http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_b8b85ccd860354c5b7bc7db912483076
Outgoing Links
Predicate | Object |
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family-name | Li Yun Li |
name | Yun Li |
given-name | Yun |
organization-name | Department of Environmental Sciences, Rutgers University, 14 College Farm Road, New Brunswick, New Jersey 08901, United States Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Research Center of TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China Department of Thoracic Surgery People’s Hospital of Peking University No. 11 Xizhimen South Street, Xicheng District 100044 Beijing People’s Republic of China Department of Otolaryngology Head and Neck Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University; Ear Institute, Shanghai Jiaotong University School of Medicine; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China University of North Carolina, Chapel Hill, NC; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA Department of Genetics, Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599 Test Center for Feed Quality Supervision and Inspection (Chengdu) of the Ministry of Agriculture, Chengdu, Sichuan, China Department of Haematology Affiliated People's Hospital of Jiangsu University Zhenjiang China Nanjing Maternity and Child Health Care Institute Nanjing Maternity and Child Health Care Hospital Obsterics and Gynecology Hospital Affiliated to Nanjing Medical University Nanjing 210004 China Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, the First Affiliated Hospital, and Collaborative Innovation Center of Hematology and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, China Key Laboratory of Molecular Biophysics of the Ministry of Education College of Life Science and Technology Huazhong University of Science and Technology Wuhan China Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing, China From the Department of Neurobiology (F.B., R.P.S., Y.L., A.Z.), and Clinical Research Center (J.W.), Morehouse School of Medicine, Atlanta, GA; Marcus Stroke and Neuroscience Center, Grady Memorial Hospital, Atlanta, GA (R.P.S., M.F.); Department of Biochemistry, Oregon Health Science University, Portland (L.D.); and Department of Neurology, Emory University, Atlanta, GA (C.L.H., M.F.). Department of Biostatistics, Epidemiology & Informatics Perelman School of Medicine of the University of Pennsylvania Philadelphia Pennsylvania USA; Department of Pediatrics Perelman School of Medicine of the University of Pennsylvania Philadelphia Pennsylvania USA School of Medicine and Pharmacy Ocean University of China Qingdao Shandong China; Laboratory for Marine Drugs and Bioproducts Qingdao National Laboratory for Marine Science and Technology Shandong China Department of Hematology, Central Laboratory, Jiangsu University People's Hospital, Zhenjiang 212002, Jiangsu Province, China. The National Engineering Laboratory for Advanced Municipal Wastewater Treatment and Reuse Technology, Beijing University of Technology, Beijing 100124, China Department of Obstetrics and Gynecology, The Affiliated Cixi Hospital, Wenzhou Medicine University, Cixi, Zhejiang 325000, P.R. China Institute of Human Genetics University of Cologne Cologne Germany; Center for Molecular Medicine Cologne (CMMC) University of Cologne Cologne Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging‐Associated Diseases (CECAD) University of Cologne Cologne Germany Laboratoire de Chimie des Processus Biologiques, UMR 8229 CNRS Collège de France, Université Paris Sorbonne 11 Place Marcelin Berthelot 75231 Paris Cedex 05 France Department of Psychiatry (Guintivano, Bauer, Watson, Krohn, Rubinow, Meltzer-Brody, Sullivan), Department of Genetics (Raffield, Li, Sullivan), and Department of Biostatistics (Li), University of North Carolina at Chapel Hill; Child Health Research Centre (Byrne, Kiewa), Institute for Molecular Bioscience (Byrne, Walker), Frazer Institute (Olsen), School of Public Health (Whiteman), and Queensland Brain Institute (Wray), University of Queensland, Brisbane, Australia; Department of Medical Epidemiology... Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7420;; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7264; and Laboratory for Marine Drugs and Bioproducts Pilot National Laboratory for Marine Science and Technology (Qingdao) Qingdao 266237 China; Key Laboratory of Marine Drugs of Ministry of Education Shandong Key Laboratory of Glycoscience and Glycotechnology School of Medicine and Pharmacy Ocean University of China Qingdao 266003 China Department of Ophthalmology, China-Japan Union Hospital, Jilin University, Changchun 130033 Jilin, China. Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Genetics, University of North Carolina at Chapel Hill, NC 27599, USA Research Center of Rural Vitalization, Hebei Normal University of Science and Technology, Qinhuangdao, China Department of Marine Biology, College of Marine Life Science, Ocean University of China, 5 Yushan Road, Qingdao 266003, Peoples Republic of China. Department of Nephrology, HuaShan Hospital, Fudan University, Shanghai, P.R. China School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore College of Chemistry and Food Science, Yulin Normal University, Yulin, China Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Department of Molecular Nutrition (I.N., Y.L., I.L., F.D.), Christian-Albrechts-University of Kiel, 24118 Kiel, Germany National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China; Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Suzhou University, Suzhou, China; Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, China School of Public Health, North China University of Science and Technology, Tangshan, China. From the Sleep Medicine Center, Mental Health Center, Translational Neuroscience Center, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China (Y.L., Y.S., J.Z., R.R., T.L., X.T.) and Department of Psychiatry, Sleep Research and Treatment Center, Pennsylvania State University College of Medicine, Hershey (Y.L., A.N.V., J.F.-M., E.O.B.). Department of Thoracic Surgery, Peking University People's Hospital, Beijing 100044, China. The State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, China School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore Institute of Cardiovascular Sciences, St. Boniface Research Center, 351 Taché Avenue, Winnipeg, MB R2H 2A6, Canada. MRL, Merck & Co., Inc. Kenilworth New Jersey USA Department of Immunology, The University of Texas Southwestern Medical Center Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China Department of Traditional Chinese Medicine, Dezhou People’s Hospital, Dezhou, P.R. China Department of Geriatrics Xuanwu Hospital Capital Medical University China National Clinical Research Center for Geriatric Medicine Beijing China Ningbo Yunmi Biological Science and Technology Co., Ltd Zhejiang China Department of Thoracic Surgery, Peking University People’s Hospital , Beijing, China The Affiliated Children's Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China. yunlee6610@yahoo.com.cn State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China, and CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China School of Chemistry Beihang University Beijing 100191 P. R. China Key Laboratory of Mariculture (Ocean University of China) , Ministry of Education, , Qingdao , P. R. China; Ocean University of China , Ministry of Education, , Qingdao , P. R. China Department of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing 100053, P.R. China Dept. of Mechanical Engineering The Hong Kong Polytechnic University Hung Hom Hong Kong Anticoagulation Clinic, Wuhan Asia Heart Hospital, Wuhan, 430022, China; Nursing Department, Wuhan Asia Heart Hospital, Wuhan, 430022, China Department of Anesthesiology