangdong Provincial Emergency Hospital, Guangzhou, China Department of Orthopedics, General Hospital of Tianjin Medical University, 300052, P.R. China. Department of Clinical Laboratory, Yue Bei People’s Hospital, Shaoguan, Guangdong, China; Morning Star Academic Cooperation, Shanghai, China Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536; Microbial Sciences Institute University, West Haven, CT 06516 Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, China State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China Department of Chemistry, Department of Biochemistry and Molecular Biology, Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637, USA Institute of Crop Science Chinese Academy of Agricultural Sciences National Key Facility for Crop Resources and Genetic Improvement Beijing China Institute of Nuclear Physics and Chemistry; CAEP; Mianyang; China China National Clinical Research Center for Respiratory Diseases Beijing China; Department of Respiratory Medicine, Beijing Children’s Hospital Capital Medical University Beijing China; National Center for Children’s Health Beijing China Department of Cardiology, The First Hospital of Hebei Medical University, Shijiazhang, China Institute of Human Virology, Sun Yat-sen University, Guangzhou, China; Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical University, Changzhou 213164, China; Dalian Medical University, Dalian 116044, China Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, Canada. Department of Cardiothoracic Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, P. R. China Department of Bioscience and Bioengineering, South China University, Guangzhou, Guangdong 510641, P.R. China Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou 510006, China. Department of Endocrinology of the Fifth People’s Hospital of Shanghai and the Molecular and Cell Biology Lab of the Institutes of Biomedical Sciences Fudan University Shanghai China Department of Biological Science and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306; and AIDS Vaccine Program, SAIC-Frederick, Incorporated, National Cancer Institute, Frederick, MD 21702 College of Pharmacy; Jinan University; Guangzhou 510632; P. R. China State Key Laboratory of Fine Chemicals; School of Pharmaceutical Science and Technology; Dalian University of Technology; Dalian; P.R. China The State Key Lab of Elemento‐Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Institute of Elemento‐Organic Chemistry Nankai University Tianjin 300071 China Materials Design & Simulation Technology Co., Ltd, Chengdu 610065, China Beijing Engineering Research Center of Advanced Elastomers; Beijing University of Chemical Technology; People's Republic of China Department of Late Stage Pharmaceutical and Processing Development, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080 Laboratory of Plant Molecular Biology The Rockefeller University 1230 York Avenue New York NY 10065‐6399 USA; National Key Facility for Crop Resources and Genetic Improvement Institute of Crop Science Chinese Academy of Agricultural Sciences Beijing 100081 China Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226; Department of Pathology and Laboratory Medicine University of Texas Medical School at Houston Houston TX 77030 USA Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials, Beijing University of Chemical Technology, Beijing, 100029, China 1Department of Endocrinology, Jinling Hospital, Affiliated Hospital of Medical College of Nanjing University Department of Otorhinolaryngology-Head and Neck Surgery, Renji Hospital of Shanghai Second Medical University, Shanghai 200001. Department of Urology; Huashan Hospital; Fudan University; Shanghai China Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China Department of Radiology, Second Xiangya Hospital, Central South University, Changsha 410011 junliu123@csu.edu.cn. Department of Radiology Quality Control Center, Hunan Province, Changsha 410011, China junliu123@csu.edu.cn. Jiangxi Provincial Engineering Research Center for Seed-breeding and Utilization of Camphor Trees of Nanchang Institute of Technology (CCTNIT), Nanchang 330099, China Department of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China State Key Laboratory of Natural Medicine and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases China Pharmaceutical University 24 Tongjia Xiang Nanjing 210009 P.R. China Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts. Fujian Key Laboratory of Polymer Materials College of Chemistry and Materials Science Fujian Normal University Fuzhou 350007 China Joint Center for Energy Storage Research, Energy Processes & Materials Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United States Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China Department of Chemistry, College of Chemistry and Chemical Engineering, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, Xiamen University, Xiamen 361005, People’s Republic of China Department of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China. National Center for Drug Screening and State Key Laboratory of Natural Medicines, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing, Jiangsu 210009, China Department of Genetics, Yale University School of Medicine, New Haven, CT;; Yale Stem Cell Center, Yale Cancer Center, New Haven, CT; Department of Rheumatology Affiliated Hospital of Guizhou Medical University Guiyang PR China From the Departments of Biomedical Engineering and 2Ophthalmology, The Ohio State University, Columbus, Ohio. From the Division of Pharmacoepidemiology and Pharmacoeconomics (J.J.J., H.K., C.-Y.C., L.A.W., J.L., A.T.R., J.D.S.), Vascular and Endovascular Surgery (L.L.N.), and Cardiovascular Medicine (M.D.G.-H.), Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA; LASER Analytica, New York, NY (J.J.J.); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (H.K.); Department of Cardiology, Division of Cardiovascular Medicine, Massachusetts... University of Colorado 1 Department of Mechanical Engineering, , Boulder, Colorado 80309, USA Department of General Surgery Zhecheng People's Hospital Shangqiu Henan China Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences , China Department of Chemistry School of Chemistry, Chemical Engineering and Life Science Wuhan University of Technology Wuhan 430070 P. R. China School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China; Institute of Dermatology and Venereology, Dermatology Hospital, Southern Medical University, Guangzhou, China Genetic Reprogramming Group, Agricultural Biotechnology Center, Godollo, Hungary. Institute of Solid State Physics Chinese Academy of Sciences Hefei 230031 China Institute of Nuclear Physics and Chemistry; China Academy of Engineering Physics; Mianyang; P. R. China Department of Pathology and Laboratory Medicine University of Texas Health Science Center Houston TX 77030 USA; Department of Microbial Pathogenesis Microbial Sciences Institute, Yale University New Haven CT 06536 USA ¶College of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, China; and; ‖National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China Department of Orthopaedics, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210011, P.R. China University of Michigan Department of Chemical Engineering, , Ann Arbor, Michigan 48109, USA School of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 210038, China. firejj217@hotmail.com Key Laboratory of Women's Reproductive Health of Jiangxi Province, Jiangxi Provincial Maternal and Child Health Hospital, Nanchang, Jiangxi, China; Department of Gynecology, Jiangxi Provincial Maternal and Child Health Hospital, Nanchang, Jiangxi, China Center for Drug Delivery Systems, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China Thermo Fisher Scientific (China) Co. Ltd Shanghai China Department of Medical Imaging The Third Xiangya Hospital of Central South University Changsha China Sericultural & Agri‐Food Research Institute Guangdong Academy of Agricultural Sciences Guangzhou China; Key Laboratory of Functional Foods Ministry of Agriculture Guangzhou China; Guangdong Key Laboratory of Agricultural Products Processing Guangzhou China Department of Biochemistry and Molecular Biology; Michigan State University; East Lansing, MI USA Department of Natural Products Chemistry, Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences and ‡Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University, No. 44 West Wenhua Road, Jinan 250012, P. R. China Key Laboratory of Potato Biology and Biotechnology Ministry of Agriculture and Rural Affairs Huazhong Agricultural University Wuhan 430070 China Department of Biochemistry and Molecular Biology, Mayo Clinic in Arizona, Scottsdale, AZ; HEALth Program, Mayo Clinic in Arizona, Scottsdale, AZ State Key Laboratory of Biocontrol and Collaborative Innovation Center of Genetics and Development Guangdong Provincial Key Laboratory of Plant Resources School of Life Sciences Sun Yat‐sen University Guangzhou 510275 China Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials; People's Republic of China State Key Laboratory of Chemical Biology and Drug Discovery and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon 852, Hong Kong Department of Immunology School of Basic Medical Sciences Fudan University Shanghai China Hand & Foot Surgery and Reparative & Reconstructive Surgery Center, No. 2 Hospital of Jilin University, Changchun 130025, China Department of Infectious Disease, The Third People's Hospital of Kunming, Kunming, Yunnan, China. Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine Brigham and Women's Hospital Boston Massachusetts USA Department of Hepatobiliary Surgery Zhujiang Hospital, Southern Medical University Guangzhou China Technical Institute of Physics and Chemistry, Chinese Academy of Sciences Beijing 100190 China Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China; Hubei Provincial Clinical Research Center for Digestive Disease Minimally Invasive Incision, Renmin Hospital of Wuhan University, Wuhan, China; Hubei Key Laboratory of Digestive System, Renmin Hospital of Wuhan University, Wuhan, China; Engineering Research Center for Artificial Intelligence Endoscopy Interventional Treatment of Hubei Province, Renmin Hospital of Wuhan University, Wuhan, China School of life science and technology Wuhan Polytechnic University Wuhan China Laboratory for Shock Waves and Detonation Physics Research , Institute of Fluid Physics, P.O. Box 919-109, Mianyang, Sichuan 621900, People's Republic of China Department of Hepatobiliary Surgery, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China (mainland) Department of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China Department of Nephropathy Third Xiangya Hospital of Central South University Changsha China Department of Pathology, The Affiliated Hospital of Southwest University of Medicine, Luzhou, Sichuan 646000, China. Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Fudan University, Shanghai 200240, China Department of Plastic & Reconstructive Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX Radiology Department, The Second Xiangya Hospital, Central South University , Changsha, Hunan , China Department of Gastroenterology, Laboratory of Translational Gastroenterology, Shandong University Qilu Hospital, Jinan, Shandong Province, China. Department of Oncology, Xiantao First People's Hospital Affiliated to Yangtze University, Xiantao, Hubei 433000, P.R. China Institute of Plant Protection and Soil Fertilizer, Hubei Academy of Agricultural Sciences, Wuhan, Hubei, China; Key Laboratory of Integrated Pest Management on Crops in Central China, Ministry of Agriculture, Wuhan, Hubei, China; Hubei Key Laboratory of Crop Disease, Insect Pests and Weeds Control, Wuhan, Hubei, China Department of Chemistry and Innovation Center of Pesticide Research, China Agricultural University, 2 Yuanmingyuan West Road, Beijing 100193, P. R. China State Key Laboratory of Optoelectronic Materials and Technologies; Sun Yat-sen University; Guangzhou 510275; P. R. China State Key Laboratory of Elemento‐Organic Chemistry Research Institute of Elemento‐Organic Chemistry of Nankai University Tianjin People's Republic of China Seed Science Center, Institute of Crop Science, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China Department of Orthopedic Trauma, Weifang People’s Hospital, Weifang, Shandong, China (mainland) Department of Energy and Power Engineering, School of Mechanical Engineering, Beijing Institute of Technology, Beijing 100081, People’s Republic of China State Key Laboratory of High Field Laser Physics; Shanghai Institute of Optics and Fine Mechanics; Chinese Academy of Sciences; Shanghai 201800; China Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121 Department of Orthopaedics, the 9th People 's Hospital of Wuxi, Hospital of Hand Surgery, Jiangsu, China. liujun-jiangxin@163.com Huazhong Agricultural University, Wuhan 430070, China2; Bio-X Life Science Research Center, Shanghai Jiaotong University, Shanghai 200030, China1 College of Veterinary Medicine Northwest A&F University Yangling Shaanxi China Department of Radiation Oncology, Shanghai Chest Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China jinbohu@mail.sioc.ac.cn Laboratory of Printable Functional Nanomaterials and Printed Electronics; School of Printing and Packaging; Wuhan University; Wuhan 430072; P. R. China Jiangsu Key Laboratory of Chinese Medicine and Characteristic Preparations for Paediatrics, Jumpcan Pharmaceutical Co., Ltd. Taixing 225400, China. Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Department of Physiology and Pathophysiology, Fudan University Shanghai Medical College, Shanghai, China. National Center for Vegetable Improvement (Central China); Key Laboratory of Potato Biology and Biotechnology, Ministry of Agriculture; Huazhong Agricultural University, Wuhan 430070, People's Republic of China Department of Spinal Surgery, The Central Hospital of Enshi Autonomous Prefecture, Enshi, Hubei 445000, P.R. China Radiation Oncology, the University of Texas MD Anderson Cancer Center, Houston, Tex. State Key Laboratory of Genetic Engineering School of Life Sciences Fudan University Shanghai 200433 China; Department of Molecular Genetics University of Toronto Toronto ON M5S1A8 Canada Department of Biomedical Engineering The Chinese University of Hong Kong Shatin, NT Hong Kong SAR P. R. China; Center for Neuromusculoskeletal Restorative Medicine Hong Kong Science Park Shatin, NT Hong Kong SAR P. R. China Department of Sports Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China; Guangdong Second Traditional Chinese Medicine Hospital (Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine), Guangzhou, China; The Fifth Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China 1 Department of Cardiothoracic Surgery, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China ; 2 Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease, Guangzhou 510120, China ; 3 National Clinical Research Center for Respiratory Disease, Guangzhou 510120, China. International Ocular Surface Research Center and Institute of Ophthalmology, Jinan University, Guangzhou, China 2Key Laboratory for Regenerative Medicine, Ministry of Education, Jinan University, Guangzhou, China MIRA Research Institute, Department of Tissue Regeneration; University of Twente; Enschede The Netherlands Shanghai Institute of Optics and Fine Mechanics; University Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences Department of Epidemiology, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Municipal Key Laboratory of Clinical Epidemiology Department of Clinical Laboratory, Yue Bei People's Hospital, Shantou University Medical College, Shaoguan, Guangdong 512026, P.R. China State Key Laboratory of Organic/Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, China Department of Radiology, The Second Xiangya Hospital, Central South University, No. 139 Middle Remin Rd, Changsha, Hunan, 410011, P.R. China.; Department of Radiology, Quality Control Center, Changsha, Hunan, P.R. China. 1Epidemiology and Departments of Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China. Department of Embryology, Carnegie Institute of Washington, Baltimore, Maryland 21210 Laboratory for Sustainable Technology, School of Chemical and Biomolecular Engineering, University of Sydney, NSW 2006, Australia Department of Otolaryngology-Head & Neck Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China Sandia National Laboratories, Albuquerque, N, 87185 Department of Medical Imaging, Tianjin Union Medicine Center, Tianjin 300120, China State Key Laboratory of Biocontrol and Guangdong Provincial Key Laboratory of Plant Resource, School of Life Sciences, Sun Yat-Sen University, Guangzhou, China Department of Nephrology, The Third Xiangya Hospital Central South University Changsha China Pacific Northwest National Laboratory Richland WA 99354 USA Jiangsu Institute of Hematology, The First Affiliated Hospital and Collaborative Innovation Center of Hematology, Soochow University, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Suzhou 215006, Jiangsu, China State Key Laboratory of Materials‐Oriented Chemical Engineering College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University Nanjing People's Republic of China; National Engineering Technique Research Center for Biotechnology Nanjing People's Republic of China Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Shandong Yuwang Ecogical Food Industry Co. Ltd. Yucheng China From the Departments of Pediatrics (G.A.V., F.L., H.Z., J.L., K.K.) and Medicine (A.A.), College of Medicine, University of Florida, Gainesville. 1Cell and Molecular Biology and Departments of Department of Ophthalmology, The First People’s Hospital of Yunnan Province, Ocular Fundus Disease Research Center of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Yunnan 650032, China Institute of Nuclear Physics and Chemistry China Academy of Engineering Physics Mianyang 621900 P. R. China Max Planck Institute for Solid State Research, Heisenbergstrasse 1, Stuttgart, 70569, Germany Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210; The Program On Regulation, Therapeutics, and Law, Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts Department of Joints, Tianjin Hospital, Tianjin, China Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China College of Food Science and Engineering, Yangzhou University, Yangzhou 225127, Jiangsu, China State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing, 100094, China Department of Neurology, Framingham Heart Study Genetics Laboratory, Boston University School of Medicine, Boston, Massachusetts, USA Departments of Molecular Pharmacology and Laboratory of Plant Molecular Biology Rockefeller University New York NY 10065‐6399 USA College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China Computer and Information Science and Engineering, University of Florida Gainesville, FL 32611, USA Laboratory of Pathogenic Biology; Guangdong Medical University; Zhanjiang 524023; China Jiangsu University of Science and Technology School of Microelectronics; Dalian University of Technology; Dalian; P. R. China 116024 From the Department of Neurosurgery (J.L., X.Y., Q.J.), and Department of Recovery Medicine (W.Z.), The Affiliated Ganzhou Hospital of Nanchang University, Jiangxi, China; and Department of Neurosurgery (S.Z.), West China Hospital of Sichuan University, Chengdu. Plastic and Reconstructive Surgery Huayun Sounding Meteorological Technology Company, Limited, Beijing 100081, P. R. China Department of Orthopaedic, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China Jiangsu Institute of Haematology, Key Laboratory of Thrombosis & Haemostasis of Ministry of Health, The First Affiliated Hospital, Collaborative Innovation Center of Haematology, Soochow University, Suzhou, China Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, China. Department of Medical Imaging, Shanghai Fifth People's Hospital, Shanghai, China. Department of Laboratory Medicine, The Fifth People’s Hospital of Wuxi, Affiliated to Jiangnan University, Wuxi, People’s Republic of China Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA; Biophysics Interdisciplinary Group, The Ohio State University, Columbus, OH, USA; Department of Ophthalmology and Visual Science, The Ohio State University, Columbus, OH, USA Department of Microbial Pathogenesis & Microbial Sciences Institute, Yale School of Medicine New Haven Connecticut USA Department of Obstetrics Pingxiang Maternity and Child Health Hospital Pingxiang P. R. China Department of Radiotherapy Changzhou Fourth People's Hospital Changzhou China State Key Laboratory for Reliability and Intelligence of Electrical Equipment, Hebei Key Laboratory of Smart Sensing and Human-Robot Interaction, School of Mechanical Engineering, Hebei University of Technology, Tianjin, 300401, China Department of Epidemiology, Capital University of Medical Science, Beijing 100029, China. Jiangsu Key Laboratory of Drug Discovery for Metabolic DiseaseState Key Laboratory of Natural MedicinesChina Pharmaceutical University Nanjing China The State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China Pediatric Intensive Care Unit, Beijing Children's Hospital affiliated to Capital Medical University Beijing China Guangdong Provincial Key Laboratory of Functional Soft Condensed Matter, Smart Energy Research Centre, School of Materials and Energy, Guangdong University of Technology, Guangzhou 510006, China From the Department of Plastic & Reconstructive Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX. School of General Education, Anhui Medical University, Hefei, Anhui, People's Republic of China. Central Lab, First Affiliated Hospital of Fujian Medical University Fuzhou Fujian China Department of Otolaryngology-Head and Neck Surgery, Central Hospital of Enshi Prefecture, Enshi, 445000, China. dalia00589@163.com Department of Dermatology, Sunshine Union Hospital, Weifang, Shandong, China Department of Acupuncture and Moxibustion, Guang An Men Hospital, China Academy of Chinese Medical Sciences, Beijing, China. College of Resources and Environment, Hunan Agricultural University, Changsha 410128, China Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, Jilin, China Department of Plant Sciences University of Saskatchewan Saskatoon SK Canada Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, PR China. Department of Pathology and Laboratory Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030;; Department of Microbial Pathogenesis, Microbial Sciences Institute, Yale School of Medicine, New Haven, CT 06536; Department of Endocrinology and Metabolism, Zhejiang University Affiliated Sir Run Run Shaw Hospital, School of Medicine, Hangzhou, P.R. China Department of Pathogenic Microbiology and Immunology School of Basic Medical Sciences Xi’an Jiaotong University Xi’an China; Institute of Infection and Immunity Translational Medicine Institute Xi’an Jiaotong University Health Science Center Xi’an China Pacific Northwest National Laboratory, Energy and Environment Directorate, 902 Battelle Boulevard, Richland, Washington 99352 Department of Environment Science and Engineering, Tsinghua University, Beijing 100084, China. liujun99@mails.tsinghua.edu.cn Department of Traumatology and Orthopaedics II Ward, Weifang People's Hospital, Weifang, China. Department of Critical Care Medicine, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou 215001, Jiangsu, China. Corresponding author: Wu Yunfu,Email:icuwu@163.com. Department of Neurology Sun Yat‐sen Memorial Hospital, Sun Yat‐sen University Guangzhou Guangdong China Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada M5S 1A8; State Key Joint Laboratory of Environment Simulation and Pollution Control, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences , Beijing 100085 , China; College of Resources and Environment, University of Chinese Academy of Sciences , Beijing 100049 , China Department of Nephrology, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, 100 Haining Road, Shanghai 200080, China Programme in Cell Biology, Hospital for Sick Children, Toronto, ON M5G 0A4, Canada Key Laboratory of Semiconductor Materials Science, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China Sandia National Laboratories, Albuquerque, New Mexico 87185 Traditional Chinese Medicine Department, The Fourth Hospital of Changsha, Changsha, China Department of Nutrition and Food Hygiene, School of Public Health, Zunyi Medical University, Zunyi 563006, Guizhou, China; Experimental Teaching Demonstration Center for Preventive medicine of Guizhou Province, Zunyi 563006, Guizhou, China. Department of Pharmaceutical Chemistry and the Cardiovascular Research Institute, University of California San Francisco, 555 Mission Bay Boulevard South, San Francisco, California 94158, United States Department of Endocrinology Fifth People’s Hospital of Shanghai, Fudan University Shanghai China Department of Chemistry and Biochemistry, University of Delaware, Newark, DE, United States; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, United States. Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center , Houston, TX Biomedical Engineering Center, The Ohio State University, Columbus, Ohio 43210 Department of Molecular Biology and Genetics Cornell University Ithaca New York Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Energy and Environmental Directorate, Pacific Northwest National Laboratory, 902 Battelle Boulevard, Richland, Washington 99352, United States Department of Molecular Pharmacology and The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461; Department of Medicine, Yale University School of Medicine, New Haven, Connecticut; Departments of Surgery and Pathology, University of Virginia School of Medicine, Charlottesville, Virginia; and Department of Molecular Biomedical Research, VIB, Ghent University, Ghent, Belgium Department of Cardiovascular Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China Department of Gastroenterology Renmin Hospital of Wuhan University Wuhan Hubei Province China; Department of Nursing Renmin Hospital of Wuhan University Wuhan Hubei Province China School of Materials and Energy, Smart Energy Research Centre, Guangdong University of Technology, Guangzhou 510006, China Laboratory of Radiobiology, Fujian Medical University Cancer Hospital, Fuzhou, Fujian 350014, P.R. China The First Department of Orthopaedics, Shaanxi Provincial People's Hospital, Xi'an 710068, Shaanxi, China. Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, and ‡Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials; Beijing University of Chemical Technology; People's Republic of China; Engineering Research Center of Elastomer Materials on Energy Conservation and Resources of Ministry of Education; Beijing University of Chemical Technology Department of Gynecology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, PR China. liujun_haikou@126.com. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease and State Key Laboratory of Natural Medicines China Pharmaceutical University Nanjing China Department of Orthopedics, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000, P.R. China Department of Critical Care Medicine, Suzhou Ninth People's Hospital, The Affiliated Wujiang Hospital of Nantong University, Suzhou, Jiangsu 215001, P.R. China Houston Methodist Cancer Center; Shanghai Jiao Tong University Scientific Research Department, The First Affiliated Hospital of Shaoyang University, Shaoyang, China. Wuxi No. 5 People’s Hospital, Wuxi 214005, China Jiangxi Province Key Laboratory for Bamboo Germplasm Resources and Utilization, Jiangxi Agricultural University, Nanchang, China; Jiangxi Agricultural University, Nanchang, China From the Department of Plastic Surgery, The University of Texas M. D. Anderson Cancer Center. Department of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China; Department of Gastroenterology, The Fourth Affiliated Hospital of Guangxi Medical University/Liu Zhou Worker’s Hospital, Liuzhou, China College of Forestry, Jiangxi Agricultural University, Nanchang 330045, China. Department of Gastrointestinal Surgery, Dongfeng Hospital, Renmin Hospital, Hubei Medical College, Shiyan, Hubei 442000, China. Postgraduate Training Base, Hubei Medical College, Jinzhou Medical University, Shiyan, Hubei 442000, China. Department of Immunology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning, China Department of Orthopedics, Tianjin Hospital, Tianjin, China. Computer Network Information Center, Chinese Academy of Sciences, Beijing, China College of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, China From the Departments of Neurology (G.L.J.O., J.A.P., D.A.K., R.Z., I.d.B., M.D.F., G.M.T., A.M.J.M.v.d.M.), Human Genetics (A.D., L.S.V., P.A.C.'tH., A.M.J.M.v.d.M.), Molecular Epidemiology (M.B., P.E.S.), Radiology (D.A.K.), and Medical Statistics (J.J.G.), Leiden University Medical Centre; Department of Biological Psychology (L.L., R.P., D.I.B.), Vrije Universiteit Amsterdam; Amsterdam Public Health Institute (L.L.); Amsterdam Neuroscience and Amsterdam Public Health (M.B., C.S.T., Y.M., D.I.B., B... Centre for Lipid Research, Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. Pinghu Food and Drug Inspection Center Pinghu Zhejiang 314200 P. R. China Authors' Affiliations: Departments of 1Surgical Oncology, 2Cancer Biology, and 3Pathology, 4The Sarcoma Research Center, and 5The Division