http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_c341988e8599008a45820ebade28cd23
Outgoing Links
Predicate | Object |
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family-name | Huang Ying Huang |
name | Ying Huang |
given-name | Ying |
organization-name | From the Department of Medicine, Division of Cardiology and the Marc and Ruti Bell Program in Vascular Biology, New York University School of Medicine (B.H., S.P., T.B., W.K.K.C., Y.M.A., T.H., B.R., E.A.F.); Medizinische Klinik für Kardiologie und Angiologie, Charité-Universitaetsmedizin Berlin, Berlin, Germany (B.H.); and Department of Cellular and Molecular Medicine, Cleveland Clinic Lerner Research Institute, OH (T.C.T., M.S.S.Y., J.A.D., Y.H., J.B., S.Z.B., J.D.S., S.L.H.). Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China Department of Cardiology, First Affiliated Hospital of Xinjiang Medical , University , P.R. China Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA, USA Department of Pain, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210008, China Department of Radiation Oncology, State Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China Fred Hutchinson Cancer Research Center, Seattle, 1100 Fairview Ave N., WA 98109, USA and Department of Biostatistics, University of Washington, Seattle, WA 98195, USA Department of Pediatrics Division of Gastroenterology Children's Hospital of Fudan University Shanghai PR China Department of Ophthalmology, Shanghai Children’s Hospital, Shanghai Jiaotong University, Shanghai 200062, China Department of Gastroenterology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750000, P.R. China Pharmaceutical Analytical & Solid-State Chemistry Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China Department of Clinical Laboratory, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002 Fujian, China; Engineering Research Centre of Fujian-Taiwan Special Marine Food Processing and Nutrition, Ministry of Education, Fuzhou, 350002, Fujian, China National Center for Protein Science Shanghai, State Key Laboratory of Molecular Biology, Shanghai State Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences Shanghai 201203 China Department of Ophthalmology, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China Institute of Plant Sciences Paris-Saclay (IPS2), UMR 9213/UMR1403, CNRS, INRA, Université Paris-Sud, Université d’Evry, Université Paris-Diderot, Sorbonne Paris-Cité, Bâtiment 630, 91405 Orsay, France *Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892; Beijing Keda Advanced Technology Company; Beijing City; China Nanjing Engineering and Technology Research Center for Microbiology, Jiangsu Key Laboratory for Biodiversity and Biotechnology, School of Life Sciences, Nanjing Normal University, Nanjing 210046, China Department of Medicinal Chemistry, ‡Department of Biology, and §Department of Drug Metabolism & Pharmacokinetics, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States Fishery Resource and Environment Research Center, Chinese Academy of Fishery Sciences, Beijing 100141, China State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, PR China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, PR China 14Institute of Genetics, Zhejiang University, and Department of Genetics, School of Medicine, Zhejiang University, Hangzhou, China. Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China The Engineering and Research Center for Southwest Bio-Pharmaceutical Resources of National Education Ministry of China, Guizhou University, Guiyang 550025, China Key Laboratory of Brain, Cognition and Education Sciences, Ministry of Education; School of Psychology, Center for Studies of Psychological Application, and Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University , Guangzhou, Guangdong 510631, China Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, Chongqing Key Laboratory of Non-linear Circuit and Intelligent Information Processing, College of Electronic and Information Engineering, Southwest University, Chongqing 400715, China Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA. Frontier Institute of Science and Technology and State Key Laboratory for Mechanical Behavior of Materials, Xi’an Jiaotong University, Xi’an 710049, China Department of Human Cancer Genetics Program, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 3Fred Hutchinson Cancer Research Center, Seattle, Washington. Key Laboratory of Infectious Diseases, Institute for Viral Hepatitis, Chongqing University of Medical Sciences, Chongqing 400016, China. State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, 650091, PR China Fred Hutchinson Cancer Research Center and University of Washington, Seattle WA, USA Department of Cardiology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China; Department of Ultrasound, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China Center for Programmable Materials, School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore 1State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China Key Laboratory for Medical Virology, Ministry of Health, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (IVDC, China CDC), Beijing 102206, China. Department of Colorectal Surgery Union Hospital Fujian Medical University Fuzhou China College of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China. Community Health Service Center of Baihe Street, Shanghai, People’s Republic of China School of Environment and Safety Engineering, North University of China, Taiyuan 030051, Shanxi, China College of Chemistry and Testing & Analysis Center, Jilin University, 119 JieFang Road, Changchun 130023, People's Republic of China Division of Hematology, The Ohio State University Wexner Medical Center, Columbus, OH, USA Department of Reproductive Center, Navy General Hospital, Fucheng Road, Beijing 100048, China; Department of Obstetrics and Gynecology, Navy General Hospital, Fucheng Road, Beijing 100048, China Stomatology Center, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan 528308, China. Huai’an Hospital Affiliated to Xuzhou Medical University, Huai’an 223002, Jiangsu, China Frontier Institute of Science and Technology and State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University Xi'an 710049 China Statistical Center for HIV/AIDS Research and Prevention (SCHARP), Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA; and Regeneron Pharmaceuticals, Inc., Tarrytown, New York 10591, USA National Clinical Research Center for Mental Disorders; Department of Psychiatry, Second Xiangya Hospital, Central South University, Changsha 410011, China. 208202077@csu.edu.cn. School of Pharmacy, Fujian Medical University, Fuzhou, P.R. China The Third Department of Medicine Oncology, General Hospital of Ningxia Medical University, Yinchuan, P.R. China. Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China Department of Pediatrics Division of Gastroenterology Children's Hospital of Fudan University Shanghai P.R. China Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun 130041, China State Key Laboratory of Cellular Stress Biology Fujian Provincial Key Laboratory of Innovative Drug Target Research School of Pharmaceutical Sciences Xiamen University Xiang'an South Road Xiamen Fujian 361102 China Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830011, PR China. Department of Colorectal Surgery, Union Hospital, Fujian Medical University , People's Republic of China Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China (mainland). Department of Laboratory Medicine Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong 226001, JS, People’s Republic of China Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing Research Center for Preventive Medicine, Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing, China School of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical University, Anhui, Hefei 230032, China; The Key Laboratory of Anti-Inflammatory and Immune, Anhui Medical University, Ministry of Education, Hefei 230032, China; Department of Cardiology, the First Affiliated Hospital of Anhui Medical University, Hefei 230032, China Department of Radiation Oncology, State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center of Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong 510060, China State Key Laboratory of New Textile Materials and Advanced Processing Technologies, School of Textile Science and Engineering, Wuhan Textile University, Wuhan 430200, China Nursing Huashan Hospital Fudan University Shanghai China; Dermatology Huashan Hospital Fudan University Shanghai China Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, PR China Department of Pathology, University of Georgia College of Veterinary Medicine, Athens, Georgia, USA Peking University Department of Psychology, Department of Machine Intelligence, Speech and Hearing Research Center, and Key Laboratory on Machine Perception (Ministry of Education), , Beijing 100871, People's Republic of China Department of Colorectal Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian 350001, People's Republic of China Department of Advanced Technology and Department of Research and Development, Nanogen Inc., 10398 Pacific Center Court, San Diego, California 92121 Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China. School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006 Guangdong, P. R. China Central Research Laboratory, Second Hospital of Jilin University, Changchun, People's Republic of China Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou, Fujian 350007, China Key Laboratory of Arrhythmias Ministry of Education of China, East Hospital, Tongji University School of Medicine Shanghai 200092 China; Department of Anatomy and Neurobiology Tongji University School of Medicine Shanghai 200092 China Department of Nursing, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong 518101, P.R. China College of Chemistry and Materials Sciences, Fujian Normal University, Fuzhou 350108, China. huangying@fjnu.edu.cn Department of Obstetrics and Gynecology Peking University Third Hospital Haidian District Beijing China Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of Stomatology and State Key Laboratory for Mechanical Behavior of Materials and Frontier Institute of Science and Technology and Xi'an Jiaotong University Xi'an 710049 China Division of Hematology Department of Internal Medicine The Ohio State University Columbus OH USA School of Materials Science and Engineering Yunnan University Kunming Yunnan 650091 China National Key Laboratory on Machine Perception, Speech and Hearing Research Centre, Peking University, Beijing, China Department of Biosciences & Informatics, Keio University, Yokohama, Japan Department of Oncology, The Affiliated Huai’an Hospital, Xuzhou Medical University, Huai’an, China Department of Surgery, The Saban Research Institute and Heart Institute of Children's Hospital Los Angeles, Los Angeles, CA 90027, USA 1Department of Environmental Medicine, New York University School of Medicine, Tuxedo, New York; Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, 606-8501, Kyoto, Japan BGI‐Shenzhen Shenzhen 518083 China 10Department of Oncology Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts. College of Pharmaceutical Sciences, South-CentralUniversity for Nationalities, Wuhan 430074, China Department of General Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University; Department of General Surgery, Union Hospital, Fujian Medical University Laboratory for Protein Engineering, Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China. Department of Microbiology, Pathogenic Biology, Harbin Medical University, Harbin, Heilongjiang 150081, China; Heilongjiang Provincial Key Laboratory of Immunity and Infection, Harbin, Heilongjiang 150081, China Biobricks of Microbial Natural Product Syntheses, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute (HKI), Jena, Germany; Faculty of Biological Sciences, Friedrich Schiller University Jena, Jena, Germany Department of Gastroenterology National Children's Medical Center, Children's Hospital of Fudan University Shanghai China Graduate Program in Pharmaceutical Sciences, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, Department of Pharmaceutics, Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 Division of Hematology The Ohio State University Columbus OH USA Department of Cardiology, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning College of Oceanography Hohai University Nanjing China; Postdoctoral Innovation Practice Base Jiangsu Shuixian Industrial Company Limited Yangzhou China Department of Ultrasound, Second Affiliated Hospital, Third Military Medical University, Chongqing, China (mainland) The Key Laboratory of Molecular Epigenetics of Ministry of Education (MOE), Northeast Normal University, Changchun 130024, People's Republic of China School of Food Science and Engineering Hefei University of Technology Hefei Anhui China Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, China Laboratory for Conservation and Utilization of Bioresources and Key Laboratory for Microbial Resources of the Ministry of Education; Yunnan University; Kunming 650091 China College of Pharmacy, Jinan University, Guangzhou, China School of Pharmacy Shanghai Jiao Tong University Shanghai 200240 PR China Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, P.R. China.; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, P.R. China.; Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Changsha, P.R. China.; National Clinical Research Center for Geriatric Disorders, Changsha, P.R. China. Meiji Fisheries Company, Sansha, China State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China MOE Key Laboratory of Material Physics and Chemistry Under Extraordinary Conditions School of Chemistry and Chemical Engineering Northwestern Polytechnical University Xi'an 710072 China Department of Clinical Laboratory, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China, School of Food Engineering, Anhui Science and Technology University, Chuzhou 233100, China Department of Civil, Construction, and Environmental Engineering, North Dakota State University, Fargo, ND 58105, USA Department of Respiratory Medicine, The Third Military Medical University, Chongqing, P.R. China. liuguoxiang@162.com Department of Physiology, Medical Center of Fudan University, Shanghai 200032. Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, China, Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China AstraZeneca R&D Shanghai China Shenyang Institute of Automation, Guangzhou, Chinese Academy of Science, Guangzhou 511400, PR China; Guangdong Engineering and Technology Research Center for Environmental Purification and Functional Materials, Guangzhou 511400, PR China School of Civil and Environmental Engineering, Ningbo University, Ningbo 315211, China School of Life Science & Technology, Huazhong University of Science & Technology, Wuhan 430074, P. R. China College of Chemistry and Materials Science, Fujian Normal University, Fuzhou 350007, China. huang-ying@fzu.edu.cn Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Provincial People's Hospital, Nanjing 210029, Jiangsu Province, China. Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, China Maternity and Child Health Hospital of Pudong New District Shanghai China State Key Laboratory of Physical Chemistry of Solid Surfaces Department of Chemistry; College of Chemistry and Chemical Engineering; Xiamen University; Xiamen 361005, China Division of Hematology The Ohio State University Columbus Ohio USA Department of Orthopedics, Tianjin Hospital, Tianjin 300211, P. R. China Center for Programmable Materials School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Avenue, Singapore 639798 Singapore State key laboratory of oncology in South China, Collaborative Innovation Center of Cancer Medicine, Department of Research Laboratory, Sun Yat-sen University Cancer Center, Guangzhou, China Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province; Guizhou University; Guiyang 550025; China State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China Vaccine and Infectious Disease Division; Fred Hutchinson Cancer Research Center; Seattle 98109 WA U.S.A. College of Veterinary Medicine, National Risk Assessment Laboratory for Antimicrobial Resistant of Microorganisms in Animals, Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, China School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Avenue Singapore 639798 Singapore Yunnan Key Laboratory of Animal Nutrition and Feed Science, Yunnan Agricultural University, Kunming, China Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China 1Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts. School of Medicine, Institute of Translational Medicine, Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu 225009, China State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat‑sen University, Guangzhou, Guangdong 510000, P.R. China Key Laboratory of Brain, Cognition and Education Sciences, Ministry of Education, School of Psychology, Center for Studies of Psychological Application, Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou 510631, China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. 2Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA Institute of Modern Physics Fudan University Shanghai China; Key Laboratory of Nuclear Physics and Ion‐beam Application (MOE) Fudan University Shanghai China; Department of Radiation Oncology Shanghai Chest Hospital School of Medicine Shanghai Jiao Tong University Shanghai China Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of biostatistics, University of Washington, Seattle, WA, USA Basic Research Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702 Department of Colorectal Surgery Fujian Medical University, Union Hospital Fuzhou China Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, Hubei 430030, China Second Affiliate Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China. State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China Affiliations of authors: Department of Translational Molecular Pathology (SB, NC, SSe, AMK) and Department of Biostatistics (SL, JJL), The University of Texas M. D. Anderson Cancer Center, Houston, TX; Fred Hutchison Cancer Research Center, Seattle, WA (YH, TM); Department of Epidemiology (JC, MLF), University of Maryland Medical Center (SAS, DK), Baltimore, MD; University of Pittsburgh Medical Center, Pittsburgh, PA (R Georgia Prevention Institute, Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA Key Laboratory of Space Applied Physics and Chemistry, Ministry of Education, School of Science, Northwestern Polytechnical University, Xi’an 710129, PR China Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, China Department of Basic Medicine, Changde Vocational and Technical College, Changde, Hunan, China College of Veterinary Medicine National Risk Assessment Laboratory for Antimicrobial Resistant of Microorganisms in Animals, Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, Key Laboratory of Zoonosis of Ministry of Agricultural and Rural Affairs South China Agricultural University , Guangzhou, China College of Oceanography, Hohai University, 1 Xikang Road, Nanjing, Jiangsu 210098, China Eye Institute Eye and ENT Hospital College of Medicine Fudan University Shanghai China Agriculture Department of Jilin University, Changchun 130062, China. Department of Integrated Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (mainland) Department of Obstestrics of People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang China State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, PR China Department of Hematology, the First Affiliated Hospital of Kunming Medical College, Kunming Yunnan, 650032, P.R.China. Fudan University, Shanghai, China 1 Laboratory of Disease Genomics and Personalized Medicine & Center of Computational Biology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, China, 2University of Chinese Academy of Sciences, Beijing 100049, China, 3Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA, 4Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA, 5Department of Epidemiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100730, China and 6Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA The Third Department of Medicine Oncology, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia, P.R. China China Military Institute of Chinese Medicine, Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China College of Management, Sichuan Agricultural University, Chengdu 611130, China Department of Colorectal Surgery Union Hospital, Fujian Medical University Fuzhou Fujian Province People's Republic of China Department of Pathology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China College of Food Science; Fujian Agriculture and Forestry University; Fuzhou; China State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, PR China Department of Laboratory Medicine, Affiliated Hospital of Nantong University Nantong Jiangsu China; Medical School of Medicine, Nantong University Nantong Jiangsu China State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, PR China Department of Nuclear Medicine, The Second Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China Department of Vascular Surgery Intensive Care Unit, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N., Seattle, WA 98109, USA and Department of Biostatistics, University of Washington, 1705 NE Pacific Street, Seattle, WA 98195, USA Department of Food Science and Technology, The Ohio State University, Columbus, Ohio 43210 Department of Ultrasound, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, China Department of Neurology, Shanghai Xuhui Central Hospital, Fudan University, Shanghai, People’s Republic of China; Department of General Medicine, Shanghai Xuhui Central Hospital, Fudan University, Shanghai, People’s Republic of China Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China. West China School of Basic Medical Science and Forensic Medicine, Sichuan University, Chengdu, China Population Sciences, Statistics, Vaccine & Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA Experimental Research Center, China Academy of Chinese Medical Sciences Beijing 100700, China. Cardiac Centre in First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China. College of Life Science, Tarim University, Alar, Xinjiang, PR China; Xinjiang Product and Construction Group Key Laboratory of Agricultural Products Processing in Xinjiang South, Alar, Xinjiang South, China Division of Hematology, The Ohio State University, Columbus, OH, USA; The Department of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China Department of Colorectal Surgery Fujian Medical University Union Hospital Fuzhou Fujian Province People's Republic of China Department of Oncologic Pathology, Dana–Farber Cancer Institute, Harvard Medical School, Boston, MA 02215; School of Food Science and Technology Dalian Polytechnic University Dalian China; National Engineering Research Center of Seafood Dalian Polytechnic University Dalian China Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 Department of Nutrition, School of Medicine, Jinan University, Guangzhou 510632, China Department of Ultrasound, the People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, China Gastroenterology Department/Endoscopy Center Department of Radiation Oncology Sun Yat‐sen University Cancer Centre, State Key Laboratory of Oncology in South China, Collaborative Innovation Centre of Cancer Medicine Guangzhou China Forest Pest Control and Quarantine Station of Honghua’erji Forestry Bureau, Hulunbuir, 021112, P.R. China College of Management, Sichuan Agricultural University, Chengdu, 611130, PR China Department of Clinical Laboratory, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China Department of Hematology, Hainan General Hospital, Haikou, Hainan School of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA State Key Laboratory of Environment‐Friendly Energy Materials School of Material Science and Engineering Southwest University of Science and Technology Mianyang 621010 China Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China State Key Laboratory of Microbial Resources; Institute of Microbiology; Chinese Academy of Sciences; Beijing 100101; China Institute of New Energy for Vehicles, School of Materials Science and Engineering, Tongji University, Shanghai 201804, China Renal Division Department of Medicine Emory University School of Medicine Atlanta GA USA School of Pharmaceutical Science, Jinan University, Guangzhou, PR China; School of Pharmaceutical Science, Sun Yat-Sen University, Guangzhou, PR China Department of Cardiothoracic and Vascular Surgery, Advanced Aortic Research Program at the University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX Department of Gastroenterology Children's Hospital of Fudan University Shanghai China Institute of Plant Sciences Paris‐Saclay (IPS2) CNRS INRA University Paris‐Sud University of Evry University Paris‐Diderot Sorbonne Paris‐Cite University of Paris‐Saclay Batiment 630 91405 Orsay France School of Pharmacy,Hunan University of Chinese Medicine,Changsha,Hunan,China; China Military Institute of Chinese Medicine,Fifth Medical Center of Chinese PLA General Hospital,Beijing,China 1Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, New York, and Key Laboratory of Green and Precise Synthetic Chemistry and Applications, Ministry of Education, Department of Chemistry, Huaibei Normal University, Huaibei 235000, P. R. China Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Collaborative Innovation Center For Cancer Personalized Medicine, Nanjing Medical University Nanjing 210029, Jiangsu, China. Department of Head and Neck Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing People's Republic of China School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, People’s Republic of China, and Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, People’s Republic of China State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People’s Republic of China China National GeneBank, BGI-Shenzhen, China.; BGI-Shenzhen, China. Biostatistics, Bioinformatics, and Epidemiology Program, Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N., Seattle, WA, USA; Department of Biostatistics, University of Washington, 1705 NE Pacific Street, Seattle, WA, USA Department of Colorectal Surgery, Union Hospital Fujian Medical University Fuzhou People's Republic of China Department of Gastroenterology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China (mainland) Cancer Drug Research Laboratory Department of Medicine McGill University Health Center/Royal Victoria Hospital 687 Pine Avenue West Montreal QC H3A 1A1 Canada Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China; Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, China Kunming Medical University Kunming P. R. China Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Ministry of Education), Department of Physiology and Pharmacology, Tongji Hospital, School of Medicine Tongji University Shanghai China; Department of Biology York University Toronto Ontario