Tianjin Medical University General Hospital Tianjin China; Tianjin Institute of Anesthesiology Tianjin China Department of Genetics,; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, NY, USA; Department of Urology, Roswell Park Cancer Institute, Buffalo, NY, USA Collaborative Innovation Center of Advanced Microstructures, Jiangsu Provincial Key Laboratory of Photonic and Electronic Materials, School of Electronic Science and Engineering, Nanjing University, Nanjing 210093, China China Novartis Institutes for BioMedical Research Co. Ltd., Building 8, lane 898 Halei road, Shanghai 201203, China, and Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China Laboratoire de Chimie des Processus Biologiques UMR CNRS 8229 Collège de France-CNRS-Sorbonne Université PSL Research University 11 Place Marcelin Berthelot 75005 Paris France 1 Bioinformatics Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, 2SCBIT-Inforsense Joint Lab, Shanghai Center for Bioinformation Technology, 100 Qinzhou Road, Shanghai 200235, 3Life Science and Technology College of Shanghai Jiao Tong University, Shanghai and 4School of Life Sciences, Fudan University, Shanghai 200433, China Department of Otolaryngology Head & Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, China Intensive Care Unit, Jinan Central Hospital Affiliated to Shandong University, Jinan, P.R. China Department of Geriatrics, Xuanwu Hospital Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan 430070, P. R. China; Rizhao Biomedicine and New Materials Research Institute Of Wuhan University of Technology, 276826, P. R. China Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602-5700 Department of Genetics University of North Carolina Chapel Hill North Carolina; Department of Biostatistics University of North Carolina Chapel Hill North Carolina; Department of Computer Science University of North Carolina Chapel Hill North Carolina Department of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China. liyun0124@126.com School of Chinese Pharmacy Beijing University of Chinese Medicine Beijing 100102 China School of Chemistry & Chemical Engineering; South China University of Technology; Guangzhou 510640; China Hematology Department Daqing Oil Field General Hospital Daqing China Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Zhejiang, China Kindstar Global Precision Medicine Institute , Gaoxin 2nd Road, Jiangxia District, Wuhan, Hubei 43000 , China; Department of Scientific Research Project, Wuhan Kindstar Medical Laboratory Co., Ltd. , Guanggu Biological City, No. 666 Gaoxin Avenue, Hongshan District, Wuhan, Hubei 43000 , China BGI‐Shenzhen Shenzhen China; China National Genebank‐Shenzhen, BGI‐Shenzhen Shenzhen China Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen 518036, China Department of Ophthalmology, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin, China. Pediatric IDEAS Research Group of the Center for Pediatric Clinical Effectiveness Children’s Hospital of Philadelphia Philadelphia Pennsylvania USA; Department of Pediatrics Perelman School of Medicine of the University of Pennsylvania Philadelphia Pennsylvania USA; Department of Biostatistics, Epidemiology and Informatics Perelman School of Medicine of the University of Pennsylvania Philadelphia Pennsylvania USA Respiratory Drugs Laboratory of State Food and Drug Administration of China, College of Medicine, Zhejiang University, Hangzhou 310031, China. From the Department of Genome Dynamics (I.K., H.H., K.W.C.), Institute of Molecular Genetics of the Czech Academy of Sciences, Czech Republic; Genome Damage and Stability Centre (H.H., K.W.C.), School of Life Sciences, University of Sussex, Falmer, Brighton, UK; Institute of Human Genetics (Y.L., B.W., G.Y.), University Medical Center Göttingen, Germany; Cologne Center for Genomics (J.A.), University of Cologne, Germany; Institute of Cancer and Genomic Sciences (J.J.R., G.S.S.), College of Medical... Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles Laboratory of Lighting and Physio‐psychological Health, School of Psychology South China Normal University Guangzhou China International Joint Research Center for Biomass Materials, Southwest Forestry University, Kunming 650224, China Department of Preventive Medicine, North China Coal Medical University, Tangshan, China. liyun8022@163.com CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology; Chinese Academy of Sciences; Beijing China Department of Pediatrics Hunan Provincial People's Hospital The First Affiliated Hospital of Hunan Normal University Changsha Hunan China Department of Infectious Disease Linyi Central Hospital Linyi China Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China Department of Chemistry and Biochemistry, Queens College-CUNY, Flushing, New York 11367, United States Department of Neurology, Xuanwu Hospital Capital Medical University Beijing China National Engineering Laboratory for Tree Breeding College of Biological Sciences and Technology Beijing Forestry University Beijing 100083 China; Key Laboratory for Genetics and Breeding in Forest Trees and Ornamental Plants Ministry of Education College of Biological Sciences and Technology Beijing Forestry University Beijing 100083 China The First Affiliated Hospital of Wenzhou Medical University Wenzhou China Key Laboratory of Radiopharmacokinetics for Innovative Drugs, Chinese Academy of Medical Sciences, and Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China Laboratoire de chimie et biochimie pharmacologiques et toxicologiques (CNRS UMR8601), Université René Descartes, 45 rue des Saints Pères, 75270 Paris Cedex 06, France, Laboratoire de chimie inorganique et matériaux moléculaires (CNRS UMR7071), Université Pierre et Marie Curie, 4 place Jussieu, 75252 Paris Cedex 05, France, and Laboratoire de chimie de coordination du CNRS, UPR 8241, 205 route de Narbonne, 31077 Toulouse Cedex 04, France The Third Central Clinical College of Tianjin Medical University Tianjin China Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions, High Magnetic Field Laboratory, HFIPS, Chinese Academy of Sciences, Hefei 230031, Anhui, P. R. China; Department of Materials Science and Engineering, ARC Centre of Excellence in Future Low-Energy Electronics Technologies (FLEET), Monash University, Clayton, Victoria 3800, Australia University of Michigan Department of Thoracic Surgery People’s Hospital of Peking University No. 11, Xizhimen South Street, Xicheng District 100044 Beijing China Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.; Department of Biostatistics, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA. College of Chmistry&Chemical Engineering, Yantai University, Yantai, China Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, First Affiliated Hospital and Collaborative Innovation Center of Hematology, Soochow University, Suzhou 215123, China; Beijing Center for Disease Control and Prevention, Beijing 100013, People’s Republic of China Capital Medical University, Department of Public Health and Domestic Medicine, Beijing 100069, People’s Republic of China Department of Immunobiology, Jinan University, Guangzhou, Guangdong, China Department of Biostatistics, Epidemiology and Informatics University of Pennsylvania Philadelphia Pennsylvania U.S.A.; Department of Pediatrics, Children's Hospital of Philadelphia University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania U.S.A.; University of Pennsylvania Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania U.S.A. Departments of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY, USA; Urology, Roswell Park Cancer Institute, Buffalo, NY, USA Department of Endocrinology and Metabolism, West China Hospital Sichuan University Chengdu China; Department of Endocrinology and Metabolism Deyang People's Hospital Deyang China Department of Hematology, Affiliated