of Quantitative Sciences, University of Texas MD Anderson Cancer Center; and 6The Graduate School of Biomedical Sciences, Houston, Texas The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou 213164, China; Dalian Medical University, Dalian, 116044, China Institute of Oncology; Tianjin Union Medical Center; Tianjin 300121; China Department of Hepato-Pancreato-Biliary Surgery, Shandong Provincial Hospital, Jinan, Shandong, China. Institute of AIDS Control and Prevention, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China College of Environmental Science and Engineering, North China Electric Power University, Beijing 102206, China. State Key Joint Laboratory of Environment Simulation and Pollution Control, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts Affiliated Hospital of Yangzhou University, Yangzhou, People’s Republic of China. Affiliated Hospital of Jiangsu University, Zhenjiang, PR China Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037; The Salk Institute for Biological Studies, P.O. Box 85800, La Jolla, CA 92186; and Genomics Institute of The Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121 State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China Laboratory of Plant Molecular Biology Rockefeller University 1230 York Avenue New York NY 10065 USA Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China College of Information Engineering, Zhejiang University of Technology , Hangzhou 310023, China Key Lab of Quantum Sensing and Precision Measurement MOE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China School of Chemical Engineering and Environment, Weifang University of Science and Technology, Weifang, 262700, China; Shandong Engineering Laboratory for Clean Utilization of Chemical Resources, Weifang, 262700, China Department of Hematology/Hematological Lab, The Second Hospital of Anhui Medical University, Hefei, People’s Republic of China; Center of Hematology Research, Anhui Medical University, Hefei, People’s Republic of China School of Electrical Engineering, University of South China, Hengyang 421001, Hunan, China Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, State Key Laboratory of Natural Medicines China Pharmaceutical University Nanjing China Jiangsu Key Laboratory for Horticultural Crop Genetic Improvement, Institute of Vegetable Crops, Jiangsu Academy of Agricultural Sciences, Nanjing, China International Ocular Surface Research Center, Institute of Ophthalmology and Key Laboratory for Regenerative Medicine, Jinan University, Guangzhou, China Shanghai Institute of Biochemistry, the Chinese Academy of Sciences, Shanghai 200031, China. Department of Respiratory and Critical Care Medicine, Jiangshan People’s Hospital, Jiangshan, Zhejiang, China Department of Biochemistry and Molecular Biology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu 215123, P.R. China Department of Urology, Guangzhou General Hospital of Guangzhou Military Region, Guangzhou, Guangdong 510010, China. liujun1980s@hotmail.com School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, Hainan, China Departments of Epidemiology, Beijing Anzhen Hospital, Capital Medical University, the Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing Institute of Heart , Lung and Blood Vessel Diseases, Beijing , China Department of Clinical Laboratory, Wuxi Hospital for Infectious Disease, Wuxi, Jiangsu 214005, PR China Fuyang People’s Hospital, Fuyang, China Institute of Nuclear Physics and Chemistry; Mianyang; China Department of Information Engineering, Nanchang Hangkong University, Nanchang 330063, Jiangxi, China Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China. Department of Radiotherapy, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China Photosynthesis Research Center, Key Laboratory of Photobiology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China; Graduate University of Chinese Academy of Sciences, Beijing 100049, China Department of Internal Medicine, National Gaucher Disease Treatment Center Yale University School of Medicine 333 Cedar Street, LMP 4093 New Haven CT 06562 USA d Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA Department of Radiology Second Xiangya Hospital of Central South University Changsha China Beijing Engineering Research Center of Advanced Elastomers; Beijing University of Chemical Technology; Beijing 100029; P. R. China Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, China; Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, China; and Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, China Suncor AgroScience, 2489 North Sheridan Way, Mississauga, ON, Canada L5K 1A8 †Department of Medical Microbiology and Immunology, Creighton University Medical Center, Omaha, NE 68178 Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190 China College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China Department of Laboratory Medicine, The Fifth People’s Hospital of Wuxi Affiliated to Jiangnan University Wuxi China Department of Pathology, Beth Israel Hospital, Harvard Medical School Department of Nephrology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, Guangdong, China. Department of Hand Surgery, The Second Hospital of Jilin University, Changchun, Jilin 130000, P.R. China School of Instrument and Electronics, North University of China, Taiyuan, Shanxi 030051, People’s Republic of China; National Key Laboratory for Dynamic Measurement Technology, North University of China, Taiyuan 030051, People’s Republic of China *Clinical Sciences Division,; †Department of Immunology, and Department of Chemical Engineering, University of Virginia, Charlottesville, Virginia 22904 2Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas *Department of Medicine, Yale University School of Medicine, New Haven, CT 06516; Department of Nephrology, Affiliated First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China. Center for Influenza Research and Early Warning (CASCIRE), Chinese Academy of Sciences, Beijing, China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China College of Biotechnology Engineering Sichuan Univ. of Science and Engineering Yibin 644000 China School of Physics and Technology and School of Printing and Packaging; Wuhan University; Wuhan 430072; P. R. China State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China, and Departments of Chemistry, Biology, and Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180 duyuguo@mail.rcees.ac.cn Department of Chemistry and the Materials Research Center, Northwestern University, Evanston, Illinois 60208 Department of Chemistry, China Agricultural University, Beijing 100193, P. R. China Department of Endocrinology; Shanghai Fifth People's Hospital; Fudan University; Shanghai P.R. China Department of Obstetrics and Gynecology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China Information Systems Technology and Design Pillar, Singapore University of Technology and Design, Singapore Department of Ophthalmology, No. 181 Hospital of the PLA, Guilin, Guangxi, China Zhejiang Key Laboratory of Large-Scale Integrated Circuit Design, Hangzhou Dianzi University, Hangzhou 310018, China College of Energy, Xiamen University, Xiamen 361102, China Department of Neurology, Sun Yat‐Sen Memorial Hospital Sun Yat‐Sen University Guang Zhou China Arizona State University, Tempe, AZ, USA Department of Liver Transplantation and Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Texas, USA Brigham and Women’s Hospital Harvard Medical School Boston Massachusetts Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences Beijing China Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio 3Department of Ophthalmology and Visual Science, The Ohio State University, Columbus, Ohio Acupuncture and Rehabilitation Department of Cangxi Hospital of TCM, Guangyuan 628400, Sichuan Province, China. xjg48@hotmail.com Department of Breast‐Thyroid Surrey Shanghai First People Shanghai First People's Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200080 P. R. China Department of Mechanical and Industrial Engineering, University of Toronto, Toronto M5S 3G8, Canada China National Clinical Research Center for Respiratory Diseases Department of Respiratory Medicine Beijing Children's Hospital Capital Medical University, National Center for Children's Health Beijing China Department of Medicine Georgetown University School of Medicine Washington DC USA Division of Child and Adolescent Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032; Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio, United States; Department of Ophthalmology and Visual Sciences, The Ohio State University, Columbus, Ohio, United States Department of Chemistry, Jilin Province Key Laboratory of Organic Functional Molecular Design and Synthesis, Northeast Normal University, Changchun 130024, China Department of Epidemiology, Erasmus Medical Center , 3015 GD Rotterdam , The Netherlands; Nuffield Department of Population Health, University of Oxford , Oxford OX1 2JD, UK Department of Thoracic Surgery The First Affiliated Hospital of Guangzhou Medical University Guangzhou China; State Key Lab of Respiratory Diseases Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou China Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, China Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi’an, Shaanxi 710071, China State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University Yuanmingyuan Xilu #2, Haidai Dist Beijing 100094 China Division of Nephrology and Hypertension, Department of Medicine, Georgetown University, Washington, D.C.; Department of Neurology, Ruijin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Department of Cardiovascular Surgery, Shanghai East Hospital Tongji University School of Medicine Shanghai PR China Urology and Lithotripsy Center, Peking University People's Hospital, Beijing 100034, China Department of Medicine, University of Toronto, Toronto, Canada; Keenan Research Center, St. Michael’s Hospital, Toronto, Canada TechnoCom Corporation, 16133 Ventura Blvd., Suite 640, Encino, CA 91436, USA. jliu@technocom-wireless.com ASPEC Technologies Limited, 100101 Beijing, China; Chongqing Population and Family Planning Science and Technology Institute, Jiangbei, Chongqing 400020, China. Energy & Environment Directorate Pacific Northwest National Laboratory Richland WA 99352 USA; Joint Center for Energy Storage Research Pacific Northwest National Laboratory Richland WA 99352 USA State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun 130022 P.R. China Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education of China), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, China State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; Zhenjiang Environmental Monitoring Center of Jiangsu Province, Zhenjiang 212009, China Key Laboratory of Instrumentation Science and Dynamic Measurement, Ministry of Education, School of Instrument and Electronics, North University of China 1 , Taiyuan 030051, People’s Republic of China Jiangsu Province Key Laboratory of Oral Diseases, Department of Prosthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing 210029, China Department of Breast Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China, 100020 College of Food Science and Engineering Yangzhou University Yangzhou China Department of Radiation Oncology, Changzhou Fourth People's Hospital, Changzhou, Jiangsu Province, China State Key Joint Laboratory of Environment Simulation and Pollution Control National Engineering Laboratory for Multi Flue Gas Pollution Control Technology and Equipment School of Environment Tsinghua University 100084 Beijing China; College of chemistry and chemical engineering Taiyuan University of Technology 030051 Taiyuan China Coherus Biosciences, Redwood City, CA, United States. Fundamental and Computational Science Directorate, Pacific Northwest National Laboratory, Richland, Washington 99352, United States Tenaya Therapeutics, Inc, South San Francisco, CA (H.Z., J.Y., C.S., A.Z., I.W., E.C.L., T.N.Q., C.A.R., E.R.N., E.X., Z.D., T.M.A.M., F.F., A.F., J. Liu, S.J., C.F., T.W.C., F.J., W.S.P., J. Lin, T.H., K.N.I., L.M.L.). Department of Molecular Biology and Genetics Cornell University Ithaca New York USA The Key Laboratory of Ecological Environment and Critical Human Diseases Prevention, Education Department of Hunan Province, Department of Biochemistry, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China; The Key Laboratory of Typical Environmental Pollution and Health Hazards, Hunan Province, University of South China, Hengyang, Hunan 421001, China Department of Materials Science and Engineering, University of California Los Angeles, Los Angeles, CA 90095, USA Institute of Ageing Research School of Medicine Hangzhou Normal University Hangzhou China Department of Oncology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Department of Thoracic Surgery The First People's Hospital of Yunnan Province Kunming City Yunnan Province China Department of Electronic and Nanostructured Materials, Sandia National Laboratories, 1515 Eubank SE, Albuquerque, New Mexico 87123, and Department of Biomolecular Interfaces and Systems, Sandia National Laboratories, 1515 Eubank SE, Albuquerque, New Mexico 87123 Department of Endocrinology The Fifth People's Hospital of Shanghai, Fudan University Shanghai China Pacific Northwest National Laboratory 902 Battelle Boulevard, P.O. Box 999 Richland WA 99352 USA Department of Epidemiology and Health Statistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China. Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, P.R. China Hunan University of Arts and Science; Changde 415000; China Program on Regulation, Therapeutics, and Law, Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts From the Departments of Plastic Surgery, Neurosurgery, and Orthopaedic Oncology, University of Texas M. D. Anderson Cancer Center. Department of Biology, Institute of Life Science, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China Department of Otolaryngology Head and Neck surgery West China Hospital Sichuan University Chengdu Sichuan 610041 China Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University , Beijing , China; National Center for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University , Beijing , China Department of Biomedical Engineering, Ohio State University, 1080 Carmack Road, Columbus, OH 43210 e-mail: Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China Shanxi Province Key Laboratory of Quantum Sensing and Precision Measurement School of Instrument and Electronics North University of China Taiyuan Shanxi 030051 China Energy and Environment Directorate, Pacific Northwest National Laboratory, Richland, WA 99354; Sichuan Drug Rehabilitation Administration, Chengdu, China National High‐tech Industrial Development Zones of Taiyuan 030006 Taiyuan People's Republic of China Department of Chemistry, Department of Materials Science and Engineering, and the Materials Research Center, Northwestern University, Evanston, Illinois 60208-3113 Jiangsu Center for Drug Screening, China Pharmaceutical University Department of Obstetrics, Pingxiang Maternal and Child Health Hospital, Pingxiang, China Department of gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China; Digestive endoscopy center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, China Department of Anesthesiology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin 300350, P.R. China Department of Neurology & Institute of Neurology, Ruijin Hospital/Lu Wan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, China; CAS Center for Excellence in Brain Science and Intelligence Technology, Ruijin Hospital/Lu Wan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Microbial Pathogenesis, Yale School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA.; Yale Microbial Sciences Institute, P.O. Box 27389, West Haven, CT 06516, USA. First Clinical Medical College of Gansu University of Traditional Chinese Medicine, Lanzhou 730000. ljdyx0@163.com. Department of Urology, The 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou 730050. ljdyx0@163.com. Institute of Functional Nano and Soft Materials (FUNSOM); Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices; Joint International Research Laboratory of Carbon-Based Functional Materials and Devices; Soochow University; Suzhou, 215123 Department of Microbial Pathogenesis, Microbial Sciences Institute, Yale University, West Haven, Connecticut, USA; Department of Pathology and Laboratory Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA College of Materials, Xiamen University, Xiamen 361005, People’s Republic of China. Genomics Institute of Novartis Research Foundation, San Diego, CA 92121; International Center for Bamboo and Rattan, Key Laboratory of Bamboo and Rattan Science and Technology, State Forestry Administration, Beijing 100102, People’s Republic of China.; International Center for Bamboo and Rattan, Key Laboratory of Bamboo and Rattan Science and Technology, State Forestry Administration, Beijing 100102, People’s Republic of China. Acupuncture Department, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, No. 5, Beixiange Street, Xicheng District, Beijing 100053, China Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine; Brigham and Women's Hospital, Harvard Medical School; Boston MA USA Department of Biochemistry and Molecular Biology, Mayo Clinic, Scottsdale, Arizona;; HEALth Program, Mayo Clinic, Scottsdale, Arizona;; Division of Endocrinology, Mayo Clinic, Scottsdale, Arizona; Department of Orthopedics, The Second Affiliated Hospital of Nanjing Medical University Nanjing 210011, China. Department of Orthopaedics, General Hospital of Lanzhou Command, Lanzhou 730000, Gansu, China. liujunmn18@sina.com Department of Cardiology, Peking University People's Hospital, Beijing, China. School of Mechanical Engineering, Northwestern Polytechnical University, Xi’an 710072, China Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials, Beijing University of Chemical Technology, Beijing 100029, China Research Institute of Subtropical Forestry Chinese Academy of Forestry Fuyang China Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China. Department of Radiology, The Second Xiangya Hospital Central South University Changsha China; Clinical Research Center For Medical Imaging in Hunan Province Changsha China Authors' Affiliations: Departments of 1Neuro-Oncology, 2Thoracic/Head and Neck Medical Oncology, and 3Applied Mathematics and Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas; 4university of California, Los Angeles, California; 5University of Wisconsin, Madison, Wisconsin; 6Memorial Sloan–Kettering Cancer Center, New York, New York; 7Radiation Oncology Branch, National Cancer Institute; 8Cancer Therapy Evaluation Program, National Cancer Institute; 9University of California, San Francisco, California; and 10Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts Program in Bioorganic Chemistry, Division of Bioorganic Chemistry, and Departments of Molecular Biology and Pharmacology and Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, Missouri 63110 Department of Otolaryngology, Qilu Hospital, Shandong University, Jinan, China. Department of Pulmonary and Critical Care Medicine, Guangzhou First People’s Hospital, The Second Affiliated Hospital of South China University of Technology, Guanzhou, China Departments of 1Medical Microbiology and Immunology and Department of Orthopedics, General Hospital of Northern Theater Command, Shenyang, Liaoning 110015, P.R. China Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Clinical Neuroscience Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Radiology, Third Xiangya Hospital, Central South University, Changsha 410013, China. Emergency Surgery of Chinese Medicine Hospital of Gaomi, Weifang Medical University, Weifang 261053, China. Division of Pharmacoepidemiology and Pharmacoeconomics Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston MA USA International Center for Bamboo and Rattan, Key Laboratory of Bamboo and Rattan Science and Technology, State Forestry Administration, Beijing, People’s Republic of China.; International Center for Bamboo and Rattan, Key Laboratory of Bamboo and Rattan Science and Technology, State Forestry Administration, Beijing, People’s Republic of China. Department of Pathology and Laboratory Medicine, The University of Texas—Houston Medical School, Houston, Texas, USA Brigham and Women's Hospital Boston Massachusetts Department of Clinical Laboratory, Zhejiang Xiaoshan Hospital, Hangzhou, Zhejiang, China Department of Pharmacology and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA From the Departments of Plastic and Reconstructive Surgery and Health Services Research, University of Texas M. D. Anderson Cancer Center; private practice; and the Baker Institute for Public Policy, Rice University. Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China;; Key Laboratory of Hubei Province for Digestive System Disease, Renmin Hospital of Wuhan University, Wuhan, China;; Hubei Provincial Clinical Research Center for Digestive Disease Minimally Invasive Incision, Renmin Hospital of Wuhan University, Wuhan, China; Department of Respiration, Jiangshan People’s Hospital, Hangzhou, Zhejiang, China (mainland) Department of ultrasound Wuxi No.2 People's Hospital, Affiliated Hospital of Nanjing Medical University Wuxi City China Department of Gastroenterology, the Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, P.R. China; Department of Gastroenterology, the Fourth Affiliated Hospital of Guangxi Medical University/Liu Zhou Worker’s Hospital, Liuzhou, Guangxi, P.R. China Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, NM 87131, USA; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA Key Lab of Quantum Sensing and Precision Measurement; North University of China Department of Pathology and Laboratory Medicine, Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA; Department of Microbiology and Molecular Genetics, Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials, Beijing University of Chemical Technology, P. R. China; Beijing Engineering Research Center of Advanced Elastomers, Beijing University of Chemical Technology, P. R. China; Engineering Research Center of Elastomer Materials on Energy Conservation and Resources, Beijing University of Chemical Technology, P. R. China Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada Key Laboratory of Biotechnology in Lianyungang Normal College, Lianyungang 222006, China CAS Key Laboratory of Forest Ecology and Management Institute of Applied Ecology Shenyang 110016 China; University of Chinese Academy of Sciences Beijing 100049 China State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China; Department of Histology and Embryology, Laboratory of Stem Cell and Tissue Engineering Chongqing Medical University Chongqing 400016 China Huazhong University of Science and Technology State Key Laboratory of Advanced Electromagnetic Engineering and Technology, , Wuhan, Hubei 430074, China Guangdong Xi'an Jiaotong University Academy, 528300, China Centre for Molecular Medicine and Therapeutics at the Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada V5Z4H4; Department of Urology, Huashan Hospital, Fudan University 1Department of Gastrointestinal Surgery, Zhongshan Hospital of Xiamen University, Xiamen, Fujian, China.; 2Institute of Gastrointestinal Oncology, Medical College of Xiamen University, Xiamen, Fujian, China. Department of Neurosurgery, Liuzhou People’s Hospital, Liuzhou 545006, China School of Electrical and Electronic Engineering, Tianjin Key Laboratory of Film Electronic & Communication Devices, Advanced Materials and Printed Electronics Center, Tianjin University of Technology, Tianjin 300384, China Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts USA Department of Materials Science and Engineering and the Materials Research Center and Department of Chemistry, Northwestern University, Evanston, Illinois 60208 Key Laboratory of Materials Physics and Anhui Key Laboratory of Nanomaterials and Nanotechnology Institute of Solid State Physics Chinese Academy of Sciences Shushanhu Road 350 Hefei 230031 China Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases Department of Epidemiology, Beijing Anzhen Hospital, , Beijing, China Department of Otorhinolaryngology, Central Hospital of Enshi Prefecture, Enshi, China From the Capital Medical University Affiliated Beijing Anzhen Hospital, Beijing Institute of Heart, Lung & Blood Vessel Diseases, Beijing, China. The Social Welfare Hospital of Guilin, No. 89 North Zhongshan Road, Guilin 541001, China Department of Plastic Surgery, the University of Texas MD Anderson Cancer Center, Houston, Texas Department of Otolaryngology, the Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. National Key Facility for Crop Resources and Genetic Improvement, Institute of Crop Science Chinese Academy of Agricultural Sciences Beijing China College of Urban Construction, Nanjing Tech University, Nanjing, People’s Republic of China The 2nd Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, 6431 Fannin Street, MSB 2.228, Houston, Texas 77030 Department of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Microbial Sciences Institute Yale University West Haven Connecticut USA; Department of Microbial Pathogenesis Yale School of Medicine New Haven Connecticut USA Centre for Reproduction and Development, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia Key Laboratory of Animal Biotechnology College of Veterinary Medicine Ministry of Agriculture Northwest A&F University Yangling China Department of Nuclear Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, PR China State Key Laboratory of Biobased Material and Green Papermaking; Qilu University of Technology; Shandong Academy of Sciences; Jinan; P. R. China School of Petroleum and Natural Gas Engineering, Changzhou University, Changzhou, Jiangsu 213164, P. R. China Institute of Military Veterinary, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, 666 Liuying W Rd., Changchun, Jilin 130122, Republic of China State Key Laboratory of Polymer Physics and Chemistry; Changchun Institute of Applied Chemistry; Chinese Academy of Sciences; Changchun 130022; People's Republic of China State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing, 100193, China Joint Center for Energy Storage Research, Pacific Northwest National Laboratory, Richland, Washington 99352, United States Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan, and Howard Hughes Medical Institute, Departments of Medicine and Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110 Key Laboratory of Materials Physics and Anhui Key Laboratory of Nanomaterials and Nanotechnology, Institute of Solid State Physics, Chinese Academy of Sciences, Hefei 230031, China Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Houston, Texas 77030 Neurology Department, Affiliated Second Hospital of Guangzhou Medical University, Guangzhou 510260, P. R. China. Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts Department of Radiology, Second Xiangya Hospital of Central South University, Changsha, China; Clinical Research Center for Medical Imaging in Hunan Province, Changsha, China; Department of Radiology Quality Control Center, Hunan Province, Changsha, China Department of General Surgery, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China Departments of Epidemiology and Cardiology, Beijing Anzhen Hospital, Capital Medical University, the Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education, Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases , No.2 Anzhen Road, Chaoyang District , Beijing 100029, China Shandong Engineering Laboratory for Clean Utilization of Chemical Resources, Weifang University of Science and Technology, Weifang 262700, China South China Normal University 1 School of Physics and Telecom Engineering, , Guangzhou 510006, China Department of Breast‑Thyroid‑Vascular Surgery, Shanghai General Hospital, Shanghai 201620, P.R. China Laboratory of Molecular Pathology and Tuberculosis Diseases, Ankang Central Hospital, Shaanxi, China Sandia National Laboratories, Albuquerque, New Mexico 87185-1413 National Drug Screening Center and Jiangsu Key Laboratory of TCM Evaluation and Translational Research, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China Chengdu Customs Technology Center, Chengdu, 610041, PR China Department of Thoracic and Cardiovascular Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210 Department of Internal Medicine Yale University School of Medicine New Haven Connecticut Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials; People's Republic of China; State Key Laboratory of Organic–Inorganic Composites; Beijing University of Chemical Technology; 100029 Beijing Cheeloo College of Medicine,Shandong University,Jinan,Shandong Province,China; Department of Hepatobiliary Surgery and Center of Organ Transplantation, Shandong Provincial Hospital, Cheeloo College of Medicine,Shandong University,Jinan,Shandong Province,China Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA Key Laboratory of Hengyang City on Ecological Impedance Technology of Heavy Metal Pollution in Cultivated Soil of Nonferrous Metal Mining Area, Hengyang 421001, China. Department of Clinical Laboratory, Wuxi Fifth People's Hospital, Wuxi, Jiangsu 214005, PR China Key Laboratory of Potato Biology and Biotechnology, Ministry of Agriculture, Wuhan 430070, People’s