http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_ea3350f222cf23200985c83f69b6ed0d
Outgoing Links
Predicate | Object |
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family-name | Zhang |
name | Yuan Zhang |
given-name | Yuan |
organization-name | State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing, China Genetics and Pathogenesis of Allergy Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 1 Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China. Clinical College, Jilin University, Changchun, Jilin 130021, P.R. China State Key Laboratory of Medicinal Chemical Biology, Nankai University , Tianjin, China; Key Laboratory of Bioactive Materials Ministry of Education, Nankai University , Tianjin, China; Department of Immunology, Nankai University School of Medicine, Nankai University , Tianjin, China Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON L8S 4K1, Canada Department of Immunology Fourth Military Medical University Xi'an Shaanxi China State Key Laboratory of Oncology in South China Department of Radiation Oncology Sun Yat‐sen University Cancer Center Collaborative Innovation Center for Cancer Medicine Guangzhou China Mailman School of Public Health Columbia University New York New York USA Joint Disease & Sport Medicine Centre Department of Orthopaedics Xinqiao Hospital Army Medical University Chongqing 400038 China College of Food, Heilongjiang Bayi Agricultural University, Daqing 163319, China CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, South China Sea Institute of Oceanology Chinese Academy of Sciences, Guangzhou 510301, China Department of Otolaryngology Head and Neck Surgery Beijing Tongren Hospital Capital Medical University Beijing China; Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology Beijing China; Department of Allergy Beijing Tongren Hospital Capital Medical University Beijing China Department of Gastroenterology Peking University Third Hospital Beijing China; Beijing Key Laboratory for Helicobacter pylori Infection and Upper Gastrointestinal Diseases Beijing China Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P.R. China Department of Ophthalmology; Changhai Hospital Affiliated to the Navy Military Medical University; Shanghai; People's Republic of China Center for Brain and Cognitive Sciences and Department of Psychology Peking University Beijing China; Department of Psychology and Department of Neuroscience University of New Mexico Albuquerque New Mexico USA Central Laboratories, Shantou University Medical College, Shantou 515031, China. Department of Physiology and Neurobiology & Centre for Ion Channelopathy Medical College of Soochow University Suzhou China; Department of Geriatrics & Institute of Neuroscience the Second Affiliated Hospital of Soochow University Suzhou China University of Adelaide,Australian Institute for Machine Learning,Australia Clinical College, Jilin University, Changchun, Jilin 130012, P.R. China OrigiMed Inc., Shanghai, People's Republic of China Analytical and Testing Center, Wenzhou Medical University Department of Cardiology, General Hospital of Guangzhou Military Command of People's Liberation Army, Guangzhou 510010, China. yuanzhang_1980@163.com. Measurement, Statistics and Evaluation Department of Human Development and Quantitative Methodology University of Maryland College Park USA Department of Orthopaedics, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, China International Science and Technology Cooperation Base of Child Development and Critical Disorders Chongqing 400014, People's Republic of China. Beijing Engineering Research Center of Syntheses and Applications of Waterborne Polymers, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China Beijing Key Laboratory of Energy Conversion and Storage Materials; College of Chemistry; Beijing Normal University; Beijing 100875; China Department of Cardiology, General Hospital of Guangzhou Military Command of People’s Liberation Army, Guangzhou, Guangdong, China State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, P. R. China Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, Wuhan 430074, China Department of Chemistry and Biochemistry, College of Computer, Mathematical and Natural Science, University of Maryland, College Park, Maryland 20742, United States Department of Geriatrics, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province 510150, P. R. China Institute for Translational Medicine; Medical College; Qingdao University; Qing Dao; China State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China Department of Orthopedics; Xinqiao Hospital; Third Military Medical University; Chongqing; China Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi 710062, China Cancer Research Center, School of Medicine, Xiamen University, Xiamen 361005, China; College of Acupuncture and Moxibustion, Hunan University of Traditional Chinese Medicine, Changsha 410208, China Department of Cardiology, General Hospital of Guangzhou Military Command of People's Liberation Army, Guangdong 510010, China *State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China; State Key Laboratory of Environmental Criteria and Risk Assessment/Laboratory of Riverine Ecological Conservation and Technology, Chinese Research Academy of Environmental Sciences, Beijing 100012, China. The First Affiliated Hospital, Nanjing Medical University, China State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; College of Chemistry and Material Science, Hebei Normal University, Shijiazhuang 050024, China Department of Respiratory and Critical Care Medicine Beijing Institute of Respiratory Medicine and Beijing Chao‐Yang Hospital, Capital Medical University Beijing China Jining Animal Husbandry Development Center Jining China College of Instrumentation & Electrical Engineering; Jilin University; Changchun 130012; PR China Department of Allergy, Beijing TongRen Hospital Capital Medical University Beijing China National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, College of Life Sciences, Shaanxi Normal University, 710119, Xi’an, P. R. China 1Department of Immunology, College of Medicine; Center for Precision Medicine, Institute for Translational Medicine, College of Medicine, Qingdao University, Qingdao, Shandong 266021, P.R. China State Key Laboratory of Inorganic Synthesis & Preparative Chemistry; College of Chemistry; Jilin University; Changchun; China Center of Evidence‑Based Medicine, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China Department of Radiation Oncology Sun Yat‐sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou China School of Materials Science and Engineering, Xiangtan University, Hunan 411105, China Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China Department of Integrative Medicine, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, P. R. China Materials Genome Institute, Shanghai University , Shanghai 201800, China Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China Nanoscience and Technology Division, Argonne National Laboratory, Lemont, Illinois 60439, United States; Department of Physics, Old Dominion University, Norfolk, Virginia 23529, United States Department of Immunology, Fourth Military Medical University, Xi'an 710032, China. University of Melbourne Department of Medicine, St. Vincent’s Hospital, Melbourne, Australia Center of Evidence-Based Medicine, The Second Hospital of Shandong University, Jinan, Shandong Province, China Department of Chemistry, Renmin University of China, 59# Zhongguancun Street, Haidian, Beijing 100872, China Center for Drug Safety Evaluation and Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai 201203, China Institute for Energy Research, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, 212013, P. R. China State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China; Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin, China; Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou Fujian 350002 P. R. China Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112 Institute of HematologyMedical College of Jinan University, Guangzhou, China School of Basic Medical Science, Lanzhou University, Lanzhou, Gansu 730000, P.R. China CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, No.164, Xingangxi Rd, Haizhu District, Guangzhou 510301, PR China; University of Chinese Academy of Sciences, 19 A Yuquan Rd, Shijingshan District, Beijing 100049, PR China Department of Histology and Embryology, School of Pre-Clinical Medicine, Guangxi Medical University , Nanning, Guangxi 530021, P. R. China School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing 100876, China Department of Sociomedical Sciences Columbia University New York City New York USA; Robert N. Butler Columbia Aging Center Columbia University New York City New York USA Key Laboratory of the Three Gorges Reservoir Region's Eco-Environment, Ministry of Education, Chongqing University, Chongqing 400045, China. windy0327@126.com State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China Institute of Basic Medicine, Hebei Medical University, Shijiazhuang, China E-mail: liyanling20@126.com. Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo 255049, China College of Chemistry, Beijing Normal University, Beijing, 100875, China; Key Laboratory of Energy Conversion and Storage Materials, College of Chemistry, Beijing Normal University, Beijing, 100875, China Department of Immunology Fourth Military Medical University Xi'an Shaanxi China; Institute of Medical Research Northwestern Polytechnical University Xi'an Shaanxi China Department of Gynecological Oncology, First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233030, P.R. China Columbia University Mailman School of Public Health New York NY USA School of Pharmaceutical Sciences and Technology; Health Sciences Platform; Tianjin University; Tianjin 300072; China Medical School of Kunming University of Science and Technology, Kunming, Yunnan 650500, China 1 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University , Beijing , China ;; 4 China National Clinical Research Center for Neurological Diseases , Beijing , China ; Institute for Translational Medicine Qingdao University Qingdao China School of Mechanical Engineering, Beijing Institute of Graphic Communication, Beijing 102600, China; State Key Laboratory of Rail Traffic Control and Safety, Beijing Jiaotong University, Beijing 100044, China Department of Hematology, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China. State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences (RAD‐X) Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Soochow University Suzhou 215123 P. R. China Department of Veterinary Medicine, College of Animal Science, Zhejiang University, Hangzhou 310058, China. Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, China. School of Physics, Changchun University of Science and Technology, Changchun 130022, China Shenzhen Key Laboratory of Nanobiomechanics, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China Department of Radiation Oncology, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong, China Clinical College, Jilin University, Changchun Department of Immunology, Nankai University School of Medicine; Nankai University, Tianjin, China; Translational Medicine Institute, Affiliated Tianjin Union Medical Center of Nankai University, Tianjin, China; State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China Materials Genome Institute Shanghai University Shanghai 200444 China State Key Laboratory of Coal Resources and Safe Mining, School of Mines, China University of Mining and Technology, Xuzhou 221116, China Department of Hematology, General Hospitol of Beijing Military Command, Chinese PLA, Beijing 100700, China. Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment & Bio-Resource of The Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China School of Biology and Food Engineering, Fuyang Normal University, Fuyang, Anhui 236037, China; Fuyang Fruit wine Engineering Technology Center, Fuyang, Anhui 236037, China Department of Immunology, Nankai University School of Medicine, Nankai University , Tianjin , China 1 Department of Computer Science and Engineering and 2Center for Microbial Ecology, Michigan State University, East Lansing, MI 48824, USA Department of Neurological Surgery, Columbia University, New York, New York; Avant Immunotherapeutics, Inc., Needham, Massachusetts; and Department of Medicine, University of Michigan, Ann Arbor, Michigan Center for Polymers and Organic Solids, University of California, Santa Barbara, Santa Barbara, California 93106, United States Genomic Medicine Institute, Lerner Research Institute of Cleveland Clinic, Cleveland, OH, U.SA. Department of Obstetrics The Third Affiliated Hospital Sun Yat‐sen University Guangzhou China Department of Allergy Beijing Tongren Hospital Capital Medical University Beijing China University of Chinese Academy of Science, Beijing, China Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital Shenzhen China College of Chemistry, Beijing Normal University, Beijing, 100875, China; Key Laboratory of Energy Conversion and Storage Materials, College of Chemistry Beijing Normal University, Beijing, 100875, China Ping An Healthcare Technology, Beijing, 100027, China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences 350002, Fujian Fuzhou P. R. China Institute of Pharmacy and Pharmacology Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study University of South China Hengyang China Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. Shenzhen Key Laboratory of Nanobiomechanics Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen Guangdong 518055 China Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, Jilin University, Changchun, PR China Department of Physics, North Carolina State University, Raleigh, North Carolina 27695, United States Shandong Provincial Hospital for Skin Diseases and Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences , Jinan, Shandong , China Department of Neurosurgery Beijing Tiantan Hospital China National Clinical Research Center for Neurological Diseases Beijing Neurosurgical Institute Capital Medical University Beijing 100070 China Yunnan Academy of Biodiversity, Southwest Forestry University, Kunming, China; College of Biodiversity Conservation, Southwest Forestry University, Kunming, China School of Materials Science and Engineering, Xiangtan University, Xiangtan 411105, China Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China. 1Department of Immunology, College of Medicine, Department of Cardiology & Beijing Key Laboratory of Hypertension Disease, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, PR China State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, Frontiers Science Center for Cell Responses, and College of Life Sciences, Nankai University, Tianjin 300071, China Institute of Food Safety Chinese Academy of Inspection and Quarantine Beijing China; Department of Pharmacy, National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China From the Department of Medicine (H.V.B.), University of California, San Francisco; Department of Medical Affairs (H.V.B., L.J.B., T.B.), Genentech Inc, South San Francisco, Calif; University of Alabama Medical Center, Birmingham (W.J.R., J.G.C.); ClinTrials Research (Y.Z.), Lexington, Ky; Washington University School of Medicine (A.J.T.), St. Louis, Mo; and Henry Ford Medical Center (W.D.W.), Detroit, Mich. China National Tobacco Quality Supervision and Test Center Zhengzhou China; Key Laboratory of Tobacco Biological Effects Zhengzhou China Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) State Key Laboratory of Materials‐Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University No. 5 Xin Mofan Road Nanjing 210009 P. R. China Department of Medicine, The University of Melbourne, Saint Vincent's Hospital, and Department of Psychiatry and Behavioral Sciences Stanford University School of Medicine Stanford California USA Department of Head and Neck Oncology, The Affiliated Jiangsu Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu 210009, P.R. China State Key Laboratory of Tree Genetics and Breeding, College of Biological Sciences and Technology Beijing Forestry University Beijing 100083 China Department of Pharmacy, The First People’s Hospital of Bijie, Bijie, China Key Laboratory of Special Pathogens and Biosafety; Center for Emerging Infectious Diseases; Wuhan Institute of Virology; Chinese Academy of Sciences; Wuhan 430071 Department of Medicine, Saint Vincent's Hospital, Fitzroy, Victoria, Australia; Department of Anesthesiology, The First Hospital of Jilin University, Jilin, China Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida;; Center for Stem Cell and Regenerative Medicine, The Second Hospital of Shandong University, Jinan, China; Department of Pathology, West China Hospital of Sichuan University Chengdu, China. Chengdu Women and Children's Central Hospital Chengdu, China. Department of Institute for Cancer Research, The Third Affiliated Teaching Hospital of Xinjiang Medical University, Affiliated Cancer Hospital, Urumuqi, Xinjiang Uyghur Autonomous Region 830010, P.R. China State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University 222 South Tianshui Road Lanzhou 730000 P. R. China Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, United States State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, Nanjing 211816, China University of Massachusetts Lowell Department of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu610072, Sichuan Province, China; Personalized Drug Therapy Key Laboratory of Sichuan Province, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, Sichuan Province, China Department of Cardiology, General Hospital of Guangzhou Military Command of People’s Liberation Army, Guangdong, China Department of Obstetrics the Third Affiliated Hospital of Sun Yat‐senn University Guangzhou China College of Chemistry, Beijing Normal University, Beijing, 100875, China Department of Orthopaedics Xinqiao Hospital the Third Military Medical University Chongqing China State-Province Joint Engineering Laboratory of Marine Bioproducts and Technology, Xiamen University, Xiamen, China Department of Ophthalmology, Changhai Hospital The Second Military Medical University Shanghai China Department of Ultrasound Pudong New Area People's Hospital affiliated to Shanghai University of Medicine and Health Sciences Shanghai China School of Information Science and Engineering, University of Jinan, Jinan 250022, P.R.China.yuan.zhang@ieee.org. Department of Pathology, Cancer Research Center Yanbian University Medical College Yanji China National Engineering Laboratory for Animal Breeding Key Laboratory of Animal Genetics and Breeding and Reproduction of MOA College of Animal Science and Technology China Agricultural University Beijing 100193 China Department of Neurosurgery, The 175th Hospital of PLA, Affiliated Southeast Hospital of Xiamen University, Center of Traumatic Neurosurgery in Nanjing Military Command, Zhangzhou, China. School of Life Science/Institutes of Biomedical Sciences, Fudan University, 220 Han Dan Road, Shanghai 200433, China. Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu Department of Orthopaedics Xinqiao Hospital, Army Medical University Chongqing China Department of Gastroenterology, The Second Affiliated Hospital, School of Medicine South China University of Technology Guangzhou China; Department of Gastroenterology, Guangzhou First People's Hospital South China University of Technology Guangzhou China Department of Otolaryngology–Head and Neck Surgery, Beijing TongRen Hospital Capital Medical University Beijing China; Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology Beijing China Department of Biostatistics and Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, People's Republic of China Department of Animal Genetics and Breeding. College of Animal Science and Technology, China Agricultural University, Beijing, China. Institute of Functional Nano & Soft Materials (FUNSOM), Joint International Research Laboratory of Carbon-Based Functional Materials and Devices, Soochow University, Suzhou 215123, People’s Republic of China; Jiangsu Key Laboratory of Advanced Negative Carbon Technologies, Soochow University, Suzhou 215123, People’s Republic of China Department of Biostatistics, Columbia University Mailman School of Public Health, New York, New York. School of Chemistry Beijing Advanced Innovation Center for Biomedical Engineering Beihang University Beijing 100191 China Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital Chengdu China Department of Basic Medical Sciences; Medical College, Xiamen University; Xiamen China Institute of Mental Health, Southern Medical University Guangzhou 510515 China; Key Laboratory of Psychiatric Disorders of Guangdong Province China Guangzhou 510515 Shanxi Key Laboratory of Integrated Pest Management in Agriculture, College of Plant Protection, Shanxi Agricultural University, Taigu 030801, Shanxi Province, P. R. China Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada Department of Cardiovascular Surgery, Qingdao Municipal Hospital Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, Medical College, Qingdao University, Qingdao, P.R. China School of Psychology, Henan University, Jinming Campus, Kaifeng 475001, China Department of Pharmacology, Jiangsu Provincial Key Laboratory of Critical Care Medicine, School of Medicine, Southeast University, Nanjing 210009, China. Department of Chemistry, Shanghai University School of Kinesiology and Health Science, and the Muscle Health Research Centre, York University, Toronto, Ontario, Canada Department of Medicine St Vincent's Hospital, University of Melbourne Australia Department of Gastrointestinal Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China Innovation Center for Chemical Science, College of Chemistry Chemical Engineering and Materials Science Soochow University, Suzhou 215123, P. R. China Key Laboratory of Subsurface Hydrology and Ecological Effects in Arid Region, Ministry of Education, Chang'an University, Xi'an, 710064 China; School of Water and Environment, Chang'an University, Xi'an, 710064 China Cell and Experimental Pathology; Department of Laboratory Medicine; Clinical Research Center; Lund University; Malmö, Sweden Department of Laboratory Medicine, Shandong Medical College, Jinan, 250002, China School of Electrical and Computer Engineering, RMIT University, Melbourne, VIC, Australia Department of Cardiology, Beijing Chao-yang Hospital Attached to Capital Medical University, Beijing, China (mainland) Department of Biostatistics Mailman School of Public Health Columbia University New York New York USA Department of Education, the Attached Hospital of Inner Mongolia Medical University, Hohhot, China Department of Geriatrics, The Third Affiliated Hospital of Guangzhou Medical University, China (Y.Z.).; Department of Cardiology, General Hospital of Guangzhou Military Command of People’s Liberation Army, China (Y.Z.). Henan Key Laboratory of Diamond Optoelectronic Materials and Devices; Key Laboratory of Material Physics; Ministry of Education; School of Physics and Microelectronics; Zhengzhou University State Key Laboratory of Materials‐Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Nanjing 210009 China College of Instrumentation and Electrical Engineering; Jilin University; Changchun 130022; People's Republic of China Department of Clinical Laboratory Medicine Guangzhou Women and Children's Medical Centre Guangzhou Medical University Guangzhou China School of Materials Science and Engineering; Ocean University of China; Qingdao 266100; China 9Department of Head and Neck Surgery, Jiangsu Cancer Hospital/Jiangsu Institute of Cancer Research/The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China. Institute of Reproductive Health Tongji Medical College Huazhong University of Science and Technology Wuhan China School of Chemical Engineering Shandong University of Technology Zibo 255000 China Guangdong Sports Science Research Institute, Guangzhou, China Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; School of Basic Medical Science, Air Force Military Medical University, Xi'an 710032, China. *Corresponding author, E-mail: zhangyuan@fmmu.edu.cn. College of Chemistry; Beijing Normal University; Beijing; China Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of China Zhongda Hospital, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University State Key Laboratory of Bioelectronics, Department of Otolaryngology Head and Neck Surgery, ,87# Dingjiaqiao, Nanjing 210096 , China; Nantong University Co-Innovation Center of Neuroregeneration, , Nantong 226001 , China; The First Affiliated Hospital of Zhengzhou University Department of Otology, , Zhengzhou, Henan 450000 , China Beijing Beike Deyuan Bio-Pharm Technology Co. Ltd., 7 Fengxian road, Beijing 100094, China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin Provincial International Cooperation Key Laboratory of Advanced Inorganic Solid Functional Materials College of Chemistry Jilin University Changchun 130012 P. R. China Department of Mathematical Sciences, University of Texas at Dallas, Richardson, TX, USA. Department of Physics, North Carolina State University, Raleigh, North Carolina 27695, United States; Center for High Performance Simulations (CHiPS), North Carolina State University, Raleigh, North Carolina 27695, United States R and D Department Tissue Tech, Inc. Miami FL USA School of Psychological and Cognitive Sciences and Center for Brain and Cognitive Sciences Peking University Beijing 100871 China; Department of Psychiatry and Behavioral Sciences Stanford University School of Medicine Stanford CA USA Materials Genome Institute; Shanghai University; Shanghai 200444; P. R. China Research Institute of Yanchang Petroleum (Group) Co., LTD.; Xi'an 710075; China Department of Pharmacy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Department of Computer Science and Engineering, Michigan State University, East Lansing, MI 48824, USA. zhangy72@msu.edu State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin Provincial International Cooperation Key Laboratory of Advanced Inorganic Solid Functional Materials College of Chemistry Jilin University Qianjin Street 2699 Changchun 130012 China Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, Texas 75390 From the Guangdong Provincial Key Laboratory of Food, Nutrition, and Health, Guangzhou, Guangdong Province, China (Y.L., H.C., D.M., D.L., Y.Z., N.J., M.X.); Department of Nutrition, School of Public Health, Sun Yat-sen University (Northern Campus), Guangzhou, Guangdong Province, China (Y.L., H.C., D.M., D.L., Y.Z., N.J., M.X.); and Department of Cardiology, General Hospital of Guangzhou Military Command of People’s Liberation Army, Guangdong, China (Y.Z.). College of Chemistry, Beijing Normal University, Beijing 100875, China; Key Laboratory of Energy Conversion and Storage Materials, Beijing Normal University, Beijing 100875, China State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China Department of Immunology, Fourth Military Medical University, Xi'an, China. Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, People's Republic of China Department of Medicine, St. Vincent’s Hospital, Melbourne, VIC 3065, Australia Yunnan Academy of Biodiversity Southwest Forestry University Kunming Yunnan 650224 China Department of Pediatric Oncology, The First Hospital of Jilin University Department of Anesthesiology, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin 300100, P.R. China Hubei Hongshan Laboratory Wuhan 430070 China; Hubei Key Laboratory of Agricultural Bioinformatics College of Life Science and Technology Interdisciplinary Sciences Institute Huazhong Agricultural University Wuhan 430070 China Department of Integrative Medicine, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, The Ministry of Education, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi 710119, China Global Health Drug Discovery Institute, Haidian, Beijing 100192, China College of Biological; Chemical Sciences and Engineering; Jiaxing University; Jiaxing 314001; China Department of Respiratory Diseases, Shanghai Pulmonary Hospital, Tongji University School of Medicine, China Susan and Alan Solomont School of Nursing, Zuckerberg College of Health Sciences, University of Massachusetts Lowell, 113 Wilder Street, MA 01854Lowell, United States of America Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, Shenzhen Institute of Translational Medicine The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital Shenzhen China INM - Leibniz Institute for New Materials, Campus D2 2, 66123 Saarbrücken, Germany; Department of Materials Science and Engineering, Saarland University, 66123 Saarbrücken, Germany State Key Laboratory of Chemical Engineering School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China Department of Ophthalmology Shanghai Key Laboratory of Fundus Disease Shanghai General Hospital Shanghai Jiao Tong University Shanghai China Department of Pathology, Immunology and Laboratory Medicine University of Florida Gainesville FL USA Department of Pharmacology Zhongshan School of Medicine Sun Yat‐Sen University 74 Zhongshan 2nd Road Guangzhou 510080 China Department of Materials Science and Engineering Southern University of Science and Technology Shenzhen 518055 P. R. China Department of Rhinology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) Nanjing Tech University Nanjing 211816 P. R. China Department of Cardiology, General Hospital of Guangzhou Military Command of People’s Liberation Army, Guangzhou, Guangdong Province, P.R. China (Y.Z.) The School of Life Sciences of Beijing University of Chinese Medicine Beijing China State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University Tianjin China School of Materials Science and Engineering; Xiangtan University; China Department of Pharmacy, School of Pharmacy, Hengyang Medical School, Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan, 421001, China Key Laboratory of Functional Materials Physics and Chemistry of the Ministry of Education, Jilin Normal University, Changchun 130103, China Second Ward of Department of Neurology, XuZhou Children’s Hospital, Xuzhou Medical University, Xuzhou, Jiangsu, China School of Chemistry and Materials Science; Jiangsu Normal University; Xuzhou; P. R. China Department of Internal Medicine, The University of Iowa, Iowa City, IA, USA INSERM, UMR935, Malignant and Therapeutic Stem Cells Models, Villejuif, France; Paris-Saclay University, Saint-Aubin, France Department of MathematicsYuxi Normal UniversityYuxi653100People's Republic of China Eileen M. Crimmins and Yuan Zhang are with the Davis School of Gerontology, University of Southern California, Los Angeles. Yasuhiko Saito is with the University Research Center and School of Medicine, Nihon University, Tokyo, Japan. Department of Hematology, Seventh Medical Center, Chinese PLA General Hospital, Beijing 100700, China. Department of Plastic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 East Qingchun Road, Hangzhou 310016, China Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital From the Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China; 1Department of Interventional Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. School of Pharmaceutical Sciences Wenzhou Medical University Wenzhou Zhejiang P. R. China Fujian Bote Biotechnology Co. Ltd., Fuzhou, Fujian 350013, P. R. China Department of Plant Protection, College of Horticulture and Plant Protection, Henan University of Science and Technology, Luoyang 471023, China School of Chemical Engineering and Materials Science, Nanjing Polytechnic Institute, Nanjing 210048, China; Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing, China Department of Physics, Old Dominion University, Norfolk, Virginia 23529, United States Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Developmentof Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi 710062, China Department of Orthopedics, Xinqiao Hospital, Third Military Medical University, Chongqing, China. Department of Infectious Disease, Qingdao Sixth People’s Hospital of Shandong Province, Qingdao, Shandong, China (mainland) Department of Rheumatology Fangshan Hospital Beijing University of Chinese Medicine Beijing China Blue Cross and Blue Shield of Louisiana USA Hubei Hongshan Laboratory, College of Life Science and Technology, College of Biomedicine and Health, Interdisciplinary Sciences Institute, Huazhong Agricultural University , Wuhan 430070 , PR China Department of Oncology, Shaanxi Provincial People's Hospital, Xi'an 710068, China Translational Medicine Institute, Tianjin Union Medical Center of Nankai University, Tianjin, China; Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China; and State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China Liaoning Institute for Food Control Shenyang 110015 P. R. China The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research Nanjing Jiangsu China Pfizer Worldwide Medicinal Chemistry, Eastern Point Road, Groton, Connecticut 06340, United States Department of Otolaryngology Head and Neck Surgery, Capital Medical University, Beijing Tongren Hospital, Beijing, People’s Republic of China; Department of Allergy, Capital Medical University, Beijing Tongren Hospital, Beijing, People’s Republic of China; Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, People’s Republic of China Department of Otolaryngology Head and Neck Surgery Beijing TongRen Hospital, Capital Medical University Beijing China; Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology Beijing China Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, People’s Republic of China; Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, People’s Republic of China; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, People’s Republic of China Department of Hematology and Oncology, Soochow University Affiliated Taicang Hospital (The First People’s Hospital of Taicang), Jiangsu, China Department of Pediatrics of Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, P. R. China Department of Food Science Purdue University West Lafayette Indiana USA; College of Food Science Southwest University Chongqing China Department of Mathematical Sciences, University of Texas at Dallas , Richardson, Texas 75080 , U.S.A. Respiratory Medicine, Zhenhai Hospital of Traditional Chinese Medicine Ningbo 315200, Zhejiang, China. Beijing Beike Deyuan Bio-Pharm Technology Co. Ltd.; Beijing 100094; China Department of Nursing,PUMC Hospital,CAMS and PUMC,Beijing 100730,China. *Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin 300071, China; School of Biomedical Sciences and Engineering South China University of Technology Guangzhou 511442 P.R. China; National Engineering Research Center for Tissue Restoration and Reconstruction South China University of Technology Guangzhou 510006 P. R. China; Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education South China University of Technology Guangzhou 510006 P. R. China; Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of Technology Guangzhou 510006 P. R. China Center of Evidence-based Medicine, Second Hospital of Shandong University Jinan, P.R. China. Department of Ultrasound, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China Department of Physics and ‡Center for High Performance Simulations (CHiPS), North Carolina State University, Raleigh, North Carolina 27695-8202, United States Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, PR China Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; Department of Geriatrics & Institute of Neuroscience, The Second Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China College of Plant Protection, Henan Agricultural University, Zhengzhou 450046, China; National Key Laboratory of Wheat and Maize Crop Science, Zhengzhou 450046, China Xiangya Hospital, Central South University, Hunan, China Center for Polymers and Organic Solids, Department of Chemistry & Biochemistry, Department of Materials, University of California, Santa Barbara, California 93106, United States School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China Clinical Cancer Research Center, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and The Affiliated Cancer Hospital of Nanjing Medical University Nanjing China Shanghai Institute of Applied Mathematics and Mechanics, Shanghai University, Shanghai 200072, China Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China From the Departments of Radiation Oncology (Y.Z., L.C., Y.