People's Hospital of Jiangsu University, Zhenjiang, People's Republic of China. Department of Neurology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing 100053, P. R. China. dayuwei100@hotmail.com. Department of Nutrition, Food Hygiene and Toxicology, West China School of Public Health, Sichuan University, Chengdu, Sichuan, PR China. liyun_611@163.com. Healthy Food Evaluation Research Center, Sichuan University, Chengdu, Sichuan, PR China. Key Laboratory of Marine Drugs (Ocean University of China) Ministry of Education and School of Medicine and Pharmacy (S.J., L.L., Y.Liu, J.Z., Y.Li), Ocean University of China, Qingdao, Shandong 266003, China; Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Zhengzhou Road 53, Qingdao 266042, China Department of Pharmaceutical Analysis, Shenyang Pharmaceutical University, Shenyang, PR China The Fish Molecular Genetics and Biotechnology Laboratory, Aquatic Genomics Unit, School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, Auburn, Alabama Zhejiang University of Technology Department of Pharmaceutical Analysis School of Pharmacy Shenyang Pharmaceutical University Shenyang PR China Department of Otolaryngology – Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China; Department of Chemistry, School of Science, Xihua University, Chengdu 610039, China Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021, Shandong, China. Department of Obstetrics and Gynecology, Weihai Municipal Hospital Weihai 264200, Shandong, China. 1 Department of Biostatistics,; 2 Department of Genetics,; 3 Department of Computer Science, State Key Laboratory of Heavy Oil Processing; China University of Petroleum; Beijing; China Sleep Medicine Center, Shantou University Medical College, Shantou, China; Shantou University Mental Health Center, Shantou University Medical College, Shantou, China Departments of Genetics, Biostatistics, and Computer Science, University of North Carolina, Chapel Hill, NC; Shanghai Research Center for Modernization of Traditional Chinese Medicine; National Engineering Laboratory for TCM Standardization Technology; Shanghai Institute of Materia Medica; Chinese Academy of Sciences; Shanghai 201203 Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China The Second Hospital Affiliated to Nanchang University, Nanchang 330006, Jiangxi Province, China. Institute of Tropical Medicine Guangzhou University of Chinese Medicine Guangzhou China University of Maryland School of Medicine From the Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (H.Q., Y.L., Z.X., A.K., H.W.); Department of Anesthesiology, The Eye Ear Nose and Throat Hospital of Fudan University, Shanghai, People’s Republic of China (H.Q., W.L.); Department of Pain Medicine, Provincial Hospital Affiliated with Shandong University, J State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China; CAS Center for Excellence in Deep Earth Science, Guangzhou 510640, China Department of Operative and Endodontics, Faculty of Stomatology, Capital University of Medical Sciences, Beijing 100050, China. liyun-prc@263.net Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA Department of Endocrinology, Shanxi Yuncheng Central Hospital, Yuncheng, China Division of Endocrinology, Diabetes, and Metabolism, Departments of Medicine and Genetics, and The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 Department of Otolaryngology Head and Neck Surgery,the Second Hospital of Shanxi Medical University. 1 Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, 48109 and 2Department of Genetics, Department of Biostatistics, University of North Carolina; 1 Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, 48109 and 2Department of Genetics, Department of Biostatistics, University of North Carolina Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: yunli@med.unc.edu. West China School of Public Health and Healthy Food Evaluation Reasearch Center, Sichuan University, Chengdu 610041, China. The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China The Key Laboratory of Mariculture, Ministry of Education Ocean University of China Qingdao China The State Key Laboratory of Translational Medicine and Innovative Drug Development, Jiangsu Simcere Diagnostics Co., Ltd. Nanjing China Department of Biostatistics, The University of North Carolina at Chapel Hill , Chapel Hill, NC 27599, USA; Department of Genetics, The University of North Carolina at Chapel Hill , Chapel Hill, NC 27599, USA; Department of Computer Science, The University of North Carolina at Chapel Hill , Chapel Hill, NC 27599, USA Department of Genetics, Department of Biostatistics, Department of Computer Science (Y.L.), University of North Carolina, Chapel Hill. Key Laboratory of Marine Drugs (Ocean University of China), Chinese Ministry of Education, and School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao, Shandong 266003, China From the Duke Clinical Research Institute, Durham, North Carolina. Departments of Genetics, Biostatistics and Computer Science at the University of North Carolina at Chapel Hill, NC 27599, USA State Key Laboratory of Military Stomatology, National Chinical Research Center for Oral Disease, Shannxi Clinical Research Center for Oral Disease, Department of Oral and Maxilofacial Surgery School of Stomatology, Fourth Military Medical University Xi’an China Department of Thoracic Surgery, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China College of Resource & Environment Sichuan Agricultural University Chengdu 611130 China 1 Department of Biostatistics; 2 Department of Genetics; 3 Department of Computer Science Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390; and Department of Pediatrics, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha 410005,China Department of Physiology and Pathophysiology, School of Basic Medicine; Institute of Brain Science and Disease, Qingdao University, Qingdao 266071, China. State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China KU Leuven; Centre for Surface Chemistry and Catalysis; 3001 Leuven; Belgium Otorhinolaryngology Hospital, The First Affiliated Hospital Sun Yat‐sen University Guangzhou China School of Electronic Science and Engineering and Jiangsu Provincial Key Laboratory of Photonic and Electronic Materials, Nanjing University, Nanjing, 210093, People’s Republic of China; International Center for Materials Nanoarchitectronics(WPI-MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan Department of Rehabilitation Medicine, The Third Affiliated Hospital of Nanchang University, Nanchang, China; Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USA; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA; Department of Computer Science, University of North Carolina, Chapel Hill, NC, USA Department of Pediatrics, Hunan People's Hospital, Changsha, China. liyunpd@163.com Department of Critical Care Medicine, Chinese PLA General Hospital, Beijing 100853, China Key Laboratory for NeuroInformation of Ministry of Education, High‐Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Psychiatry and Psychology, School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China 610054; School of Management Chengdu University of Traditional Chinese Medicine Chengdu China 611137 Institute of Human Genetics University Medical Center Göttingen Göttingen Germany Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, P.R. China. Radionuclide Diagnosis and Treatment Center, Beijing Nuclear Industry Hospital, Beijing 102413, China Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Department of OtolaryngologyHead and Neck Surgery,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine. Laboratory of Virology and Pharmocology, College of Life Science and Bio-engineering, Beijing University of Technology, Beijing 100052, China. Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 Department of General Surgery, Jingmen First People's Hospital Jingmen, Hubei Province, China. Department of General Practice, West China Hospital, Sichuan University, Chengdu 610041, China. Institute of Clinical Pharmacology, Peking University, Beijing, China Department of Neurology, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Chongqing, China Department of Biostatistics,; Department of Genetics, and; Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; From the Sleep Medicine Center, Department of Respiratory and Critical Care Medicine, Translational Neuroscience Center, State Key Laboratory, West China Hospital, Sichuan University, Chengdu, China (R.R., L.Y., Y.L., Y.Z., J. Zhou, L.T., T.L., X.L., Y.W., W.L., X.T.); Sleep Medicine Center, Shantou University Medical College, China (Y.L.). School of Food Science and Engineering; Jiangxi Agricultural University; Nanchang 330045; P.R. China Department of Immunology, Capital University of Medical Sciences, Beijing 100069, China. ly23338@sohu.com Guangdong Procapzoom Biosciences Inc., Guangzhou, Guangdong Province, China Department of Biology Woods Hole Oceanographic Institution Woods Hole Massachusetts; College of Marine Science University of South Florida St. Petersburg Florida National Engineering Laboratory for Tree Breeding, Key Laboratory of Genetics and Breeding in Forest Trees and Ornamental Plants, Ministry of Education, College of Biological Sciences and Technology, Beijing Forestry University, No. 35, Qinghua East Road, Beijing 100083, China School of Chemistry and Chemical Engineering, Yantai University, Yantai, PR China Shijiazhuang Livestock Products Quality Inspection and Supervision Center, Shijiazhuang, Hebei, People's Republic of China Department of Radiology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, China. National Laboratory of Solid State Microstructures, School of Electronic Science and Engineering, and Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210093, China. School of Biological and Food Processing Engineering Huanghuai University Zhumadian China State Key Laboratory of Biocontrol College of Ecology and Evolution School of Life Sciences Sun Yat‐Sen University Guangzhou 510006 Guangdong Province China State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China Key Laboratory of Molecular Biophysics of Ministry of Education College of Life Science and Technology and the Collaborative Innovation Center for Brain Science Huazhong University of Science and Technology Wuhan China International Therapeutics, Seattle, Washington 98122 Department of Radiology, Clinical Medical College, The First Affiliated Hospital of Yangtze University, Hubei Province; and Department of Pathology and Laboratory Medicine University of British Columbia Vancouver Canada Department of Pharmaceutics, University of Washington, Seattle, Washington, USA Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA Institute of Human Genetics University Medical Center Göttingen Germany Shenzhen Academy of Metrology and Quality Inspection, Shenzhen 518102, People’s Republic of China Nanjing Maternal and Child Health Medical Institute Nanjing Maternity and Child Health Care Hospital Women's Hospital of Nanjing Medical University China Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia; Pediatric IDEAS Research Group of the Center for Pediatric Clinical Effectiveness, Children’s, Phildelphia Division of Immunology; and Division of Information Sciences, Beckman Research Institute of the City of Hope, Duarte, California 91010 Key Laboratory of Separation Sciences for Analytical Chemistry; Dalian Institute of Chemical Physics, Chinese Academy of Sciences; Dalian China Department of Developmental Biology and Kent Waldrep Center for Basic Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, TX 75390; and Department of Thoracic Surgery, Center for Mini-Invasive Thoracic Surgery, People’s Hospital, Peking University, Beijing, China National Key Facility for Crop Gene Resources and Genetic Improvement, Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China; Shanghai Minhang Maternal and Children Health Care Hospital Shanghai China Department of Respiratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. E-mail: liyun.welcom@163.com. From the IMBA (V.N., T.-P.P., P.M., A.K., I.K., R.N., J.M.P.), Institute of Molecular Biotechnology of the Austrian Academy of Sciences, VBC—Vienna BioCenter Campus, Austria; Department of Medical Genetics (J.M.P.), Life Science Institute, University of British Columbia, Vancouver, Canada; Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (V.N., E.L.), Vienna, Austria; Section for Functional Genetics at the Institute of Human Genetics (R.H., F.J.K.), University of Lübeck; German Center... Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599; Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599 School of Chemistry and Food Science, Yulin Normal University, Yulin 537000, China Department of Intensive Care Unit, Jinan Central Hospital, Cheeloo College of Medicine, Shandong University , Jinan 250013 , People's Republic of China Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University, College of Medicine, Penn State Hershey Medical Center, Hershey, PA Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Research Center of TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People’s Republic of China Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor Institute of Materials, China Academy of Engineering Physics 2 , No. 9, Huafengxincun, Jiangyou, Sichuan 621908, China Department of Cardiology, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China. Department of Ophthalmology, The Second Xiangya Hospital of Central South University, Changsha, China; Hunan Clinical Research Center of Ophthalmic Disease, Changsha, China Department of Genetics, Department of Biostatistics, Department of Computer Science, University of North Carolina, Chapel Hill, NC, USA Department of Geriatrics, Key Laboratory on Neurodegenerative Disease of Ministry of Education, Beijing Geriatric Healthcare Center, Xuanwu Hospital, Beijing Institute of Geriatrics, Beijing Institute for Brain Disorders, China National Clinical Research Center for Geriatric Disorders Capital Medical University Beijing China Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA Department of Thoracic Surgery , Center of Thoracic Mini-invasive Surgery, , Beijing , China; Peking University People’s Hospital , Center of Thoracic Mini-invasive Surgery, , Beijing , China Department of Sleep Medicine, Shantou University Mental Health Center Shantou University Medical College Shantou Guangdong Province China Department of Electrical and Computer Engineering, Rice University, Houston, Texas 77005, United States Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9148, USA Faculty of Architectural, Civil Engineering and Environment, Ningbo University, Ningbo 315211, China. Department of Respiratory Medicine, The 309th Hospital of People's Liberation Army Department of Otolaryngology Head and Neck Surgery, Shandong Provincial Hospital, Jinan, PR China; West China Hospital/West China School of Nursing Sichuan University Chengdu China The Central Laboratory and Medical Genetics & Molecular Diagnostic Center, The First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen Second People's Hospital, Shenzhen 518035, China Department of Biostatistics, Epidemiology, and Informatics University of Pennsylvania Philadelphia PA USA China Novartis Institutes for BioMedical Research Co.,Ltd. Department of Urology, The Fifth Hospital of Wuhan, Wuhan, Hubei 430050, P.R. China Department of Anesthesiology, Chifeng Municipal Hospital, Chifeng Clinical Medical College of Inner Mongolia Medical University, Chifeng Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Hunan Normal University, Hunan Provincial