Canada Department of Colorectal Surgery, Union Hospital, Fujian Medical University, Fuzhou, Fujian 350001, China National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing, People's Republic of China State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, China. Biostatistics, Bioinformatics, & Epidemiology Program , Seattle , WA , USA; Fred Hutchinson Cancer Research Center , Seattle , WA , USA Department of Pathophysiology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610000, P.R. China Women's Hospital and Institute of Genetics, Zhejiang University School of Medicine, Hangzhou 310058, China Department of Pain Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing 210008 China Public Health Sciences Fred Hutchinson Cancer Research Center 1100 Fairview Avenue N., M2‐B500 Seattle 98109 WA U.S.A.; Department of Biostatistics University of Washington Seattle 98195 WA U.S.A. Department of Civil and Environmental Engineering, North Dakota State University, Fargo, ND 58102, USA Department of Biochemistry and Molecular Biology, Beijing Medical University, Beijing 100083, China. biochem@mail.bjmu.edu.cn Department of Neurology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China (mainland) Department of Ultrasonography, The Fifth People’s Hospital of Suzhou, Suzhou, Jiangsu 215002, China State Key Laboratory of Biology for Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, People's Republic of China Department of Colorectal Surgery, Union Hospital Fujian Medical University Fuzhou Fujian China Division of Respiratory Disorders, Children's Hospital, Chongqing Medical University, Chongqing 400014, China. Email: huangying62@126.com. Department of Oncology, Xinhua Hospital Chongming Branch (Chongming Hospital Affiliated to Shanghai University of Medicine and Health Sciences), Shanghai 202150, China Centre for Programmable Materials, School of Materials Science and Engineering, Nanyang Technological University, 639798, Singapore Jiangsu Key Laboratory for Microbes and Functional Genetics, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, Hunan 410081, People's Republic of China, School of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha, Hunan 410007, People's Republic of China, Department of Chemistry, Taizhou College, Linhai, Zhejiang 317000, People's Republic of China, and Renaissance Computing Institute, University of North Carolina, Chapel Hill, North Carolina 27599-3455 Preclinical R&D, Slaoui Center for Vaccines Research, GSK Vaccines, 14200 Shady Grove Road, Rockville, Maryland 20850, United States Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin Department of Gastroenterology, Children’s Hospital of Fudan University, Shanghai CNOOC Energy Tech-Drilling & Production Co., Tianjin 300452, China; CNOOC Energy Technology & Services Limited Key Laboratory for Exploration & Development of Unconventional Resources, Beijing 100029, China; National Engineering Research Center of Offshore Oil and Gas Exploration, Tianjin 300452, China Department of Pathology, Harbin First Hospital, Harbin, People’s Republic of China. From the Department of Medicine, Georgia Prevention Institute, Medical College of Georgia, Augusta University, Augusta, GA (L.C., Y.D., Y.H., G.A.H., H.Z.) Department of Medicinal Chemistry Biostatistics Program, Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA Guangdong Foreign Trade School, Guangzhou, Guangdong 510520, China Key Laboratory of Arrhythmias Ministry of Education of China East Hospital Tongji University School of Medicine Shanghai 200092 China; Department of Anatomy and Neurobiology Tongji University School of Medicine Shanghai 200092 China Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China Division of Vascular Surgery, Gonda Vascular Center, Mayo Clinic, Rochester, Minnesota The Comprehensive Cancer Centre, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, 321 Zhongshan Road, Nanjing 210008, China State Key Laboratory of Environment-friendly Energy Materials; National Engineering Technology Center for Insulation Materials; School of Material Science and Engineering; Southwest University of Science and Technology; Mianyang Center for Cancer Prevention Research, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States; Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States State Key Laboratory of Environment‐friendly Energy Materials Southwest University of Science and Technology Mianyang 621010 P. R. China Department of Cardiology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, China; Department of Ultrasound, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China Department of Anaesthesia, Xinhua Hospital, an affiliate of Shanghai Jiao Tong University, School of Medicine, Shanghai, China Research Center of Biomedical Engineering, Kunming Medical University, Kunming, PR China; From the Human Cancer Genetics Program; Clinical Cancer Genetics Program; Comprehensive Cancer Center; Division of Human Cancer Genetics, Department of Molecular Virology, Immunology, and Medical Genetics; Division of Human Genetics, Department of Internal Medicine; and Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH; Department of Surgery, Martin-Luther-University, Halle-Wittenberg, Halle/Saale, Germany; Division of Medical Genetics, University of Leicester, Leicester;... Fred Hutchinson Cancer Research Center, Seattle, WA Department of Infectious Diseases, State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China Institute of Modern Physics, Fudan University, Shanghai, China Department of Geriatric Dentistry, Peking University School and Hospital of Stomatology, Beijing 100081, China Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun Jilin 130022 P. R. China; School of Applied Chemistry and Engineering University of Science and Technology of China Hefei Anhui 230026 P. R. China Surgical Anesthesiology Guangxi Medical University College of Stomatology Guangxi Nanning P. R. China Division of Pediatric Gastroenterology, Hepatology, & Nutrition, Department of Pediatrics, The Saban Research Institute, Children’s Hospital Los Angeles, Los Angeles, California Department of Pharmacy, College of Pharmacy, Central South University, Changsha 410011, PR China Department of Oncologic Pathology Dana‐Farber Cancer Institute Boston Massachusetts USA Shanghai Institute of Medical Genetics, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, People's Republic of China.; Key Lab of Medical Embryo Molecular Biology, Ministry of Health, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.; Shanghai Key Lab of Embryo and Reproduction Engineering, Shanghai Municipal Committee of Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China. Institute of Semiconductors, South China Normal University, Guangzhou, 510631, Guangdong, P. R. China Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China Department of Ultrasound Shengjing Hospital of China Medical University Shenyang China Laboratory of Protein Engineering Beijing Institute of Biotechnology Beijing China Department of Food Science and Technology, The Ohio State University, Columbus, Ohio, USA Fujian Normal University, College of Chemistry and Materials Science, Fuzhou 350007, China; State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China The Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province Department of Chemistry Guizhou University Guiyang 550025 P. R. China; The Engineering and Research Center for Southwest Bio-Pharmaceutical, Resources of National Education Ministry of China Guizhou University Guiyang 550025 P. R. China State Key Laboratory of Environment‐friendly Energy Materials Southwest University of Science and Technology Mianyang 621010 China Department of Ophthalmology, Shanghai Children’s Hospital, School of medicine, Shanghai Jiaotong University, Shanghai, China School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China and Center for Programmable Materials, School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore Department of Pathophysiology; Preclinical and Forensic Medicine; Sichuan University Heart Centre, First Affiliated Hospital of Xinjiang Medical University, China; Coronary Artery Disease Laboratory, Xinjiang Key Laboratory of Cardiovascular Disease, China Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China School of Chemistry Chemical Engineering and Life Sciences Wuhan University of Technology Wuhan Hubei 430070 China Jiangsu Key Laboratory for Microbes and Functional Genomics, School of Life Sciences, Nanjing Normal University, 1 Wenyuan Road, Nanjing 210023, PR China College of Marine Science and Engineering, Nanjing Normal University, 1 Wenyuan Road, Nanjing, Jiangsu 210023, People's Republic of China; College of Oceanography, Hohai University, 1 Xikang Road, Nanjing, Jiangsu 210098, People's Republic of China Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-2753, USA. Departments of aSurgery and Fred Hutchinson Cancer Research Center Hunan Province Key Laboratory of Edible Forestry Resources Safety and Processing Utilization, National Engineering Laboratory for Deep Process of Rice and Byproducts, Central South University of Forestry and Technology, Changsha, PR China College of Material Engineering, Fujian Agriculture and Forestry University, Fuzhou 350108, China College of Veterinary Medicine, National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, Key Laboratory of Zoonosis of Ministry of Agricultural and Rural Affairs, South China Agricultural University, Guangzhou, China; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, China 2State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, Washington 98109, USA School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China; University of Chinese Academy of Sciences, Beijing, China Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100080, China Jiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Industrialization of Microbial Resources, College of Life Science, Nanjing Normal University, Nanjing, People's Republic of China Eye Hospital, Wenzhou Medical University, WenZhou 325000, China Jiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Microbiology, College of Life Sciences, Nanjing Normal University, Nanjing, China The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Qingchun Rd, Hangzhou, China Guangdong Institute for Drug Control Guangzhou Guangdong China University at Albany Department of Health Statistics, School of Public Health, Shanxi Medical University, Taiyuan, China 1Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts. Division of Vascular and Endovascular Surgery (R.R.D., I.S., Y.H., T.C.B., G.S.O., M.K., J.J., F.S., S.W.) Department of Oncology, Shengli Oilfield Central Hospital, Shandong, China Department of Gastroenterology, Children’s Hospital of Fudan University, Shanghai, China; Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China Institute of Plant Sciences Paris-Saclay (IPS2), CNRS, INRAE, Université d’Évry , F-91405 Orsay , France Institute of Modern Physics, Fudan University, Shanghai, China; Key Lab of Nucl. Phys. & Ion-Beam Appl. (MOE), Fudan University, Shanghai, China; Shanghai Chest Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Department of Gastroenterology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China Eppley Institute for Research in Cancer and Allied Diseases University of Nebraska Medical Center Omaha NE 68198 USA Department of Medicine Georgia Prevention Institute Medical College of Georgia Augusta University Augusta Georgia USA State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, No. 1 Beichenxi Road, Chaoyang District, Beijing 100101, P. R. China Department of Biostatistics, University of Washington, Seattle, Washington;; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Biochemistry, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas 78284-7760, and Ribozyme Pharmaceuticals Incorporated, 2950 Wilderness Place, Boulder, Colorado 80301 Department of Clinical Laboratory The Fifth Hospital of Shijiazhuang Shijiazhuang 050011 China Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0540 The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital,Chongqing Medical University,Chongqing,China Center for Programmable Materials; School of Materials Science and Engineering; Nanyang Technological University; Singapore 639798; Singapore College of Pharmacy, Jinan University, Guangzhou 511443, Guangdong, P. R. China Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province Department of Chemistry Guizhou University Guiyang 550025 China; The Engineering and Research Center for Southwest Bio-Pharmaceutical resources of National Education Ministry of China Guizhou University Guiyang 550025 China State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China College of Food Science Fujian Agriculture and Forestry University Fuzhou China; National Engineering Research Center of JUNCAO Technology Fujian Agriculture and Forestry University Fuzhou China Department of Pediatrics, Yichun People's Hospital, Yichun, Jiangxi, China Feed Research Institute; Chinese Academy of Agricultural Sciences; Beijing; PR China School of Pharmaceutical Sciences; Sun Yat-sen University; Guangzhou 510006; PR China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, People's Republic of China Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin 300060, China. State Key Laboratory of Microbial Resources Institute of Microbiology Chinese Academy of Sciences, 1 Beichen West Road Beijing 100101 China Authors' Affiliations: 1Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, New York; and 2Laboratory of Chinese Herbal Drug