-P.C., W.-H.H., W.-F.L., L.-L.T., Y.-P.M., G.-Q.Z., R.S., X.L., R.G., F.H., J.-W.L., X.-J.D., C.X., N.L., Y.-Q.L., F.-Y.X., Ying Sun, J.M.), Medical Oncology (Y.-H.L.), and Nasopharyngeal Carcinoma (H.-Y.M.) and the Clinical Trials Center (Y.G.), Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma... Engineering Research Center of Bioreactor and Pharmaceutical Development, Ministry of Education, College of Life Science, Jilin Agricultural University, Changchun 130118, P. R. China Peking University Health Science Center, Peking University, Beijing, China College of Resource and Environment, Southwest University, Beibei, Chongqing400715, China Center for Stem Cell and Regenerative Medicine, The Second Hospital of Shandong University, Jinan, People’s Republic of China; Shandong University Qilu Hospital Research Center for Cell Therapy, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan, People’s Republic of China Central Laboratories, Shantou University Medical College, Shantou 515041, China. yzhang@stu.edu.cn Department of Molecular and Clinical Pharmacology, The University of Liverpool, Liverpool, United Kingdom Department of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, China (Fang, Yi Zhang, Sun, Yuan Zhang, S Zhang); Beijing Dairy Cattle Center, Beijing, China (Li, Liu) College of Information Science and Engineering, Henan University of Technology, Zhengzhou, Henan, China Department of Medicine, University of Melbourne, St. Vincent’s Hospital, Fitzroy, Victoria, Australia OrigiMed Shanghai China School of Pharmacy, Sun Yat-sen University, Guangzhou 510275, China. Department of Pharmaceutics, School of Pharmacy, Nanjing Medical University, Nanjing 211116, China; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, and College of Life Sciences, Nankai University, Tianjin 300071, P. R. China Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China 1State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China.; 2Key Laboratory of Bioactive Materials Ministry of Education, Nankai University, Tianjin, China.; 3Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China. Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250022, China National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, Shaanxi Normal University, Xi’an, Shaanxi 710062, People’s Republic of China Department of Anesthesiology and Critical Care Medicine, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin, China Department of Materials Science and Engineering Southern University of Science and Technology Shenzhen Guangdong 518055 P. R. China; Guangdong Provincial Key Laboratory of Functional Oxide Materials and Devices Southern University of Science and Technology Shenzhen Guangdong 518055 P. R. China Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, Xizang Minzu University, Xianyang 712082, Shaanxi, China; Key Laboratory of High Altitude Environment and Gene Related to Disease of Tibet Ministry of Education, School of Medicine, Xizang Minzu University, Xianyang 712082, Shaanxi, China Department of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, P.R. China School of Psychology, Shanghai University of Sport, Shanghai, China; zhanglhm@163.com Institute for Translational Medicine, Qingdao University, Qingdao, China Department of Neurology, Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou, Jiangsu 221000, P.R. China Shantou University Medical College Central Laboratory, Shantou 515041, China. Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China. Tissue Tech, Inc., Miami, FL, United States Huazhong Univ. of Science and Technology From the Departments of Neurological Surgery and Medicine (D.J.P.), Columbia University College of Physicians and Surgeons, New York, NY. Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, 38 Xueyuan Road, Haidian District, Beijing 100191, China Key Laboratory of the Ministry of Education for Modern Metallurgy Technology, North China University of Science and Technology, Tangshan 063210, China Clinical Medical College of Guizhou Medical University, Guiyang 550004, China. Department of Orthopedics Xinqiao Hospital, Third Military Medical University Xinqiao Street Chongqing 400037 People's Republic of China Key Laboratory of the Ministry of Education for Modern Metallurgy Technology, College of Metallurgy and Energy, North China University of Science and Technology, Tangshan 063210, China School of Public Health, Tianjin Medical University, Tianjin, People’s Republic of China Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, 712082 Shaanxi, China; Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, 712082 Shaanxi, China; Key Laboratory of High Altitude Environment and Gene Related to Disease of Tibet Ministry of Education, School of Medicine, Xizang Minzu University, Xianyang 712082, Shaanxi, China Ohio State University Department of Statistics, , 1958 Neil Ave, Columbus, OH 43210, USA McMaster University; Department of Health Research Methods, Evidence, and Impact; 1280 Main Street West Hamilton ON Canada L8S 4K1 Department of Health Research Methods, Evidence, and Impact, McMaster University, Ontario, Canada Department of Medicine; St Vincent's Hospital; University of Melbourne; Fitzroy; Australia State Key Laboratory of Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University Changsha 410082 P. R. China School of Medicine and Institute of Laboratory Animal Science, Jinan University, Guangzhou, 510632, China Department of Medicine (Y.Z., D.J.K.), University of Melbourne, St. Vincent’s Hospital, Victoria 3065, Australia College of Chemistry Beijing Normal University Beijing 100875 P. R. China; Key Laboratory of Energy Conversion and storage Materials College of Chemistry Beijing Normal University Beijing 100875 P. R. China Department of Nephrology Xi'an No. 4 Hospital Xi'an China Transplant Immunology Laboratory and School of Basic Medical SciencesFourth Military Medical UniversityXi'anChina College of Chemistry; Beijing Normal University; Beijing; China; Key Laboratory of Energy Conversion and Storage Materials Department of Medicine St. Vincent's Hospital, University of Melbourne, Melbourne, Victoria, Australia College of Science, Nanjing Agricultural University , Nanjing 210095, China Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Songjiang, China Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, Beijing 100191, China Department of Otology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China Clinical Cancer Research Center, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China College of Veterinary Medicine, Northeast Agricultural University Harbin People's Republic of China Tianjin Key Laboratory of Electronic Materials and Devices, Hebei Key Laboratory of Advanced Laser Technology and Equipment, School of Electronics and Information Engineering, Hebei University of Technology, 5340 Xiping Road, Tianjin 300401, P.R. China Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Canton, Guangdong, China Department of Nephrology Affiliated Hospital of Nantong University Nantong Jiangsu China Center for Nanoscale Materials; Argonne National Laboratory; Lemont; USA National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, People’s Republic of China; Frontiers Science Center for Animal Breeding and Sustainable Production, Wuhan, People’s Republic of China; Key Laboratory of Preventive Veterinary Medicine of Hubei Province, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, People’s Republic of China Department of Ophthalmology, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China Department of Physical Education, China University of Geosciences (Beijing), Beijing 100083, China Dalian Medical University , Dalian, Liaoning, 116044, China; Department of Pediatric Hematology-Oncology, Dalian Municipal Women and Children's Medical Center , Dalian, Liaoning, 116037, China Translational Medicine Center Institute for Translational Medicine, Qingdao University Qingdao China University of Massachusetts Lowell, MA, USA Center for Polymers and Organic Solids University of California Santa Barbara CA 93106 USA; School of Chemistry and Environment Beihang University Beijing 100191 P. R. China Department of Cardiology, Zhongshan Hospital Fudan University Shanghai China Department of Neurobiology, Medical College of Soochow University, Suzhou 215123, P.R. China.; Department of Geriatrics, Institute of Neuroscience, The Second Affiliated Hospital of Soochow University, Suzhou 215004, P.R. China. Department of Chemistry, Iowa State University, Ames, Iowa 50011, United States Department of Orthopedic Affiliated Hospital of North Sichuan Medical College Nanchong China Author Affiliations:Solomont School of Nursing, Zuckerberg College of Health Sciences, University of Massachusetts Lowell; Department of Cardiology, Guangzhou Military General Hospital, Number 111 Liuhua Road, Guangzhou, Guangdong 510010, China Department of Materials Science and NanoEngineering, Rice University, Houston, Texas 77005, United States Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China Department of Clinical Laboratory, The Third Affiliated Teaching Hospital of Xinjiang Medical University (Affiliated Cancer Hospital), Xinjiang, Urumqi 830011, China Collaborative Innovation Center of Henan Grain Crops, Zhengzhou, China; Grain Information Processing and Control, Key Laboratory of Ministry of Education, Henan University of Technology, Zhengzhou, China; Grain Photoelectric Detection and Control, Key Laboratory of Henan Province, Henan University of Technology, Zhengzhou, China Department of Ecology, College of Natural Resources and Environment, South China Agricultural University, Guangzhou, Guangdong, China; Key Laboratory of Agro-Environment in the Tropics, Ministry of Agriculture, South China Agricultural University, Guangzhou, Guangdong, China; Guangdong Engineering Research Center for Modern Eco-agriculture and Circular Agriculture, South China Agricultural University, Guangzhou, Guangdong, China Department of Medical Administration Huizhou Institute of Occupational Diseases Control and Prevention Huizhou Guangdong China Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences , Southwest University , Chongqing 400700 , China Department of Oncology, The State Key Discipline of Cell Biology, Xijing Hospital, The Fourth Military Medical University, Xi’an, 710032, Shaanxi, China School of Psychology, Shanghai University of Sport, Shanghai, China China Agricultural University, China Chinese Research Academy of Environmental Sciences, Beijing 100012, PR China The Fifth Subcenter of Air Force Health Care Center for Special Services Hangzhou Wuxi China State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, 200031, China. School of Mechanical Engineering University of Science and Technology Beijing Beijing 100083 China Key Laboratory of Pollution Processes and Environmental Criteria of Ministry of Education, Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering of Nankai University, Tianjin 300350, China Department of Cardiology, Liaocheng People’s Hospital of Taishan Medical University, Shandong Province, China. Department of Chemistry and Biochemistry University of California at Santa Barbara Santa Barbara CA 93106 California USA Waksman Institute, Rutgers University, New Brunswick, New Jersey 08854, United States Shanxi Key Laboratory of Integrated Pest Management in Agriculture, College of Plant Protection, Shanxi Agricultural University, Taigu 030801, Shanxi, P. R. China Cancer Research Institute, Key Laboratory of Cancer Cellular and Molecular Pathology of Hunan Province, Hengyang Medical College, University of South China, Hengyang Hunan 421001. 1261923532@qq.com. State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, China State Key Laboratory of Environmental Criteria and Risk Assessment and Laboratory of Riverine Ecological Conservation and Technology Chinese Research Academy of Environmental Sciences Beijing China Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemistry & Chemical Engineering and ‡College of Energy, Nanjing Tech University, Nanjing 210009, P. R. China Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Sun Yat‐sen University Cancer Center Guangzhou 510060 Guangdong P. R. China Center of Evidence-based Medicine, The Second Hospital of Shandong University, Jinan, Shandong Province, China. Key Laboratory of Flexible Electronics & Institute of Advanced Materials Nanjing Tech University Nanjing 211800 China Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, China Center of Cardiology; Chongqing Zhongshan Hospital; Chongqing 400013; China Key Laboratory of Biology and Genetic Improvement of Horticultural Crops (Northeast Region), Ministry of Agriculture and Rural Affairs, Harbin, People’s Republic of China; College of Horticulture and Landscape Architecture, Northeast Agricultural University, Harbin, People’s Republic of China Henan Provincial Key Laboratory of Grain Photoelectric Detection and Control; Henan University of Technology University of Florida Gainesville Department of Biostatistics Mailman School of Medicine, Columbia University New York New York Chinese Research Academy of Environmental Sciences; Beijing 100012; PR China Department of Neurology, Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou, Jiangsu 221006, P.R. China Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, Guangdong, China; Department of Medicine, University of Chicago Medicine and Biological Sciences, Chicago, Illinois Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, People's Republic of China Cancer Epigenetics Laboratory, Department of Clinical Oncology, State Key Laboratory of Oncology in South China, Sir YK Pao Center for Cancer, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong College of Chemistry Beijing Normal University Beijing 100875 China; Key Laboratory of Energy Conversion and Storage Materials College of Chemistry Beijing Normal University Beijing 100875 China Division of Nephrology Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital Chengdu China Department of Orthopaedics, Children’s Hospital of Chongqing Medical University, Chongqing 400014, P. R. China; Ministry of Education Key Laboratory of Child, Children’s Hospital of Chongqing Medical University, Chongqing 400014, P. R. China Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China; National Clinical Research Center for Neurological Diseases, Beijing 100070, China Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei 430071, China; University of Chinese Academy of Sciences, Beijing 100049, China State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, 100012 Beijing, China Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Department of Clinical Epidemiology and Biostatistics McMaster University Hamilton Ontario Canada Department of Neurosurgery Shenzhen Key Laboratory of Neurosurgery, Shenzhen Institute of Translational Medicine, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital Shenzhen China State Key Laboratory for Novel Software Technology, Nanjing University, Nanjing 210093, China Life Science College of Northwest University, Biotechnology Key Laboratory of Shanxi Province, Xi' an 710069, China. State Key Laboratory of Continental Dynamics, Shaanxi Key Laboratory of Early Life and Environment, Department of Geology, Northwest University, Xi’an 710069, PR China. Institute for Translational Medicine, The Affiliated Hospital, College of Medicine Qingdao University Qingdao China Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China Department of Community Health, Wuhou Health Bureau Department of Clinical Laboratory Center, Cancer Hospital of Xinjiang Medical University , No. 789, Suzhou East Street, Xinshi District , Urumqi 830000, Xinjiang , China Department of General Surgery, Nanjing Medical University Affiliated Wuxi People's Hospital, Wuxi, Jiangsu 214023, P.R. China Clinical College, Jilin University, Changchun, China Library of Donghu Campus, Zhejiang A&F University, Lin’an, Hangzhou, China From the University of Melbourne (D.J.K., A.J.C., R.M.G., Y.Z., R.E.G.), Department of Medicine, St. Vincent’s Hospital, and St. Vincent’s Institute of Medical Research (B.E.K.), Victoria, Australia. Department of Microbiology, School of Medicine, Meharry Medical College, Nashville, Tennessee 37208,1 and Basic Medical College, Tianjin Medical University, Tianjin 300070, China Key Lab of Combined Multi‐Organ Transplantation Ministry of Public Health The First Affiliated Hospital College of Medicine Zhejiang University Hangzhou China Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, China; Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, The First Affiliated Hospital, School of Medicine, Zhejiang University, China; Clinical