People’s Hospital, Changsha, P. R. China Infectious Disease Department, Linyi Central Hospital, Shandong Province, China, 276400 Research & Development Centre, Infinitus (China) Company Ltd., Guangzhou, Guangdong 510663, P. R. China Department of Evidence Based Medicine and Division of Population Genetics, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Department of Oncology, NHC Key Laboratory of Cancer Proteomics, State Local Joint Engineering Laboratory for Anticancer Drugs, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China Sleep Medicine Center Shantou University Medical College Shantou China; Mental Health Center Shantou University Medical College Shantou China Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China Department of Pharmaceutics, China Pharmaceutical University, Nanjing, China Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Biostatistics, University of North Carolina Gillings School of Global Public Health, Chapel Hill, North Carolina; Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China. Department of Ophthalmology, Second Xiangya Hospital, Central South University, Changsha 410011, China. yunli0904@yahoo.com.cn State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, Fourth Military Medical University, Xincheng, Xi'an, Shaanxi, China Nanjing Maternity and Child Health Care Institute Nanjing Maternity and Child Health Care Hospital, Obsterics and Gynecology Hospital Affiliated to Nanjing Medical University Nanjing China Environmental Engineering Research Centre, Department of Civil Engineering, The University of Hong Kong, Pokfulam, Hong Kong, China Department of Cardiology, Shanghai Children’s Hospital, Shanghai Jiao Tong University, 355 Lu Ding Road, Shanghai 200062, China Department of Otolaryngology Head and Neck Surgery, Sino-French Joint Clinic Research Center on Otology and Neuro-Otology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University; Ear Institute, Shanghai Jiaotong University School of Medicine; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases (14DZ2260300), Shanghai, China Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, and Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing 210023, China Department of Nephrology, Jiangxi Provincial People’s Hospital, Nanchang, China Sleep Medicine Center, Translational Neuroscience Center, Department of Otolaryngology, West China Hospital, Sichuan University, Chengdu City, Sichuan Province, China Department of Neurology, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. Centre for Lipid Research & Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. School of Electronic Science and Engineering Nanjing University Nanjing 210046 China Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China Department of Physiology, School of Basic Medical Sciences, Shandong Second Medical University, Weifang 261021, Shandong, China. Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, People's Republic of China Institute of Tissue Transplantation and Immunology, Department of Immunobiology Jinan University Guangzhou Guangdong China Tianjin Key Laboratory of Digestive Diseases, Department of Gastroenterology and Hepatology, Tianjin Institute of Digestive Diseases, National Key Clinical Specialty, General Hospital, Tianjin Medical University, Tianjin 300052, China; Department of Pharmacy, General Hospital, Tianjin Medical University, Tianjin 300052, China The State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University 730000 P. R. China Institute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Kunming, China Whitehead Institute for Biomedical Research, Cambridge, MA 02142; Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian China Department of Anesthesiology and Center for Shock Trauma and Anesthesiology Research (STAR), University of Maryland School of Medicine Baltimore Maryland USA Nanjing Maternal and Child Health Medical Institute Nanjing China Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599, USA. HuidaGene Therapeutics Co. , Ltd., Shanghai 200131 , China Department of Genetics University of North Carolina Chapel Hill North Carolina United States of America; Department of Biostatistics University of North Carolina Chapel Hill North Carolina United States of America; Department of Computer Science University of North Carolina Chapel Hill North Carolina United States of America Department of Neurobiology and Beijing Institute for Brain Disorders Capital Medical University Beijing China Laboratoire de Chimie des Processus Biologiques, UMR 8229, Collège de France/CNRS/Sorbonne Université, 11 place Marcellin-Berthelot, 75231 Paris, France Merchant Marine College, Shanghai Maritime University, Shanghai 201306, China; Shanghai High-level Local University Innovation Team (Maritime Safety & Technical Support), Shanghai 201306, China Department of Dermatology, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100070, China; Department of Dermatology, Chinese Academy of Medical Sciences, Peking Union Medical College, Peking Union Medical College Hospital, Beijing 100730, China Single‐Cell Center CAS Key Laboratory of Biofuels Shandong Key Laboratory of Energy Genetics and Shandong Institute of Energy Research Qingdao Institute of BioEnergy and Bioprocess Technology Chinese Academy of Sciences Qingdao 266101 China; Qingdao National Laboratory of Marine Science and Technology Qingdao 266237 China; University of Chinese Academy of Sciences Beijing 100049 China Department of Nephrology, Huashan Hospital of Fudan University, Shanghai, PR China Laboratoire de Chimie des Processus Biologiques, UMR 8229 CNRS, Collège de France, Université Paris 6, 11 Place Marcelin Berthelot, 75231 Paris Cedex 05, France Nanjing Maternal and Child Health Institute The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University (Nanjing Maternity and Child Health Care Hospital) Nanjing China Key Laboratory of Fishery Drug Development, Ministry of Agriculture and Rural Affairs, Guangdong Provincial Key Laboratory of Aquatic Animal Immunology and Sustainable Aquaculture, Pearl River Fisheries Research Institute Chinese Academy of Fishery Sciences Guangzhou China; Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City and Aquaculture Engineering Technology Research Center, College of Fisheries Southwest University Chongqing China From the Department of Neurology (Y.L.), Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, China; and Department of Neurosurgery (S.Z.), West China Hospital of Sichuan University. Department of Thoracic Surgery Peking University People's Hospital Beijing China Institute of Pharmaceutical Biotechnology and The First Affiliated Hospital Department of Radiation Oncology Zhejiang University School of Medicine Hangzhou China Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan 250021 PR China; Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan 250021 PR China 1 Faculty of Kinesiology, University of Calgary, Calgary, AB T2N1N4, Canada, 2Department of Biostatistics, 3Department of Genetics, University of North Carolina, Chapel Hill, NC 27599-7264, 4Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109 and 5Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599-7264, USA; 1 Faculty of Kinesiology, University of Calgary, Calgary, AB T2N1N4, Canada, 2Department of Biostatistics, 3Department of Genetics, University of North Carolina, Chapel Hill, NC 27599-7264, 4Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109 and 5Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599-7264, USA; 1 Faculty of Kinesiology, University of Calgary, Calgary, AB T2N1N4, Canada, 2Department of Biostatistics, 3Department of Genetics, University of North Carolina, Chapel Hill, NC 27599-7264, 4Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109 and 5Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599-7264, USA *Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, People’s Republic of China; School of Physics and Electronic Engineering Hanshan Normal University Chaozhou 521041 P. R. China Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Centre National de la Recherche Scientifique UMR8601, Université Paris Descartes, 75270 Paris, France; Infinitus (China) Company Ltd; Guangzhou; People's Republic of China Tianjin Key Laboratory of Environmental Remediation and Pollution Control College of Environmental Science and Engineering Nankai University Tianjin 300071 P. R. China Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS, Université Paris Descartes, 45 rue des Saints Pères, 75270 Paris Cedex 06, France Department of Chemistry, Nanjing University, Nanjing 210093, People's Republic of China; Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, People's Republic of China; and X-ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, 11800 USM, Penang, Malaysia Key Laboratory of Behavioral and Mental Health of Gansu Province, Department of Psychology Northwest Normal University Lanzhou People's Republic of China Children’s Hospital of Zhejiang University School of Medicine, Hangzhou, China Institute of Human Genetics; University Medical Center Göttingen; Göttingen Germany Department of Urology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA Department of Neurology, The First Affiliated Hospital of Dali University, Dali, Yunnan, China (mainland) Institute of Human Genetics; University Medical Center Goettingen; Goettingen Germany College of Agronomy Guangxi University Guangxi China Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Clinical Research Center of Ophthalmic Disease, Changsha, Hunan, China Department of Anesthesiology the Third Central Clinical College of Tianjin Medical University, Nankai University Affinity the Third Central Hospital, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Artificial Cell Engineering Technology Research Center, Tianjin Institute of Hepatobiliary Disease Tianjin China Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599, USA Institute of Human Genetics University Medical Center Goettingen Goettingen Germany Department of Nutrition and Food Hygiene, Huaxi School of Public Health, Sichuan University, Chengdu 610041, China. Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Laboratoire de chimie et biochimie pharmacologiques et toxicologiques (CNRS UMR8601), Université René Descartes, 45, rue des Saints Pères, 75270 Paris Cedex 06, France, Laboratoire de chimie inorganique et matériaux moléculaires (CNRS UMR7071), Université Pierre et Marie Curie, 4 place Jussieu, 75252 Paris Cedex 05, France, and Laboratoire de chimie de coordination du CNRS, UPR 8241, 205, route de Narbonne, 31077 Toulouse Cedex, France School of Metallurgy and Environment, Central South University, Hunan Province, Changsha 410083, China Department of Medical Oncology, Jingmen No. 1 People's Hospital, Jingmen, Hubei 448000, P.R. China Department of Urology; Second Military Medical University, Changhai Hospital; Shanghai China Child Mental Health Research Center The Affiliated Brain Hospital of Nanjing Medical University Nanjing China Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY, USA; Department of Urology, Roswell Park Cancer Institute, Buffalo, NY, USA National Key Laboratory of Green Pesticide, South China Agricultural University, Guangzhou, Guangdong, China; Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou, Guangdong, China The State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China School of Public Health, North China University of Science and Technology Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen 518055, China School of Psychology, South China Normal University, Guangzhou, China Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, Jinan, Shandong, Peoples's Republic of China Key Laboratory of Marine Drugs (Ocean University of China) Chinese Ministry of Education Qingdao China; School of Medicine and Pharmacy Ocean University of China Qingdao China; Laboratory for Marine Drugs and Biological Products Qingdao National Laboratory for Marine Science and Technology China Department of Respiratory Medicine, The Eighth Medical Center of Pla General Hospital, Beijing, China Department of Biostatistics, University of North Carolina at Chapel Hill; Department of Genetics, University of North Carolina at Chapel Hill NHC Key Laboratory of Cancer Proteomics & State Local Joint Engineering Laboratroy for Anticancer Drugs, Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China Department of Pharmacy, the Second Xiangya Hospital Central South University Changsha Hunan China Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM) & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, China Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109-2029; Institute of Human Genetics, University of Cologne Cologne Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne Cologne Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging‐Associated Diseases (CECAD), University of Cologne Cologne Germany Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, People’s Republic of China Department of Statistics, University of Michigan, Ann Arbor, Mi., U.S.A. Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular Imaging, Center for Artificial Intelligence Biology, Department of Bioinformatics and Systems Biology, College of Life Science and Technology Huazhong University of Science and Technology Wuhan Hubei 430074 P. R. China Department of Dermatology, Peking Union Medical College Hospital, Beijing 100730, China. Department of Plastic and Reconstructive Surgery, Shanghai Jiao Tong University School of Medicine, Shanghai Ninth People’s Hospital, 639 Zhizaoju Road, 200011 Shanghai, People’s Republic of China The First Clinical Medical College, Shanxi Medical University, Taiyuan, China Center for Molecular Medicine Cologne (CMMC) University of Cologne 50931 Cologne Germany; Institute of Human Genetics University of Cologne 50931 Cologne Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging‐Associated Diseases (CECAD) University of Cologne 50931 Cologne Germany Department of Thoracic Surgery, People’s Hospital Peking University No. 11, Xizhimen South Street, Xicheng District 100044 Beijing China Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.; Department of Urology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA. Laboratory of Molecular Medicine, Ocean University of China, 5 Yushan Road, Qingdao 266003, PR China; Laboratory of Microbiology, Ocean University of China, 5 Yushan Road, Qingdao 266003, PR China Department of Neurology (Sleep Disorders) the Affiliated Chaohu Hospital of Anhui Medical University Hefei Anhui P. R. China Department of Anesthesiology, Chifeng Municipal Hospital, Chifeng Clinical Medical College of Inner Mongolia Medical University, Chifeng 024000, China The Second Hospital of Hebei Medical University Department of Marine Biology, Ocean University of China, 5 Yushan Road, Qingdao 266003, People's Republic of China Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, Canada L8S 4K1 Department of Chemistry and Biochemistry and Department of Statistics, Brigham Young University, Provo, Utah 84602 PASTEUR, Département de chimie, École normale supérieure, PSL Université, Sorbonne Université, CNRS, 75005 Paris, France College of Animal Science and Technology, Southwest University, Chongqing, China North China University of Science and Technology, 128790, Tangshan, China; Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang, China Department of Urology, Shanghai Shibei Hospital of Jingan District, Shanghai, China Institute of Human Genetics, University Medical Center Göttingen, 37073 Göttingen, Germany. Key Laboratory of Marine Drugs (Ocean University