Discovery, Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou, China Authors' Affiliations: 1Fred Hutchinson Cancer Research Center, Seattle, Washington; 2Perlegen Sciences, Inc., Mountain View, California; 3Harbor-University of California at Los Angeles Research and Education Institute, Torrance, California; 4NIH, Bethesda, Maryland; and 5Kaiser Permanente Division of Research, Oakland, California The Cancer Center of the Fifth Affiliated Hospital of Sun Yat‐sen University Zhuhai China Department of Gynecology, Jingzhou Hospital of Traditional Chinese Medicine, The Third Clinical Medical College of Yangtze University, Jingzhou, Hubei 434000, P.R. China Department of Nursing Yan'an Hospital Affiliated to Kunming Medical University Kunming City Yunnan Province China School of Pharmaceutical Sciences Sun Yat‐Sen University Guangzhou Guangdong China Center for Molecular Sciences, Institute of Chemistry, The Chinese Academy of Sciences, Beijing 100080, China Department of Colorectal Surgery Fujian Medical University Union Hospital Fuzhou China; Department of General Surgery Fujian Medical University Union Hospital Fuzhou China From the Department of Immunology (R.E.T., B.P., R.P., Y.S., L.K.C., N.M.), The Scripps Research Institute, La Jolla, Calif; the Department of Cell Biology (N.M.), The Scripps Research Institute, La Jolla, Calif; University of New South Wales (J.H.E.), Sydney, Australia; the Department of Internal Medicine (Y.S., S.D., Y.H., D.T.E.), University of Michigan Medical School, Ann Arbor, Mich; the Department of Vascular Medicine Research (W.A.B.), Harvard Medical School, Cambridge, Mass; and the... Jiangsu Key Laboratory for Microbes and Functional Genomics, School of Life Sciences Nanjing Normal University Nanjing China Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang 110004, China Division of Hematology The James Cancer Hospital and Solove Research Institute The Ohio State University Columbus Ohio USA State Key Laboratory of Microbial Resources; Institute of Microbiology; Chinese Academy of Sciences; Beijing 100101; P. R. China Department of Geriatric Dentistry Peking University School and Hospital of Stomatology Beijing People's Republic of China NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China School of Materials Science and Engineering Yunnan Key Laboratory for Micro/Nano Materials and Technology Yunnan University Kunming Yunnan 650091 P. R. China CAS Key Laboratory of Synthetic Chemistry of Natural Substances; Shanghai Institute of Organic Chemistry; Chinese Academy of Sciences; Shanghai 200032, China Agriculture Depatment of Jilin University, Changchun 130062, China. College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, China; Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225009, China †Laboratory of Experimental Immunology, National Cancer Institute-Frederick, Frederick, MD 21702; and Shanghai Institute of Hematology, Rui-Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China Department of Colorectal Surgery, Union Hospital, Fujian Medical University, Fuzhou 350001, China. hy9033sy@sina.com. Georgia Prevention Institute Department of Population Health Sciences Medical College of Georgia Augusta University 1120 15th Street, HS‐1640 Augusta Georgia USA Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital Southern Medical University Guangzhou China Center for Studies of Information Resources, Center for Science, Technology, & Education Assessment (CSTEA), School of Information Management, Wuhan University, Wuhan 430072, China;; Centre for R&D Monitoring (ECOOM), KU Leuven, Leuven 3000, Belgium;; Department of Management, Strategy and Innovation (MSI), KU Leuven, Leuven 3000, Belgium Department of Ultrasound Shengjing Hospital of China Medical University Shenyang Liaoning China Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA and Department of Biostatistics, University of Washington, Seattle, WA 98109, USA Fred Hutchinson Cancer Research Center , Seattle , USA Center for Advanced Drug Research and Evaluation, College of Pharmacy, Western University of Health Sciences, Pomona, CA, USA School of Pharmacy, Hunan University of Chinese Medicine, Changsha Hunan 410208, People's Republic of China 1Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California. Graduate Program in Pharmaceutical Sciences, Department of Pharmaceutics, Ernest Mario School of Pharmacy, ‡Center for Cancer Prevention Research, Department of Pharmaceutics, Ernest Mario School of Pharmacy, §Departments of Chemical and Biochemical Engineering, and ∥Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, United States Department of Operating Theatre, Zhejiang Cancer Hospital, No. 38 Guangji Road, Banshan Bridge, Hangzhou 310022, China Division of Hematology, Department of Medicine, The Ohio State University, 460 W 10th Ave., Columbus, OH 43210, USA Authors' Affiliation: Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, New York 1State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, PR China GSK, Rockville, MD, USA. Department of Cardiology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, China Program of Pharmacogenomics, Department of Pharmacology and the Comprehensive Cancer Center, College of Medicine, The Ohio State University, Columbus Ohio 43210, and Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California 91766 College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA Department of Cardiology, Shanghai Changzheng Hospital, Shanghai 200433, P.R. China Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala University, Uppsala, Sweden Department of Radiation Oncology Sun Yat‐sen University Cancer Center Guangzhou Guangdong Province People's Republic of China; State Key Laboratory of Oncology in South China Guangzhou Guangdong Province People's Republic of China; Collaborative Innovation Center for Cancer Medicine Guangzhou Guangdong Province People's Republic of China; Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou Guangdong Province People's Republic of China The Children's Hospital, Chongqing University of Medical Sciences, Chongqing, China College of Chemical and Biological Engineering; Key Laboratory of Biomass Chemical Engineering of Ministry of Education; Zhejiang University; Hangzhou 310027; China Key Laboratory of Brain, Cognition and Education Sciences, Ministry of Education, School of Psychology, Center for Studies of Psychological Application and Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou 510631, China Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China Human Cancer Genetics Program, Comprehensive Cancer Center, Department of Pathology, Divisions of Sensory Biophysics and Endocrinology and Nuclear Medicine, Ohio State University, Columbus, OH 43210; and Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104 Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province Guizhou University No. 515 Jiaxiu Road, Huaxi District Guiyang 550025 China Division of Public Health Sciences (Y.H., M.P., L.T., R.P.), Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 Department of Microbiology Harbin Medical University Harbin China Georgia Prevention Institute, Department of Medicine (L.C., H.Z., G.H., X.W., Y.H., G.K., Y.D.), Medical College of Georgia, Augusta University. Zhejiang University; Research Institute of Intelligent Networks Molecular Biology Laboratory of Infectious Diseases, Institute for Viral Hepatitis, Chongqing University of Medical Sciences, Chongqing 400010, China. Authors' Affiliations: 1Urologic Oncology Branch and 2Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland; 3Departments of Urology, Biochemistry, and Molecular Biology, Cancer Research Institute, SUNY Upstate Medical University, Syracuse, New York; and 4Department of Urology, Hokkaido University Graduate School of Medicine, Sapporo, Japan Vaccine and Infectious Disease Division and Public Health Sciences Division Fred Hutchinson Cancer Research Center Seattle, Washington 98109 U.S.A. Department of Burns Center The First Affiliated Hospital of Wenzhou Medical University Wenzhou China; Department of Infection The First Affiliated Hospital of Wenzhou Medical University Wenzhou China State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02215; Key Laboratory of Molecular BiophysicsMinistry of EducationCollege of Life Science and TechnologyCenter for Human Genome Research Wuhan China Department of Respiratory Medicine, The First Hospital Affiliated to AMU (Southwest Hospital), Chongqing 400038, P.R. China 2State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing 102206, PR China Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat‐sen University Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science Guangzhou 510060 P. R. China Division of Gastroenterology, Children's Hospital of Fudan University, Shanghai, P.R. China Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China 1Program of Pharmacogenomics, Department of Pharmacology, Comprehensive Cancer Center and *Institute of Neuroscience and State Key Laboratory of Neuroscience, Chinese Academy of Sciences, Shanghai 200031, China; California Institute for Telecommunications and Information Technology, University of California, La Jolla, San Diego, California, USA Fred Hutchinson Cancer Research Center, Seattle Washington 98109 U.S.A. Department of Intensive Care Unit, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University Huai'an, Jiangsu Province, China. School of Pharmacy Hunan University of Chinese Medicine Changsha Hunan China Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, New York Division of Hematology, Department of Internal Medicine The Ohio State University Wexner Medical Center Columbus Ohio National Center for Protein Science Shanghai, Graduate University of the Chinese Academy of Sciences, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China (Y.L., Y.H.) Department of Chemistry, Columbia University, New York, New York 10027 Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN, USA Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA, USA Georgia Prevention Institute, Department of Population Sciences The Third Department of Medical Oncology, General Hospital of Ningxia Medical University, Yinchuan, P.R. China. Department of General Surgery, Shanghai Key Laboratory of Biliary Tract Disease Research, State Key Laboratory of Oncogenes and Related Genes, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai 200092, China Institute of Health Sciences, Shanghai Institutes for Biological Sciences of Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, United States. State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, People's Republic of China Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Ministry of Education), Department of Physiology and Pharmacology, Tongji Hospital, School of Medicine Tongji University Shanghai China School of Automation, Northwestern Polytechnical University , Xi’an 710072, China School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, People's Republic of China Department of Geriatric Dentistry NMPA Key Laboratory for Dental Materials National Engineering Laboratory for Digital and Material Technology of Stomatology Beijing Laboratory of Biomedical Materials Peking University School and Hospital of Stomatology Beijing 100081 P. R. China ACEA Biosciences, Inc., San Diego, California 92121 State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China Dermatology Department, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China (P.-S.H., Y.H., M.-L.C.) Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, China From the Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH (X.-M.L., W.H.W.T., Y.H., V.G., D.S., J.A.D., J.D.S., S.L.H.); Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH (W.H.W.T., J.D.S., S.L.H.); Lilly Research Laboratories, Indianapolis, IN (M.K.M., W.M.); Department of Mathematics, Cleveland State University, Cleveland, OH (Y.W.); and Department of Medicine, New York University, New York,... Laboratory of Internal Medicine, The Second Affiliated Hospital Guangdong Technology Research Center for Marine Algal Bioengineering, Guangdong Provincial Key Laboratory for Plant Epigenetics, Shenzhen Engineering Laboratory for Marine Algal Biotechnology, Longhua Innovation Institute for Biotechnology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China Department of Anatomy, Histology and Embryology, Jinzhou Medical University, Jinzhou, China Department of Cardiology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-2753, USA. Institute of Laser and Optoelectronics Technology, Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education Fujian Normal University Fuzhou China Department of Pediatrics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, Pudong, 201399 China Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education) Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University Chongqing China Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; and Center for the Advancement of Drug Research and Evaluation, College of Pharmacy, Western University of Health Sciences, Pomona, California. Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai 200032, China Department of Biochemistry, Kansas State University, Manhattan, Kansas 66506, and Department of Chemistry, Western Illinois University, Macomb, Illinois 61455 State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China Technology and Standards Research Institute, China Academy of Information and Communications Technology, Beijing, The People’s Republic of China; Key Laboratory of Internet and Industrial Integration Innovation, MIIT, Beijing, The People’s Republic of China Colorectal Surgery Department Fujian Medical University Union Hospital 29 Xinquan Road Fuzhou PR China Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. E-mail: orioles217@126.com. School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Kunming 650201, China; University of Chinese Academy of Sciences, Beijing 100049, China Division of Hematology, The Ohio State University James Comprehensive Cancer Center, Columbus, OH, USA Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Fred Hutchinson Cancer Research Center , Seattle , WA , USA From the Georgia Prevention Institute (D.G., H.Z., Y.H., F.A.T., G.A.H., H.S., Y.D.), Department of Pediatrics, Medical College of Georgia, Augusta; and the Twin Research and Genetic Epidemiology Unit (H.S.), St Thomas’ Hospital, London, United Kingdom. Research Group Comparative Neuroscience, Leibniz Institute for Neurobiology 1Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland. Department of Microbiology and Molecular Genetics; Rutgers-New Jersey Medical School; Newark New Jersey Institute of Plant Sciences Paris of Saclay (IPS2), UMR 9213/UMR1403, CNRS, INRA, Université Paris-Sud, Université d’Evry, Université Paris-Diderot, Orsay, France Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA 02215; Department of Rheumatology and Immunology, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Fei Shan Street, Guiyang 550001, China; Guizhou Medical University, Beijing Road, Guiyang, Guizhou Province 550004, China School of Environment, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou310024, China; University of Chinese Academy of Science, Beijing100049, China Department of Hematology, Kunming Medicine College, Kunming, Yunan Province, China. The Fifth Hospital of Shijiazhuang, Shijiazhuang, Hebei, China Key Laboratory for the Integrated Management of Crop Diseases and Pests, Ministry of Education, Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, PR China School of Materials Science and Engineering; Nanyang Technological University; Singapore 639798; Singapore Division of Vascular and Endovascular Surgery, Mayo Clinic, Rochester, MN, USA School of Science, Northwestern Polytechnical University, Xi’an 710072, Peoples Republic of China National Clinical Research Center for Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the Department of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China. The Affiliated Stomatology Hospital; College of Medicine; Zhejiang University; Hangzhou; P. R. China 1The Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska. Department of Gastroenterology, Fudan University children's Hospital, Shanghai 201102, China. Department of Auricular Reconstruction, Plastic Surgery Hospital Email: yhuang815@163.com. Xinhua Hospital Chongming Branch, Shanghai Jiao Tong University School of Medicine, China. Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China Department of Ultrasound, Shengjing Hospital of China Medical University, 110004, Shenyang, China Department of Clinical Laboratory The First Affiliated Hospital of Anhui Medical University Hefei Anhui Province China Yunnan Provincial Key Laboratory of Animal Nutrition and Feed Yunnan Agricultural University Kunming Yunnan China From Invivoscribe, Inc, San Diego, California (Jacobsen, Vigil, Hutt, Huang, Miller). Department of Pharmaceutical Sciences, Western University of Health Sciences, Pomona, CA 91766, United States State Key Laboratory for Molecular Virology and Genetic Engineering, Institute for Viral Disease Control and Prevention, China CDC, Bingjing, China. Division of Hematology Department of Internal Medicine College of Medicine The Ohio State University Columbus Ohio USA Department of Medical Oncology Tumor Hospital of Baotou Baotou China Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China Molecular Pathology Core Laboratory, Dana-Farber Cancer Institute, Boston, MA 02115, USA. Department of Pathophysiology, Huaxi School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan Province, China. State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China Division of Hematology, Nanogen, Inc., San Diego, California 92121 Division of Spinal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, P.R. China Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China, Department of Neurosurgery, Tianjin Huanhu Hospital; Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Disease, Tianjin, China Department of Cardiology, Renmin Hospital, Wuhan, China; Cardiovascular Research Institute of Wuhan University, Wuhan, China W. M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.; Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599–7295, USA.; The University of Texas M. D. Anderson Cancer Center, Science Park-Research Division, Post Office Box 389, Smithville, TX 78957, USA. Department of Dermatology The Third Affiliated Hospital of Sun Yat‐sen University Guangzhou China Ecology & Soil Remediation Institute, Shandong Academy of Environmental Sciences, Ji'nan 250013, China. 3State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, PR China Nuclear Medicine Technology Institute, Southeast University, Nanjing, Jiangsu, People's Republic of China.; Central Laboratory of Southeast University, Nanjing, Jiangsu, People's Republic of China. The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; Guangdong Lung Cancer Institute, Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Medical Research Center of Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou 510080, China The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Qingchun Rd, Hangzhou, China Department of Colorectal Surgery, Union Hospital Fujian Medical University 29 Xin‐Quan Road 350001 Fuzhou Fujian People's Republic of China From the Health Science Center, Shanghai Second Medical University (SSMU)–Shanghai Institutes for Biological Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China; the Department of Pathophysiology, Shanghai Terry Fox Cancer Center and Institute of Hematology, Rui-Jin Hospital, SSMU, Shanghai, China; and the Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA. Authors' Affiliations: 1Laboratory of Pathology, State Key Laboratory of Biotherapy and Department of Pathology, West China Hospital, West China Medical School, Sichuan University; 2Department of Urology and 3Laboratory of Stem Cell Research, West China Hospital, Chengdu, China; and 4Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland Department of Intensive Care Unit, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University Huai'an, China. Department of Gastroenterology and Regeneron Pharmaceuticals Inc., Tarrytown, New York. Department of Respiratory Medicine Children's Hospital of Chongqing Medical University Chongqing China Faculty of Life Science and Technology Kunming University of Science and Technology Kunming Yunnan China Department of Hematology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA Department of Endocrinology, Zhuhai People’s Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai, 519000, China Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China Laboratory Medicine Department of Colorectal Surgery Union Hospital, Fujian Medical University Fuzhou People’s Republic of China Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun, Jilin 130022 P. R. China; School of Applied Chemistry and Engineering University of Science and Technology of China Hefei, Anhui 230026 P. R. China Department of Civil Engineering, North Dakota State University (NDSU), Fargo, ND 58102, USA State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, China; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, China 3Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio. Department of Respiratory Diseases, First Affiliated Hospital, Guangxi Medical University, Nanning 530021, China. Department of Oral & Maxillofacial Surgery, The Affiliated Stomatology Hospital, College of Medicine, Zhejiang University, 395 Yan’an Road, Hangzhou 310006, China School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore Department of Sports Arts, Hebei Sport University, Shijiazhuang 05000, Hebei, China Fishery Resource and Environment Research Center, Chinese Academy of Fishery Sciences, Beijing 100141, People’s Republic of China Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China Beijing Key Laboratory on Preparation and Processing of Novel Polymeric Materials, Beijing University of Chemical Technology, 100029, Beijing, China Division of Spinal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, P.R. China. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center Sun Yat‐sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science| Guangzhou China Department of Chemistry, School of Chemistry; Chemical Engineering and Life Sciences; Wuhan University of Technology; Wuhan 430070; P. R. China State Key Laboratory of Physical Chemistry of Solid Surfaces; Collaborative Innovation Center of Chemistry for Energy Materials; Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM); College of Chemistry and Chemical Engineering; Xiamen University Department of Gastroenterology, Fudan University Children's Hospital, Shanghai 201102, China. Email: yhuang815@163.com. GSK, Vaccine Design and Cellular Immunology, Rockville, MD, USA Department of Pathology and Laboratory of Pathology; West China Hospital; Sichuan University; Chengdu China; Department of Pathology; Fujian Provincial Hospital; Fuzhou China Department of Internal Medicine, Division of Hematology The Ohio State University Columbus Ohio USA State Key Laboratory of Crop Genetics and Germplasm Enhancement, College of Horticulture, Nanjing Agricultural University Nanjing China Beijing Key Laboratory of Ionic Liquids Clean Process; State Key Laboratory of Multiphase Complex Systems; Key Laboratory of Green Process and Engineering; Institute of Process Engineering; Chinese Academy of Sciences Department of Colorectal Surgery, Union Hospital, Fujian Medical University, Fuzhou, China. Vaccine and Infectious Disease Division and Public Health Sciences Division, Fred Hutchinson Cancer Research Center School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of Chinese Academy of Sciences, Beijing 100049, China Department of Molecular Pathology, Box 89, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030 Fred Hutchinson Cancer Research Center , Seattle Washington 98109 , U.S.A. Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province; Guizhou University; Guiyang 550025; China; The Engineering and Research Center for Southwest Bio-Pharmaceutical Resources of National Education Ministry of China School of Materials Science and Engineering; University of Science and Technology Beijing; Beijing; China Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland Department of Radiation Oncology Shanghai Chest Hospital Shanghai Jiao Tong University Shanghai China 4Regeneron Pharmaceuticals Inc., Tarrytown, New York. Department of Nuclear Medicine, the First Affiliated Hospital of Hainan Medical College, Haikou 570102, China Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, Maryland 21702 Department of Nephrology The First Affiliated Hospital of Soochow University Suzhou China Women’s Guild Lung Institute, Cedars-Sinai Medical Center; Los Angeles, California; and Jiangsu Province Key Laboratory of Anesthesiology and Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical UniversityXuzhou, China; Department of Anesthesiology and SICU, Xinhua Hospital, School of Medicine, Shanghai Jiaotong UniversityShanghai, China. Oak Ridge National Laboratory, Oak Ridge, TN Respiratory Department, People’s Hospital of Xinjiang Uyghur Autonomous Region, Urumqi 830001, Xinjiang, China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, 430070, China Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China; Integrative Microbiology Research Center, South China Agricultural University, Guangzhou 510642, China Department of Cardiology, Shanghai East Hospital, Tongji University Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40536;; Department of Microbiology, College of Biological Sciences, China Agricultural University, Beijing 100094, People’s Republic of China; Department of Operating Theatre, Zhejiang Cancer Hospital No. 38 Guangji Road, Banshan Bridge, Hangzhou 310022, China. State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for Cancer Sun Yat‐sen University Cancer Center Guangzhou 510060 China State Key Laboratory for Mechanical Behavior of Materials and Frontier Institute of Science and Technology Xi'an Jiaotong University Xi'an 710049 China 1Fred Hutchinson Cancer Research Center, Seattle, Washington; 2Perlegen Sciences, Inc., Mountain View, California; 3Harbor-UCLA Research and Education Institute, Torrance, California; 4NIH, Bethesda, Maryland; and 5Kaiser Permanente Division of Research, Oakland, California State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming 650091, PR China Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China Department of Plant Pathology, the Key Laboratory of Plant Immunity Nanjing Agricultural University Nanjing China College of Pharmacy, Jinan University, Guangzhou 511443, China Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China (mainland). Laboratory for Conservation and Utilization of Bio-resources and Key Laboratory for Microbial Resources of the Ministry of Education; Yunnan University; Kunming China Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China. Departments of Internal Medicine and Human Genetics, University of Michigan Ann Arbor, Michigan 48109 Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, College of Life Sciences, Shaanxi Normal University, Xi’an, P. R. China Greater Bay Biomedical Innocenter, Shenzhen Bay Laboratory, Shenzhen 518055, China. Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH; SCHARP, Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA Invivoscribe, Inc San Diego California Nanogen Inc., 10398 Pacific Center Court, San Diego, California 92121 State Key Laboratory for Mechanical Behavior of Materials and Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an, 710049, China Georgia Prevention Institute, Department of Medicine, Medical College of Georgia Augusta University Augusta Georgia 30912 USA School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai20024, P.R. China School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, China; Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China Department of Civil, Construction and Environmental Engineering, North Dakota State University, Fargo, ND 58105, USA Department of Cardiology, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China (T.-T.Z., Y.H., H.H.). Merck Research Laboratories, Kenilworth, NJ 07033, USA State Key Laboratory of Environment-friendly Energy Materials, School of National Defence Science & Technology, Southwest University of Science and Technology, Mianyang, 621010, P. R. China Department of Head and Neck Surgical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing P. R. China College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China Department of Inorganic Chemistry, Pharmacy School, Naval Medical University School, Shanghai, PR China for the China Patient-Centered Evaluative Assessment of Cardiac Events Million Persons Project Collaborative Group Authors' Affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin 300000, P.R. China State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing 102206, PR China College of Pharmacy, Jinan University, Guangzhou 510632, Guangdong, PR China Department of Cardiology, Sichuan Medical University, Sichuan, P.R. China Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; Fred Hutchinson Cancer Research Center Public Health Sciences 1100 Fairview Avenue N., Seattle, Washington 98109‐1024 U.S.A.; Department of Biostatistics University of Washington Seattle, Washington 98195 U.S.A. Department of Molecular Pathology, Box 89, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston Texas 77030 Department of Biostatistics, University of Washington , Seattle, WA, USA; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA Lab. for Protein Engineering, Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China. Department of Pathology, Faculty of Basic Medicine, Chongqing Medical University, Chongqing 400016, P.R. China State Environmental Protection Engineering Center for Pollution Treatment and Control in Textile Industry; College of Environmental Science and Engineering; Donghua University; Shanghai; China Structural Biology and Cancer Drug Discovery Program, Lombardi Cancer Center and Department of Oncology, Georgetown University Medical Center, 3970 Reservoir Road, Washington, D.C. 20007, and Laboratory of Medicinal Chemistry, National Cancer Institute, FCRDC, Building 376, Room 207, Fredrick, Maryland 21702 School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen 361005, China School of Materials Science and Engineering Nanyang Technological University Singapore 639798 Singapore Department of Applied Chemistry; School of Science; Northwestern Polytechnical University; Xi'an; P. R. China School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China. Novartis Institutes for BioMedical Research, Shanghai, China Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China Department of Nursing, Zhejiang Cancer Hospital, Hangzhou 310022, China Department of Biostatistics, University of Washington , Seattle, WA, USA 2Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts. Dana‐Farber Cancer Institute and Harvard Medical School, Boston, MA Department of Fujian Union Medical College Fujian Medical University Fuzhou China; Department of General Surgery Fujian Medical University Union Hospital Fuzhou China; Minimal Invasive Center Fujian Medical University Union Hospital Fuzhou China; Fujian Medical University Fuzhou China 1Cardiovascular and Metabolic Research Unit, Laurentian University, Ontario, Canada; 2School of Human Kinetics, Faculty of Health, Laurentian University, Ontario, Canada Authors' Affiliations: Cancer Drug Research Laboratory, Department of Medicine, McGill University Health Center/Royal Victoria Hospital, Montreal, Quebec, Canada Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction Ministry of Education Wuhan China; College of Animal Science and Technology and College of Veterinary Medicine Huazhong Agricultural University Wuhan China Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, People’s Republic of China Hospital of Stomatology, Tianjin Medical University, Tianjin 300070, People ’s Republic of China State Key Laboratory of Crop Genetics and Germplasm Enhancement, College of Horticulture Nanjing Agricultural University Nanjing 210095 China Environmental Engineering and Science Program, Department of Chemical and Environmental Engineering, University of Cincinnati, Cincinnati, Ohio 45221, United States; School of the Environment, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, China Institute of Sports Medicine and Health, Chengdu Sport University, Chengdu, China Laboratories of Chemical Physics and Molecular Biology National Institute of Diabetes and Digestive and Kidne Diseases, National Institutes of Health Bethesda, Maryland 20892 Engineering Research Centre of Fujian-Taiwan Special Marine Food Processing and Nutrition; Ministry of Education; Fuzhou; China; College of Food Science Yunnan Agricultural University, China Division of Hematology, The Ohio State University, Columbus, OH Department of Oncology, Zhongnan Hospital, Wuhan University, Hubei Cancer Clinical Study Center, Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, Hubei 430071, P.R. China. Department of Reproductive Medicine, Yichun People’s Hospital, Yichun, Jiangxi 336000, China National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Qingchun Rd, Hangzhou, China Department of Applied Chemistry and The Key Laboratory of Space Applied Physics and Chemistry, Ministry of Education, School of Science, Northwestern Polytechnical University, Xi’an 710072, P. R. China Georgia Prevention Center Medical College of Georgia Georgia Regents University Augusta GA Department of Civil, Construction, and Environmental Engineering, North Dakota State University, Fargo, North Dakota 58102, United States Jiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Industrialization of Microbial Resources, School of Life Sciences, Nanjing Normal University, 1 Wenyuan Road, Nanjing 210046, China College of Food Science Fujian Agriculture and Forestry University Fuzhou China State Key Laboratory for Mechanical Behavior of Materials, and Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China The Department of Neurology, Shanghai Ninth People’s Hospital Affiliated Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China Reproductive Medical Center (Y.Z., C.Z., Y.H., Y.Y., R.L., M.L., N.L., P.L., J.Q.), Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China 100191; Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology (Y.Z., Y.H., M.L., P.L., J.Q.), Beijing, China 100191 Leibniz Research Group – Biobricks of Microbial Natural Product Syntheses; Leibniz Institute for Natural Product Research and Infection Biology (HKI); 07745 Jena; Germany JC School of Public Health and Primary Care The Chinese University of Hong Kong Hong Kong Special Administrative Region China National Fuel Cell Research Center, Advanced Power and Energy Program, University of California, Irvine, Irvine, California 92697, United States; Department of Materials Science and Engineering, University of California, Irvine, Irvine, California 92697, United States Department of Rheumatology and Immunology, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, China School of Pharmacy Jinan University Guangzhou 510632 P. R. China State Key Laboratory of Microbial Resources, Chinese Academy of Sciences, Institute of Microbiology , Beijing 100101 , P. R. China; College of Life Sciences, University of Chinese Academy of Sciences , Beijing 101408 , P. R. China Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, China. School of Materials Science and Engineering; Yunnan Key Laboratory for Micro/Nano Materials & Technology; Yunnan University; Kunming; China Department of Pathophysiology, Chemical Biology Division of Shanghai Universities E-Institutes, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China; University Hospital Schleswig-Holstein, Kiel, Germany Division of Hematology, Department of Internal Medicine The Ohio State University Wexner Medical Center Columbus OH, USA Department of Cardiovascular Medicine, the Second Affiliated Hospital of Nanchang University, Nanchang of Jiangxi, China. Department of Ultrasound, Chongqing General Hospital, Chongqing 401147, China Division of Hematology, The Ohio State University, Columbus, OH, USA Department of Emergency, Hunan Provincial People's Hospital The First Affiliated Hospital of Hunan Normal University Changsha China Departments of Internal Medicine and Human Genetics, University of Michigan, Ann Arbor, MI 48109 Cancer Drug Research Laboratory, McGill University, Royal Victoria Hospital, Montreal, Quebec, Canada. Department of Gastroenterology, Children's Hospital, Fudan University, Shanghai, China; University of Auckland, New Zealand; University of Auckland, New Zealand Department of Laboratory Animal Science, Fudan University , Shanghai , China Department of Pharmacy, Hebei Key Laboratory of Neuropharmacology, Hebei North University, Zhangjiakou 075000, P.R. China Department of Integrated Traditional Chinese and Western Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 Statistical Center for HIV/AIDS Prevention and Research, Fred Hutchinson Cancer Research Center Seattle WA U.S.A. School of Marine Science and Biotechnology, Guangxi Key Laboratory for Polysaccharide Materials and Modifications, Guangxi Minzu University, Nanning 530008, PR China Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Biostatistics, University of Washington, Seattle Department of Sociology, Center for Social and Demographic Analysis, University at Albany, State University of New York, Albany, NY 12222, USA Hematology Department The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi China Department of Colorectal Surgery Fujian Medical University Union Hospital Fuzhou Fujian China Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA Department of Pathophysiology, West China School of Preclinical and Forensic Medicine, Sichuan University Chengdu 610041, Sichuan Province, China. Section of Epidemiology and Biostatistics The University of Auckland Auckland New Zealand Department of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. School of Automation, Northwestern Polytechnical University, Xi'an, China. Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, Institute of Biodiversity Science, School of Life Sciences, Fudan University, Shanghai, China Medical College, Institute of Translational Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, China Huazhong Agricultural University National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, College of Horticulture and Forestry Sciences, , Wuhan 430070, China Department of Pathophysiology, West China School of Predinical and Forensic Medicine, Sichuan University, Chengdu 610041, China. Department of Laboratory Medicine, Fifth Hospital of Shijiazhuang, Hebei Medical University, Shijiazhuang, Hebei 050021, China Laboratory of Molecular Biology, Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangdong Key Laboratory of Lung Cancer Translational Medicine, Guangzhou - China School of Physics and Astronomy; School of Materials Science and Engineering; Yunnan Key Laboratory for Micro/Nano Materials & Technology; Yunnan University; Kunming 650091 Department of Pathophysiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China. Steroid Hormones Section National Institute of Diabetes and Digestive and Kidney Diseases Laboratory of Molecular and Cellular Biology National Institutes of Health Bethesda, Maryland 20892-0805 College of Pharmaceutical Science, Yunnan University of Chinese Medicine, 1076 Yuhua Road, Kunming 650500, China; Yunnan Key Laboratory of Southern Medicine Utilization, 1076 Yuhua Road, Kunming 650500, China Department of Laboratory Medicine, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, 226001 JS, China Institute of Urban Environment, Chinese Academy of Sciences, No. 1799 Jimei Road, Xiamen 361021, China; Ningbo Urban Environment Observation and Research Station-NUEORS, Chinese Academy of Sciences, No. 88 Zhong Ke Road, Ningbo 315830, China State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing100101, China Department of Respiratory and Critical Care Medicine, Tianjin Chest Hospital, Tianjin, China Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, Xinjiang, People's Republic of China. The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China Université Paris-Saclay, CNRS, INRAE, Univ Evry, Institute of Plant Sciences Paris-Saclay (IPS2), Orsay, France Department of Radiotherapy Sun Yat‐sen University Cancer Center Guangzhou China Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; The Vascular Center, Shanghai Jiao Tong University School of