Research Center of Hepatobiliary and Pancreatic Diseases of Zhejiang Province, The First Affiliated Hospital, School of Medicine, Zhejiang University, China Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, China. Department of Materials Science and Engineering; Department of Biological Engineering; The David H. Koch Institute for Integrative Cancer Research; Massachusetts Institute of Technology; Cambridge Department of Statistic Florida State University Tallahassee Florida Department of Chemistry; Key Laboratory of Advanced Energy Materials Chemistry (MOE); Collaborative Innovation Center of Chemical Science and Engineering (Tianjin); Nankai University; Tianjin 300071 CAS Key Laboratory of Special Pathogens and Biosafety, Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, PR China Department of Pharmaceutics School of Pharmacy Nanjing Medical University Nanjing 211116 China Department of Statistics, Ohio State University , Columbus, OH 43210, USA Solomont School of Nursing, Zuckerberg College of Health Sciences, University of Massachusetts Lowell , Lowell, MA , USA Department of Radiation Oncology Sun Yat‐sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangzhou China; Sun Yat‐sen Global Health Institute, School of Public Health and Institute of State Governance, Sun Yat‐sen University Guangzhou China School of Chemical Engineering and Pharmaceutics Henan University of Science and Technology Luoyang Henan 471003 China Department of Pediatrics, Irving Medical Center, Columbia University, New York, NY, USA. Department of Orthopedic Surgery, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, P.R. China Center for Novel Target and Therapeutic Intervention, Institute of Life Sciences, Chongqing Medical University, Chongqing 400016, China HEEGER Beijing Research & Development Center School of Chemistry Beihang University Beijing 100191 China Department of Genetics, Hebei Medical University, Hebei Key Lab of Laboratory Animal, Shijiazhuang, Hebei Province 050017, People's Republic of China. College of Pharmacy, Jinan University, Guangzhou 510632, P.R. China Institute of Bioorganic & Medicinal Chemistry; Key Laboratory of Applied Chemistry of Chongqing Municipality; School of Chemistry and Chemical Engineering; Southwest University; Chongqing 400715 Clinical Research Center of Shandong University, Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan, Shandong, P.R. China School of Materials Science and Engineering, Hebei University of Technology, Tianjin300130, China; Key Laboratory of Special Functional Materials for Ecological Environment and Information (Hebei University of Technology), Ministry of Education, Tianjin300130, China Department of Dermatology, Changsha Hospital of Traditional Chinese Medicine (Changsha Eighth Hospital), Changsha, Hunan Province, P.R. China Department of Neonatology, Bethune First Hospital, Jilin University, Changchun 130021, Jilin Province, China. Department of Medical Administration, Huizhou Institute of Occupational Diseases Control and Prevention, Huizhou 516000, Guangdong, China Key Laboratory of Genetics and Breeding in Forest Trees and Ornamental Plants, Ministry of Education, College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China; Institute of Tree Development and Genome Editing, College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China The University of Melbourne Department of Medicine St Vincent's Hospital Fitzory Department of Pharmacy; Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital; Chengdu China Department of Radiology, the Affiliated Hospital of Qingdao University, Qingdao, China Department of Dermatology, Zhujiang Hospital, Southern Medical University, Guangzhou, China Department of Pharmacology; Key Laboratory of new drugs and clinical application; XuZhou Medical College, XuZhou; Jiangsu Province; 221004; People's Republic of China Research Center of New Energy Science & Technology, China University of Mining & Technology, Xuzhou 221116, China. School of Mines, China University of Mining & Technology, Xuzhou 221116, China. State Key Laboratory of Coal Resources & Safe Mining, China University of Mining & Technology, Xuzhou 221116, China. College of Pharmacy, Institute of Traditional Chinese Medicine & Natural Products, Jinan University, Guangzhou 510632, P.R. China 1Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Pharmacy National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing P. R. China CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, South China Sea Institute of Oceanology, Guangzhou, PR China;; University of Chinese Academy of Sciences, Beijing, PR China Department of Anesthesiology, Nanjing First Hospital, Nanjing, China Department of Pharmacy, Tianjin First Central Hospital, Tianjin, China State Key Laboratory of Pathogens and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China. Department of Radiation Oncology Sun Yat‐sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou People's Republic of China Department of Intensive Care Unit, Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine , Foshan 528200 , China State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, The Chinese Academy of Agricultural Sciences, Harbin, China Department of Tumor Interventional Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China Department of Gynecology, The Second Hospital of Hebei Medical University, 050004, Shijiazhuang, China dr.luozhang@gmail.com INM - Leibniz Institute for New Materials, Campus D2 2, 66123 Saarbrücken, Germany; Department of Materials Science & Engineering, Saarland University, Campus D2 2, 66123 Saarbrücken, Germany Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy Anhui Medical University Hefei China Department of Physics, and Center for High Performance Simulations (CHiPS), North Carolina State University, Raleigh, North Carolina 27695, United States Department of Chemistry University College London 20 Gordon St London WC1H 0AJ UK College of Science, Gansu Agricultural University, Lanzhou 730070, China Department 2, Institute of Surgery Research , Daping Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University, Chongqing 400042 , P. R. China. Institute for Glycomics, Griffith University, Brisbane, Queensland, Australia Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou 510080, China Department of Pharmacology and Howard Hughes Medical Institute (A.L.B., B.M.O., M.S., Y.Z., D.J.M.), University of Texas Southwestern Medical Center, Dallas, Texas 75390 State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin Provincial International Cooperation Key Laboratory of Advanced Inorganic Solid Functional Materials College of Chemistry Jilin University Qianjin Street 2699 Changchun 130012 P. R. China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Sciences Beijing China; Laboratory of Riverine Ecological Conservation and Technology Chinese Research Academy of Environmental Sciences Beijing China Department of Organic Chemistry, College of Pharmacy, Harbin Medical University, Harbin, China Department of Gynecologic Oncology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. China Institute of Applied Eco-logy, Chinese Academy of Sciences, Shenyang 110016, China. University of Chinese Academy of Sciences, Beijing 100049, China. Renmin Hospital of Wuhan University, No. 238 Jiefang Road, Wuhan, Hubei, China. Center for Nanoscale Materials, Nanoscience and Technology Division, Argonne National Laboratory, Lemont, Illinois 60439, United States; Nanoscale and Quantum Phenomena Institute, Department of Physics and Astronomy, Ohio University, Athens, Ohio 45701, United States; Department of Physics, Old Dominion University, Norfolk, Virginia 23529, United States Center of Evidence-Based Medicine, The Second Hospital of Shandong University, Jinan 250033, China School of Pharmacy, China Medical University, Shenyang, China Department of Anesthesiology, Tianjin Nankai Hospital, Tianjin, China Department of Medical Examination Shandong Medical College Jinan P. R. China Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States Department of Interventional Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R. China Department of Obstetrics and Gynecology, Nanfang Hospital, Guangzhou, China. greatsara@163.com School of Environmental Studies and State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, No. 68 Jincheng Street, Hongshan District, Wuhan 430074, China North Carolina State University, Raleigh, North Carolina (YZ); Department of Industrial and Operations Engineering, University of Michigan, Ann Arbor, Michigan (BTD); Division of Urologic Surgery, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina (MEN) National Institutes for Food and Drug Control, Beijing 100050, China. zhyuan@nicpbp.org.cn Center for Nanoscale Materials Nanoscience and Technology Division Argonne National Laboratory Lemont IL 60439 USA Materials Genome Institute Shanghai University Shanghai 200444 China; State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai 200050 China Department of Dermatology, Central Hospital of Shengli Oil Field, Shandong, People's Republic of China Department of Ultrasound, Pudong New Area Peoples’ Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai, China (mainland) College of Mechanical and Electronic Engineering, Shan Dong University of Science and Technology, Qingdao 266590, China; Libo Heavy Industries Science and Technology Co., Ltd., Tai’an 271000, China Tissue Tech, Inc., Ocular Surface Center, and Ocular Surface Research & Education Foundation, Miami, FL. Center of Clinical Reproductive Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. Chinese PLA Medical School, Beijing 100853, China (Zhang Y); Department of Biomedical Engineering and Maintenance Center, Chinese PLA General Hospital, Beijing 100853, China (Li PY, Zhang ZB, Cao DS); Department of Emergency, Chinese PLA General Hospital, Beijing 100853, China (Zhao YZ, Li TS); Medical Information Center, Chinese PLA General Hospital, Beijing 100853, China (Liu TB, Zhang ZB); Department of Computer Application and Management, Chinese PLA General Hospital, Beijing 100853, China (Liu TB); Department of Medical Device R and D and Evaluation Center, Chinese PLA General Hospital, Beijing 100853, China (Zhang ZB, Cao DS); Laboratory of Computational Physiology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 01239, United States (Celi LA); Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 01238, United States (Celi LA). Corresponding author: Zhang Zhengbo, Email: zhengbozhang@126.com. The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology The Fourth Military Medical University Xi'an Shaanxi 710032 China Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, 49 Huayuan-Bei Road, Haidian District, Beijing 100191, China; Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, 49 Huayuan-Bei Road, Haidian District, Beijing 100191, China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, 49 Huayuan-Bei Road, Haidian District, Beijing 100191, China; Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing 100191, China Department of Medicine, University of Melbourne, St. Vincent's Hospital, Victoria 3065, Australia; Department of Pharmacology, School of Medicine (L.Y., B.H., Y.B., Y.Z., Y.T., F.W., Q.Y., B.C., B.L., T.T., Y.W., L.S., G.W., M.J., H.Y.), Southeast University, Nanjing, China. Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China Key Laboratory of Grain Information Processing and Control, Henan University of Technology, Ministry of Education, Zhengzhou 450001, China; Henan Key Laboratory of Grain Photoelectric Detection and Control, Henan University of Technology, Zhengzhou 450001, China; College of Information Science and Engineering, Henan University of Technology, Zhengzhou 450001, China School of Life Sciences, Ludong University, Yantai 264025, China. zhyuan0824@sina.cn Department of Otolaryngology–Head and Neck Surgery, Hôtel-Dieu de Montréal, Centre de recherche du centre hospitalier de l'Université de Montreal (CRCHUM), Montreal, QC, Canada; Key Laboratory Otolaryngology Head and Neck Surgery, Ministry of Education of China, Beijing Institute of Otorhinolaryngology, Beijing, PR China; Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, PR China Department of Otorhinolaryngology Head and Neck Surgery, Tongren Hospital, Capital Medical University, Beijing 100730, China; Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, Chian; Beijing Institute of Otorhinolaryngology, Beijing Key Labortory of Nasal Diseases, Beijing 100005, China. Oregon Health and Science University, Oregon Hearing Research Center, Department of Otolaryngology, 3181 SW Sam Jackson Park Road, NRC 04, Portland, Oregon 97239, United States School of Mechanical and Electronic Engineering, Nanjing Forestry University, Nanjing 210037, China School of Chemistry Beihang University Beijing 100191 P. R. China Department of Orthopedics, Xinqiao Hospital, Third Military Medical University, Xinqiao Street, Chongqing, PR China College of Animal Science and Technology, Jilin Agricultural University, Changchun, Jilin 130118, China National Laboratory of Solid State Microstructures; Department of Physics; and Collaborative Innovation Center of Advanced Microstructures; Nanjing University; Nanjing 210093 Department of Laboratory Medicine, Shandong Medical College Jinan 250002, Shandong, China. Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, People’s Republic of China Department of Medicinal Chemistry China Pharmaceutical University Tongjia Xiang 24 Nanjing 210009 China Humboldt–Universität zu Berlin 1 Institut für Physik, , Newtonstraße 15, D-12489 Berlin, Germany Department of Cardiology, General Hospital of Guangzhou Military Command of People's Liberation Army, Number 111 Liuhua Road, Guangzhou, Guangdong 510010, China State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Collaborative Innovation Center for Cancer Medicine, Beijing 100850, China Contilia Heart and Vascular Center Elisabeth‐Krankenhaus Essen Germany School of Materials Science and Engineering; Ocean University of China. 238 Songling Road; Qingdao; China School of Chemistry Beihang University Beijing 100191 China Department of Hypertension, Heart Center, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China. Department of Anesthesiology The First Hospital of Jilin University 71 Xinmin Street Changchun Jilin 130021 P. R. China From the Division of Endocrinology and Metabolism, Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine (K.T., J.S., G.A.J., A.R.T., R.M., H.C.K., Y.Z., R.S., R.O.P., E.D.A.) and Department of Health and Human Physiology (V.A.L.), University of Iowa, Iowa City; Division of Endocrinology, Metabolism, and Diabetes and Program in Molecular Medicine (K.T., H.B., A.R.W., J.S., X.X.H., C.L.S., E.D.A.), Nora Eccles Harrison Cardiovascular Research and... Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, School of Medicine Xizang Minzu University Xianyang Shaanxi China; Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine Xizang Minzu University Xianyang Shaanxi China; Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine Xizang Minzu University Xianyang Shaanxi China 1Immunology and Departments of Department of Pharmacy, School of Pharmacy, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China; Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, China Laboratory Medicine Center Nanfang Hospital Southern Medical University Guangzhou Guangdong 510515 China; Clinical laboratory department Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou Guangdong 510623 China From the Keenan Research Centre in the Li Ka Shing Knowledge Institute (K.A.C., A.A., K.T., R.E.G.), St Michael’s Hospital and University of Toronto, Toronto, Canada; Department of Medicine (K.A.C., D.J.K., Y.Z., A.J.C., R.E.G.), University of Melbourne, St Vincent’s Hospital; Cardiac Investigation Unit (D.L.P.), St. Vincent’s Hospital Melbourne; and NHMRC CCRE in Therapeutics (H.K.), Department of Epidemiology and Preventive Medicine and Department of Medicine, Monash University, Faculty of... Shaanxi Province Blood Center, Xi’an, Shaanxi 710061, China Oregon Hearing Research Center, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. Center of Evidence-Based Medicine, The Second Hospital of Shandong University, Jinan, Shandong, People’s Republic of China Innovation Center for Chemical Science|College of Chemistry Chemical Engineering and Materials Science Soochow University, Suzhou, 215123, P. R. China Center of Evidence-based Medicine, The Second Hospital of Shandong University, Jinan, Shandong, China Department of Hematology, the Seventh Medical Center of Chinese PLA General Hospital, Beijing, 100700, China Henan Key Laboratory of Diamond Optoelectronic Materials and Devices, Key Laboratory of Material Physics, Ministry of Education, School of Physics and Microelectronics, Zhengzhou University, Zhengzhou 450052, China; Institute of Quantum Materials and Physics, Henan Academy of Sciences, Zhengzhou 450046, China The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, Wuhu 241001, Anhui, China; Wannan Medical College, Wuhu 241002, Anhui, China Center for Polymers and Organic Solids, Department of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, California 93106, United States School of Nursing, University of Massachusetts Lowell MA, USA. MARA Key Laboratory of Surveillance and Management for Plant Quarantine Pests, College of Plant Protection, China Agricultural University , Beijing, China Department of Medicine St Vincent's Hospital, the University of Melbourne Fitzroy Victoria 3065 Australia Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, People's Republic of China Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; Department of Nano Science and