Republic of China; National Center for Vegetable Improvement (Central China), Wuhan 430070, People’s Republic of China; Huazhong Agricultural University, Wuhan 430070, People’s Republic of China Department of Neurology SUN YAT‐SEN Medical Hospital SUN YAT‐SEN University Guangzhou Guangdong China China National Clinical Research Center for Respiratory Diseases Department of Respiratory Medicine Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing China Department of Chemistry and Argonne-Northwestern Solar Energy Research Center, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, and Division of Materials Science, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, Illinois 60439 Department of Pharmacy, Chest Hospital of Linyi Linyi, Shandong, China. Department of Joint Surgery, Institute of Orthopaedics, the 940th Hospital of PLA Joint Logistics Support Force, Lanzhou 730050, Gansu, China. Center for Hand-foot Surgery and Reparative & Reconstructive Surgery, The 2nd Hospital of Jilin University, Changchun, PR China Departments of Medicine and Immunology, University of Toronto, Toronto, Ontario, Canada Cryobiology Research Institute, Methodist Hospital of Indiana, Inc., Indianapolis, IN USA Department of Molecular Biology and Genetics, 423 Biotechnology Building,Cornell University, Ithaca, NY 14853, USA Department of Clinical Laboratory Zhejiang Xiaoshan Hospital Hangzhou China Department of Molecular Biology, University of Wyoming, Laramie, Wyoming 82071 Chinese Academy of Sciences, Beijing, China grid.27255.37 0000 0004 1761 1174 State Key Laboratory of Microbial Technology Shandong University Binhai Road 72 266237 Qingdao Shandong People’s Republic of China Shandong Yuwang Ecological Food Industry Co., Ltd, De Zhou, 251200, China Department of Pathology and Laboratory Medicine, McGovern Medical School at UTHealth, Houston, Texas, USA Department of Neurology & Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200025 China, and Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104 College of Life Sciences, Jiangxi Normal University, Nanchang, Jiangxi 330022, People’s Republic of China Beijing National Laboratory for Molecular Sciences (BNLMS), State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Analytical Instrumentation Center, Peking University, Beijing 100871, China Department of Radiology, Second Xiangya Hospital, Central South University, Changsha 410011, China;. Departments of Biomedical Engineering and Radiology, Wayne State University School of Medicine, Detroit MI 48201, USA. School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China; State Key Laboratory of Food Science and Resources, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China; Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China *Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, China;; †Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, China;; ‡Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, China; Ningbo Hygeia Medical Technology Company, Ltd., No. 1177 Lingyun Road, High-Tech Zone, Ningbo 315040, China Seed Science Center Institute of Crop Science College of Agriculture and Biotechnology Zhejiang University Hangzhou 310058 China New York State Psychiatric Institute, New York City (Amsalem, Wall, Markowitz, Fisch, LeBeau, Hinds, Liu, Fisher, Hankerson, Lewis-Fernández, Dixon, Neria); Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York City (Amsalem, Wall, Markowitz, Liu, Fisher, Smith, Hankerson, Lewis-Fernández, Dixon, Neria); School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel (Lazarov); New York State Office of Mental Health, Albany (Smith). Department of Molecular and Cellular Biology (W.H., J.Z., M.W., J.L., D.D.M.), Houston, Texas 77030 Burn Center of Yunnan Province, Second Affiliated Hospital of Kunming Medical University, Kunming, China Department of Urology, General Hospital of Guangzhou Military Command of People's Liberation Army, Guangzhou, Guangdong, China Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Houston, Texas 77030, United States National Engineering Research Center for Biomaterials; Sichuan University; Chengdu 610064; China State Key Laboratory of Precision Measuring Technology and Instruments; Tianjin University; CN-300072 Tianjin; China People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , 200025 Shanghai , China Department of Physiology and Pathophysiology School of Basic Medical Sciences Fudan University Shanghai 200032 China Center for Cardiac Function Test, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China. Department of Rheumatology and Immunology The Affiliated Hospital of Guizhou Medical University Guiyang China State Key Laboratory of Chemical Resource Engineering, Department of Organic Chemistry, College of Chemistry, Beijing University of Chemical Technology; Sinopec Beijing Research Institute of Chemical Industry Yanshan Branch g Department of HIV/AIDS Prevention , Hengyang Center for Disease Control and Prevention (CDC) , Hengyang , China From the Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts (K.S.L., E.P., K.F.H., J.L., B.T.B.); Department of Anesthesiology, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (K.S.L., B.T.B.); Department of Anesthesia, Toronto General Hospital and Univer Shanghai Key Laboratory of Functional Materials Chemistry and Institute of Fine Chemicals, East China University of Science and Technology, Meilong Road 130, Shanghai, China Beijing Engineering Research Center of Advanced Elastomers; Beijing University of Chemical Technology; Beijing 100029; China University of Leicester Department of Chemistry, , Leicester LE1 7RH, United Kingdom Center of Joint Surgery, Tianjin Hospital, Tianjin, China. Department of Food and Bioproduct Sciences; University of Saskatchewan; Saskatoon; Canada Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037; and Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121 Institute of Interdisciplinary Research Complex, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China Department of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China Department of General Surgery, China-Japan Friendship Hospital, Beijing, China From the Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine (H.K., J.J.J., L.A.W., C.-Y. C., J.D.S., J.L., J.M.F.), Department of Vascular and Endovascular Surgery (L.L.N.), and Department of Cardiovascular Medicine (M.D.G.-H.), Brigham and Women’s Hospital and Harvard Medical School, Boston, MA; Department of Epidemiology, Harvard School of Public Health, Boston, MA (H.K.); Laser Analytica, New York, NY (J.J.J.); and Duke Clinical Research Institute, Division of General... CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing 100101; China-Japan Joint Laboratory of Molecular Immunology and Molecular Microbiology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101; National Laboratory of Biomacromolecules and Center for Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101 Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (mainland) State Key Laboratory of High Field Laser Physics and CAS Center for Excellence in Ultra‐intense Laser Science, Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences Shanghai China; University Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing China Department of Nephrology, The Third Xiangya Hospital Central South University Changsha China; The Critical Kidney Disease Research Center of Central South University Changsha China Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences; University of Chinese Academy of Sciences Department of Molecular Genetics, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada The Research Team on Bone and Joint Degeneration and Injury of Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510120, China; The Fifth Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China; Guangdong Second Chinese Medicine Hospital Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine, Guangzhou, 510095, China Dermatology Hospital, Southern Medical University, Guangzhou 510091, China 1Department of Endocrinology, Shanghai Fifth People’s Hospital affiliated to Fudan University, Minhang District, Shanghai, People’s Republic of China Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, People’s Republic of China China Construction Third Bureau Green Industry Investment Company, Ltd., Wuhan 430035, P. R. China Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China College of Bio-Safety Science and Technology, Hunan Agricultural University, Changsha 410128, China. lj3209@163.com State Key Laboratory of Environmental Chemistry and Eco-toxicology; Research Center for Eco-Environmental Sciences; Chinese Academy of Sciences; Beijing 100085; China School of Materials Science and Engineering, Central South University, Changsha, Hunan, 410083, China Beijing Institude of Feed Conrrol, Beijing 100107, China College of Materials Science and Engineering, Changsha University of Science and Technology, Changsha 410114, PR China Department of Liver Transplantation and Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, People’s Republic of China Max Planck Institute for Solid State Research, Heisenbergstr. 1, Stuttgart, 70569, Germany Engineering Research Center of Intelligent Control for Underground Space, Ministry of Education, China University of Mining and Technology, Xuzhou 221116, China; School of Information and Control Engineering, China University of Mining and Technology, Xuzhou 221116, China Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education; School of Physics and Technology; Wuhan University; Wuhan 430072; P. R. China Department of Epidemiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases , Beijing , China From the Department of Plastic Surgery, Division of Surgery, The University of Texas M. D. Anderson Cancer Center. Department of Sports Medicine, Xiangya Hospital of Central South University, Changsha, China Division of Pharmacoepidemiology and Pharmacoeconomics Department of Laboratory medicine, Department of Infectious Diseases, Wuxi Fifth People’s Hospital Affiliated to Nanjing Medical University, Wuxi, People’s Republic of China MOE Key Laboratory of Macromolecule Synthesis and Functionalization; Department of Polymer Science and Engineering; Zhejiang University; Hangzhou 310027; China Department of Biosciences, Durham University, Durham DH1 3LE, UK Urology and Lithotripsy Center, Peking University People's Hospital , Beijing 100034, China; Peking University Applied Lithotripsy Institute, Peking University , Beijing 100034, China Faculty of Bioengineering, Sichuan University of Science and Engineering, Zigong 643000, China Department of Neurosurgery, Jining No.1 People’s Hospital, Jining, China State Key Laboratory of Characteristic Chinese Drug Resources in Southwest China, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China Energy and Environmental Directorate, Pacific Northwest National Laboratory, Richland, Washington 99352, United States Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China School of Materials Science and Engineering; Shanghai University; Shanghai 200072, China; Institute of NanoMicroEnergy; Shanghai University State Key Laboratory of Biocontrol, Key Laboratory of Gene Engineering of the Ministry of Education and Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, 510275 Guangzhou, People’s Republic of China *Department of Biological Science and; Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306; Department of Pathology and Laboratory Medicine, University of Texas Health Science Center, Houston, TX 77030; Department of Chemistry & Biochemistry, University of Delaware, Newark, Delaware 19716, United States Experimental Teaching Demonstration Center for Preventive Medicine of Guizhou Province, Zunyi Medical University, Zunyi, China State Key Laboratory of Organic Geochemistry Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou China; University of Chinese Academy of Sciences Beijing China Department of Cardiology Tianjin Beichen Hospital Tianjin China Department of Clinical Laboratory, Zhejiang Xiaoshan Hospital, Hangzhou, China; Joint Center for Energy Storage Research, Pacific Northwest National Laboratory, Richland, Washington 99354, United States Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center , Houston, TX , USA Tianjin Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital; Key Laboratory of Cancer Prevention and Therapy of Ministry of Education, Tianjin Medical University, Tianjin 300060, China. Key Laboratory of Semiconductor Materials Science, Beijing Key Laboratory of Low Dimensional Semiconductor Materials and Devices, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China Department of Materials Science and Engineering and Materials Research Laboratory, University of Illinois, Urbana, Illinois 61801, United States; Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, North Carolina 27695, United States Department of Cell Systems and Anatomy, The University of Texas Health San Antonio, San Antonio, TX, USA. Max Planck Institute for Solid State Research Heisenbergstr. 