Medicine; Institute of Traumatic Medicine, Shanghai Jiao Tong University School of Medicine Hefei University of Technology School of Electronic Science and Applied Physics, , Hefei 230009, People’s Republic of China State Key Laboratory for Molecular Virology and Genetic Engineering, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China. School of Food Science and Technology, Jiangnan University, Wuxi 214000, China Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, NY, 13210, USA College of Resources, Environment and Materials; Guangxi University; Nanning 530004; P. R. China 1Division of Hematology, Institute of Optoelectronic Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China. hying@mail.hust.edu.cn Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China CNOOC Energy Tech-Drilling & Production Co., Tianjin 300452, China; CNOOC Energy Technology & Services Limited Key Laboratory for Exploration & Development of Unconventional Resources, Beijing 100029, China Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, NY, USA Biostatistics and Biomathematics Program, Fred Hutchinson Cancer Research Center, Seattle, WA College of Pharmacy, Jinan University, Guangzhou 510632, PR China State Key Laboratory of Optoelectronic Materials and Technologies; School of Physics; Sun Yat-Sen University; Guangzhou 510275; China Department of Gastroenterology, Children’s Hospital of Fudan University, Shanghai, China Jiangsu Key Laboratory for Microbes and Functional Genomics, College of Life Sciences, Nanjing Normal University, 1 Wen Yuan Rd, Nanjing, 210023, China Department of Vascular Surgery, Xuanwu Hospital and Institute of Vascular Surgery, Capital Medical University, Beijing 100053, China State Key Laboratory of Microbial Resources Institute of Microbiology, Chinese Academy of Sciences Beijing 100101 China Key Laboratory for Ultrafine Materials of Ministry of Education; School of Materials Science and Engineering; East China University of Science and Technology; Shanghai 200237; China State Key Laboratory of Environment-friendly Energy Materials, Southwest University of Science and Technology, Mianyang, 621010, P. R. China State Key Laboratory for Infectious Disease Prevention and Control, and National Institute for Communicable Disease Control and Prevention, China CDC, Beijing, PR China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing, PR China Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, 100190 Beijing, China; University of Chinese Academy of Sciences, Beijing 100049, China Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province Guizhou University 550025 Guiyang China School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, Hubei, P. R. China Department of Environmental Science and Engineering, North China Electric Power University, Baoding 071003, PR China Department of Nursing, Zhejiang Cancer Hospital, Hangzhou, China. State Key Laboratory of Microbial Resources, Institute of Microbiology Chinese Academy of Sciences Beijing China College of Agriculture and Forestry Science, Linyi University, Linyi, China State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou 511443, China; College of Pharmacy, Jinan University, Guangzhou 511443, China 1State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, PR China; 2Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, 310003, PR China Institute of New Energy for Vehicles, Shanghai Key Laboratory of Development & Application for Metallic Functional Materials, School of Materials Science and Engineering, Tongji University, Shanghai 201804, China 2Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH The Dermatology Department of the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China The Third Hospital of Kunming City, Kunming 650041, China Division of Hematology The Ohio State University Columbus OH School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, P.R. China Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, 3663 North Zhongshan Rd., Shanghai 200062 China School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China Shanghai Pudong Hospital, Shanghai, China Wuhan Blood Center, Wuhan, Hubei 430000, China Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat‑sen University, Guangzhou, Guangdong 510060, P.R. China Center for Programmable Materials, School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798 Department of Ultrasound, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China Department of Cardiothoracic & Vascular Surgery, Advanced Aortic Research Program at the University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China Department of Cardiovascular Medicine The Second Affiliated Hospital of Nanchang University Nanchang Jiangxi China 1Program of Pharmacogenomics, Department of Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China, Faculty of Medicine, The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China; Guangxi Bossco Environmental Protection Technology Co., Ltd, Nanning, People’s Republic of China Vaccine and Infectious Disease Division Fred Hutchinson Cancer Research Center Seattle WA USA Center for Studies of Information Resources, School of Information Management, Wuhan University, Wuhan, P.R. China; Bioprocessing and Nutrition Sciences, North Carolina State University, Raleigh, North Carolina, USA.; Center for Science, Technology and Education Assessment (CSTEA), Wuhan University, Wuhan, P.R. China; Bioprocessing and Nutrition Sciences, North Carolina State University, Raleigh, North Carolina, USA.; Department of MSI, Centre for R&D Monitoring (ECOOM), KU Leuven, Leuven, Belgium; Bioprocessing and Nutrition Sciences, North Carolina State University, Raleigh, North Carolina, USA. Department of Pharmaceutics, Ernest Mario School of Pharmacy; Rutgers, The State University of New Jersey; Piscataway NJ 08854 USA; Graduate Program in Pharmaceutical Sciences, Ernest Mario School of Pharmacy; Rutgers, The State University of New Jersey; Piscataway NJ 08854 USA From the Gastrointestinal Oncology Service, Departments of Medicine, Biostatistics, and Psychiatry, Memorial Sloan-Kettering Cancer Center, New York, NY. Department of Chemistry, Columbia University, New York, NY 10027 National Key Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Physiology and Ecology (Q.L., Q.Y., Y.L., F.H., Z.S., L.S., Y.F.), and State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology (Y.H.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China Department of Oncology, The Fifth Hospital of Wuhan, Wuhan, Hubei 430050, P.R. China Guangxi Key Laboratory of Transplant Medicine, Institute of Transplant Medicine, 303 Hospital of People’s Liberation Army, Nanning 530021, China Division of Hematology and From the Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (Y.H., L.F.T., M.L.N., R.L.P.); Department of Preventive Medicine, Northwestern University, Chicago, IL (L.V.H.); Department of Preventive Medicine, University of Tennessee Health Sciences Center, Memphis, TN (L.C., F.T.); and Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (Y.M.-R.). The Affiliated Nanjing Drum Tower Hospital; State Key Laboratory of Analytical Chemistry for Life Science; and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, Jiangsu 210008, China The Dermatology Department of the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, China. Vaccine and Infectious Disease and Public Health Science Divisions, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Biostatistics, University of Washington, Seattle, WA 98105, USA State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, People's Republic of China Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province; Guizhou University; Guiyang 550025; P. R. China Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guizhou University, Guiyang, Guizhou 550025, China Department of Gastroenterology, Children’s Hospital, Fudan University, Shanghai, China Tobacco College of Guizhou University, Guiyang 550025, PR China Department of Rehabilitation Medicine, The Second Affiliated Hospital of Nanchang University Nanchang 330006, Jiangxi, China. Ministry of Education Key Laboratory of Child Development and Disorders Key Laboratory of Pediatrics in Chongqing Chongqing International Science and Technology Center for Child Development and Disorders Chongqing Medical University Chongqing China; Respiratory Medicine Children's Hospital of Chongqing Medical University Chongqing China College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China Department of Pathophysiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China Department of Pain Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing 210008 China State Key Laboratory of Oncology in South China, Sun Yat-Sen University, Guangzhou 510060, China; Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China Department of Orthopedics, The Second People’s Hospital of Jingmen, Jingmen, Hubei, China Department of Research & Development, HanX Biopharmaceuticals, Inc, Wuhan, China Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA and Department of Biostatistics, University of Washington, Seattle, WA 98195, USA Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, China. Department of Colorectal Surgery Union Hospital, Fujian Medical University Fuzhou Fujian China Institute of Neuroscience and The Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, P.R. China Department of Neurology, The First Affiliated Hospital, Gannan Medical University Ganzhou, Jiangxi, China. Department of Rheumatology and Immunology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China; Department of Rheumatology and Immunology, The 2nd Hospital Affiliated to Guizhou University of Chinese Traditional Medicine, Guiyang, Guizhou Province, China Jiangsu Province Key Laboratory of Anesthesiology and Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University Xuzhou, China. Renal Division, Department of Medicine Emory University Atlanta Georgia USA; Department of Nephrology The Second Xiangya Hospital of Central South University, Hunan Key Laboratory of Kidney Disease Changsha China Department of Internal Medicine, Division of Hematology b. Department of Hematology and Medical Oncology Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology , Cambridge, MA 02139, USA School of Pharmacy; Jinan University; Guangzhou 510632; P. R. China Institute of Marine Biotechnology and Bio-Resource Utilization, College of Oceanography, Hohai University , Nanjing 210024 , China National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS, USA;; TCM and Ethnomedicine Innovation & Development Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan, China; 3Program in Pharmacogenomics, Department of Pharmacology, The Ohio State University, Columbus, Ohio; and Science and Education Section, Wuhan Hankou Hospital, Wuhan, Hubei, People’s Republic of China College of Pharmacy, Jinan University, Guangzhou 510632, Guangdong, China Xinjiang Key Laboratory of Cardiovascular Disease Research, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, P.R. China; Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, P.R. China Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation & Hunan Provincial Key Laboratory of Cytochemistry, School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha 410114, China The University of North Carolina at Chapel Hill,Department of Radiology and BRIC,USA Biobricks of Microbial Natural Product Syntheses, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute (HKI), Beutenbergstrasse 11a, 07745 Jena, Germany; Faculty of Biological Sciences, Friedrich Schiller University Jena, 07743 Jena, Germany China Military Institute of Chinese Medicine, The Fifth Medical Center of Chinese, PLA General Hospital, Beijing, China Center for Vaccines and Immunology, University of Georgia, Athens, Georgia, USA College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China. Institute of New Energy for Vehicles School of Materials Science and Engineering Tongji University Shanghai 201804 P. R. China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing; Wuhan University of Technology; Wuhan; China State Key Laboratory for Mechanical Behavior of Materials, Frontier Institute of Science and Technology, and Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology Xi'an Jiaotong University Xi'an 710049 P. R. China Linyi University, Linyi, China Guangdong General Hospital Institute of Lung Cancer, Key Laboratory of Translational Medicine, Medical Research Center, Guangdong General Hospital Guangdong Academy of Medical Sciences, Guangzhou 510080, China. Center for Vaccines and Immunology, University of Georgia, Athens, GA, USA School of Public Health, Chengdu Medical College, Chengdu, China Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110122, China CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China. School of Future Technology, University of Chinese Academy of Sciences, Beijing 100094, China. Laboratory for Protein Engineering, Institute ofBiotechnology, Academy of Military Medical Sciences, Beijing 100071, China. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, and ‡College of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, People’s Republic of China Department of Cardiology, the First Affiliated Hospital Sun Yat‐Sen University Guangzhou China Department of Pathophysiology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, Sichuan Province, China. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98122, USA 1Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH Department of Internal Medicine, Division of Hematology, Arthur G. James Comprehensive Cancer Center, State Key Laboratory of Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing 102206, PR China State Key Laboratory of Microbial Resources Institute of Microbiology Chinese Academy of Sciences 100101 Chaoyang District, Beijing P. R. China Environmental Engineering and Science, Department of Chemical and Environmental Engineering, University of Cincinnati, Cincinnati, Ohio 45221, United States Pediatric Inflammatory Bowel Disease Research Center, Department of Gastroenterology Children's Hospital of Fudan University Shanghai China Hubei Key Laboratory of Lipid Chemistry and Nutrition, Key Laboratory of Oil Seed Processing of Ministry of Agriculture, Oil Crops and Lipids Process Technology National and Local Joint Engineering Laboratory, Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences, Wuhan 430062, China Jingzhou Hospital of TCM, Hubei. hy3398@126.com College of Biosystems Engineering and Food Science Zhejiang University Hangzhou 310058 China Divisions of Vaccine and Infectious Disease and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (HJ, MSP, YH); Department of Biostatistics, University of Washington, Seattle, WA (HJ, MSP, YH) State Key Laboratory Oncology in Southern China; Guangzhou People's Republic of China; Department of Radiation Oncology; Cancer Center of Sun Yat-Sen University; Guangzhou People's Republic of China Public Health Science Division, Fred Hutchinson Cancer Center Key Laboratorg for Medical Virology, Ministry of Health, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (IVDC, China CDC), Beijing 102206, China. Hemodialysis Center The First Affiliated Hospital of Soochow University Suzhou China Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center , Seattle , USA; Department of Biostatistics , University of Washington , Seattle , USA Division of Respiratory, Children's Hospital of Chongqing Medical University, Chongqing, China. 9Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts. Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, 410008, Hunan Province, China; Maternal and Child Health Hospital of Hunan Province, Changsha, 410008, Hunan Province, China California Institute for Telecommunications and Information Technology, University of California San Diego, La Jolla, CA, USA Department of Geriatric Dentistry NMPA Key Laboratory for Dental Materials National Engineering Laboratory for Digital and Material Technology of Stomatology Beijing Laboratory of Biomedical Materials Peking University School and Hospital of Stomatology Beijing 100081 China 1Urology and Molecular Genetics and Departments of Department of Dental Public Health Sciences, University of Washington, Seattle, Washington, USA State Key Laboratory of Oncology in South China Department of Radiation Oncology Collaborative Innovation Center for Cancer Medicine Sun Yat‐sen University Cancer Center Guangzhou China; Department of Radiation Oncology Houston Methodist Hospital Houston Texas USA Authors' Affiliations: 1Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington; 2Division of Health Promotion Sciences, Zuckerman College of Public Health, University of Arizona, Tucson, Arizona; 3Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York; 4Department of Preventive Medicine, University of Tennessee Health Sciences Center, Memphis, Tennessee; and 5Department of Public Health Sciences, University of California, Davis, California Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA Senior Department of Hepatology, The Fifth Medical Center of PLA General Hospital, Beijing, China; China Military Institute of Chinese Medicine, The Fifth Medical Center of PLA General Hospital, Beijing, China Division of Hypothalamic Research and Department of Internal Medicine (Y.L., Y.H., T.L., L.G.), The University of Texas Southwestern Medical Center, Dallas, Texas 75390; Department of Cardiology, Shang Hai PuDong New Area People's hospital, Shanghai, China. Department of Rheumatology and Immunology Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine Guiyang China Section of Epidemiology and Biostatistics, School of Population Health University of Auckland Auckland New Zealand Department of Gastroenterology Nanfang Hospital, Southern Medical University Guangzhou China School of Chemistry and Materials Science Huaibei Normal University Huaibei 235000 P. R. China Key Laboratory of Molecular Bio-physics, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China. huangyin588@sina.com.cn The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers The State University of New Jersey 160 Frelinghuysen Road Piscataway NJ 08854 USA Department of Colorectal Surgery Fujian Medical University Union Hospital 29 Xinquan Road 350001 Fuzhou Fujian People's Republic of China 3Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts. State Key Laboratory of Environment‐friendly Energy Materials, National Engineering Technology Center for Insulation Materials Southwest University of Science and Technology Mianyang 621010 P. R. China State Key Laboratory of Oncology in South China, Department of Radiation Oncology, Sun Yat-sen University, Guangzhou 510060, China. chenwei1001@126.com State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China Interdisciplinary Center of Sleep Medicine, Charite-University Berlin, Berlin, Germany Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation, Hunan Provincial Key Laboratory of Cytochemistry, School of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha 410114, China Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA Department of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China Department of Pathology, Fujian Provincial Hospital Fujian Medical University Fuzhou China State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, China School of Chemistry, Chemical Engineering and Life Sciences, School of Materials Science and Engineering Wuhan University of Technology 122 Luoshi Rd Wuhan, Hubei China Department of Ultrasonography, the Fifth People’s Hospital of Suzhou, Suzhou, Jiangsu, People’s Republic of China Laboratories of Chemical Physics and Molecular Biology National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Bethesda, Maryland 20892 Center for Medical Device Standardization Administration of CFDA, Beijing, 100050. Jiangsu Key Laboratory for Microbes and Functional Genomics College of Life Sciences Nanjing Normal University China Center for Molecular Science, CAS Key Laboratory of Colloid, Interfacial and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China From the Georgia Prevention Institute, Department of Population Health Sciences, Medical College of Georgia, Augusta University (L.C., Y.D., Y.H., G.A.H., H.Z.) Beijing Center for Disease Prevention and Control, Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing, China. State Key Laboratory of Microbial Resources,Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PRChina Departments of Ultrasound Department of Pulmonary and Critical Care Medicine, The Fourth Affiliated Hospital of Guangxi Medical University, No. 1, Liushi Road, Liuzhou 545000, China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang, Hangzhou 310006, China; The First Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, Hangzhou 310006, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang, Hangzhou 310006, China Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, PR China; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, PR China Department of Biochemistry and Molecular Biology, The Second Clinical Hospital of Jilin University, Changchun 130041, People's Republic of China Department of Head and Neck Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N., Seattle, WA 98109, USA Department of Biochemistry, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Texas 78284-7760, and Max-Planck-Institut fur Experimentelle Medizin, Hermann-Rein-Strass-3, D-3705 Gottingen, Germany Department of Ultrasound, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China. Departments of Chemical and Screening Sciences, Inflammation, and Protein Technologies, Wyeth Research, 87 Cambridge Park Drive, Cambridge, Massachusetts 02140 Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education of China, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China. College of Pharmacy, Western University of Health Sciences, Pomona, California. School of Materials Science and Engineering Shanghai Jiao Tong University Shanghai 20024 P. R. China Charité - Universitätsmedizin Berlin, Interdisciplinary Sleep Medicine Center, Berlin, Germany. ying.huang@charite.de. Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China Center for Programmable Materials School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Avenue Singapore 639798 Singapore Department of Neurology, Guangdong Second Provincial General Hospital, Guangzhou, China College of Chemical Engineering, Sichuan University, Chengdu 610065, PR China Department of Neurology, Shenzhen People’s Hospital, The Second Clinical Medical College of Jinan University, Shenzhen, China Department of Head and Neck Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers The State University of New Jersey Piscataway NJ 08854 USA; Graduate Program in Pharmaceutical Science, Ernest Mario School of Pharmacy, Rutgers The State University of New Jersey Piscataway NJ 08854 USA College of Pharmacy, Jinan University, Guangzhou 510006, China School of Pharmacy, Shanghai Jiao Tong University Department of Head and Neck Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China. Laboratory for Conservation and Utilization of Bio-Resources, Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming 650091, China; School of Life Sciences, Yunnan University, Kunming 650091, China Department of Pharmaceutics, China Pharmaceutical University, Jiangsu 210009, P. R. China Department of Operating Theatre, Zhejiang Cancer Hospital No.38 Guangji Road, Banshan Bridge, Hangzhou 310022, China. Department of Central Laboratory, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, Suzhou 215008, China Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, 20892-2753 Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, P.R. China Department of Respiration Third Affiliated Hospital of Zunyi Medical University Zunyi China Department of Radiation Oncology Sun Yat‐Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine Guangzhou China Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China Department of Hematology, The First Affiliated Hospital, Kunming Medicine College, Kunming 650031, China. From the Departments of Cellular and Molecular Medicine, Lerner Research Institute (J.A.D., Y.H., K.A., G.G., V.G., P.L.F., W.H.W.T., J.D.S., S.L.H.), Cardiovascular Medicine, Heart, and Vascular Institute (W.H.W.T., J.D.S., S.L.H.), and Molecular Cardiology, Lerner Research Institute (E.F.P.), Cleveland Clinic, Cleveland, OH; Department of Medicine, New York University, New York, NY (O.E.-O., E.A.F.); and Departments of Chemistry (G.G., V.G., S.L.H.) and Mathematics (Y.W.), Cleveland State... Department of Pathology, The Second Affiliated Hospital, Xi’an JiaoTong University, Xi’an, Shaan’xi Province, China Department of Rheumatology and Immunology, Affiliated to Guizhou University of Chinese Traditional Medicine, Guiyang, Guizhou Province, China Department of Urology, Xuanwu Hospital Capital Medical University, Beijing, China The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University Wenzhou 325027, China. 2Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Department of Applied Chemistry; School of Science; Northwestern Polytechnical University; Xi'an, P.R. China; Key Laboratory of Space Applied Physics and chemistry School of Applied Chemistry and Engineering University of Science and Technology of China Hefei Anhui 230026 China Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China Department of Colorectal Surgery Fujian Medical University Union Hospital Fuzhou Fujian PR China Department of Otolaryngology-Head and Neck Surgery, the Hospital of Luzhou Medical College, Luzhou, 646000, China. hy11485@sohu.com College of Pharmacy, Jinan University, Guangzhou, Guangdong, P. R. China; Department of Microbiology and Molecular Genetics, UMDNJ-New Jersey Medical School, Newark, New Jersey, USA College of Aeronautical Engineering, Taizhou University, Taizhou, P. R. China;; Sorbonne University, Pierre and Marie Curie University, Paris 6, Institut Jean le Rond d'Alembert, CNRS UMR 7190, Case 162, Paris Cedex 05, France Department of Gastroenterology General Hospital of Ningxia Medical University Yinchuan China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. College of Chemistry & Chemical Engineering; Yangzhou University; Yangzhou 225002; China; College of Medicine Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium School of Forestry, Northeast Forestry University, 26 Hexing Road, Harbin 150040, China School of Materials Science and Engineering Shanghai Jiao Tong University Shanghai 200240 P. R. China Department of Gastroenterology, Pediatric Inflammatory Bowel Disease Research Center, Children’s Hospital of Fudan University, Shanghai, China Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation; Changsha University of Science and Technology; Changsha; China College of Resources and Environmental, Hunan Agricultural University, Changsha, China State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences. No. 1 Beichenxi Road, Chaoyang District, Beijing, P. R. China Marketing Department Cyagen Biosciences (Guangzhou) Inc Guangzhou China |
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