Technology Institute, University of Science and Technology of China, Suzhou 215123, China Genomic Medicine Institute, Lerner Research Institute of Cleveland Clinic, Cleveland, OH Key Laboratory of Resource Biology and Biotechnology in Western China Northwest University, Ministry of Education Xi’an China Department of Neurosurgery, Beijing Tiantan Hospital Capital Medical University Beijing China; Beijing Neurosurgical Institute Beijing China College of Chinese Medicine, Shandong University of Chinese Medicine, Jinan, China; Department of Pediatrics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University Shi‐Changxu Innovation Center for Advanced Materials Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China College of Future Technology, Institute of Molecular Medicine, National Biomedical Imaging Center, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing 100871, China Department of Medicine University of Melbourne St. Vincent's Hospital Melbourne Victoria Australia Department of Nutrition School of Public Health Sun Yat‐Sen University Guangzhou P. R. China Zhejiang Provincial People’s Hospital, Hangzhou, Zhejiang, China; Hangzhou Medical College People’s Hospital, Hangzhou, Zhejiang, China; Bengbu Medical College, Bengbu, Anhui, China Department of Epidemiology and Biostatistics School of Public Health Peking University Beijing China Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York Department of Rhinology, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, Henan, People's Republic of China. National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry (Shaanxi Normal University), The Ministry of Education, College of Life Sciences Shaanxi Normal University Xi'an China Department of Neurology , University of Michigan, Ann Arbor, MI, USA; Department of Respiratory Medicine , Xiangya Hospital, Central South University, Changsha 410008 , China Department of Materials Science and Engineering Southern University of Science and Technology Shenzhen 518055 China College of Animal Science and Technology China Agricultural University Beijing China State Key Laboratory of ASIC and System; Institute of Advanced Nanodevices; School of Microelectronics; Fudan University; Shanghai 200433 State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, 222 Tianshui South Road, Lanzhou 730000, People’s Republic of China School of Pharmacy China Medical University Shenyang 110122 China Department of Radiation Oncology Sun Yat‐sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine Guangzhou China Department of Immunology, Nankai University School of Medicine , Peking, China Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, Guangdong, China Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center Sun Yatsen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science Guangzhou China Department of Respiratory Medicine Shanghai Pulmonary Hospital, Tongji University School of Medicine Shanghai China State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China Healthcare Informatics, Blue Cross Blue Shield of Louisiana, Baton Rouge, LA, USA Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otorhinolaryngology, Department of Allergy, Beijing Tongren Hospital, Capital Medical University. Department of Respiratory and Critical Care Medicine, Beijing Chao‐Yang Hospital Capital Medical University, Beijing Institute of Respiratory Medicine Beijing China Fujian Provincial Key Laboratory for Coastal Ecology and Environmental Studies, Xiamen University, Xiamen, China;; Marine Biodiversity and Global Change Research Center, Xiamen University, Xiamen, China School of Pharmacy, Wenzhou Medical University, 1210 University Town, Wenzhou, Zhejiang 325035, China Biochemical Engineering College of Beijing Uion University, Beijing 100023, China. Department of Otolaryngology–Head and Neck Surgery, Beijing TongRen Hospital Capital Medical University Beijing China; Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology Beijing China; Department of Allergy, Beijing TongRen Hospital Capital Medical University Beijing China Shaanxi Engineering Laboratory for Food Green Processing and Safety Control, and Shaanxi Key Laboratory for Hazard Factors Assessment in Processing and Storage of Agricultural Products, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi’an 710062, China State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences (RAD‐X) Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Soochow University Suzhou 215123 China Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China.; Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China.; Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China. Department of Materials Science and NanoEngineering Rice University Houston TX 77005 USA College of Environment, Hohai University, Nanjing, People’s Republic of China Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA. Department of Otolaryngology The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan China Department of Otolaryngology & Head and Neck Surgery, West China Hospital of Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China State Key Laboratory of ASIC and System; School of Microeletronics; Fudan University; Shanghai 200433; China School of Pharmaceutical Sciences, Peking University, Beijing 100083, China. INSERM UMR935, Modèles de Cellules Souches Malignes et Thérapeutiques, Villejuif, France; Université Paris-Sud, Orsay, France Nanjing Agricultural University , China Department of Physics, University of Colorado, Boulder, Colorado 80309, United States; Centre for Optical and Electromagnetic Research, Zhejiang University, Hangzhou 310058, People’s Republic of China Department of Medicine, University of Melbourne, St. Vincent's Hospital, Melbourne, Australia Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing 100083, People’s Republic of China; College of Food Science and Technology, Agricultural University of Hebei, Baoding, Hebei 071001, People’s Republic of China Department of Pharmacy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Tianjin Key Laboratory of Molecular Drug Research Nankai University Tianjin China Anhui University, Hefei 230601, Anhui, China. Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital Tongji University School of Medicine Shanghai China Department of Clinical Epidemiology, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Jinan 250012, China; Clinical Research Center, Cheeloo College of Medicine, Shandong University, 44 Wenhuaxi Road, Jinan 250012, China Department of Ophthalmology, The Affiliated Huaian No. 1 People’s Hospital of Nanjing Medical University, Huaian 223300, China Shanghai Institute of Applied Mathematics and MechanicsShanghai UniversityShanghai200072People's Republic of China; Shanghai Key Laboratory of Mechanics in Energy EngineeringShanghai UniversityShanghai200072People's Republic of China Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China; Department of Orthopedics, The Second Affiliated Hospital, Third Military Medical University, 400037 Chongqing, China; Center for Polymers and Organic Solids University of California Santa Barbara Santa Barbara CA 93106 USA Department of Traditional Chinese Medicine, Zhongshan Hospital and Shenzhen Research Institute, Xiamen University, Xiamen 361005, China; College of Acupuncture and Moxibustion, Hunan University of Traditional Chinese Medicine, Changsha 410208, China Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China; Division of Medical Psychology and Behavior Science, School of Medicine, Jinan University, Guangzhou, China Department of Pharmaceutics, Peking University School of Pharmaceutical Sciences, Beijing 100191, China. Department of Radiation Oncology State Key Laboratory of Oncology in Southern China Collaborative Innovation Center for Cancer Medicine Sun Yat‐sen University Cancer Center Guangzhou China School of Chemistry Beihang University No. 37, Xueyuan Road Beijing 100191 P. R. China Department of Gastroenterology, Guangzhou Huadu District People's Hospital, Guangzhou, China School of Sports and Health, Nanjing Sport Institute, Nanjing 210014. The Key Laboratory of Systems Biomedicine, Ministry of Education, and the Exercise Translational Medicine Centre, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240. Department of Laboratory Medicine, Peking University Third Hospital, Beijing, China From the Department of Anesthesiology, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin, China (J.Y., J.S., D.W., S.D., Y.Z., M.W., L.G.); Department of Intensive Care Medicine, Fourth Center Clinical College of Tianjin Medical University, Tianjin, China (Q.F.); and Department of Pharmacology, Institute of Acute Abdominal Diseases of Integrated Traditional Chinese and Western Medicine National Engineering Laboratory for Tree Breeding No.35, Qinghua East Road, Haidian District 100083 Beijing People's Republic of China; Key laboratory of Genetics and Breeding in Forest Trees and Ornamental Plants, Ministry of Education Beijing Forestry University No.35, Qinghua East Road, Haidian District 100083 Beijing People's Republic of China; School of Bioscience and Biotechnology Beijing Forestry University No.35, Qinghua East Road, Haidian District 100083 Beijing People's Republic of China CAS Key Laboratory of Special Pathogens and Biosafety, Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China Department of Orthopedics, Xinqiao Hospital, Affiliated Hospital of Army Medical University, Chongqing, 400037, P.R.China. Department of Immunology, Air Force Medical University, Xi’an 710032, China Institute of Population Research, China Center on Population Health and Development, Peking University, Beijing 100871, China. 7Department of Biostatistics, Columbia University Medical Center, New York, New York. Sun Yat‐sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou China National Health Commission Key Laboratory of Cardiovascular Regenerative Medicine, Fuwai Central China Cardiovascular Hospital, Central China Branch of National Center for Cardiovascular Diseases, Zhengzhou University, Zhengzhou 450046, China. Genomic Medicine Institute, Lerner Research Institute of Cleveland Clinic, Cleveland, OH, U.S.A Department of Ophthalmology, Ehime University School of Medicine, Toon, Ehime, Japan Hubei Hongshan Laboratory, College of Biomedicine and Health, Huazhong Agricultural University , No. 1, Shizishan Street, Wuhan, Hubei 430070, China; Hubei Key Laboratory of Agricultural Bioinformatics, College of Life Science and Technology, Huazhong Agricultural University , No. 1, Shizishan Street, Wuhan, Hubei 430070, China; Shenzhen Institute of Nutrition and Health, Huazhong Agricultural University , 97 Buxin Road, Shenzhen 518000, China; Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences , 97 Buxin Road, Shenzhen 518000, China University of Melbourne, Department of Medicine, St Vincent's Hospital, Fitzroy, Victoria, Australia Department of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital; Personalized Drug Therapy Key Laboratory of Sichuan Province, School of Medicine, University of Electronic Science and Technology of China School of Chemistry Beihang University No. 37 Xueyuan Road Beijing 100191 P. R. China Department of Anesthesiology and Critical Care Medicine Tianjin Nankai Hospital Tianjin Medical University Tianjin China Department of Head and Neck Surgery, Jiangsu Cancer Hospital, Nanjing, China. Department of Geriatrics, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China Department of Geriatric Neurology Qianfoshan Hospital of Shandong Province Jinan China School of Life Sciences, Fudan University, Shanghai 200433, China School of Pharmaceutical Sciences, Wenzhou Medical University Wenzhou 325035, China. Nutrition and Health Research Institute, COFCO Corporation , No. 4 Road, South District, Beiqijia Town, Changping District, Beijing 102209 , China; COFCO Corporation , COFCO Fortune Plaza, No.8, Chao Yang Men South St., Chao Yang District, Beijing 100020 , China Department of Cardiology, Guangzhou Military Region General Hospital; Department of Cardiology, Guangzhou Military Region General Hospital State Key Laboratory of Organic–Inorganic Composites Beijing Laboratory of Biomedical Materials Beijing Advanced Innovation Center for Soft Matter Science and Engineering College of Life Science and Technology Beijing University of Chemical Technology Beijing 100029 China State Key Laboratory of Coordination Chemistry, Nanjing National Laboratory of Microstructures, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu Province 210093, P. R. China Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570203, P.R. China Department of Dermatology, Shengli Oilfield Central Hospital, Shandong, China Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072 Department of Allergy, Beijing TongRen Hospital Capital Medical University Beijing China; Department of Otolaryngology–Head and Neck Surgery, Beijing TongRen Hospital Capital Medical University Beijing China; Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology Beijing China Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China; Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, China; Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China Department of Food Science and Technology School of Life Science Anqing Normal University Anqing China Shanxi Medical University School and Hospital of Stomatology Taiyuan China; Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials Taiyuan China Department of Biostatistics Columbia University New York New York From the Heart Rhythm Institute (B.J.S., M.G., E.P., T.W.D., S.Z., R.L., W.M.J., S.S.P.), College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Okla; Arrhythmia Center (G.N.), Cardiovascular Institute, Fuwai Hospital, Beijing, China; the Department of Cardiology (Z.L.), Renmin Hospital of Wuhan University, Wuhan, China; and the Cardiovascular Department (Y.Z.), Third Hospital of Beijing University, Beijing, China. School of Chinese Pharmacy, Beijing University of Chinese Medicine Department of Neonatology, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huai’an 223300, China From the Institute of Pediatrics (Y.Z., L.X., M.Z., Z.Z., Y.L., X.F., K.W., M.S., W.H.T.), Guangzhou Women and Children’s Medical Centre, Guangzhou Medical University, China Department of Orthopedics Trauma, Qinghai University Affiliated Hospital, Xining School of Electronic Information Engineering, Tianjin University, Tianjin, China Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing, China Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, USA Department of Pharmacology, School of Medicine, Southeast University, Nanjing, Jiangsu, China State Key Joint Laboratory of Environmental Simulation and Pollution Control, International Joint Laboratory for Regional Pollution Control, Ministry of Education (IJRC), College of Environmental Sciences and Engineering, Beijing 100871, China Department of Chemistry and Supercomputing Institute, University of Minnesota, Minneapolis, Minnesota 55455-0431 School of Materials Science and Engineering, Ocean University of China, Qingdao 266100, China Department of Pharmaceutics; School of Pharmacy; Nanjing Medical University; Nanjing; China Key Laboratory of Genetics and Breeding in Forest Trees and Ornamental Plants Ministry of Education, College of Biological Sciences and Biotechnology, Beijing Forestry University, Beijing 100083, China; Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, Beijing Forestry University, Beijing 100083, China Institute of Functional Material Chemistry, Faculty of Chemistry, Northeast Normal University, Changchun, 130024, China Key Laboratory of Special Pathogens and Biosafety, Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China Shaanxi Engineering Laboratory for Food Green Processing and safety Control, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710062, China Teaching Hospital, School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province College of Information Science and Engineering, Henan University of Technology, Zhengzhou 450001, China School of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou 511442, P.R. China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, P.R. China; Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou 510006, P.R. China Guangdong Provincial Key Laboratory of Water Quality Improvement and Ecological Restoration for Watersheds, School of Ecology, Environment and Resources, Guangdong University of Technology, Guangzhou510006, China School of Electrical and Information Engineering, Tianjin University, Tianjin, China Basic Experiment Teaching Center, Gansu Agricultural University, Lanzhou 730070, China Institute for Translational Medicine, Medical College, QingDao University, Qing Dao 266071, China Research, Development & Analytics Department, Gateway Health, Pittsburgh, PA, USA Sun Yat‐sen Global Health Institute Sun Yat‐sen University Guangzhou China; Department of Radiation Oncology Sun Yat‐sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou China Department of Ultrasonography, Children’s Hospital of Fudan University, Shanghai, China Division of Cell and Experimental Pathology, Department of Translational Medicine, Clinical Research Centre, Lund University Skåne University Hospital Malmö Sweden Department of Ultrasound Medicine, Yunnan Cancer Hospital, the Third Affiliated Hospital of Kunming Medical University, Kunming, China Center for Polymers and Organic Solids University of California, Santa Barbara Santa Barbara CA 93106 USA COFCO Nutrition and Health Research Institute, Beijing, China Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing, China Beijing Institute of Otorhinolaryngology, Key Laboratory of Otorhinolaryngology, Head and Neck Surgery (Capital Medical