1 Stuttgart 70569 Germany; School of Materials Science and Engineering South China University of Technology Key Laboratory of Advanced Energy Storage Materials of Guangdong Province Guangzhou 510641 China Department of Pathology and Laboratory Medicine, McGovern Medical School at UTHealth, 6431 Fannin Street, MSB 2.228, Houston, TX, 77030, USA. jun.liu.1@uth.tmc.edu. Respiratory Department of Beijing Children's Hospital, China National Clinical Research Center of Respiratory Diseases, National Center for Children's Health Capital Medical University Beijing China Department of Radiology, The First Affiliated Hospital, Nanjing Medical University Nanjing, Jiangsu, China. Enzon Pharmaceuticals, Incorporated, 20 Kingsbridge Road, Piscataway, New Jersey 08854, and Laboratory of Molecular Biology, National Cancer Institute, NIH, Bethesda, Maryland 20892 Department of Gastroenterology, Tenth People's Hospital of Tongji University, Shanghai 200072, China. Department of Orthopedics, General Hospital of Shenyang Military Area Command of Chinese PLA, Shenyang, Liaoning, China Department of Hepatobiliary Surgery, Shandong Provincial Hospital affiliated to Shandong University, Jinan 250021, China Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada State Key Laboratory of Organic–Inorganic Composites Beijing Laboratory of Biomedical Materials College of Materials Science and Engineering Beijing University of Chemical Technology 15 North Third Ring Road Beijing 100029 P. R. China Department of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University , No. 107 Yanjiang West Road, Guangzhou , Guangdong , China; Guangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-Sen University , Guangzhou , China National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China College of Chemistry, Taiyuan University of Technology, Taiyuan030024, P. R. China Key Laboratory of Bamboo and Rattan Science and Technology, International Center for Bamboo and Rattan, State Forestry Administration, Beijing, People's Republic of China. International Ocular Surface Research Center, Key Laboratory for Regenerative Medicine, Institute of Ophthalmology, Jinan University, Guangzhou 510632, China; Department of Ophthalmology, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou 510630, China College of Plant Protection and Key Laboratory of Integrated Management of Crop Diseases and Pests, Ministry of Education, Nanjing Agricultural University, Nanjing 210095, China Deparment of Medicine, University of Toronto, Toronto, Canada Center of Electron Microscopy, State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, P. R. China Department of Radiotherapy, Changzhou Tumor Hospital Affiliated to Soochow University, Changzhou, China. State Key Laboratory of High Field Laser Physics and CAS Centre for Excellence in Ultra-intense Laser Science, Shanghai Institute of Optics and Fine Mechanics (SIOM), Chinese Academy of Sciences (CAS), Shanghai 201800, China; University Centre of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, China School of Physical Science and Technology & Guangxi Key Laboratory of Nuclear Physics and Technology, Guangxi Normal University, Guilin, 541004, China CAS Center for Excellence in Brain Science and Intelligence Technology, Ruijin Hospital affiliated with the Shanghai Jiaotong University School of Medicine, Shanghai, China. From the Department of Surgery, University of Chicago Medicine and Biological Sciences; and Department of Plastic Surgery, The University of Texas M. D. Anderson Cancer Center. Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas Department of Hand and Foot Surgery and Microsurgery, Affiliated to the First People’s Hospital of Chenzhou, P.R. China Department of Acupuncture and Moxibustion, Guang An Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China Department of Information Engineering, Nanchang Hangkong University, Nanchang, Jiangxi 330036, China Institute of Interdisciplinary Medical Science, Shanghai University of Traditional Chinese Medicine, Pudong New Area, Shanghai 201203, P.R. China Department of Pathophysiology, School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, P.R. China Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University; Guangdong Provincial Clinical and Engineering Center of Digital Medicine Wuhan University Department of Orthopedics, The 967th Hospital of Joint Logistic Support Force of PLA, Dalian, Liaoning, China Shanghai General Hospital of Nanjing Medical University, Shanghai 201620, P.R. China Pulmonary and Critical Care Medicine, Chongqing Red Cross Hospital (People’s Hospital of Jiangbei District), Chongqing, China Guangdong Second Traditional Chinese Medicine Hospital, Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine, Guangzhou, Guangdong 510095, China. Department of Intensive Care Unit, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou 215001, Jiangsu, China. Energy and Environment Directorate Pacific Northwest National Laboratory Richland WA 99352 USA Dermatology Hospital of Southern Medical University, Guangzhou, Guangdong 510091, P.R. China Department of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, No. 197 Ruijin Second Road, Huangpu District, Shanghai 200025, China Department of Nephrology Shanghai General Hospital, Shanghai Jiao Tong University Shanghai 200080 China Center for Studies of Psychological Application, South China Normal University, Guangzhou, China. Department of Geriatrics, Department of General Medicine, Xiangya Hospital, Central South University; Changsha; P. R. China College of Information Engineering, Nanchang Hangkong University, Nanchang, Jiangxi, 330063, China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China; Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China Laboratory of Pathogenic Biology, Guangdong Medical University, Zhanjiang 524023, China Department of HIV/AIDS Control and Prevention Guangdong Provincial Center for Disease Control and Prevention Guangzhou China Department of Endocrinology, Nanjing Jinling Hospital, School of Medicine, Nanjing University Nanjing 210002, Jiangsu, China. School of Materials Science and Engineering and Guangdong Provincial Key Laboratory of Advanced Energy Storage Materials South China University of Technology Guangzhou 510640 P. R. China Department of Epidemiology, Beijing Anzhen Hospital Affiliated to the Capital University of Medical Science, Beijing 100029, China. Shenzhen Ritzcon Biological Technology Co, Ltd Shenzhen Guangdong China Department of Medical College, Nanchang University, Nanchang, Jiangxi 330006, China Changchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun 130122, China Department of Urology, People Hospital of Peking University, Beijing 100044, China. Brigham and Women's Hospital, Boston, MA Department of Urology, General Hospital of Guangzhou Command, Guangzhou 510010, China. looselj@fimmu.com Howard Hughes Medical Institute, Departments of Medicine and Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8230, St. Louis, MO 63110 Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Biology and Genetic Improvement of Oil Crops, Ministry of Agriculture and Rural Affairs, Wuhan, China. Department of Biochemistry and ‡Harold C. Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038, United States Key Lab for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Meilong Road 130, Shanghai, China Department of Laboratory Medicine, Yue Bei People's Hospital, Shaoguan, Guangdong 512026, P.R. China Department of Urology, Guizhou Provincial People's Hospital, The Affiliated Hospital of Guiyang Medical College, Guizhou, China. Department of Chemotherapy, Affiliated Hospital of Nantong University, Nantong 226001, China Department of Endocrinology, Shanghai Fifth People’s Hospital, Fudan University, Shanghai 200240, China Department of Pathology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China. Department of Cardiology, Guangdong Second Provincial General Hospital, Guangzhou City, Guangdong, People’s Republic of China Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, 199 Ren'ai Road, Suzhou, 215123, Jiangsu, People's Republic of China Research Team on Bone and Joint Degeneration and Injury, Guangdong Academy of Traditional Chinese Medicine, Guangzhou, China; The Second Affiliated Hospital, Guangzhou University of Chinese Medicine (Guangdong Province Hospital of Traditional Chinese Medicine), Guangzhou, China Department of Macromolecular Science and Engineering, Case School of Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, United States Department of Microbial Pathogenesis Microbial Sciences Institute Yale School of Medicine New Haven CT USA Key Laboratory of Instrumentation Science & Dynamic Measurement, Ministry of Education, Science and Technology on Electronic Test and Measurement Laboratory, Taiyuan 030051, P. R. China The Fifth Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China; Guangdong Second Chinese Medicine Hospital (Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine), Guangzhou, 510095, China; The Research Team on Bone and Joint Degeneration and Injury of Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510120, China Department of Critical Care Medicine, Zhongda Hospital, Southeast University, Nanjing 210009, China. Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, Illinois 60637, United States; Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois 60637, United States Department of Anesthesiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510630, P.R. China From the Department of Plastic and Reconstructive Surgery, University of Texas M. D. Anderson Cancer Center; and McGovern Medical School. Department of Medical Imaging, Tianjin Union Medicine Center, Tianjin 300121, China Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China; Department of Nursing, Renmin Hospital of Wuhan University, Wuhan, China Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Operation Management Department, West China Hospital, Sichuan University, Chengdu 610041, China. Department of Orthopaedics, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou Guangdong, 510120, P.R.China.liujun.gdtcm@hotmail.com. Department of Nephrology, Southern Medical University Nanfang Hospital, Guangzhou, PR China; The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, P. R. China Departments of 1Surgical Oncology, 2Neurosurgery, 3Pediatrics and Child Neurology, 4Experimental Therapeutics, 5Systems Biology, 6Pathology, and 7Cancer Biology and 8Division of Quantitative Sciences, The University of Texas M. D. Anderson Cancer Center, Houston, Texas Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials, Beijing University of Chemical Technology, Beijing 100029, P. R. China University of California, San Francisco, Department of Pharmaceutical Chemistry, 555 Mission Bay Boulevard South, San Francisco, California 94158, United States Institute of Human Virology, Sun Yat-Sen University, Guangzhou, Guangdong, China; Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China; Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China Department of Neurology & Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shandong Engineering Laboratory for Clean Utilization of Chemical Resources, Weifang University of Science and Technology, Weifang 262700, China; Key Laboratory of Mesoscopic Chemistry, MOE, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China Department of Otorhinolaryngology Head and Neck Surgery, PLA General Hospital, Beijing 100853, China. Institute of New Energy and Low-Carbon Technology, Sichuan University, Chengdu 610065, China State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-Sen University , 510275 Guangzhou, China; Department of Geology and Environmental Earth Science, Miami University , Oxford, OH 45056, USA Key Laboratory of Biomedical Photonics of Ministry of Education, Huazhong University of Science and Technology, 430074, P. R. China Institute of High Performance Computing, A*STAR Research Entities, Singapore, Singapore. Department of Pulmonary Medicine, Shanghai Chest Hospital Shanghai Jiao Tong University Shanghai China State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University Changchun P. R. China Department of Urology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China; Department of Neurosurgery, Ganzhou People’s Hospital, Ganzhou 341000, China Department of Epidemiology, Erasmus Medical Center , Rotterdam , the Netherlands; Nuffield Department of Population Health, University of Oxford , Oxford , UK Stem Cell and Genetic Engineering Group, Department of Materials Engineering, Faculty of Engineering, Monash University-Clayton Campus, Wellington Road, Clayton, VIC, 3800, Australia. jun.liu@monash.edu. Contribution from Sandia National Laboratories, P.O. Box 5800, Albuquerque, New Mexico 87185 Pacific Northwest National Laboratory, Richland, Washington 99352 Department of Hematology, Xinqiao Hospital, Army Medical University, Chongqing, People's Republic of China Zhangmutou Forest Farm of Guangdong Institute of Marine Biotechnology Collaborative Innovation Center of Deep Sea Biology School of Life Science Tsinghua University Beijing China Department of Neurosurgery Yale University New Haven CT 06510 USA Clinic Medical College of Yangzhou University, Department of Hepatobiliary and Pancreatic Surgery, Northern Jiangsu People's Hospital Yangzhou China Key Laboratory of Materials Physics and Anhui Key Laboratory of Nanomaterials and Nanotechnology, Institute of Solid State Physics, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, Tex. Cryobiology Research Institute, Wells Center for Pediatric Research, Indiana University Medical Center, Indianapolis, IN; Department of Veterinary Clinical Sciences, and Hillenbrand Biomedical Engineering Center, Purdue University, West Lafayette, IN Department of Otorhinolaryngology–Head and Neck Surgery, West China Hospital, West China School of Medicine, Sichuan University, Chengdu From the Departments of Biomedical Engineering and2Ophthalmology, The Ohio State University, Columbus, Ohio. State Key Laboratory of Tree Genetics and Breeding, Key Laboratory of Tree Breeding of Zhejiang Province, Research Institute of Subtropical Forestry, Chinese Academy of Forestry, Hangzhou, China Beijing National Laboratory for Molecular Sciences, Key laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China Department of Biochemistry and Molecular Biology, Medical College, Soochow University, Suzhou, Jiangsu 215123, PR China. Department of Pathogenic Organisms, Fourth Military Medical University, Xi'an 710032, China. MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology, Ministry of Education, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, People’s Republic of China; Fubio (Suzhou) Biomedical Technology Co., Ltd., Suzhou, People’s Republic of China Breast Cancer Centre, China-Japan Friendship Hospital, Beijing, China Associate Professor, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China. College of Science; National Research Center of Engineering Technology for Utilization of Functional Ingredients from botanica; College of Agronomy; Hunan Agricultural University; Changsha Department of Molecular Biology and Genetics, Cornell University , Ithaca, NY 14853 , USA College of Materials Science and Engineering, Xi’an University of Science and Technology, Xi’an 710054, China Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China; Hubei Provincial Clinical Research Center for Digestive Disease Minimally Invasive Incision, Renmin Hospital of Wuhan University, Wuhan, China National Key Laboratory on Electromagnetic Environment Effects and Electro-Optical Engineering, Nanjing 210007, China Guangdong Key Laboratory for Crop Germplasm Resources Preservation and Utilization, Agro-biological Gene Research Center, Guangdong Academy of Agricultural Sciences, Guangzhou, China Department of Orthopaedics; Changhai Hospital; Second Military Medical University; Shanghai 200433; China School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, China School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8; and Department of Molecular and Cell Biology, 229 Stanley Hall, University of California, Berkeley, CA 94720-3206 State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University Changchun 130012 P. R. China State Key Laboratory of Biocontrol, Key Laboratory of Biodiversity Dynamics and Conservation of Guangdong Higher