http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_cceacfd66012939cd96b0ecb160719b5
Outgoing Links
| Predicate | Object |
|---|---|
| family-name | Juan Liu Liu |
| name | Juan Liu |
| given-name | Juan |
| organization-name | Department of Pathogenic Biology Key Laboratory of Infection and Immunity of Shandong Province School of Basic Medical Sciences Shandong University Jinan Shandong China Institute of Functional Nano & Soft Materials (FUNSOM); Soochow University; China Department of Respiratory and Critical Care Medicine; Key Laboratory of Pulmonary Diseases of Health Ministry; Key Cite of National Clinical Research Center for Respiratory Disease, Tongji Hospital, Tongji Medical College; Huazhong University of Sciences and Technology; Wuhan China Department of Pharmacognosy, College of Pharmacy, Jiamusi University, Jiamusi 154007, China Department of Chemistry, Inorganic Chemistry Laboratory, University of Oxford, South Parks Road, Oxford, OX1 3QR, U.K. The Key Laboratory of Water and Sediment Sciences, Ministry of Education, College of Environmental Sciences and Engineering, Peking University, Beijing 100871, P. R. China College of Life Science, Capital Normal University, Beijing 100048, Peoples’ Republic of China Immunology Research Center of Medical Research Institute, Southwest University, Chongqing 402460, China; College of Veterinary Medicine, Southwest University, Chongqing 402460, China National Center of Biomedical Analysis, Beijing 100850, China Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers University, State University of New Jersey, New Brunswick, NJ, USA Beijing Center for Disease Prevention and Control, Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing 100013, China; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China Department of Environmental Science and Engineering, Tsinghua University, Beijing, 100084, China. Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, PR China Rice Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China; Key Laboratory of Genetics and Breeding of High Quality Rice in Southern China (Co-Construction by Ministry and Province), Guangzhou 510640, China; Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of New Technology in Rice Breeding, Guangzhou 510640, China; Guangdong Rice Engineering Laboratory, Guangzhou 510640, China Department of Transfusion, General Hospital of PLA Air Force, Beijing 100142, China Chengdu Institute of Biology Chinese Academy of Sciences Chengdu 610041 China; University of Chinese Academy of Sciences Beijing 100049 China Tissue Engineering Lab, Institute of Health Service and Transfusion Medicine, Beijing 100850, China Department of Anesthesiology, HELIOS Klinikum Krefeld, Krefeld, Germany Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, United States 1The Key Laboratory of Reproductive Genetics (Zhejiang University), Ministry of Education, Hangzhou, Zhejiang, China CNRS, Centre Interdisciplinaire de Nanoscience de Marseille, UMR 7325, Equipe Labellisée Ligue Contre le Cancer Aix‐Marseille Université Marseille France; Laboratory of Controllable Nanopharmaceuticals Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience Beijing China; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology of China Beijing China; University of Chinese Academy of Sciences Beijing China; Hepato‐Pancreato‐Biliary Center, Beijing Tsinghua Changgung Hospital, School of Medicine Tsinghua University Beijing China Army Engineering University of PLA Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences Wuhan China; Aquatic Plant Research Center, Wuhan Botanical Garden, Chinese Academy of Sciences Wuhan China Yantai Center for Disease Control and Prevention, Yantai, Shandong Province, PR China Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, PR China; Early Intervention Unit, Department of Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, PR China; Functional Brain Imaging Institute of Nanjing Medical University, Nanjing, Jiangsu, PR China Shenzhen Children’s Hospital, Shenzhen, China From the *Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou; †The First People’s Hospital of Chenzhou, Chenzhou; and ‡Biomedicine Research Center and Department of Surgery, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. College of Architecture and Civil Engineering, Yancheng Polytechnic College, Yancheng 224005, China Department of Chemistry, University of Basel, Mattenstrasse 24a, CH-4058 Basel, Switzerland Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China; Duke University School of Medicine, Durham, North Carolina, United States Department of Physiology and Pathophysiology, Peking University Health Science Center Department of Otolaryngology, Eye, Ear, Nose, and Throat Hospital, Fudan University, Shanghai, China College of Life Science, Capital Normal University, Beijing 100048, People’s Republic of China School of Chemical and Material Engineering; Jiangnan University; Wuxi 214122; China High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031, Anhui, P. R. China; University of Science and Technology of China, Anhui, Hefei, 230036, P. R. China School of Foreign Languages and Tourism, Wuxi Institute of Technology, Wuxi, Jiangsu, China; College of Agriculture, Food & Natural Resources, University of Missouri, Columbia, MO, USA Yangzhou Maternal and Child Care Service Centre, Yangzhou 225000, China College of Resource and Environment Science, Yunnan AgriculturalUniversity, Kunming 650201, China China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China Department of Neurology, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing, China. Department of Geriatric Endocrinology, The First Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China Health Care Rehabilitation Ward, Jinan Municipal Hospital of Traditional Chinese Medicine, Jinan 250012, Shandong, China Department of Endocrinology The First Affiliated Hospital of Sun Yat‐Sen University Guangzhou China Department of Pediatrics, Nanchong Central Hospital, The Second Clinical Medical College, North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China Department of Dermatology University of Maryland Baltimore MD USA Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences , Wuhan, Hubei 430074 , China; Aquatic Plant Research Center, Wuhan Botanical Garden, Chinese Academy of Sciences , Wuhan, Hubei 430074 , China High Magnetic Field Laboratory, Chinese Academy of Sciences, Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China; University of Science and Technology of China, Hefei, Anhui 230036, P. R. China Wuhan National High Magnetic Field Center & School of Physics, Huazhong University of Science and Technology, Wuhan 430074, People’s Republic of China Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Anhui, PR China CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, P.R. China Department of Stomatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. liujuan197@126.com Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Institute of Respiratory Diseases, School of Medicine, Zhejiang University, Zhejiang Sheng, China;; Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Center for Lung Research, Oberschleißheim, Germany; and School of Sports Medicine and Health, Chengdu Sport University, Chengdu, China. Sports Medicine Key Laboratory of Sichuan Province, Chengdu, China. Department of Food Science and Technology, School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, 2 Xuelin Road, Nanjing, Jiangsu 210023, People’s Republic of China College of Environmental Sciences and Engineering Peking University Beijing 100871 China Department of Hematology, The Third Affiliated Hospital of Soochow University, Changzhou, People’s Republic of China Department of Pharmacy, The Second Affiliated Hospital of Harbin Medical University, Harbin, China Key Laboratory of Plant Pathology of Hubei Province, Huazhong Agricultural University, Wuhan 430070, China Institute of Organic Contaminant Control and Soil Remediation, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing, People’s Republic of China Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China; Department of Gynecology Nanjing Maternity and Child Health Care Hospital, The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University Nanjing P. R. China Institute of Organic Contaminant Control and Soil Remediation, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China School of Materials Science and Engineering, Anhui University of Technology, Ma’anshan 243002, P. R. China State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China Kangda College of Nanjing Medical University; Lianyungang; China Department of Emergency Hubei Provincial Traditional Chinese Medical Hospital Wuhan P.R. China Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices; Institute of Functional Nano & Soft Materials (FUNSOM); Soochow University; Suzhou; PR China School of Medicine Guizhou University Guiyang China Department of Geratology, the First Hospital Affiliated to Nanjing Medical University, Nanjing, P.R.China Department of Endocrinology The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University Changzhou China Shandong Research Center of Stem Cell