of China), Chinese Ministry of Education, and School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, China Medical School of Chinese PLA Beijing China; The 305 Hospital of PLA Beijing China Education Psychology, Texas A&M University, Houston, Texas Department of Biochemistry & Molecular Biology, College of Life Science, Nanjing Agriculture University, Nanjing, Jiangsu, China The Third Central Clinical College of Tianjin Medical University Tianjin China; Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases Artificial Cell Engineering Technology Research Center Tianjin Institute of Hepatobiliary Disease Tianjin China; Department of Anesthesiology Chifeng Municipal Hospital Chifeng Clinical Medical College of Inner Mongolia Medical University Chifeng China Department of Biostatistics, University of Michigan, Ann Arbor, Michigan; The Department of Breast Surgery Ward 2, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China Beijing Institute of Technology College of Agricultural Engineering, Shanxi Agriculture University, Jinzhong 030801, China Department of Neonatology, The Affiliated Wuxi Children's Hospital of Jiangnan University, Wuxi, China Department of Neurology, Xuanwu Hospital, Capital Medical University , Beijing, China Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular-imaging, Center for Artificial Biology, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China Department of Genetics, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA; Department. of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA School of Chemistry and Chemical Engineering, Yangzhou University, 180 Siwangting Street, Yangzhou 225002, Jiangsu, P. R. China Departments of Genetics, Biostatistics, Computer Science, University of North Carolina, Chapel Hill, NC 27599, USA Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China;; Collaborative Innovation Center of Hematology, Soochow University, Suzhou 215006, China; Institute of Human Genetics (G.Y., Y.L., G.S., C.M., I.A., B.W.) Tianjin Medical University General Hospital Tianjin China Department of Child Health, Minhang Maternal and Child Health Hospital, Shanghai, China; 1Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine,; 3Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania Department of Nephrology, Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai, People’s Republic of China School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, People's Republic of China, Department of Chemistry and Technology, Liaocheng University, Liaocheng, 252059, People's Republic of China, and Institute of Theoretical Chemistry, Shandong University, Jinan, 250100, People's Republic of China Survey Methodology Program, Institute for Social Research University of Michigan, Ann Arbor Michigan 48106 U.S.A. Sarah T. Hawley, Lawrence C. An, Michael S. Sabel, Reshma Jagsi, Timothy P. Hofer, and Steven J. Katz, University of Michigan Medical School; Sarah T. Hawley, Yun Li, Kenneth Resnicow, Nancy K. Janz, and Steven J. Katz, University of Michigan School of Public Health; Sarah T. Hawley, VA Health Center for Clinical Management Research, Ann Arbor, MI; Kevin C. Ward, Emory University, Atlanta, GA; Angela Fagerlin, University of Utah, School of Medicine, Salt Lake City, UT; and Monica Morrow, Memorial Sloan... Department of Sleep Medicine, Mental Health Center of Shantou University, Shantou, Guangdong, China; Sleep Medicine Center, Shantou University Medical College, Shantou, Guangdong, China Department of Pharmacy The Second Xiangya Hospital of Central South University Changsha China Department of Neurobiology and Beijing Institute for Brain Disorders; Capital Medical University; Beijing; People's Republic of China Department of Pain Management, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, Jinan, Shandong 250021, P.R. China The State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University 222 Tianshui South Road Lanzhou 730000 China Nursing Department The Second Hospital of Hebei Medical University Shijiazhuang China Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health Baltimore Maryland CAS Key Laboratory of Mineralogy and Metallogeny, Guangdong Provincial Key Laboratory of Mineral Physics and Materials, Guangzhou Institute of Geochemistry, Institutions of Earth Science, Chinese Academy of Sciences (CAS), Guangzhou 510640, China; University of Chinese Academy of Sciences, Beijing 100049, China Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, China Department of Pulmonary and Critical Care Medicine, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; From the Department of Preventive Medicine, School of Public Health, North China University of Science and Technology, Tangshan (Y. Li) Department of General Surgery, Jingmen First People's Hospital, Jingmen 448000, Hubei Province, China Department of Otolaryngology–Head and Neck Surgery, Ninth People's Hospital; Ear Institute, Shanghai Jiaotong University School of Medicine; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases Department of Dermatology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. Departments of 1Physiology and State Key Laboratory of Estuary and Coastal Research, East China Normal University, Shanghai 200062, China. sslixly@yahoo.com.cn Department of Immunology, University of Texas Southwestern Medical Center, Dallas, United States Department of Pulmonary and Critical Care Medicine, Institute of Respiratory Disease, The First Hospital of China Medical University, Shenyang, China; Department of Geriatric Respiratory, The First Hospital of Kunming Medical University, Kunming, China. Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, Hunan, PR China Department of Geriatric Medicine, Capital Medical University, Xuan Wu Hospital, Beijing 100053, China Department of Otolaryngology‐Head and Neck Surgery, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China; Ear Institute Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases (14DZ2260300) Shanghai China Department of Genetics, University of North Carolina, Chapel Hill, NC, USA; Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USA; Department of Computer Science, University of North Carolina, Chapel Hill, NC, USA College of Fisheries, Ocean University of China, Qingdao, China; The Key Laboratory of Mariculture (Ocean University of China), Ministry of Education, Ocean University of China, Qingdao, China Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116011, China Department of Geriatrics, Xuan Wu Hospital, Capital Medical University, Beijing, China. National Laboratory of Solid‐State Microstructures School of Electronic Science and Engineering Key Lab of Optoelectronic Devices and Systems with Extreme Performances and Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjing 210093 China Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou, PR China National Laboratory of Solid State Microstructures, School of Electronic Science and Engineering, and Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210093, China Medicine Program, Geisel School of Medicine, Dartmouth College, Hanover, NH. 1 Department of Biostatistics, University of North Carolina, 3101 McGavran-Greenberg Hall, Chapel Hill, NC 27599, USA, 2Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA and 3Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599, USA; 1 Department of Biostatistics, University of North Carolina, 3101 McGavran-Greenberg Hall, Chapel Hill, NC 27599, USA, 2Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA and 3Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599, USA; 1 Department of Biostatistics, University of North Carolina, 3101 McGavran-Greenberg Hall, Chapel Hill, NC 27599, USA, 2Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA and 3Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599, USA