Education Institutes, College of Ecology and Evolution, Sun Yat-sen University , Guangzhou, PR China Key Laboratory of Synthetic Chemistry of Natural Substances Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 P. R. China Department of Respiratory Medicine, Changsha Central Hospital Affiliated to Nanhua University, Hunan, China North University of China Laboratory of Plant Molecular Biology, Rockefeller University, 1230 York Avenue, New York, NY 10065 Tianjin Cerebral Vascular and Neural Degenerative Disease Key Laboratory, Tianjin Neurosurgical Institute, Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin 300350, P.R. China Department of Infectious Diseases, Tianjin First Central Hospital, Tianjin, China Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, China Department of Critical Care Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China. Corresponding author: Zuo Xiangrong, Email: 13913979197@139.com. Department of Gynecology, Beijing Ditan Hospital Capital Medical University, Beijing 100200, P.R. China Department of Cardiology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China;; Key Laboratory of Assisted Circulation, Ministry of Health, Sun Yat-Sen University, Guangzhou, China; Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials, Beijing University of Chemical Technology 1 , Beijing, People’s Republic of China; Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology 4 , 100029 Beijing, People’s Republic of China; State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology 5 , 100029 Beijing, People’s Republic of China Department of Cardiology, The First Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei Province 050031, China. Department of Epidemiology, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases. Department of Urology, Peking University People’s Hospital, Beijing 100034, China Department of Radiation Oncology, Jiangxi Cancer Hospital, Nanchang City, China. Department of Pathology, University of Medicine and Dentistry of New Jersey/School of Osteopathic Medicine, West Cherry Hill, New Jersey 08002, USA. liuju@umdnj.edu Department of Orthopaedic Surgery, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, China Department of Hepato-Pancreato-Biliary Surgery, Shandong Provincial Hospital, Shandong, China Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital, Boston, MA College of Veterinary Medicine Northwest A&F University, Key Laboratory of Animal Biotechnology of the Ministry of Agriculture Yangling Shaanxi Province China Sandia National Laboratories, Albuquerque, New Mexico 87185, and University of New Mexico, Albuquerque, New Mexico 87131 Department of Epidemiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China Department of Neurosurgery Yale University New Haven CT 06511 USA Key Laboratory of Instrumentation and Science and Dynamic Measurement, Ministry of Education, North University of China 1 , Taiyuan 030051, People’s Republic of China; School of Instrument and Electronics, North University of China 2 , Taiyuan 030051, People’s Republic of China School of Electrical Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, P. R. China The Natural Products and Glycoconjugate Research Group 1805, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China, State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China, and Graduate University of the Chinese Academy of Sciences, China West Virginia University Cancer Institute West Virginia University Morgantown WV USA Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China; Key Laboratory of Hubei Province for Digestive System Disease, Renmin Hospital of Wuhan University, Wuhan, China; Hubei Provincial Clinical Research Center for Digestive Disease Minimally Invasive Incision, Renmin Hospital of Wuhan University, Wuhan, China Department of Thoracic Oncology and Surgery, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease the First Affiliated Hospital of Guangzhou Medical University Guangzhou China Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghafi, China Pulmonary and Critical Care Medicine, The Second Hospital of Longyan, Longyan, Fujian, China; Key Laboratory of Synthetic Chemistry of Natural Substances Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 P.R. China College of Horticulture Shenyang Agricultural University Shenyang China Oto‐Rhino‐Laryngology‐Head and Neck West China Hospital/West China Medical School Sichuan University Chengdu Sichuan China Department of Neurology Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou China Stem Cells and Genome Editing, Genomics and Cellular Sciences, Agriculture Victoria Research, Bundoora, VIC, Australia. Department of Plastic Surgery, Division of Surgery, University of Texas M. D. Anderson Cancer Center. Department of Nephrology, Nanfang Hospital,First Military Medical University, Guangzhou 510515, China. Department of Orthopaedics, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon‐Based Functional Materials & Devices Soochow University Suzhou Jiangsu 215123 P. R. China Department of Epidemiology, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China Department of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine , Shanghai , China CAS Key Laboratory of Nutrition, Metabolism and Food Safety, CAS Center for Excellence in Molecular Cell Sciences, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences (CAS) Beijing China; National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention (China CDC) Beijing China School of Medicine, Nantong University , Nantong, 226001 , China Department of General Surgery, Shanghai Jiaotong University Affiliated First People's Hospital, People's Republic of China. Key Laboratory of Horticultural Plant Biology (HAU) Ministry of Education National Centre for Vegetable Improvement (Central China) Huazhong Agricultural University Wuhan China Department of Obstetrics and Gynecology, Ditan Hospital, Beijing 100015, China. Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China;; Laboratory of RNA and Major Diseases of Brain and Heart, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China;; Guangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China Renmin University of China Institute of Fluid Physics , CAEP, P.O. Box 919-109, Mianyang, Sichuan 621900, People's Republic of China The State Key Laboratory of Molecular Oncology, Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, People's Republic of China. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Section, South Renmin Road, Chengdu, 610041 Sichuan, China; Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China Department of Neurosurgery, Huishan People’s Hospital of Wuxi, Wuxi, Jiangsu, China (mainland) Department of Materials Science and Engineering and the Materials Research Center, Northwestern University, 2220 Campus Drive, Evanston, Illinois 60208-3108, and Department of Chemistry and the Materials Research Center, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113 University of Michigan 2 Department of Chemical Engineering, , 2300 Hayward St., Ann Arbor, Michigan 48109, USA National Key Laboratory on Electromagnetic Environmental Effects and Electro-optical Engineering, Nanjing 210094, Jiangsu, China College of Animal Science, South China Agricultural University, Tianhe District, Guangzhou, Guangdong, People's Republic of China MOE Key Laboratory of Horticultural Plant Biology, National Center for Vegetable Improvement, Potato Engineering and Technology Research Center of Hubei Province, and Huazhong Agricultural University, Wuhan 430070, China Institute of Crop Sciences (ICS) Chinese Academy of Agricultural Sciences (CAAS)/National Key Facility for Crop Gene Resources and Genetic Improvement, Key Laboratory of Biology and Genetic Improvement of Triticeae Crops Ministry of Agriculture Beijing China 1 Computer and Information Science and Engineering, University of Florida, Gainesville, FL, USA and 2 Institute for Molecular Biology, University of Zurich, Zurich, Switzerland Department of Chemistry, the Materials Research Center, and the Argonne Northwestern Solar Energy Research Institute, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113 Department of Nephrology, the third Xiangya Hospital, Central South University, Changsha, Hunan 410011, China Department of Preventive Medicine, School of Public Health Zunyi Medical University Zunyi China Department of Food Science and Engineering; Jinan University; Guangzhou; P. R. China College of Pharmaceutical Sciences Zhejiang University of Technology Hangzhou 310014 People's Republic of China Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China Genentech Incorporated, Late Stage Pharmaceutical and Processing Development, 1 DNA Way, South San Francisco, California 94080 Departments of Protein Engineering and of Pharmaceutical Research and Development, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080 Department of Molecular Biology and Genetics, Cornell University, Ithaca,NY 14853, USA. Clinical Laboratory, Zhejiang Xiaoshan Hospital, Hangzhou, Zhejiang, China (mainland) Department of Cardiology, Key Laboratory on Assisted Circulation, Ministry of Health The First Affiliated Hospital of Sun Yat‐sen University Guangzhou Guangdong People's Republic of China Department of Laboratory Medicine, The Fifth Peoples Hospital of Wuxi, Wuxi Department of Orthopaedics, Jiangsu Rugao Boai Hospital, Nantong, Jiangsu, China Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121 Department of Otorhinolaryngology-Head and Neck Surgery, West China Hospital of Sichuan University, Chengdu, China Guangdong Academy of Agricultural Sciences, 117866, Sericultural & Agri-Food Research Institute, Guangzhou, Guangdong, China; Department of Orthopedics, General Hospital of Northern Theater Command of Chinese PLA, Shenyang, Liaoning 110016, China Department of Laboratory Medicine Wuxi No. 5 People's Hospital Affiliated Jiangnan University Wuxi Jiangsu 214005 P.R. China College of Chemistry and Chemical Engineering; Hunan Normal University; Changsha; China d Hengyang Center for Disease Control and Prevention , Hengyang , Hunan , China Department of Microbial Pathogenesis and Microbial Sciences Institute, Yale School of Medicine, Advanced Biosciences Center, New Haven, CT, USA. jun.liu.jl2996@yale.edu. Department of Laboratory Medicine The Fifth People’s Hospital of Wuxi Affiliated to Jiangnan University Wuxi China Department of Joint Surgery, Tianjin Hospital, Tianjin 300211, PR China Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing; and Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University; Department of Medical Parasitology, Xinjiang Medical University From the Department of Geriatrics, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shanxi, People's Republic of China. School of Basic Medicine and Clinical Pharmacy State Key Laboratory of Natural Medicines China Pharmaceutical University Nanjing China Microbial Sciences Institute & Department of Microbial Pathogenesis Yale School of Medicine New Haven Connecticut USA Joint Department, Tianjin Hospital, Tianjin 300211, P.R. China Department of preventive medicine laboratory, School of Public Health, Zunyi Medical University, Zunyi, 563006, China Key Laboratory of Human Performance, Shanghai University of Sport, Shanghai 200438, China Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin, China; Department of Obstetrics and Gynecology,Hohhot First Hospital, Hohhot, Inner Mongolia, China College of Plant Protection and Key Laboratory of Integrated Management of Crop Diseases and Pests, Ministry of Education, Nanjing Agricultural University College of chemistry and molecular science, Wuhan University, 430072, Wuhan, People's Republic of China Bone and Joint Research Team of Degeneration and Injury Guangdong Provincial Academy of Chinese Medical Sciences Guangzhou China; Guangdong Second Traditional Chinese Medicine Hospital (Guangdong Province Engineering Technology Research Institute of Traditional Chinese Medicine) Guangzhou China Key Laboratory of Animal Biotechnology of the Ministry of AgricultureCollege of Veterinary MedicineNorthwest A&F University Yangling China Jiangsu Key Laboratory of Chinese Medicine and Characteristic Preparations for Paediatrics, Jumpcan Pharmaceutical Group Co.,Ltd. Taixing 225400, China. Key Laboratory of Optoelectronic Technology and Systems, Ministry of Education, Department of Optoelectronic Engineering, Chongqing University, Chongqing 400044, P. R. China Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Beijing Chao‐Yang Hospital Capital Medical University Beijing P. R. China Institute of Chemical Biology and Pharmaceutical Chemistry, Zhejiang University, Hangzhou 310028, China. Department of Cardiology, The Third Xiangya Hospital of Central South University, No. 138, Tongzipo Road, Changsha, Hunan 410013, China State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, No. 270, Xueyuan Road, Wenzhou, Zhejiang, 325027, China Department of Endocrinology, The Fifth People’s Hospital of Shanghai, Fudan University, Shanghai, China (mainland) Department of Spine and Spinal Cord Surgery of Wendeng Orthopaedics Hospital, Weihai 264400, Shandong, China. liujun0528@yahoo.com.cn Department of Chemical Engineering, Tsinghua University, Beijing 100084, China Department of Pathology, Tongde Hospital of Zhejiang Province, Hangzhou, China Key Laboratory of Nutrition and MetabolismCAS Center for Excellence in Molecular Cell ScienceInstitute for Nutritional SciencesShanghai Institutes for Biological SciencesUniversity of Chinese Academy of SciencesChinese Academy of Sciences Shanghai China From the Division of Plastic Surgery, Baylor College of Medicine; and the Department of Plastic Surgery, University of Texas M. D. Anderson Cancer. Department of Biomedical Engineering, The Ohio State University, Columbus, OH;; Department of Ophthalmology and Visual Sciences, The Ohio State University, Columbus, OH. Department of Neurosurgery, Jining No. 1 People's Hospital, Jining, Shandong 272111, P.R. China Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials, Beijing, People’s Republic of China; Beijing Engineering Research Center of Advanced Elastomers, Beijing, People’s Republic of China; Engineering Research Center of Elastomer Materials on Energy Conservation and Resources, Ministry of Education, Beijing, People’s Republic of China Contribution from the Pacific Northwest National Laboratory, Richland, Washington 99352, University of New Mexico, Albuquerque, New Mexico 87131, and Sandia National Laboratories, Albuquerque, New Mexico 87185 Department of Ultrasonic Diagnosis, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, China Department of Orthopedics, General Hospital of Shenyang Military Area Command of Chinese