Engineering/Central Laboratory, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, China. juan1202@126.com School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei 230012, Anhui Province, China; Graduate School of Anhui, Anhui University of Chinese Medicine, Hefei 230012, Anhui, China The Affiliated Stomatological Hospital of Kunming Medical University, Kunming 530102, China. Department of General Surgery, Bailou Hospital, Tianjin 300040, PR China CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China Department of Cardiothoracic Surgery The Second Affiliated Hospital of Xi'an Medical University Xi'an Shaanxi Province China College of Chemical Engineering; Northwest University for Nationalities; Lanzhou; P. R. China Department of Computer Science, Xiamen University, China Precision Targeted Therapy Discovery Center, Institute of Technology Innovation, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230088, P. R. China Department of Otolaryngology, Eye Ear Nose and Throat Hospital, Fudan University Department of Otolaryngology, Eye, Ear, Nose, and Throat Hospital Shanghai Medical College of Fudan University Shanghai China Administrative Bureau of Baihe National Nature Reserve, Ngawa 623400, China Shenzhen Grubbs Institute and Department of Chemistry, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen 518055, China Department of Pathology, The Affiliated Hospital of Hangzhou Normal University Hangzhou 310015, China. Center for the Study of Itch and Sensory Disorders and Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110, USA. Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices; Institute of Functional Nano and Soft Materials (FUNSOM); Soochow University; Suzhou; China State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, P. R. China Department of Pharmacology, University of Texas Health at San Antonio, San Antonio, TX 78229; Dept. of Periodontology, Guangdong Provincial Stomatological Hospital, Southern Medical University, Guangzhou 510280, China. Department of Pediatrics, Nanchong Central Hospital Institute of Functional Molecules, Shenyang University of Chemical Technology, Shenyang 110142, China Department of Environmental Science, School of Resources and Environmental Science, Wuhan University, Wuhan 430079, P. R. China Rice Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China; Key Laboratory of Genetics and Breeding of High Quality Rice in Southern China (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Guangzhou 510640, China; Guangdong Key Laboratory of New Technology in Rice Breeding, Guangzhou 510640, China; Guangdong Rice Engineering Laboratory, Guangzhou 510640, China Institute of Organic Contaminant Control and Soil Remediation, College of Resources and Environmental Sciences Nanjing Agricultural University Nanjing 210095 China State Key Laboratory of Fine Chemicals, School of Pharmaceutical Science and Technology, Dalian University of Technology, Dalian 116024, P.R. China Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou 215123, China Central Laboratory, Yantai Yu-Huang-Ding Hospital, Yantai, Shandong Province, People's Republic of China College of Environmental and Safety Engineering, Fuzhou University, Fuzhou 350108, Fujian, China Department of Internal Medicine 1, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, China College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China Shandong Rehabilitation Research Center, Jinan, China. Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology; Laboratory of Biological Targeted Therapy of the Ministry of Education, Wuhan, P. R. China State Key Laboratory of Structural Chemistry; Fujian Institute of Research on the Structure of Matter; Chinese Academy of Sciences; Fuzhou; China National Resource Center for Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing 100700 China Department of Neurology The First Affiliated Hospital of Chongqing Medical University Chongqing China Research Institute of Family Planning, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. liujuan197@126.com Department of Endocrinology, The First Affiliated Hospital, Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China *Institute of Immunology and National Key Laboratory of Medical Immunology, Second Military Medical University, Shanghai, and Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy Chengdu University of Traditional Chinese Medicine Chengdu China Department of Human Anatomy, Medical School Nantong University 19 Qixiu Road Nantong Chongchuan District 226001 PR China Beijing Institute of Remote Sensing Equipment, Beijing 100854, China Key Laboratory of Marine Bio-resources Sustainable Utilization/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, P. R. China Department of Geriatrics, Wuhan University, Renmin Hospital Wuhan 430060, Hubei Province, P.R.C. Chinese Academy of Sciences Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, and Laboratory of Controllable Nanopharmaceuticals, National Center for Nanoscience and Technology of China, Beijing 100190, China Department of Control Science and Engineering, College of Electronic and Information Engineering, Tongji University, Shanghai, China Chinese Academy of Sciences Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Chinese Academy of Sciences, 100190 Beijing, People’s Republic of China;; Aix-Marseille Université, CNRS, Centre Interdisciplinaire de Nanoscience de Marseille, UMR 7325, 13288 Marseille, France;; University of Chinese Academy of Sciences, 100049 Beijing, People’s Republic of China; Chinese Academy of Sciences (CAS) Key Laboratory for Biological Effects of Nanomaterials and Nanosafety; National Center for Nanoscience and Technology; Beijing, P. R. China Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China Department of Hematology The First Affiliated Hospital of Xi’an Jiaotong University Xi’an China Laboratory of Oral Biomedical Engineering, Ministry of Education, Sichuan University, Chengdu 610041, China Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Institute of Pharmacy and Pharmacology, University of South China, Hengyang, China Department 4 of Comprehensive Internal Medicine of Healthy Care Center for Cadres, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, China Central Laboratory, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, China. Research Center for Human Tissues and Organs Degeneration, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 518055 Shenzhen, PR China Department of Science and Education, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic, Edong Healthcare Group, Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, No. 141 Tianjin Road, Huangshi, Hubei 435000, China Department of Hematology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150000, China Liaoning Key Laboratory of Optoelectronic Films and Materials, School of Physics and Materials Engineering, Dalian Nationalities University, Dalian 116600, China Department of Oncology, Affiliated Hospital of Nantong University, Nantong, China Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, Beijing, China XinAo Science and Technology Development Co., Ltd., LangFang, HeBei, People's Republic of China College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072, P R China, and College of Science, Huazhong Agricultural University, Wuhan 430070, P R China Department of Rehabilitation Hengshui People's Hospital Hengshui China Key Laboratory of Agricultural Water Resource, Hebei Key Laboratory of Soil Ecology, Center for Agricultural Resources Research, Institute of Genetic and Developmental Biology, The Chinese Academy of Sciences, 286 Huaizhong Road, Shijiazhuang 050021, Hebei, P. R. China; University of Chinese Academy of Sciences, 19 A Yuquan Road, Shijingshan District, Beijing 100049, P. R. China High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei 230031, Anhui, P. R. China Department of Oncology and Hematology, people’s Hospital of Leshan, Leshan, Sichuan Department of Pharmacy, Shandong Provincial Qianfoshan Hospital Shandong University Jinan China Department of Internal Medicine Tianjin Union Medicine Center & Tianjin People's Hospital Tianjin China Changzhou Second People’s Hospital, Nanjing Medical University, Changzhou 213000, China State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China Huahui Health Ltd. Beijing China Jiamusi University, College of Pharmacy, Jiamusi 154007, China. Department of Cardiology, Cangzhou Central Hospital, Cangzhou, Hebei 061000, P.R. China School of Pharmacy, Hunan University of Chinese Medicine Changsha 410208, China Hunan Engineering Technology Research Center for Bioactive Substance Discovery of Chinese Medicine Changsha 410208, China. Research Center for Human Tissue and Organs Degeneration Institute Biomedical and Biotechnology Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 China Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, Chinese Academy of Sciences, South China Sea Institute of Oceanology , Guangzhou, China Department of Chemistry University of Basel Mattenstrasse 24a Basel 4002 Switzerland CAS Key Laboratory of Tropical Marine Bio-resources Ecology/Guangdong Key Laboratory of Marine Materia Medica South China