University), Ministry of Education, Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Affilitiated to Capital Medical University, Beijing, China. Research Center for Human Tissues & Organs Degeneration, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Guangdong 518055, Shenzhen, China Department of Otolaryngology Head and Neck Surgery and Department of allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China.; Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China. Department of Materials Science and Engineering, College of Mechanics and Materials, Hohai University, Nanjing 211100, China Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University (Y.Z., Z.L.). Department of Chemistry, Renmin University of China, 59 Zhongguancun Street, Haidian District, Beijing 100872, China Department of Emergency, Shengjing Hospital of China Medical University, Shenyang, China Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China The Sixth Affiliated Hospital of Guangzhou Medical University Qingyuan Guangdong China Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China; Sun Yat-sen Global Health Institute, School of Public Health and Institute of State Governance, Sun Yat-sen University, Guangzhou, China Dalian Medical University, Dalian, Liaoning, PR China Department of Materials Science and Engineering Southern University of Science and Technology Shenzhen Guangdong 518055 China; Guangdong Provincial Key Laboratory of Functional Oxide Materials and Devices Southern University of Science and Technology Shenzhen Guangdong 518055 China Institute of Cardiovascular Disease and Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang City, Hunan Province, People's Republic of China Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York, USA Institute of Basic Medicine Hebei Medical University Shijiazhuang China Key Laboratory of Advanced Manufacturing Intelligent Technology of Ministry of Education, Harbin University of Science and Technology, Harbin 150080, China College of Electronic and Information Engineering, Southwest University, Chongqing, China Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Department of Chemistry, Wuhan University, Wuhan 430072, China Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; National Clinical Research Center for Neurological Diseases, Beijing, China Department of Radiology, Suzhou Guangji Hospital, Suzhou, Jiangsu 215006, P.R. China Department of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, USA; ; Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. School of Physics National Laboratory of Solid State Microstructures Collaborative Innovation Center of Advanced Microstructures, Nanjing University Nanjing 210093 P. R. China; Eco-Materials and Renewable Energy Research Center (ERERC) Nanjing University Nanjing 210093 P. R. China Department of Electronics and Electrical Engineering, Rankine Building, University of Glasgow, Glasgow G12 8LT, U.K. Department of Cardiac Surgery, Qingdao Municipal Hospital, Qingdao, Shandong 266021, China Guangdong Key Laboratory of Age-related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China; Institute for Translational Medicine, College of Medicine, Qingdao University, Qingdao, China Department of Nephrology, Affiliated Hospital of Nantong University, Nantong, China Institute of Medical Research, Northwest Polytechnic University , Xi'an, Shaanxi, China Heart Center, Beijing Chaoyang Hospital Capital Medical University Beijing China; Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital Capital Medical University Beijing China Department of Genetics, College of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China College of Chemistry Beijing Normal University Beijing 100875 China State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031 Shanghai, China; Department of Internal Medicine, Xinglin Branch, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China Institute of Population Research/China Center on Population Health and Development, Peking University, Beijing 100871, China Department of Anesthesiology and Critical Care Medicine, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin 300100, China Ultrasound and Functional Diagnosis Center, Beijing Youan Hospital Capital Medical University Beijing China Department of Head and Neck Surgery, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000, P.R. China Department of Health Services, Policy, and Practice & Center for Gerontology Brown University School of Public Health Providence Rhode Island USA Institute für Physik, Humboldt-Universität zu Berlin , Netwonstraße 15, D-12489 Berlin, Germany Department of Respiratory Medicine and Institute of Vascular Medicine Peking University Third Hospital Beijing China; Beijing Key Laboratory of Cardiovascular Receptors Research Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Ministry of Health Beijing China Department of Otolaryngology Head and Neck Surgery Beijing TongRen Hospital Capital Medical University Beijing China; Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology Beijing China; Department of Allergy Beijing TongRen Hospital Capital Medical University Beijing China Department of Anesthesiology and Critical Care Medicine Tianjin Nankai Hospital, Tianjin Medical University 6 Changjiang Road Tianjin People's Republic of China Institut für Physik, Humboldt-Universitäat zu Berlin, Newtonstraße 15, D-12489 Berlin, Germany Provincial Key Laboratory of Biological Macro‐Molecules Research, Wannan Medical College Wuhu Anhui China Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island 02881, United States Department of Anesthesiology and Critical Care Medicine, Tianjin Nankai Hospital, Tianjin 300100, China. Corresponding author: Yu Jianbo, Email: 30717008@nankai.edu.cn. Division of Endocrinology, Metabolism, and Diabetes, Program in Molecular Medicine, University of Utah, Salt Lake City, UT; Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA Department of Obstetrics, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China Department of Anatomy and Physiology, Stomatological College, Fourth Military Medical University, Xi'an 710032, Shanxi Province, China. Department of Chemistry and Ames Laboratory School of Public Health, Nanchang University, Jiangxi, China Department of Otolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, People's Republic of China; Key Laboratory of Otolaryngology, Head and Neck Surgery, Ministry of Education of China, Beijing Institute of Otorhinolaryngology, Beijing, People's Republic of China School of Public Health, Tianjin Medical University, Tianjin, China College of Environmental Science and Engineering, Zhejiang Gongshang University, Hangzhou 310018, China Department of Immunology, Nankai University School of Medicine and Key Laboratory of Bioactive Materials, Nankai University, Ministry of Education, People’s Republic of China College of Environment, Hohai University, Nanjing 210098, PR China *State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; Department of Neurosurgery Shenzhen Key Laboratory of Neurosurgery The First Affiliated Hospital of Shenzhen University/Shenzhen Second People’s Hospital Graduate School of Guangzhou Medical University, Shenzhen China; Department of Pathophysiology Baotou Medical College Baotou China Department of State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, 710032, China Genomic Medicine Institute Cleveland Clinic Cleveland Ohio; Lerner Research Institute Cleveland Clinic Cleveland Ohio Department of Neurosurgery, Qilu Hospital of Shandong University and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan City, Shandong Province, People’s Republic of China; Shandong Key Laboratory of Brain Function Remodeling, Jinan City, Shandong Province, People’s Republic of China Department of Pediatrics, Third Xiangya Hospital, Central South University; Hunan Clinical Research Center of Pediatric Cancer, Changsha 410013, China. 1209525492@qq.com. Joint Disease & Sport Medicine Center, Department of Orthopedics, Xinqiao Hospital, Army Medical University, Chongqing, 400038, China 1Department of Orthopedics, Joint Disease and Sport Medicine Center, Xinqiao Hospital, Army Medical University, Chongqing, China Department of Gynecology Hebei Provincial People's Hospital Shijiazhuang China The First Affiliated Hospital of Xiamen University, Xiamen, China. Department of Biostatistics, Mailman School of Public Health Columbia University New York NY USA State Key Laboratory of Clean and Efficient Coal Utilization, Taiyuan University of Technology, Taiyuan 030024, Shanxi, P. R. China; College of Chemical Engineering and Technology, Taiyuan University of Technology, Taiyuan 030024, Shanxi, P. R. China The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China Ultrasound and Functional Diagnosis Center, Beijing You An Hospital Capital Medical University Beijing China Department of Pharmacy; The First Affiliated Hospital of Chongqing Medical University; Chongqing; People's Republic of China From the School of Public Health (H.L., H.Y., Y.Z., S.Z., Y.M., Y.H., X.Z., K.N., Y.W.), Tianjin Medical University; School of Management (S.L.), Tianjin University of Traditional Chinese Medicine; and Department of Clinical Sciences in Malmö (Y.B.), Lund University, Sweden. School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China Engineering Research Center of Standardized Production of Chinese Medicinal Materials, Ministry of Education Beijing 102488, China. Aix Marseille Univ, CNRS, Centrale Marseille, iSm2, Marseille, France Department of Cardiology, Beijing Chaoyang Hospital, Beijing 100020, P.R. China College of Veterinary Medicine, China Agricultural University, Beijing 100193, P. R. China Department of Medicine St Vincent's Hospital University of Melbourne Melbourne Vic. Australia Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China School of Electronics and Information, Northwestern Polytechnical University, 1 Dongxiang Road, Chang’an District, Xi’an, Shaanxi 710129, P. R. China Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education); Department of Chemistry; Wuhan University; Wuhan 430072; P R China Institute of Neuroscience & Department of Neurology of the Second Affiliated Hospital (J.Q., S.G., Y.Z., J.T.), Soochow University, Suzhou 215004, China From Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University (Northern Campus), Guangzhou, Guangdong Province, People’s Republic of China. Department of Neurobiology Medical College of Soochow University Suzhou China; Department of Geriatrics and Institute of Neuroscience The Second Affiliated Hospital of Soochow University Suzhou China Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, Jilin, China Institute of Animal Sciences of Chinese Academy of Agricultural Sciences, Scientific Observing and Experiment Station of Animal Genetic Resources and Nutrition in North China, Ministry of Agriculture and Rural Affairs, No. 2 Yuanmingyuan West Road, Haidian District, Beijing 100193, China; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, P. R. China. Tel: +8645155190407 College of Life Sciences, Shaanxi Normal University, Xi’an, China Shantou University Medical College, Central Laboratory, Shantou 515041, China. College of Animal Science Inner Mongolia Agricultural University Hohhot China Key Laboratory for Regenerative Medicine Ministry of Education School of Biomedical Sciences Faculty of Medicine The Chinese University of Hong Kong Hong Kong Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Department of Hematology, The Second Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China. Key Lab of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, P.R. China St Vincent's Hospital, University of Melbourne, Melbourne, Australia; Department of Mathematics, Duke University, Durham, NC 27708 Institute of Medical Research Northwestern Polytechnical University Xi'an China Department of Hematology, PLA Army General Hospital, Beijing, 100700, People's Republic of China Institute for Translational Medicine, College of Medicine, Qingdao University Qingdao China Division of Biostatistics School of Public Health University of Minnesota Minneapolis MN USA Institute of Translational Medicine Shanghai University Shanghai 200444 China; Musculoskeletal Organoid Research Center Shanghai University Shanghai 200444 China; School of Medicine Shanghai University Shanghai 200444 China Fujian Normal University, College of Chemistry and Materials Science, Fuzhou 350007, China; State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China 4Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York. Department of Immunology, Fourth Military Medical University, Xi'an-Shaanxi Province, P.R. China. Center for Polymers and Organic Solids Department of Chemistry and Biochemistry University of California Santa Barbara CA 93106 USA Department of Gynecology Hebei General Hospital Shijiazhuang China Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, Shaanxi Normal University, Xi’an, 710062, P. R. China Department of Head and Neck Surgery, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, China. Heart Center and Beijing Key Laboratory of Hypertension Research, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P.R. China Department of Pharmacy; National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital; Chinese Academy of Medical Sciences and Peking Union Medical College; Beijing; China Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton L8S 4L8, Ontario, Canada. Department of Molecular Cell Biology and Toxicology, School of Public Health, Nanjing Medical University, Nanjing 211166; Department of Anesthesiology, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029; Department of Anesthesiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China. State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University, and Shandong Academy of Medical Sciences, Qingdao, China Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, China Department of Anatomy and Physiology, College of Stomatology, The Fourth Military Medical University, Xi'an 710032, China. Department of Geology, State Key Laboratory of Continental Dynamics, and Shaanxi Key Laboratory of Early Life and Environments Northwest University Xi'an China Department of Gynecology, Hebei General Hospital, Shijiazhuang, Hebei 050051, P.R. China Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology, School of Chemistry, Beihang University, Beijing, 100191, People’s Republic of China School of Information, North China University of Technology, Beijing 100144, China College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China State Key Laboratory of Trauma, Burns and Combined Injury, The Second Department of Research Institute of Surgery, Daping Hospital, The Third Military Medical University, Chongqing 400042, China. Department of Pharmacology, Zhongshan School of Medicine Sun Yat‐Sen University 74 Zhongshan 2nd Road Guangzhou 510080 P.R. China Institute for Energy Research, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, P. R. China Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, People's Republic of China Department of Obstetrics and Gynecology; the Third Affiliated Hospital of Sun Yat-sen University; Guangzhou China Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China; Shandong Energy Institute, Qingdao 266101, China; Qingdao New Energy Shandong Laboratory, Qingdao 266101, China Department and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Avenue, 430030 Wuhan, China Key Laboratory of the Ministry of Education for Medicinal Resource and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi'an, Shaanxi 710062, PR China. Department of Cardiology, Haining People’s Hospital, Zhejiang Province, China Shenzhen Key Laboratory of Nanobiomechanics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China Department of Epidemiology and Biostatistics , School of Public Health, , Tianjin , China; Tianjin Medical University , School of Public Health, , Tianjin , China Hospital of Chengdu University of Traditional Chinese Medicine State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China; College of Chemistry and Materials Science, Fujian Normal University, Fuzhou 350007, China Institute of Environmental Sciences, State Joint Key Laboratory of Environment Simulation and Pollution Control, Key Laboratory for Water and Sediment Sciences of Ministry of Education, Beijing Normal University. zhangsongming@263.net Key Laboratory of Advanced Energy Materials Chemistry (MOE), Renewable Energy Conversion and Storage Center College of Chemistry Nankai University Tianjin 300071 China School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China; Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan, China; Clinical Research Center, Shandong University, Jinan, China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Sciences Beijing China Department of Hematology, Military General Hospital of Beijing PLA, Beijing 100700, P.R. China Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China National Clinical Research Center for Interventional Medicine, Shanghai, China Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery; Eshelman School of Pharmacy; University of North Carolina at Chapel Hill; Chapel Hill, USA Pharmacology (D.R.S., C.L.C., Y.Z., D.J.M., S.A.K.), Dallas, Texas 75390; the Howard Hughes Medical Institute (D.R.S., C.L.C., Y.Z., D.J.M.), University of Texas Southwestern Medical Center, Dallas, Texas 75390 Northwest University, China School of Environmental Science and Engineering, Suzhou University of Science and Technology, Suzhou, People’s Republic of China The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for NeuroInformation, Center for Information in Medicine University of Electronic Science and Technology of China