PLA, Shenyang, Liaoning; and *CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101 China;; †Graduate University, Chinese Academy of Sciences, Beijing, 100049 China; AXYS Analytical Services Ltd. 2045 Mills Road West, Sidney, British Columbia V8L 5X2, Canada Institute of Cell Biology Zhejiang University School of Medicine Hangzhou China Department of Breast Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100043, P.R. China Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences, Institute of Vertebrate Paleontology and Paleoanthropology, Beijing, China Department of Neurology Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou Guangdong China Medical Research Center, Yue Bei People's Hospital Shantou University Medical College Shaoguan China Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences Xi'an Jiaotong University Xi'an Shaanxi China; Institute of Infection and Immunity, Translational Medicine Institute Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China; Xi'an Key Laboratory of Immune Related Diseases Xi'an Shaanxi China Department of Materials Engineering, Monash Institute of Medical Engineering, Faculty of Engineering, Monash University, Clayton, VIC 3168, Australia Department of Otorhinolaryngology, Head and Neck Surgery West China Hospital, Sichuan University Chengdu People's Republic of China Beijing Advanced Innovation Center for Food Nutrition and Human Health College of Food Science & Nutritional Engineering China Agricultural University Beijing China Department of Thoracic Surgery and Oncology, China State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China Burn and Plastic Department, Gansu Province People's Hospital, Lanzhou 730000, Gansu, China. Department of Neurosurgery, The Affiliated Hospital of Jiangsu University, 438 Jiefang Road, Zhenjiang 212001, Jiangsu Province, China Guangdong Provincial Key Laboratory of Functional Soft Condensed Matter; School of Material and Energy; Guangdong University of Technology; Guangzhou 510006; China Departments of Clinical Laboratory, Yue Bei People’s Hospital, Shantou University Medical College, Shaoguan, Guangdong, China The First Affiliated Hospital of Guangzhou Medical College, Guangzhou, China. College of Chemistry and Chemical Engineering Central South University Changsha 410083 P. R. China Department of General Surgery, China-Japan Friendship Hospital, Beijing, China. Beijing University of Chemical Technology 1 Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials, , Beijing 100029, People’s Republic of China; Beijing University of Chemical Technology 2 Division of Molecular and Materials Simulation, Key Lab for Nanomaterials, Ministry of Education, , Beijing 100029, People’s Republic of China Department of Cell Systems and Anatomy, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA Second Department of Breast Surgery Tianjin Medical University Cancer Institute and Hospital Tianjin China; National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy Tianjin China; Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Preventionand Therapy Tianjin Medical University Tianjin China Chengdu Customs Technology Center, Chengdu 610041, China Xiangya Hospital, Central South University, Changsha, Hunan 410008, China Key Laboratory of Evolutionary Systematics of Vertebrates, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, People's Republic of China Guangdong Provincial Key Laboratory for Crop Germplasm Resources Preservation and Utilization, Agro-biological Gene Research Center, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China Energy & Environment Directorate; Pacific Northwest National Laboratory; Richland; USA Department of Anesthesiology, The Third Affiliated Hospital of Sun Yat‑Sen University, Guangzhou, Guangdong 510630, P.R. China Department of Thoracic Surgery Peking University People's Hospital Beijing China Department of Gastroenterology, Clinical Medical College of Yangzhou University, Northern Jiangsu People’s Hospital, Yangzhou, P. R. China Pharmaceutical Sciences Division School of Pharmacy Wisconsin Center for NanoBioSystems Carbone Cancer Center School of Medicine and Public Health University of Wisconsin Madison (UW‐Madison) Madison Wisconsin 53705 USA Fourth Military Medical University Xi'an China Pacific Northwest National Laboratory, Richland, Washington 99352, and University of New Mexico, Albuquerque, New Mexico 87131 Department of Pathology, Peking University Shenzhen Hospital, Shenzhen, 518036, Guangdong, China Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China State Key Laboratory of Biocontrol, Key Laboratory of Biodiversity Dynamics and Conservation of Guangdong Higher Education Institutes, College of Ecology and Evolution, Sun Yat-sen University, Guangzhou 510275, P. R. China Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi’an, Shanxi 710071, China Institute of High Performance Computing (IHPC), A*STAR, 138632 Singapore, Singapore Chongqing University Department of Optoelectronic Engineering, , Chongqing 400044, People’s Republic of China Departments of Laboratory Medicine and Pathobiology and of Medical Genetics and Microbiology, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8 Department of Otolaryngology, Henan Province Hospital, Zhengzhou, 450003, China. lj0371ent@sina.com College of Veterinary Medicine, Northwest A&F University, Key Laboratory of Animal Biotechnology of the Ministry of Agriculture, Yangling, Shaanxi Province, PR China. From the Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (A.K., J.A.R., J.M., S.S., J.G., J.M.P., J.L., M.A.F., N.K.C.); and the Lynn Heart and Vascular Institute, Boca Raton Regional Hospital, and Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL (A.K.). State Key Laboratory of Optoelectronic Materials and Technologies; School of Physics & Engineering; Sun Yat-sen University; Guangzhou 510275; P. R. China Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China; Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin, China College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China. Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, PR China, Pacific Northwest National Laboratory, Richland, Washington 99352, and Department of Chemical Engineering, Princeton University, Princeton, New Jersey 08544 Department of Otolaryngology Head and Neck Surgery, Institute of Otolaryngology, Chinese PLA General Hospital, Beijing, China (mainland) Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, People's Republic of China; Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin, People's Republic of China Department of Medical Microbiology and Immunology, Creighton University Medical Center, Omaha, NE 68178 College of Materials, Xiamen University, Xiamen 361005, People’s Republic of China Institute of Governance Modernization, Shanghai University of Engineering Science, Shanghai, China Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Department of Thoracic Surgery, Shengjing Hospital, China Medical University, Shenyang 110001, China. Department of Chemistry, University of Saskatchewan, 110 Science Place, Saskatoon SK S7N 5C9, Canada Medical Research Center Yue Bei People's Hospital, Shantou University Medical College Shaoguan China Energy Processes & Materials Division; Pacific Northwest National Laboratory; Richland; USA Department of Biochemistry and Biophysics, University of North Carolina Chapel Hill, North Carolina 27599, USA. School of Life Sciences, Peking University, Beijing 100871, China. Institute of Mental Health, the Second Xiangya Hosipital, Central South University, Changsha, Hunan 410011, China. Department of Hepatobiliary Surgery, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia. Department of Gastroenterology Qilu Hospital of Shandong University Jinan Shandong Province China Department of New Energy Materials and Devices, School of Materials and Energy, Guangdong University of Technology, Guangzhou 510006, China Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022. Innovative Center of Molecular Genetics and Evolution School of Life Sciences, Guangzhou University Guangzhou 510006 China Department of Andrology, Shiyan People's Hospital / People's Hospital Affiliated to Hubei Medical College, Shiyan, Hubei 442000, China. Department of Otolaryngology, Head and Neck Surgery; West China Hospital, Sichuan University, Chengdu, China Technical Institute of Physics and Chemistry; Chinese Academy of Sciences; Beijing; P.R. China Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158;; The Cardiovascular Research Institute, University of California, San Francisco, CA 94158; Department of Neurology and Institute of Neurology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China School of Physical Science and Technology Guangxi Normal University Guilin 541004 P. R. China Department of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, 410013, China; The Critical Kidney Disease Research Center of Central South University, Changsha, 410013, China State Key Laboratory of Clean Energy Utilization, Zhejiang University, Hangzhou 310027, PR China Department of Orthopedic Surgery, Xuzhou Central Hospital, The Affiliated Xuzhou Hospital of Medical College of Southeast University, Xuzhou, China Department of Chemical and Materials Engineering; University of Alberta; Edmonton; Canada Department of Neurosurgery, Liuzhou People's Hospital, Liuzhou, Guangxi, China State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China Department of Epidemiology, Institute of Beijing Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China. Plastic Surgery State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, People’s Republic of China Hubei Jiu Feng Shan Laboratory, Wuhan 430074, China School of Materials Science and Engineering, Central South University, Changsha 410083, Hunan China Department of Food Science and Engineering, Jinan University, No. 601 West Huangpu Avenue, Guangzhou, Guangdong 510632, P. R. China Key Laboratory of Groundwater Resources and Environment of Ministry of Education, Jilin University, Changchun, 130012, PR China; College of New Energy and Environment, Jilin University, Changchun, 130012, PR China Department of Etiology, Fourth Military Medical University, Xi'an 710032, China. Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China Department of Information, Air Force General Hospital, PLA, Beijing, China. Guangzhou Institute of Energy Conversion; Chinese Academy of Sciences; Guangzhou 510640; China; CAS Key Laboratory of Gas Hydrate Department of Orthopaedics Tianjin Medical University General Hospital Tianjin P. R. China Pacific Northwest National Laboratory, Richland, Washington 99354 Northwest Institute of Nuclear Technology; Xi'an; China Guangdong Provincial Center for Disease Control and Prevention Department of Hepato-Pancreato-Biliary Surgery, Shandong Provincial Hospital, Shandong 250000, China. Departments of Gastrointestinal Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China State Key Laboratory of Marine Resource Utilization in South China Sea School of Material Science and Engineering Hainan University Haikou Hainan 570228 China The First Affiliated Hospital of Jinan University Guangzhou, Guangdong, China. Department of Pulmonary and Critical Care Medicine, Guangzhou First People's Hospital, South China University of Technology Guangzhou, Guangdong, China. Northwest Institute of Nuclear Technology, Xi’an 710024, China Department of Pathology Brigham and Women's Hospital Harvard Medical School Boston Massachusetts USA Department of Biology, Indiana University, Bloomington, IN 47405 Key Lab of New Drugs Design and Discovery of Liaoning Province, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University Cryobiology Research Institute, Wells Center for Pediatric Research, Indiana University Medical Center, Indianapolis, IN The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University; Wuxi; China Department of Orthopedics, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, China Department of Molecular Biology and Genetics, Cornell University, Ithaca,NY 14853, USA Key Laboratory for Advanced Materials and Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P.R. China College of Chemistry and Chemical Engineering Hexi University Zhangye City 734000 Gansu Province China From the Department of Plastic Surgery, University of Texas M. D. Anderson Cancer Center. Institute of Nuclear Physics and Chemistry; Chinese Academy of Engineering Physics; Mianyang; China Waksman Institute, Rutgers University, 190 Frelinghuysen Rd., Piscataway, NJ 08854, USA Department of Pediatrics, Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, People's Republic of China Department of Mechanical Engineering, University of Akron, Akron Ohio 44325, United States Electrochemical Materials & Systems Group; Energy & Environment Directorate; Pacific Northwest National Laboratory (PNNL); Richland; USA 1Department of Endocrinology, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, China CAS Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences (CAS), Beijing 100101, China Reproductive Medical Center Renmin Hospital Wuhan University Wuhan China; Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital) Tongji Medical College Huazhong University of Science &Technology Wuhan China Center for Disease Control and Prevention of Deyang City, Deyang, China. Hubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan, P.R. China.; Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Wuhan, P.R. China. Department of General Surgery, The First Hospital of Jiaxing, Jiaxing, Zhejiang 314001, P.R. China From the Departments of Plastic Surgery and Cardiothoracic Surgery, M. D. Anderson Cancer Center; the Department of Plastic Surgery, Baylor College of Medicine; and the Department of Plastic Surgery, Houston Methodist Hospital. Institute of High Performance Computing, Agency for Science Technology and Research, 1 Fusionopolis Way, 138632, Singapore School of Electrical and Electronic Engineering, Advanced Materials and Printed Electronics Center, Tianjin Key Laboratory of Film Electronic & Communication Devices, Tianjin University of Technology, Tianjin 300384, China Department of Biology Williams College Williamstown Massachusetts Department of Medicine and Department of Molecular Microbiology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, Missouri Department of Infectious Disease, First Affiliated Hospital of Wenzhou Medical College, Wenzhou Zhejiang 325000, China. National Key Laboratory for Electronic Technology, School of Instrument and Electronics, North University of China , Taiyuan 030051, People’s Republic of China Tianyou Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei, P. R. China |
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