Sea Institute of Oceanology Chinese Academy of Sciences 164 West Xingang Road Guangzhou 510301 P. R. China RESCUE BT Trial Investigators Institute of Advanced Synthesis (IAS), Nanjing Tech University, 30 South Puzhu Road, Nanjing 211816, China Department of Endocrinology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China. Pacific Northwest National Laboratory, Richland, Washington 99352, United States Department of Chemistry and Catalysis Research Center Technical University of Munich Lichtenbergstraße 4 85748 Garching bei München Germany The First Department of Orthopedics, The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an, Shaanxi Province, China. Department of Biomedical Information and Library, Tianjin Medical University, Tianjin, China Department of Biomedical Engineering Fourth Military Medical University Xi'an China Department of Pharmacology, Medical College, Wuhan University of Science and Technology, Wuhan 430065, China. College of Chemical Engineering, Key Laboratory for Utility of Environment-Friendly Composite Materials and Biomass in University of Gansu Province, Northwest Minzu University (Northwest University for Nationalities), Lanzhou, 730070, China Key Laboratory of Re/productive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, PR China Department of Endocrinology First Affiliated Hospital Sun Yat‐sen University Guangzhou China School of Information Engineering, Jiangxi University of Science and Technology, Ganzhou 341000, China School of Educational Science, Cognition and Human Behavior Key Laboratory of Hunan Province, Hunan Normal University, Changsha, China Department of Ophthalmology, Qingdao West Coast New Area Traditional Chinese Medicine Hospital, 158 Hainan Island Road, West Coast New Area, Qingdao 266555, China From The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation (J.G., B.B.B., X.G., H.Z., L.L., Y.F., S.H., Huafu Chen), School of Medicine (J.G.), and School of Life Science and Technology, Center for Information in Medicine (X.G., H.Z., L.L., Y.F., S.H.), University of Electronic Science and Technology of China, Chengdu; Departments of Radiology (Hui Chen, Y.Z., J.L, J.W., C.L., Huafu Chen) and Laboratory Medicine (L.F.), Southwest Hospital, Department of Medical... Longping Branch, College of Biology, Hunan University, Changsha 410125, China; Agriculture Product Processing Institute, Hunan Academy of Agricultural Sciences, Changsha 410125, China; Hunan Key Lab of Fruits & Vegetables Storage, Processing, Quality and Safety, Hunan Agricultural Products Processing Institute, Changsha 410125, China; Department of Life Sciences, Chalmers University of Technology, SE412 96 Gothenburg, Sweden School of Environmental Science and Engineering, Guangzhou University, Guangzhou, Guangdong, China Department of Blood Transfusion, General Hospital of Air Force, PLA, Beijing, China Hubei Key Laboratory of Plant Pathology, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, People's Republic of China MOA Key Laboratory of Animal Virology, Center for Veterinary Sciences, Zhejiang University, Hangzhou, China; Collaborative Innovation Center and State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University, Hangzhou, China Faculty of Computer and Information Science, Southwest University, Chongqing 400715, China Department of Clinical Electrophysiology Harrison International Peace Hospital Hengshui China Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Beijing University of Chinese Medicine Beijing China State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, China State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical Engineering Nanjing University Nanjing 210023 China Department of Epidemiology and Biostatistics School of Public Health Anhui Medical University Hefei Anhui China; Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis Anhui Medical University Hefei Anhui China Department of Neurology, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China; Email: liujuan961@163.com. State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, China, Graduate School of the Chinese Academy of Science, Beijing, 100039, China, and School of Life Science, Sun Yat-Sen University, Guangzhou, 510275, China The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, Jiangsu 210008, China Nanjing University of Science and Technology Department of Obstetrics and Gynecology , Zhongnan Hospital of Wuhan University , Wuhan Hubei , P.R. China; Clinical Medicine Research Centre of Prenatal Diagnosis and Birth Health in Hubei Province , Wuhan , Hubei , P.R. China State Key Laboratory of Structural Chemistry; Fujian Institute of Research on the Structure of Matter; Chinese Academy of Sciences; Fuzhou; P. R. China †Department of Dermatology, University of Maryland, Baltimore, MD 21201; and Food College; Shihezi University; Shihezi China Central Laboratory the Affiliated Yantai Yuhuangding Hospital of Qingdao University Yantai Shandong China School of Pharmacy; Guangdong Pharmaceutical University; Guangzhou 510006; China School of Computer, Wuhan University, No. 37, Luoyu Road, Wuchang, Wuhan, 430072, China, liujuan@whu.edu.cn. Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710; Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention, National Observations and Research Station for Wetland Ecosystems of the Yangtze Estuary, Department of Environmental Science and Engineering, Fudan University, Shanghai200433, People’s Republic of China Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700,China. Institute of Pediatric Research Nanjing Children's Hospital Affiliated to Nanjing Medical University Nanjing China Institute of Organic Contaminant Control and Soil Remediation, College of Resource and Environmental Sciences, Nanjing Agricultural Univ.; Nanjing 210095 P.R. China Department of Food Science and Technology, School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, 2 Xuelin Road, Nanjing 210023, China Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou, Guangdong 510080, China State Key Laboratory of Animal Biotech Breeding, Key Laboratory of Animal Genetics, Breeding and Reproduction of the Ministry of Agriculture and Rural Affairs, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University , Beijing 1000193 , P.R. China Department of Dermatology The Second Xiangya Hospital, Central South University Changsha China Graduate School Guizhou Medical University University Town Guian New District Guiyang 550025 P. R. China Department of Internal Medicine, Dongzhimen Hospital, Beijing University of TCM, Beijing 100700, China. juanjuan000@sina.com Department of Dermatology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China (mainland) Department of Operating Room, The First Affiliated Hospital of Guizhou University of traditional Chinese medicine, Guiyang, Guizhou, 550001, P.R. China. Department of Ultrasound, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. E-mail: liujuan1013@163.com. Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC (J.Liu, J.W.L.). Department of Chemistry and Institutes of Biomedical Sciences; Fudan University; Shanghai; P.R. China National Institute of Biological Sciences, Beijing, China Jihua Laboratory, Foshan 528200, China Department of Endocrinology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China Innovation Center and Key Laboratory of Water Quality and Conservation in the Pearl River Delta, Ministry of Education, School of Environmental Science and Engineering, Guangzhou University, Guangzhou, China Guangdong Key Lab of Sugarcane Improvement & Biorefinery, Guangdong Bioengineering Institute (Guangzhou Sugarcane Industry Research Institute), Guangdong Academy of Sciences, Guangzhou 510316, China Department of Stomatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China Department of Chemistry; University of Basel; Basel-4058; Switzerland *Department of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China; Tasmanian Institute for Agriculture, College of Science and Engineering, University of Tasmania, Hobart, Tasmania, Australia College of Chemistry and Pharmacy of Jiamusi University, Jiamusi 154002. Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers, State University of New Jersey, New Brunswick, NJ, USA. School of Medicine, Guizhou University, Guiyang, Guizhou 550025, China Department of Radiology West China Hospital, Sichuan University Chengdu China Institute of Pharmacy and Pharmacology; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study; University of South China; Hengyang; China Authors' Affiliations: 1School of Materials Science and Engineering, Tianjin Polytechnic University, Tianjin; 2CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing; and 3College of Chemistry and Environmental Science, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding, China Beijing Center for Disease Prevention and Control Beijing China; Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning Beijing China Department of Hematology, General Hospital of PLA Rocket Force, Beijing 100088; Beijing Institute of Biotechnology, Military Medical Academy, Beijing 100850, China. Central Laboratory of Yantai Yuhuangding Hospital, Yantai 264000, China. School of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China Department of Rehabilitation Hunan Children's Hospital Changsha China Department of Pediatrics, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China College of Pharmacy, Pusan National University, Busan 609-735, Korea; Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, P. R. China; Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, Anhui 230031, P. R. China Department of Gerontology, First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China College of arts and sciences, Shanxi Agricultural University, Taigu, Shanxi, P. R. China Beijling University of Chemical Technology Beijing 100029, China. Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China Institute of Computer Software, School of Computer Wuhan University Wuhan 430072 China College of Animal Science Southwest University Rongchang, Chongqing China Department of Food Science and Technology, School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, 2 Xuelin Road, Nanjing, Jiangsu 210023, People's Republic of China State Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breeding and Reproduction of the Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology China Agricultural University Beijing China; College of Animal Science and Technology, Hunan Provincial Key Laboratory for Genetic Improvement of Domestic Animal Hunan Agricultural University Changsha China Department of Gastroenterology, the First Clinical Medical College of Shanxi Medical University, Taiyuan 030001, China. School of Chinese Materia Medica, Beijing University of Traditional Chinese Medicine, Beijing 100102, China. moonriver24@yahoo.cn Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, 199 Ren’ai Road, Suzhou 215123, Jiangsu, People’s Republic of China Graduate School, Guizhou Medical University, Guiyang, PR China State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, P. R. China; University of Chinese Academy of Sciences, 100049 Beijing, P. R. China Department of Neurosurgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China Department of Endocrinology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, People's Republic of China Department of Chemistry, Oakland University, Rochester, Michigan 48309, United States Department of Oncology, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing, China Innovation Center and Key Laboratory of Water Quality and Reservation in the Pearl River Delta, Institute of Environmental Research At Greater Bay, School of Environmental Science and Engineering, Guangzhou University, Guangzhou, China High Magnetic Field Laboratory, Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, P. R. China University of Science and Technology of China, Hefei, Anhui, P. R. China Department of Obstetrics; Foshan Women and Children Hospital; Foshan Guangdong China Chinese Academy of Sciences (CAS) Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, CAS, Guangzhou, China Departments of Hematology and Blood Transfusion, General Hospital of the PLA Rocket Force, Beijing, China. Beijing Key Laboratory of Mineral Environmental Function, School of Earth and Space Sciences, Peking University, 100871 Beijing, People’s Republic of China;; School of Environmental Sciences and Engineering, Peking University, 100871 Beijing, People’s Republic of China; School of Mathematics and Physics & School of Mechatronics, Handan University 1 , Handan 056005, China Department of Ophthalmology & Visual Sciences, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Ophthalmology, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan, Ningxia, China Department of Endocrinology The First Affiliated Hospital of Sun Yat‐sen University Guangzhou P. R. China Department of Radiotherapy, Zhongshan Hospital, Fudan University, Xuhui, Shanghai 200032, P.R. China Public Health Ontario, Toronto, Ontario, Canada Hepato-Pancreato-Biliary Center, Translational Research Center, Beijing Tsinghua Changgung Hospital, School of Medicine, Tsinghua University, Beijing102218, China Institute of Pathogenic Biology, Shandong University School of Medicine, Jinan, Shandong, China Department of Neurology People's Hospital of Rizhao Rizhao Shandong China Pediatrics Department, Shenmu Hospital, Shenmu, Yulin, Shaanxi 719300, China Department of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Southwest University, Chongqing 402460, China; National Center of Technology Innovation for Pigs (NCTIP-XD/C17), Chongqing 402460, China; Immunology Research Center, Medical Research Institute, Southwest University, Chongqing 402460, China Department of Ultrasound Tianjin People's Hospital Tianjin China School of Environmental Sciences and Engineering, Peking University, Beijing, China, 100871 School of Medicine, Guizhou University, Guiyang, China; Department of Reproductive Medicine, Guizhou Provincial People’s Hospital, Guiyang, China Department of Pediatrics, Nanchong Central Hospital, the Second Clinical Medical College, North Sichuan Medical College, Nanchong, P.R. China Department of Human Anatomy and Histo-Embryology, Basic Medical College, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China The Seventh People’s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, 358 Daotong Road, Pudong New Area, Shanghai 200137, China Pathology Key Laboratory of Microbiological Engineering of Agricultural Environment; Ministry of Agriculture; College of Life Science; Nanjing Agriculture University; Nanjing; China School of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming, China School of Computer; Wuhan University; Wuhan 430072; China State Key Laboratory of Software Engineering and School of Computer Sciences Wuhan University Wuhan 430072 China Department of Ultrasound Second Affiliated Hospital of Kunming Medical University Kunming China Public Health Ontario, Toronto, Ontario, Canada. Ningxia Key Laboratory of Cerebrocranial Diseases, Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Institute of Basic Medical Sciences, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention, National Observations and Research Station for Wetland Ecosystems of the Yangtze Estuary, IRDR International Center of Excellence on Risk Interconnectivity and Governance on Weather, Department of Environmental Science & Engineering, Fudan University, Shanghai 200433, Peoples’ Republic of China Department of Radiology, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, China (mainland) Zhejiang PuLuoTing Health Technology Co. Ltd. 3rd floor, Building 5, NO. 2622 Yuhangtang Road, Yuhang District Hangzhou, Zhejiang P. R. China Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, China Department of Chemistry; Georgia State University; Atlanta; USA Collaborative Innovation Center of Jiangxi Typical Trees Cultivation and Utilization Jiangxi Agriculture University Nanchang China College of Biological, Chemical Science and Engineering Jiaxing University Jiaxing China Department of Hematology, The General Hospital of the PLA Rocket Force, Beijing 100088, China. *Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, P.O. Box 643, Beijing 100044, China; CAS Key Laboratory for Biological Effects of Nanomaterials & Nanosafety National Center for Nanoscience and Technology No 11 Beiyitiao, Zhongguancun Beijing 100190 China Institute of Economic Crops, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China. Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers-State University of New Jersey, New Brunswick, NJ 08903, USA Beijing Engineering Research Center for Mixed Reality and Advanced Display, School of Optics and Photonics, Beijing Institute of Technology, Beijing 100081, China Zhongning County Goji Industry Development Service Bureau, Zhongwei 755100, Ningxia, P. R. China State Key Laboratory of Software Engineering, School of Computer, Wuhan University, Wuhan, China Department of Pharmacology and Experimental Therapeutics, Department of Chemistry, Shanghai Tongji University, Shanghai, P. R. China School of Pharmaceutical Sciences Shenzhen Campus of Sun Yat‐sen University Gongchang Road 66 Guangming Shenzhen Guangdong 518107 China State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, People’s Republic of China Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, P. R. China Anhui Province Key Laboratory of Medical Physics and Technology, CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology Institute of Health and Medical Technology Hefei Institutes of Physical Science Chinese Academy of Sciences Hefei China; University of Science and Technology of China Hefei China; Hefei Cancer Hospital Chinese Academy of Sciences Hefei China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, 100190, People’s Republic of China Department of Radiology and Biomedical Imaging Yale University New Haven Connecticut USA Department of Biomedical Information and Library Tianjin Medical University Tianjin China Early Intervention Unit, Department of Psychiatry, Affiliated Nanjing Brain Hospital Nanjing Medical University Nanjing Jiangsu China; Functional Brain Imaging Institute of Nanjing Medical University Nanjing China State Environmental Protection Key Laboratory of Soil Health and Green Remediation, Hubei