Chengdu Sichuan China State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, P. R. China Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui 230032, P.R. China Department of Otolaryngology & Head and Neck Surgery, West China Hospital of Sichuan University, China School of Aerospace Medicine The Fourth Military Medical University Xi‘an China Institute of Bioorganic & Medicinal Chemistry, Key Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin 300071, People’s Republic of China; and Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071, People’s Republic of China Shanxi Medical University School and Hospital of Stomatology Taiyuan 030001 China; Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials Taiyuan 030001 China East China Normal University, China School of Kinesiology and Health Science; and Muscle Health Research Centre; York University; Toronto Ontario M3J 1P3 Canada; Department of Sport and Health Science; Nanjing Sport Institute; Nanjing China; Key Laboratory of Adolescent Health Assessment and Exercise Intervention; Ministry of Education of China; East China Normal University; Shanghai China Section for Microbial Ecology and Biotechnology, Department of Plant and Environmental Sciences, University of Copenhagen, Frederiksberg C, Denmark School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada; and; Muscle Health Research Centre, York University, Toronto, Ontario, Canada Department of Allergy,Beijing Tongren Hospital,Capital Medical University. Department of Hematology, The Fifth Medical Center, Chinese People’s Liberation Army (PLA) General Hospital, Beijing, China Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China The Second Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China; Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, Dalian, China Key Laboratory for Regenerative Medicine, Ministry of Education, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR 999077, China; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China. zhangyuanbjcm@gmail.com Laboratory of Parasitology, College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong Province 510642, China Department of Orthopedics, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Laboratory of Biomaterials, 136# Zhongshan 2 road, Yuzhong District, Chongqing 400014, People's Republic of China State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, The Chinese Academy of Agricultural Sciences, Harbin, P. R. China Materials Science and NanoEngineering, Rice University, Houston, TX 77005, USA. State Key Laboratory of ISN, School of Telecommunications Engineering, Xidian University, Xi’an 710126, China Department of Ultrasound, Pudong New Area People's Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai 201299, P.R. China Authors' Affiliations: 1Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences; 2Clinical Laboratory, Cancer Hospital, Chinese Academy of Medical Sciences; and 3National Center for Clinical Laboratories, Beijing Hospital of the Ministry of Public Health, Beijing, People's Republic of China; Authors' Affiliations: 1Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences; 2Clinical Laboratory, Cancer Hospital, Chinese Academy of Medical Sciences; and 3National Center for Clinical Laboratories, Beijing Hospital of the Ministry of Public Health, Beijing, People's Republic of China Chongqing Key Laboratory for Pharmaceutical Metabolism Research; College of Pharmacy; The First Affiliated Hospital; Chongqing Medical University; Chongqing From the Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, China (X.C., Q.C., Y.L., W.L.); Guangdong Provincial Key Laboratory of Food, Nutrition, and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, China (X.C., Q.C., Y.L., W.L.); Department of Cardiology, General Hospital of Guangzhou Military Command of People’s Liberation Army, China (Y.Z.); and Department of Epidemiology, School of Public Health, Guilin Medical... Clinical Epidemiology Unit, Qilu Hospital of Shandong University, 107 Wenhua W Road, Jinan, Shandong 250012, China; Clinical Research Center of Shandong University, 107 Wenhua W Road, Jinan, Shandong 250012, China State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Sun Yat‐sen University Cancer Center Guangzhou China Laboratory of Hepatitis Research, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892 Key Laboratory of Modern Acoustics; MOE; Institute of Acoustics; School of Physics; Nanjing University Guangdong Provincial Key Laboratory of Water Quality Improvement and Ecological Restoration for Watersheds, Institute of Environmental and Ecological Engineering Guangdong University of Technology Guangzhou 510006 China Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland;; Baltimore Veterans Affairs Medical Center, Baltimore, Maryland Institute of Food Safety Chinese Academy of Inspection & Quarantine Beijing P.R. China; Department of Pharmacy National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing P.R. China Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Science, Jinan, Shandong, China; Shandong Provincial Key Lab for Dermatovenereology, Jinan, Shandong, China Key Laboratory of Functional Inorganic Material Chemistry; Ministry of Education; P. R. China; School of Chemistry and Materials Science; Heilongjiang University Institute of Otorhinolaryngology, General Hospital of Chinese People's Liberation Army, Beijing 100853, China. *Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107; From the Molecular Signaling Section (J.B., Y.Z., P.M.M.) and Inflammation Biology Section (J.F.F.), Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China Department of Orthopedics, Xinqiao Hospital, Army Medical University, Chongqing, China Institute of Otorhinolaryngology, General Hospital of Chinese People's Liberation Army, Beijing 100853, China. zhaisq@plagh.com.cn Department of Health Research Methods, Evidence, and Impact McMaster University Hamilton Ontario Canada State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China; Key Laboratory of Preventive Veterinary Medicine of Hubei Province, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, 266101, China College of Chemistry and Chemical Engineering; Institute of Environmental Science; Shanxi University; Taiyuan; PR China Department of Epidemiology and Health Statistics, School of Public Health, Chongqing Medical University, Yixue Road, Chongqing 400016, China Department of Oncology, Shanxi Provincial People's Hospital, Xi’an, China. Department of Computer Science and Engineering, Michigan State University, East Lansing, MI 48824, USA Department of Ultrasound, Pudong New Area People's Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai 201200, P.R. China School of Public Health Tianjin Medical University Tianjin 300070 China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry; College of Chemistry; Jilin University; Changchun 130012; P.R. China Department of General Surgery, Yangpu Hospital, School of Medicine, Tongji University, Shanghai 200090, P.R. China Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; Key Laboratory of Combined Multiorgan Transplantation, Ministry of Public Health, Key Laboratory of Organ Transplantation, Zhejiang Province, Hangzhou 310003, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China Analytical and Testing Center of Wenzhou Medical University Wenzhou 325035 China; Forensic Toxicology Laboratory of Forensic Center Wenzhou Medical University Wenzhou 325035 China Université Lille, CNRS, Central Lille, ISEN, Université Valenciennes, UMR 8520, IEMN, F-59000 Lille, France Fujian Bote Biotechnology Co. Ltd, Fuzhou, Fujian, 350013, P. R. China School of Chemistry and Chemical Engineering, North Minzu University, Yinchuan750021, P. R. China From Department of Pharmacology, University of California at Davis (Q.W., Y.L., Q.F., B.X., S.K., R.T., F.B., T.W., Y.K.X); Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, China (Q.W, W.W.); Shuguang Hospital, Shanghai University of Traditional Chinese Medicine (Y.L.); Department of Pharmacology, Tongji Medical College,... *Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin, China; Department of Orthopedics, Tianjin Medical University General Hospital, No. 154 Anshan Road, Tianjin 300052, China Tissue Tech, Inc. Ocular Surface Center Ocular Surface Research & Education Foundation Miami Florida Laboratory of Hepatitis Viruses, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892 State Key Laboratory of Biocontrol, School of Life Sciences, College of Ecology and Evolution Sun Yat‐Sen University Guangzhou China State Key Laboratory of Clean and Efficient Coal Utilization Taiyuan University of Technology Taiyuan Shanxi 030024 P. R. China R&D Department, Tissue Tech, Inc, Miami, Florida, USA Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital Capital Medical University Beijing China; Beijing Key Laboratory of Nasal diseases Beijing Institute of Otolaryngology Beijing China; Department of Allergy, Beijing TongRen Hospital Capital Medical University Beijing China; Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences Beijing China Hebei Key Laboratory of Advanced Laser Technology and Equipment, School of Electronics and Information Engineering, Hebei University of Technology, 5340 Xiping Road, Tianjin 300401, P. R. China Tianjin First Central Hospital, Tianjin 300192, China.; Tianjin Medical University, Tianjin 300070, China. College of Biological Sciences and Technology Beijing Forestry University Beijing China University of Massachusetts Lowell, USA School of Food Science and Technology, Jiangnan University, Wuxi 214122, China; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; Collaborative Innovation Center of Food Safety and Quality Control, Jiangnan University, Wuxi 214122, China School of Chemistry and Pharmaceutical Sciences, State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin, 541004, P. R. China Jiangxi Key Laboratory for Microscale Interdisciplinary Study, Institute for Advanced Study, Nanchang University, Nanchang 330031, China 6Head and Neck Surgery (Department), Jiangsu Cancer Hospital (Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital), Nanjing, China. School of Chemistry and Chemical Engineering, Xi'an Shiyou University, Xi'an 710065, China School of Pharmacy China Medical University Shenyang P.R. China Medical Research Center, North China University of Science and Technology, Tangshan, Hebei 063000, P.R. China Department of Aerospace Medicine, Fourth Military Medical University, Xi'an, China Department of Ophthalmology, Shanghai Changhai Hospital, Shanghai 200433, P.R. China Cancer Institute, The Second Hospital of Dalian Medical University, Institute of Cancer Stem Cell, Dalian Medical University, Dalian 116044, China Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada;; Muscle Health Research Centre, York University, Toronto, Ontario, Canada;; Key Laboratory of Adolescent Health Assessment and Exercise Intervention, Ministry of Education of China, Shanghai, China; and; College of Physical Education and Health, East China Normal University, Shanghai, China Department of Cardiology Shanghai Institute of Cardiovascular Diseases Zhongshan Hospital Fudan University Shanghai China Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China; Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China; Key Laboratory of High Altitude Environment and Gene Related to Disease of Tibet Ministry of Education, School of Medicine, Xizang Minzu University, Xianyang 712082, Shaanxi, China Key Laboratory of Functional Materials Physics and Chemistry of the Ministry of Education Jilin Normal University 130103 Changchun (P. R. China Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, China; Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, China; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, China; Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing 100191, China Laboratory of Neural Circuit Plasticity , School of Brain and Cognitive Sciences , Beijing Normal University, Beijing , P. R. China Laboratory for Reproductive Immunology Hospital of Obstetrics and Gynecology Fudan University Shanghai Medical College Shanghai China Ecomaterials and Renewable Energy Research Center (ERERC); Nanjing University; 22 Hankou Road; Nanjing; P. R. China Oregon Hearing Research Center, Department of Otolaryngology, Oregon Health & Science University, Portland, OR 97239-3098; Susan and Alan Solomont School of Nursing University of Massachusetts Lowell Lowell MA USA Central Laboratories, Medical College of Shantou University, Shantou 515041, China. yzhang@stu.edu.cn National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry The Ministry of Education College of Life Sciences Shaanxi Normal University Xi’an China State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China; Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA; Baltimore Veterans Affairs Medical Center, Baltimore, Maryland, USA Department of Pulmonary and Critical Care Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China Bio-analytical Laboratory, Shantou University Medical College, Shantou, PR China. State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China; Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071, China; and Department of Immunology, Nankai University School of Medicine, Nankai University, Tianjin 300071, China Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL Department of Plant Pathology, College of Plant Protection Henan Agricultural University/Collaborative Innovation Center of Henan Grain Crops/National Key Laboratory of Wheat and Maize Crop Science Zhengzhou China Department of Ultrasound, Pudong New Area People’s Hospital affiliated to Shanghai University of Medicine and Health Sciences, Shanghai, China Medicine and Pharmacy Research Center, Binzhou Medical University, Laishan District, No. 346, Guanhai Road, Yantai, Shandong Province 264003, China Department of Ultrasound, Shanghai Pudong New Area People's Hospital, Shanghai 201299, P.R. China From the Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China; From the Department of Cardiovascular Medicine, General Hospital of Guangzhou Military Command, Guangzhou, China (Yuan Zhang, J.Q., X.W., Yuhua Zhang, M.X.); Guangdong Provincial Key Laboratory of Food, Nutrition and Health (X.W., Yuhua Zhang, M.X.); Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, China (X.W., Yuhua Zhang, M.X.). State Key Laboratory of Biogeology and Environmental Geology China University of Geosciences Wuhan China Administration of Sports of Guangdong Province, Guangzhou, Guangdong, 510105, China College of Life Sciences and Key Laboratory of Bioactive Materials Ministry of Education, Nankai University, Tianjin, PR China National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, The Ministry of Education, Shaanxi Normal University, Xi’an, Shaanxi, China Department of Ophthalmology Shanghai General Hospital National Clinical Research Center for Eye Diseases Shanghai Key Laboratory of Ocular Fundus Diseases Shanghai Engineering Center for Visual Science and Photomedicine Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases Shanghai Jiao Tong University School of Medicine Shanghai China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry and Jilin Provincial International Cooperation Key Laboratory of Advanced Inorganic Solid Functional Materials, College of Chemistry, Jilin University, Qianjin Street 2699, Changchun, 130012, China INSERM, UMR935 Modèles de cellules souches malignes et thérapeutiques, Villejuif, Val-de-Marne, France; Université Paris-Sud, Orsay, Essonne, France National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry The Ministry of Education College of Life Sciences Shaanxi Normal University Xi'an Shaanxi 710119 P. R. China Department of Emergency Shengjing Hospital of China Medical University Shenyang China Department of Infectious Diseases, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China School of Chemistry and Chemical Engineering, Chongqing University, 174 Shazheng Street, Chongqing 400044, China Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, Shaanxi, China; Key Laboratory of High Altitude Environment and Gene Related to Disease of Tibet Ministry of Education, School of Medicine, Xizang Minzu University, Xianyang 712082, Shaanxi, China Fujian GTR Biotech Co. Ltd. Fuzhou Fujian 350108 P. R. China Medicine and Pharmacy Research Center, Binzhou Medical University, Yantai, Shandong Province, 264003 China Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.; Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China.; Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, China. College of Veterinary Medicine; Northeast Agricultural University; Harbin 150030; P. R. China From the Departments of Neurological Surgery (J.M., T.C., J.H., Y.Z., W.M., E.S.C.) and Medicine (D.J.P.), and the Institute of Comparative Medicine (S.P.), Columbia University College of Physicians and Surgeons, New York, NY; Protein Design Labs, Inc (E.H., L.E., C.K., V.V.), Fremont, Calif; and Pathology Associates (W.H.), A Charles River Company, Frederick, Md. Department of Medicine St Vincent's Hospital The University of Melbourne Fitzroy Vic. Australia From the Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China. Sino‐French Institute for Earth System Science College of Urban and Environmental Sciences Peking University Beijing China State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences (RAD-X) Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Soochow University Suzhou 215123 China Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry; National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China; College of Life Sciences; Shaanxi Normal University; Xi'an University of Massachusetts