Key Laboratory of Soil Environment and Pollution Remediation, College of Resources and Environment, Huazhong Agricultural University, Wuhan 430070, China Department of Sports Medicine Center, Southwest Hospital Army Medical University Chongqing China Central Laboratory, Yantai Yu Huang Ding Hospital/Qingdao University, Yantai, Shandong Province, People’s Republic of China Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China Zhejiang Provincial Key Laboratory of Carbon Cycling in Forest Ecosystems and Carbon Sequestration, Zhejiang A&F University, Hangzhou 311300, China. Department of Geratology the First Affiliated Hospital to Nanjing Medical University Nanjing China 1 Program in Molecular and Computational Biology, University of Southern California, Los Angeles, CA, USA, 2Academy of Mathematics and Systems Science, CAS, Beijing 100190 and 3School of Computer Science, Wuhan University, Wuhan 430079, China Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China Clinic Medicine Research Center of Hepatobiliary Diseases, Affiliated Hospital of Youjiang Medical University for Nationalities, Guangxi Zhuang Autonomous Region, Baise 533000, China Department of Gynaecology and Obstetrics, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China. Department of Pathogenic Biology, Shandong University School of Medicine, Jinan, Shandong, China Institute of Artificial Intelligence, School of Computer Science, Wuhan University, P. R. China Central Laboratory of Yongchuan Hospital, Chongqing Medical University,Chongqing 402160, China. Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience and CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology Chinese Academy of Sciences 100190 Beijing China Department of Pharmacology and Cancer Biology, Duke University, USA Department of Nephrology, The Second Hospital of Jilin University, Changchun, People’s Republic of China; Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology, Women’s Hospital, Zhejiang University School of Medicine , Hangzhou, Zhejiang , P.R. China Department of Gynecology, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China. Email: liujuan90011@aliyun.com. Department of Rehabilitation, Hunan Provincial Children's Hospital, Changsha, Hunan 410007, China. 1211584458@qq.com. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China. Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science of Ministry of Education; Shandong Key Laboratory of Biochemical Analysis; College of Chemistry and Molecular Engineering; Qingdao University of Science and Technology; Qingdao 266042 National Center for Veterinary Drug Safety Evaluation, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China; Hepato-Pancreato-Biliary Center, Translational Research Center, Beijing Tsinghua Changgung Hospital, School of Medicine, Tsinghua University, Beijing, China Department of Dermatology; the First Affiliated Hospital of Nanjing Medical University; Nanjing 210029 China Key Laboratory for Tumor Precision Medicine of Shaanxi Province, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China; Department of Endocrinology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China School of Computer Science, Wuhan University, Wuhan430072, China National Key Laboratory of Medical Immunology, Institute of Immunology, Second Military Medical University, Shanghai 200433, China. Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University, Shanghai 200433, China; Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Clinical Pharmacy The First Affiliated Hospital of Shandong First Medical University Shandong First Medical University Jinan China Department of Clinical Laboratory, Tianjin First Center Hospital, Tianjin 300192, China. Corresponding author: Wang Yongqiang, Email: yongqiangwang1962@sina.com. School of Computer Science, Wuhan University, Wuhan, P.R. China. Department of Periodontology, West China School of Stomatology, Sichuan University, Chengdu 610041, China. School of Public Health, Shanxi Medical University, Taiyuan, Shanxi, People's Republic of China. Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices; Institute of Functional Nano & Soft Materials (FUNSOM); Soochow University; Suzhou; P. R. China Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, China; Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, Guizhou, China; The Clinical Stem Cell Research Institute, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, Guizhou, China; Collaborative Innovation Center of Chinese Ministry of Education, Zunyi Medical University, Zunyi 563003, Guizhou, China Department of Nephropathy, The Second Hospital of Jilin University, Changchun, Jilin Province, 130041, China Chinese Academy of Sciences (CAS) Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, No. 11, First North Road, Zhongguancun, Beijing, China 100190 Department of Cardiology, Hebei Cangzhou Central Hospital, Cangzhou, China Department of Geratology, the First Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu Province, People’s Republic of China Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, PR China Rice Research Institute, Guangdong Academy of Agricultural Sciences, Guangdong Rice Engineering Laboratory, Guangdong Key Laboratory of New Technology in Rice Breeding, Key Laboratory of Genetics and Breeding of High Quality Rice in Southern China (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Guangdong Rice Engineering Laboratory, Guangzhou 510640, China Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China Department of Geriatrics The First Affiliated Hospital of Nanjing Medical University Nanjing China #Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Duke University, Durham, NC 27710; Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangdong 510080, China Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China. Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices; Institute of Functional Nano & Soft Materials (FUNSOM); Soochow University; Suzhou, PR China Department of Hematology & Oncology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, PR China; Jiangxi Provincial Key Laboratory of Silviculture, College of Forestry, Jiangxi Agricultural University, Nanchang, China Beijing Key Laboratory of Bio-Characteristic Profiling for Evaluation of Rational Drug Use, Beijing Shijitan Hospital, Capital Medical University, Beijing, China; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China Department of Cardiovascular Medicine, Cangzhou Central Hospital, Cangzhou, Hebei 061000, P.R. China Department of Obstetrics and Gynecology, Nanjing Maternity and Child Health Care Hospital, Women’s Hospital of Nanjing Medical University, 123 Mochou Rd, Nanjing, Jiangsu 210004, P.R. China Department of Blood Transfusion, Air Force Medical Center, PLA, Beijing, China Chest Hospital of Henan Province, Zhengzhou, Henan 450000, P.R. China Department of Gastroenterology, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China. Institute of Clinical Medicine, Affiliated Hospital of Zunyi Medical College, No. 149 Dalian Road, Zunyi, Guizhou 563099, China Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, Suzhou 215123, China. Key Lab of Functional Molecular Engineering of Guangdong Province; School of Chemistry and Chemical Engineering; South China University of Technology; Guangzhou 510640; P. R. China Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China; Department of Pediatric Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China; Department of Pediatric Oncology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China Shandong University of Traditional Chinese Medicine, Jinan, China National Key Laboratory of Immunity and Inflammation, Institute of Immunology, Naval Medical University, Shanghai 200433, China Department of Ultrasonography, First Affiliated Hospital of Nanchang University Nanchang China Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers, State University of New Jersey, New Brunswick, NJ, USA Department of Chemistry and Department of laboratory Medicine; Huashan Hospital; Shanghai Medical College; Fudan University; Shanghai Immunology Research Center, Medical Research Institute, Southwest University, Chongqing, China; College of Veterinary Medicine, Southwest University, Chongqing, China; Veterinary Scientific Engineering Research Center, Chongqing, China Department of Neurology, Daping Hospital, Army Medical University, Chongqing 400042,China Changzhou Second People’s Hospital, Nanjing Medical University, Changzhou, China Chinese Academy of Inspection and Quarantine Beijing China 4Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina. Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 P. R. China; Laboratory of Controllable Nanopharmaceuticals CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology Beijing 100190 P. R. China Department of Cardiology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei 441021, P.R. China Gastroenterology Department, Affiliated Zhongda Hospital of Southeast University, Nanjing, China Department of Hematology, Harbin Medical University Second Hospital, Harbin, Heilongjiang 150086, P.R. China State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, China; School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China; Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu, China Scientific Research Office, Xiangya School of Medicine, Central South University, Changsha 410013. Xiangya School of Public Health, Central South University, Changsha 410013. College of Pharmacy and Biological Science; University of South China; Hengyang 421000; China Department of Dermatology, University of Maryland, Baltimore, MD, USA 1Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ School of Mechanical Engineering, North University of China, Taiyuan 030051, China Department of Physics and ‡Nanoscale Science and Technology Laboratory, Institute for Advanced Study, Nanchang University, Nanchang 330031, P.R. China Jiangsu Key Laboratory for Carbon‐Based Functional Materials and Devices Institute of Functional Nano and Soft Materials (FUNSOM) Soochow University Suzhou Jiangsu 215123 China College of Agronomic Sciences in Shandong Agricultural University, Taian 271000, China; Dairy Cattle Research Center, Shandong Academy of Agricultural Science, Jinan 250131, China; CAS Key Laboratory of Tropical Marine Bio‐resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou 510301 P. R. China Department of Medical Microbiology, School of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China.; Departments of Medical Microbiology and Immunology, University of Manitoba, Winnipeg, MB, Canada. Department of Ultrasonography, Tianjin Union Medical Center (Tianjin People’s Hospital), Tianjin, China (mainland) Wuxi Center for Disease Control and Prevention, Wuxi Key Laboratory of Environment and Health, Ministry of Education State Key Laboratory of Environment Health (Incubation) Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin 150040, China Department of Hematology, The 2nd Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Harbin CAS Key Laboratory of Soil Environment and Pollution Remediation, Institute of Soil Science Chinese Academy of Sciences Nanjing China State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Science, 350002 Fuzhou, P. R. China; University of Chinese Academy of Science, 100049 Beijing, P. R. China School of Medicine Guizhou University Guiyang China; Prenatal Diagnosis Center Guizhou Provincial People's Hospital Guiyang China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences; 350002 Fuzhou; P. R. China Hebei Key Laboratory of Stomatology, Hebei Clinical Research Center for Oral Disease, School and Hospital of Stomatology, Hebei Medical University, Shijiazhuang, Hebei, China Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Provincial People Hospital, Nanjing 210029, Jiangsu Province, China. School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China Department of Obstetrics and Gynecology, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, P. R. China Department of Transfusion Wuhan First Hospital Wuhan China School of Basic Medical Sciences Ningxia Medical University Ningxia China Galactophore Department, Jiangsu Huai'an Maternity and Children Hospital, Huai'an, Jiangsu 223001, P.R. China Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China Department of Chemistry and Biochemistry, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, Maryland 21250, United States Institute of Respiratory Diseases of PLA,Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China. Department of Nephrology, First Affiliated Hospital, Wenzhou Medical Collage, Wenzhou 325000, China. Department of Radiation Oncology Rutgers Cancer Institute of New Jersey, Rutgers, State University of New Jersey New Brunswick 08903 New Jersey Department of Neurology, Daping Hospital, Army Medical University, Chongqing 400042, P.R. China Computer School, Wuhan University, Hubei 430072, China Department of Geratology, The First Hospital Affiliated to Nanjing Medical University, Nanjing, People’s Republic of China Department of Ophthalmology & Visual Sciences, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA Division of Geriatric Endocrinology, the First Affiliated Hospital of Nanjing Medical University, China Department of Chemistry, University at Buffalo, Buffalo, New York 14260-3000, United States Department of Otolaryngology–Head and Neck Surgery, Affiliated Eye, Ear, Nose and Throat Hospital Fudan University Shanghai People's Republic of China Productresearch & Development Department Sansure Biotechnology Company Changsha China Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, People's Republic of China; Department of Biological Sciences, University of Alberta, Edmonton, Canada T6G 2E9 Department of Otolaryngology, Eye Ear Nose and Throat Hospital, 83 Fen Yang Rd., Shanghai 200031, PR China. Department of Gastroenterology, Dongguan People's Hospital, Dongguan 523018, China. Liujuan71@163.com Fengling Clinic, Wuhou, Chengdu 610041, China College of Plant Science and Technology Huazhong Agricultural University Wuhan China Department of Otolaryngology, Eye, Ear, Nose Throat Hospital Shanghai Medical College of Fudan University Shanghai People’s Republic of China Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Both authors are the co-authors of this article. Chongqing Key Laboratory of Biochemical and Molecular Pharmacology, Chongqing Medical University, Chongqing 400016, China. College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, 163319, Heilongjiang Daqing, China High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, Anhui 230031, P. R. China; University of Science and Technology of China, Hefei, Anhui 230036, P. R. China Binjiang College, Nanjing University of Information Science & Technology, Wuxi Jiangsu, China College of Life Science, Capital Normal University, Beijing 100048, Peoples’ Republic of China. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, Peoples’ Republic of China. Clinic for Trauma Surgery, Orthopedics and Plastic Surgery, University Medical Center Göttingen, Göttingen, Germany; Clinic for Plastic Surgery, Technische Universität München, München, Germany; Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China State Key Laboratory of Genetic Engineering Zhongshan Hospital and School of Life Sciences Fudan University Shanghai 200438 P. R. China Roche (China) Holding Ltd, Shanghai, China Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, Hunan 411105, PR China School of Foreign Languages and Tourism, Wuxi Institute of Technology, Wuxi Jiangsu, China School of Mental Health, Jining Medical University, Jining, Shandong 272000, China (Ke X-Y, Email: carrierx@163.com); Department of Child Psychiatry, Shenzhen Mental Health Center/Shenzhen Kangning Hospital, Shenzhen, Guangdong 518000, China (Liu J-B, Email: 308017398@qq. com). Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, China School of Environmental Science & Engineering, Guangzhou University, Guangzhou 510006, China. lj_brave@hotmail.com College of Plant Science Jilin University Changchun 130062 P. R. China State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, China The Key Laboratory of Reproductive Genetics (Zhejiang University), Ministry of Education, Hangzhou, China Department of Endocrinology and Diabetes Center The First Affiliated Hospital of Sun Yat‐sen University Guangzhou China Department of Endocrinology, First Affiliated Hospital of Sun Yatsen University, Guangzhou, China School of Science, Bengbu University, Bengbu, People's Republic of China Department of Hematology, Central South University Xiangya Hospital, Changsha 410008, Hunan Province, China. Testing Center Yangzhou University Yangzhou Jiangsu 225009 China Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China CAS Key Laboratory for Biological Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, No. 11 Beiyitiao, Zhongguancun, Beijing 100190, China College of Landscape Architecture, Nanjing Forestry University, Nanjing 210037, China Department of Chemical and Biological Engineering, University of Colorado Boulder, 3415 Colorado Ave, Boulder, Colorado 80301, United States Department of Respiratory Zhejiang Hospital Hangzhou China Department of Neurology, Xinqiao Hospital, The Third Military Medical University, Chongqing, China Department of Radiation Oncology; Rutgers Cancer Institute of New Jersey; Rutgers, State University of New Jersey; New Brunswick, NJ USA Department of Gastroenterology, The Second People’s Hospital of Zhangjiagang, Zhangjiagang, China Department of Endocrinology The First Affiliated Hospital of Sun Yat‐sen University Guangzhou China Department of Blood Transfusion, General Hospital of Air Force, Beijing, People’s Republic of China CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Matria Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China Department of ENT, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China School of Environmental Science and Engineering, Guangzhou University, Guangzhou 510006, China Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 151, MaLianWa North Street, Hai-dian District, Beijing 100193, P.R. China. CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China Key Laboratory of Medicinal Chemistry for Natural Resource; Ministry of Education; School of Chemical Science and Technology; Yunnan University; Kunming Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, New Brunswick, United States Department of Radiology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China Department of Animal Sciences and Veterinary Medicine, Shanxi Agricultural University, Taigu, China Department of Microbiology and Parasitology, Institute of Basic Medical Sciences/Chinese Academy of Medical Sciences, School of Basic Medicine/Peking Union Medical College, Beijing 100005, China Neijiang Centre for Diseases Control and Prevention, Dongxing District, Sichuan Province, China State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau, China Department of Chemistry, Georgia State University, Atlanta, Georgia 30303 CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, No. 11, First North Road, Zhongguancun, Beijing, China 100190 Department of Gastroenterology, Zhongda Hospital, School of Medicine, Southeast University Nanjing 210009, Jiangsu, China. Department of Hematology, The First Affiliated Hospital, Nanjing Medical University, Jiangsu Province Hospital, P.R. China. Center of Clinical Laboratory Dushu Lake Hospital Affiliated to Soochow University Suzhou China High Magnetic Field Laboratory, Chinese Academy of Sciences, Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, P. R. China Hebei Key Laboratory of Stomatology, Hebei Clinical Research Center for Oral Diseases, School and Hospital of Stomatology Hebei Medical University Shijiazhuang China Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China Department of Obstetrics, Maternal & Child Health Care Hospital of Shanxi Province, Xi’an 710003, China Department of Hematology, The Second Artillery General Hospital of Chinese PLA, Beijing 100088, China. Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey Rutgers, State University of New Jersey New Brunswick NJ 08903 USA Department of Ultrasound, First Affiliated Hospital of Nanchang University, Nanchang 330000, China Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China Gastroenterology Division, Integrated Internal Medicine and Geriatrics Department, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA. Department of Radiation Oncology; These two authors contributed equally to this work National Resource Center for Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing China State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of Education, School of Chemical Science and Technology Yunnan University Kunming 650091 China School of Mechanical Engineering and Automation, Northeastern University, Shenyang, China Paediatrics Department, Shenmu Hospital, Shenmu County, Yulin City, Shaanxi Province, China Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China Rutgers Cancer Institute of New Jersey; Rutgers University, New Brunswick, NJ, USA; Department of Radiation Oncology, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ USA Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260, United States College of Animal Science and Veterinary Medicine Heilongjiang Bayi Agricultural University Daqing China Department of Ultrasound, Tianjin People’s Hospital State Key Laboratory of Chemistry Engineering, Laboratory of Organic Functional Materials, East China University of Science and Technology, Shanghai, People’s Republic of China, 200237 Department of Materials Science and Engineering, Dalian Maritime University, Dalian, Liaoning, 116026, P. R. China CAS Center for Excellence in Nanoscience; Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety; and Laboratory of Controllable Nanopharmaceuticals; National Center for Nanoscience and Technology; Beijing 100190 , Chengdu University, , China Gene Therapy Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, Maryland 21250; Department of Pediatric Dentistry Kunming Medical University School and Hospital of Stomatology Kunming China College of Science & China Key Laboratory of National Forestry and Grassland Administration on Pest Chemical Control, China Agricultural University, Beijing 100193, China Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China Department of Orthopedics/Sports Medicine Center, State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing 400038, China Department of Pathology, The Affiliated Hospital of Hangzhou Normal University Hangzhou, Zhejiang, China. Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of Psychology, Southwest University Chongqing 400715, PR China. Department of Radiology, Southwest Hospital, Third Military Medical University (Army Medical University) Chongqing 400038, PR China. Department of Gastroenterology, Zhongda Hospital, School of Medicine Southeast University Nanjing China Key Laboratory of Reproductive Genetics; Ministry of Education (Zhejiang University); Department of Reproductive Endocrinology; Women's Hospital; Zhejiang University School of Medicine CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China Department of Gynecology and Obstetrics, Suqian Maternity Hospital, Suqian, Jiangsu, China (mainland) Department of Chemistry, Georgia State University, Atlanta, Georgia 30302, United States State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, China Department of Rheumatology and Immunology, the 980th Hospital of PLA Joint Logistics Support Force, Shijiazhuang, China. Wuxi Center for Disease Control and Prevention, Wuxi, Jiangsu, China; State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China, Graduate University of Chinese Academy of Sciences, Beijing, 100049, China, and Department of Environmental and Aquatic Animal Health, Virginia Institute of Marine Science, The College of William and Mary, Gloucester Point, Virginia 23062 Department of Cardiovascular Medicine, The First Affiliated Hospital of University of South China Hengyang 421001, Hunan Province, China. State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Keyuan Road 4, Gaopeng Street, Chengdu 610041, China Collaborative Innovation Centre of Henan Grain Crops, Henan Key Laboratory of Rice Biology Henan Agricultural University Zhengzhou China; Tasmanian Institute of Agriculture University of Tasmania Hobart Tasmania Australia State Key Laboratory of Quality Research in Chinese Medicines, Macau Institute for Applied Research in Medicine and Health Macau University of Science and Technology Macau China Department of Geriatrics, Renmin Hospital of Wuhan University, Wuhan 430060, China. School of Environmental Science and Engineering, Guangzhou University, and Key Laboratory of Waters Safety & Protection in the Pearl River Delta, Ministry of Education, Guangzhou 510006, China School of Acupuncture-Tuina, Shaanxi University of Traditional Chinese Medicine, Xi’an, Shaanxi, China. College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, 350002, China Division of Geriatric Endocrinology, the First Affiliated Hospital of Nanjing Medical University, People’s Republic of China 5Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina. Department of Veterinary Medicine, Southwest University, 160# Xue Yuan Road, Rongchang 402460, Chongqing, China Department of Chemistry, University of Basel, Klingelbergstrasse 80, Basel 4056, Switzerland Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, Chengdu, China. Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Institute of Pharmaceutical Innovation, School of Medicine, Wuhan University of Science and Technology, Wuhan 430065, China Department of Pathology, The Affiliated Hospital of Hangzhou Normal University Hangzhou, China. Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas Department of Periodontology, Dental Hospital, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China. The School of Basic Medical Sciences, Southwest Medical University, Luzhou, China Department of Animal Sciences, Shanxi Agricultural University, Taigu, China Department of Chemistry and The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, China Department of Obstetrics and Gynaecology Baylor College of Medicine Houston Texas USA; Department of Obstetrics and Gynaecology The Third Affiliated Hospital of Guangzhou Medical University Guangzhou China Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA; Department of Ophthalmology, Ning Xia Eye Hospital, Yinchuan, China State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100101 Beijing, China;; University of Chinese Academy of Sciences, 101408 Beijing, China; A College of Chemical Engineering; Northwest University for Nationalities; Lanzhou; China Department of Hematology, The Second Affiliated Hospital of Harbin Medical University, Harbin, People’s Republic of China Department of Anesthesiology, Chengdu BOE Hospital Chengdu 611743, Sichuan, China. School of economics , innovation, and technology, , Norway; Kristiania University college , innovation, and technology, , Norway School of Computer, Wuhan UniversityWuhanPeople's Republic of China Key Laboratory of Animal Virology of Ministry of Agriculture, Zhejiang University, Hangzhou, China Department of Acute Infectious Disease Control and Prevention Wuxi Center for Disease Control and Prevention Wuxi Jiangsu China Central Laboratory; Yantai Yu Huang Ding Hospital/Qingdao University; Yantai Shandong P. R. China National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, People's