Lowell, Lowell, MA, USA College of Science, China Agricultural University, Beijing 100193, China. zhangyuan861@163.com Departments of 1Immunology and 2Anatomy, Nankai University School of Medicine and 3Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin, People's Republic of China Department of Clinical Laboratory, Nanjing First Hospital, Affiliated to Nanjing Medical University, Nanjing, China College of Life Science, Huaibei Normal University, Huaibei, P.R. China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of Chemistry Jilin University Changchun 130012 P. R. China Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, China. The National Forestry and Grassland Administration Engineering Research Center for Germplasm Innovation and Utilization of Warm-Season Turfgrasses, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing Botanical Garden, Mem. Sun Yat-Sen, Nanjing 210014, China; Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing Botanical Garden, Mem. Sun Yat-Sen, Nanjing 210014, China Key Laboratory of Grain Information Processing & Control, Ministry of Education, Henan University of Technology, Zhengzhou 450001, China; Henan Provincial Key Laboratory of Grain Photoelectric Detection and Control, Zhengzhou 450001, China; College of Information Science and Engineering, Henan University of Technology, Zhengzhou 450001, China Department of Hematology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China First Affiliated Hospital of Army Medical University, Chongqing 400038, China Department of Geriatrics, Jinling Hospital of Nanjing, Nanjing, 210013, P. R. China. Department of Otolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, PR China.; Key Laboratory of Otolaryngology, Head and Neck Surgery (Ministry of Education of China), Beijing Institute of Otorhinolaryngology, Beijing 100005, PR China. State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, and Laboratory of Molecular Biochemical Engineering and Advanced Fermentation Technology, Department of Bioengineering, School of Life Sciences and Biotechnology Shanghai Jiao Tong University Shanghai China Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.; Clinical Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou, China. Central Laboratory, Shantou University Medical College, Shantou 515041, China. Department of Gastroenterology, Huadu District People's Hospital, Southern Medical University, Guangzhou, Guangdong 510800, P.R. China Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada; Health Quality Ontario, Toronto, Ontario, Canada. University of Toronto, Faculty of Pharmacy, 144 College Street, Toronto, Ontario, M5S 3M2, Canada, Tel.: , Fax.: , State-Province Joint Engineering Laboratory of Marine Bioproducts and Technology, College of Ocean and Earth Sciences, Xiamen University, Xiamen 361102, PR China School of Materials Science and Engineering, Shaanxi Normal University, Xi’an 710119, China Center for Optoelectronics Materials and Devices, Department of Physics, Zhejiang Sci-Tech University, Hangzhou 310018, People’s Republic of China School of Chemistry and Chemical Engineering, Guangdong Provincial Key Laboratory of Advanced Drug Delivery, and Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, Guangdong Pharmaceutical University, Zhongshan 528458, P. R. China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin Provincial International Cooperation Key Laboratory of Advanced Inorganic Solid Functional Materials, College of Chemistry, Jilin University, Qianjin Street 2699, Changchun 130012, People’s Republic of China Department of Pharmacy China Medical University Shenyang Shenbei New District China Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China Center for Gene Therapy and Immunotherapy, The Second Hospital of Shandong University, Jinan, China Department of Orthopedics Xinqiao Hospital Third Military Medical University Chongqing China Institute of Otolaryngology, Chinese PLA General Hospital, Beijing, 100853, China. Department of Ultrasound, Shanghai Pudong New Area People’s Hospital, Shanghai, China (mainland) Department of Health Statistics Second Military Medical University Shanghai China; Quality Control Section, Department of Medical Affairs Hangzhou China College of Biological, Chemical Science and Engineering Jiaxing University Jiaxing 314001 P. R. China Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai Medical College, Shanghai 200011, P.R. China Department of Pathology and National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China Transplant Immunology Laboratory Fourth Military Medical University Xi'an China Eye Center, Renmin Hospital of Wuhan University, Wuhan, Hubei, China (mainland) Department of Radiation Oncology Sun Yat‐sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Guangzhou China Department of Chemistry; Renmin University of China; 59# Zhongguanchun street; Haidian District; Beijing 100872 Associate Professor, Solomont School of Nursing, Zuckerberg College of Health Sciences, 113 Wilder Street, University of Massachusetts Lowell, Lowell, MA 01854. Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangdong Geriatric Institute, Guangzhou, China; Southern Medical University, Guangzhou, China Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, PRChina Department of Orthopedics, Army Medical University, Xinqiao Hospital, Chongqing, China Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital 3002# Sungang Road, Futian District Shenzhen 518035 China Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China Tsinghua University Department of Anesthesiology, Tianjin Nan Kai Hospital, Tianjin Medical University, Tianjin, China (mainland). College of Life Sciences, Hebei Normal University, Shijiazhuang 050016, China. Department of Ultrasound, Pudong New Area People's Hospital, Shanghai 201200, P.R. China Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China School of Life Science Liaoning Normal University Dalian City Liaoning Province China The National Forestry and Grassland Administration Engineering Research Center for Germplasm Innovation and Utilization of Warm-Season Turfgrasses, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing Botanical Garden, Memorial Sun Yat-Sen, Nanjing 210014, China; Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing Botanical Garden, Memorial Sun Yat-Sen, Nanjing 210014, China Hubei Hongshan Laboratory , College of Biomedicine and Health, , Wuhan 430070 , China; Huazhong Agricultural University , College of Biomedicine and Health, , Wuhan 430070 , China Center for Nanoscale Materials, Argonne National Laboratory, Lemont, Illinois 60439, United States Department of Neurosurgery, Beijing Tiantan Hospital Capital Medical University Beijing China School of Chemistry Beijing Advanced Innovation Center for Biomedical Engineering Beihang University Beijing 100191 P. R. China Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Nansihuanxilu 119, Fengtai District, Beijing, People’s Republic of China, 100070; China National Clinical Research Center for Neurological Diseases, Nansihuanxilu 119, Fengtai District, Beijing, People’s Republic of China, 100070; Center of Brain Tumor, Beijing Institute for Brain Disorders, Nansihuanxilu 119, Fengtai District, Beijing, People’s Republic of China, 100070; Beijing Key Laboratory of Brain Tumor, Nansihuanxilu 119, Fengtai District, Beijing, People’s Republic of China, 100070 Beijing Beike Deyuan Bio-Pharm Technology Co.Ltd 7 Fengxian road Beijing 100094 China Department of Immunology, School of Medicine , Tianjin , P. R. China Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital Capital Medical University Beijing China; Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology Beijing China; Department of Allergy, Beijing TongRen Hospital Capital Medical University Beijing China Research Institute of Shenzhen, Medical College of Xiamen University, Shenzhen 518000, Guangdong Province, China; College of Acupuncture-Moxibustion and Tuina, Hunan University of CM, Changsha 410208; 3Fujian University of TCM. Department of Pediatric Internal Medicine, Xuzhou Children's Hospital, Xuzhou, Jiangsu 221002, P.R. China Yunnan Academy of Biodiversity, Southwest Forestry University, Kunming, China; Forestry Resources Exploitation and Utilization Engineering Research Center for Comprehensive Healthcare of Yunnan Provincial Universities Department of Neonatology, Huai'an First Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, China. lyh0729@163.com. The Central Laboratory, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, Guangdong 518035, P.R. China Department of Anesthesiology Department of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Tx 75390-9050, USA. Department of Chemistry, Iowa State University, Ames, Iowa 50011; College of Veterinary Medicine Northeast Agricultural University Harbin China School of Architecture and Urban Planning, Shenyang Jianzhu University, Shenyang, China; School of Architecture, University of Sheffield, Sheffield, UK. Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA The State Key Laboratory Breeding Base of Bioresources and Eco-environments, Key Laboratory of Freshwater Fish Reproduction and Development, Ministry of Education, Laboratory of Molecular Developmental Biology, School of Life Sciences, Southwest University, Beibei, Chongqing, China Institute of Molecular Medicine, National Biomedical Imaging Center, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, College of Future Technology, Peking University, Beijing 100871, China Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, United States Department of Respiratory Medicine, Zhenhai Hospital of Traditional Chinese Medicine, Ningbo, 315000 Zhejiang, China Center of Evidence-based Medicine, Institute of Medical Sciences, the Second Hospital of Shandong University, Jinan, China; The Biomedical engineering research center, Kunming Medical University, Kunming Yunnan, 650500, China Department of Public Health and Preventive Medicine, School of Basic Medicine and Public Health, Jinan University , Guangzhou 510632, China; Division of Medical Psychology and Behavior Science, School of Basic Medicine and Public Health, Jinan University , Guangzhou 510632, China Yunnan Key Laboratory of Wood Adhesive and Glued Products, Southwest Forestry University, Kunming 650224, Yunnan, China; College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, Zhejiang, China Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Institutes for Life Sciences School of Biomedical Sciences and Engineering Guangzhou International Campus South China University of Technology Guangzhou 510630 China; National Engineering Research Center for Tissue Restoration and Reconstruction South China University of Technology Guangzhou 510630 China Center of Evidence‐Based Medicine Institute of Medical Sciences the Second Hospital of Shandong University Jinan China Center of Clinical Reproductive Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing, China Center of Cardiology, Chongqing Zhongshan Hospital, Chongqing 400013, China School of Pharmacy and ‡State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, People’s Republic of China State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China Center of Evidence-based Medicine, The Second Hospital of Shandong University, Jinan, Shandong, China (mainland) CAS Key Laboratory of Special Pathogens and Biosafety, Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, People's Republic of China Institute of Basic Medicine, Hebei Medical University, Shijiazhuang, China Henan Key Laboratory of Diamond Optoelectronic Materials and Devices, Key Laboratory of Material Physics, Ministry of Education, School of Physics and Microelectronics, Zhengzhou University, Zhengzhou 450052, China CAS Key Laboratory of Tropical Marine Bio‐resources and Ecology Guangdong Provincial Key Laboratory of Applied Marine Biology South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou China; University of Chinese Academy of Sciences Beijing China Department of Gynecology and Obstetrics, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, P.R. China Research and Development Department, Tissue Tech, Inc, Miami, FL, USA Key Laboratory of Genetics and Breeding in Forest Trees and Ornamental Plants, Ministry of Education, College of Biological Sciences and Technology, Beijing Forestry University , Beijing 100083 , China; Institute of Tree Development and Genome Editing, College of Biological Sciences and Technology, Beijing Forestry University , Beijing 100083 , China The First Clinical Medical College, Gansu University of Traditional Chinese Medicine, Lanzhou, China; Department of Vascular Surgery, Gansu Provincial Hospital, Lanzhou, China Department of Cell Biology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing 100142, China Center for Agricultural Resources Research Institute of Genetics and Developmental Biology Chinese Academy of Sciences 286 Huaizhong RD Shijiazhuang 050021 China; Xishuangbanna Tropical Botanical Garden Chinese Academy of Sciences Menglun Mengla Yunnan 666303 China; College of Life Science and Geography Qinghai Normal University Xining 810008 China Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada Personalized Drug Therapy Key Laboratory of Sichuan Province, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Sichuan 610072, China Engineering Research Center of AI & Robotics, Shanghai Engineering Research Center of AI & Robotics, MOE Frontiers Center for Brain Science, Institute of AI and Robotics, Academy for Engineering & Technology, Fudan University,Ministry of Education, Laboratory for Neural Interface and Brain Computer Interface, State Key Laboratory of Medical Neurobiology,Shanghai,China,200433 Department of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China Department of Pharmacology School of Medicine Southeast University Nanjing Jiangsu China Department of Ultrasound, Pudong New Area People’s Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Pudong, Shanghai, China (mainland) The Central Laboratory, Shenzhen Second People's Hospital, Shenzhen University 1st Affiliated Hospital Shenzhen University School of Medicine Shenzhen China Department of Ultrasound, Pudong New Area People's Hospital Affiliated to Shanghai University of Medicine & Health Sciences Shanghai 201299, China. Materials Genome Institute, Shanghai University 1 , Shanghai 200444, China; Chinese Academy of Sciences, State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology 2 , Shanghai 200050, China State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, People's Republic of China. Department of Orthopaedics, Xinqiao Hospital; Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, Beijing, People's Republic of China. Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States Department of Obstetrics and Gynecology Third Affiliated Hospital of Sun Yat‐sen University Guangzhou China Institute of Medical Research, Northwestern Polytechnical University, #127 West Youyi Road, Xi’an, Shaanxi 710032, China Research and Development Department, Tissue Tech, Inc., Miami, FL, USA. Department of Gastroenterology and Hepatology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, School of Medicine South China University of Technology Guangzhou China Department of Pharmacology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, United States Renal Department and Nephrology Institute, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China; Department of Hematology, Beijing General Hospital of PLA, China. College of Food Science, Southwest University, Chongqing, 400715, China; Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing, Southwest University, Chongqing, 400715, China Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University College of Veterinary Medicine, Jilin Agricultural University, Changchun, China. Department of Medicine, St Vincent’s Hospital, The University of Melbourne, Fitzroy, VIC 3065, Australia Department of Cardiology, General Hospital of Guangzhou Military Command of People's Liberation Army, Guangdong, China Solomont School of Nursing, Zuckerberg College of Health Sciences, University of Massachusetts Lowell, Lowell, MA, USA Institute for Glycomics, Griffith University, Southport, Australia Guangdong Institute of Sports Science, Guangzhou, China Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China Department of Immunology, School of Basic Medical Science, Air Force Military Medical University, Xi 'an 710032, China. College of Chemistry; Beijing Normal University; Beijing, P. R. China Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China School of Materials Science and Engineering, Ocean University of China, Qingdao 266100, People’s Republic of China Department of Neurosurgery Shenzhen Key Laboratory of Neurosurgery, Inst Translat Med, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital Shenzhen China Key Laboratory of Material Physics Ministry of Education School of Physics and Microelectronics Zhengzhou University 100 Kexue Ave. Zhengzhou 450052 China; Institute of Quantum Materials and Physics Henan Academy of Sciences 266 Mingli Rd. Zhengzhou 450046 China Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology Shandong First Medical University & Shandong Academy of Medical Sciences Jinan Shandong China Nanoscience and Technology Division, Argonne National Laboratory, Lemont, Illinois 60439, United States Department of Tumor Interventional Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, P.R. China Department of Pathology and Cancer Research Center, Yanbian University Medical College, Yanji 133002, China Department of Ultrasound, Pudong New Area People’s Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai, China (mainland) |
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