Republic of China MOA Key Laboratory of Animal Virology, Center for Veterinary Sciences, Zhejiang University, Hangzhou, PR China; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, PR China Department of Biomedical EngineeringFourth Military Medical UniversityXi'anChina Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical Garden, Chinese Academy of Sciences Wuhan 430074 China; Center of Economic Botany Core Botanical Gardens, Chinese Academy of Sciences Wuhan 430074 China Department of Health Inspection and Quarantine, School of Public Health, Anhui Medical University, Hefei, PR China 2 State Key Laboratory of Software Engineering (Wuhan University) and Wuhan University School of Computer Sciences, Wuhan 430072, People’s Republic of China and College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Henan 473061, China Sansure Biotech Inc., Changsha, China State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, P. R. China High Magnetic Field Laboratory, Chinese Academy of Sciences, Mailbox 1110, 350 Shushanhu Road, Hefei 230031, Anhui, P. R. China; CHMFL-HCMTC Target Therapy Joint Laboratory, 350 Shushanhu Road, Hefei 230031, Anhui, P. R. China Department of Chemical and Biological Engineering, University of Colorado–Boulder, Boulder, CO 80303-0596, USA; Department of Materials Science and Engineering, Dalian Maritime University, Dalian, Liaoning 116026, China Paediatric Medicine Institution of Hunan Children’s Hospital, Changsha, China Departments of Endocrinology and Diabetes Center (H.G., L.L., J.L., Y.L.) The First Affiliated Hospital of Sun Yat-sen University Department of Geratology (J.Y., X.K., J.L., Y.L., Y.S., S.L., W.D., C.W., G.D.), the First Hospital Affiliated to Nanjing Medical University, Nanjing, People's Republic of China Chinese Academy of Sciences Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, , Wuhan 430074, China †National Institute of Biological Sciences, Beijing 102206, China; Fujian Universities Key Laboratory for Plant-Microbe Interaction, College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, 350002, China Department of Endocrinology the First Affiliated Hospital of Sun Yat‐Sen University Guangzhou China Fudan University Huanshan Hospital North, Shanghai, China Beijing Engineering Research Center for Mixed Reality and Advanced Display, School of Optoelectronics, Beijing Institute of Technology, Beijing, People’s Republic of China State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute for Applied Research in Medicine and Health Macau University of Science and Technology Macau China College of Veterinary Medicine, Southwest University, Chongqing, China; Immunology Research Center, Medical Research Institute, Southwest University, Chongqing, China; Chongqing Veterinary Scientific Engineering Research Center, Southwest University, Chongqing, China State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian350002, P. R. China; University of Chinese Academy of Sciences, 100049 Beijing, P. R. China Institute of Organic Contaminant Control and Soil Remediation, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China Pediatric Intensive Care Unit, Hunan Childrens Hospital University of South China Changsha Hunan China Key Laboratory of Laser Technology and Optoelectronic Functional Materials of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China; Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science of Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China Department of Rheumatology The Affiliated Huai'an NO.1 People's Hospital of Nanjing Medical University Huai'an China Center for NanoBioEarth, Department of Geosciences, Virginia Tech, Blacksburg, Virginia 24061, Institute for Critical Technology and Applied Science, 1991 Kraft Drive, Blacksburg, Virginia 24061 Beijing Institute of Technology Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers State University of New Jersey, New Brunswick, NJ, USA Medical Affairs Department Pfizer Inc Shanghai China Department of Obstetrics, Southern Medical University Affiliated Maternal and Child Health Hospital of Foshan, Foshan, Guangdong, China National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China. Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, 199 Ren’ai Road, Suzhou, 215123, Jiangsu, PR China State Key Laboratory of Dao-di Herbs Breeding Base, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. Department of Geratology The First Hospital Affiliated to Nanjing Medical University 300 Guangzhou Road Nanjing 210029 China College of Chemical Engineering; Northwest Minzu University (Northwest University for Nationalities); Lanzhou 730070; China Shenyang Agricultural University College of Horticulture, , Shenyang 110866, China Department of Obstetrics, Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, Foshan, China Yunnan Provincial Key Laboratory of Stomatology, The Affiliated Stomatology Hospital of Kunming Medical University, Kunming, Yunnan, China Fundamental & Computational Sciences Directorate Pacific Northwest National Laboratory Richland WA 99352 USA School of Computer, Wuhan UniversityWuhanHubeiPeople's Republic of China Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, China Department of Ultrasound, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers, State University of New Jersey, New Brunswick, USA Department of Pathology Hangzhou Normal University Affiliated Hospital Hangzhou Zhejiang China Department of Head and Neck Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China Department of Oncology and Hematology, People's Hospital of Leshan Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers, State University of New Jersey, New Brunswick, NJ 08903, USA Central Laboratory, Yantai Yu-Huang-Ding Hospital, Yantai, People’s Republic of China Department of Rheumatology, The Affiliated Huai’an NO.1 People’s Hospital of Nanjing Medical University, Huai’an, China Key Laboratory of Women’s Reproductive Health of Zhejiang Province and Department of Reproductive Endocrinology, Women’s Hospital, Zhejiang University School of Medicine , Hangzhou, Zhejiang , People’s Republic of China Department of Thyroid, Beijing Beicheng Chinese Medicine Hospital, Beijing, China Key Laboratory of Environment and Health Ministry of Education & Ministry of Environmental Protection State Key Laboratory of Environmental Health School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan China School of Computer Science, Wuhan University, Wuhan, China Department of Ultrasound, Medical Imaging Center Affiliated Hospital of Yangzhou University Yangzhou China National Resource Centre for Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing P. R. China; State Key Laboratory for Quality Ensurance and Sustainable Use of Dao‐di Herbs, National Resource Centre for Chinese Materia Medica China Academy of Chinese Medical Sciences Beijing P. R. China; Key Laboratory of Biology and Cultivation of Herb Medicine Ministry of Agriculture and Rural Affairs Beijing P. R. China Department of Anesthesiology, Brain Hospital Affiliated to Nanjing Medical University, NanjingChina College of Chemical Engineering Northwest University for Nationalities Lanzhou 730070 P. R. China China-Japan Friendship Hospital Ying Hua East Road, He Ping Li, Beijing, China Department of Radiology Nursing, West China Second University Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, Sichuan, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, Sichuan, China Department of Medical Microbiology, Shandong Univeristy School of Medicine, Jinan, Shandong, P.R. China.; Departments of Medical Microbiology and Immunology, University of Manitoba, Winnipeg, MB R3E 0W3, Canada. Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, P.R. China Sichuan Institute for Food and Drug Control, Chengdu, China Laboratory of Controllable Nanopharmaceuticals, Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience, and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, No. 11 Beiyitiao, Zhongguancun, Beijing 100190, P. R. China; Tissue Engineering Lab, Beijing Institute of Transfusion Medicine, Beijing 100850, China Key Laboratory of Biology and Genetics and Breeding for Soybean, Ministry of Agriculture, MOE National Innovation Platform for Soybean Bio-Breeding Industry and Education Integration, Zhongshan Biological Breeding Laboratory, State Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, College of Agriculture, Nanjing Agricultural University, Nanjing 210095, China Institute of Functional Nano & Soft Materials (FUNSOM) and Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China.; This study is registered at ClinicalTrials.gov with trial registration identifier number NCT00948324. State Key Laboratory of Quality Research in Chinese Medicines, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau 999078, People’s Republic of China Pacific Northwest National Laboratory, PO Box 999, MSIN: K8-96, Richland, Washington 99352, United States Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, and Lab for Smart & Bioinspired Materials, College of Bioengineering, Chongqing University, Chongqing, 400030, China |
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