Department of Physiology and Pathophysiology, School of Basic Medical Science, Capital Medical University, Beijing, China; Department of Immunology, School of Basic Medical Science, Capital Medical University, Beijing, China Department of Immunology, School of Basic Medical, Zhengzhou University, Zhengzhou, China University of South Florida, College of Marine Science St. Petersburg Florida 33701 USA Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China Department of Neurology Jinling Hospital, Medical School of Nanjing University Nanjing Jiangsu China Department of Genetics University of North Carolina Chapel Hill NC USA; Department of Biostatistics University of North Carolina Chapel Hill NC USA; Department of Computer Science University of North Carolina Chapel Hill NC USA Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine , China; Ear Institute, Shanghai Jiao Tong University School of Medicine , China; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases , China Department of Medicine Jinan Maternity and Child Care Hospital Jinan Shandong China Department of Genetics Department of Biostatistics University of North Carolina Chapel Hill North Carolina Department of Endocrinology and Metabolism, The Third People’s Hospital of Chengdu, Chengdu, Sichuan 610031, China State Key Laboratory of Digital Manufacturing Equipment and Technology, School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, Hubei, People's Republic of China From the Divisions of Medical Science and Population Science, Fox Chase Cancer Center, Philadelphia, PA; Duke University, Durham, NC; Georgetown University, Washington, DC; Northwestern University, Chicago, IL; University of Maryland, Baltimore, and National Cancer Institute Office of Cancer Survivorship, Bethesda, MD; and St Vincent Catholic Medical Centers, New York, NY. Department of Biostatistics, University of North Carolina , Chapel Hill, NC , USA; Department of Genetics, University of North Carolina , Chapel Hill, NC , USA; Department of Computer Science, University of North Carolina , Chapel Hill, NC , USA Authors' Affiliations: Departments of 1Microbiology and 2Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University; 3Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Chinese Ministry of Education, Guangzhou, Guangdong, China; and 4Department of Neurology, Northwestern Brain Tumor Institute, Center for Genetic Medicine & The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Authors' Affiliations: Departments of 1Microbiology and 2Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University; 3Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Chinese Ministry of Education, Guangzhou, Guangdong, China; and 4Department of Neurology, Northwestern Brain Tumor Institute, Center for Genetic Medicine & The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois College of Physical Education and Health, Jiangxi University of Traditional Chinese Medicine, Nanchang 330000, China Key Laboratory of Mariculture, Ministry of Education, Ocean University of China , Qingdao , PR China Department of Genetics University of North Carolina at Chapel Hill Chapel Hill North Carolina USA; Department of Biostatistics University of North Carolina at Chapel Hill Chapel Hill North Carolina USA Department of Brain Function and Neuroelectrophysiology, the Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan 421002, China. Department of Burns & Plastic Surgery, Xiangya Hospital Central South University Changsha China Department of Pediatrics Hunan Provincial People's Hospital Changsha Hunan China Duke University, Durham, North Carolina Molecular Imaging Center, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, China School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514, USA Departments of Biostatistics, Genetics, and Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Department of Process Equipment and Control Engineering, Xi'an Jiaotong University, Xi'an 710049, People's Republic of China Department of Hematology, The First People's Hospital of Qinzhou Qinzhou 535099, Guangxi, PR China. School of Life Sciences, Guangxi Normal University, Guilin, China; Guangxi Universities Key Laboratory of Stem cell and Biopharmaceutical Technology, Guangxi Normal University, Guilin, China; Research Center for Biomedical Sciences, Guangxi Normal University, Guilin, China Xuan Wu Hospital, Department of Geriatrics, Capital Medical University, Beijing, China Department of Intensive Care Unit, the First Hospital of Tianshui City, Gansu, China College of Resources, Sichuan Agricultural University, Wenjiang, China Department of Dermatology, Sichuan University West China Hospital, Chengdu, China. Departments of Biostatistics, Genetics, Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Department of Urology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA Department of Pharmacy The Second Xiangya Hospital, Central South University Changsha China Department of Genetics,; Department of Biostatistics, and; Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC; Laboratoire de Chimie des Processus Biologiques, Collège de France, UMR 8229 CNRS, Sorbonne Université, PSL Research University, 11 Place Marcelin Berthelot, 75005 Paris, France Department of Genetics, Department of Biostatistics, Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599, USA Department of Chemistry, Delaware Valley University, Doylestown, PA 18901 From the Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass (Y.L., T.A., V.M.B., R.A.C); and Maine Medical Center Research Institute, South Portland, Maine (C.K., K.A.A.). Beijing Sport University, Beijing, China. Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China Key Lab of Advanced Energy Storage and Conversion Zhejiang Province Key Lab of Leather Engineering College of Chemistry and Materials Engineering Wenzhou University Wenzhou Zhejiang 325035 P. R. China; Zhejiang Engineering Research Center for Electrochemical Energy Materials and Devices Institute of New Materials and Industrial Technologies Wenzhou University Wenzhou Zhejiang 325035 P. R. China Department of Genetics University of North Carolina Chapel Hill North Carolina United States of America; Curriculum in Bioinformatics and Computational Biology University of North Carolina Chapel Hill North Carolina United States of America; Department of Biostatistics University of North Carolina Chapel Hill North Carolina United States of America; Department of Computer Science University of North Carolina Chapel Hill North Carolina United States of America College of Mathematics, Nanjing University of Aeronautics and Astronautics, Nanjing 211106, China; Key Laboratory of Mathematical Modelling and High Performance Computing of Air Vehicles (NUAA), MIIT, Nanjing 211106, China Department of Geriatrics XuanWu Hospital of Capital Medical University Beijing China Department of Geriatrics Xuanwu Hospital, Capital Medical University Beijing China; Beijing Geriatric Healthcare Center Xuanwu Hospital, Capital Medical University Beijing China; Beijing Institute of Geriatrics Beijing China; Key Laboratory on Neurodegenerative Disease of Ministry of Education Beijing China; Beijing Institute for Brain Disorders Beijing China Otorhinolaryngology Hospital The First Affiliated Hospital, Sun Yat‐sen University Guangzhou Guangdong People's Republic of China School of Forensic Medicine, Shanxi Medical University, Taiyuan 030001, China. liyun4378@yahoo.cn School of Marine Science and Policy University of Delaware Newark DE USA GaN Optoelectronic Integration International Cooperation Joint Laboratory of Jiangsu Province, Nanjing University of Posts and Telecommunications, Nanjing 210003, China Shandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences) , Jinan, People’s Republic of China; College of Pharmacy, Shandong University of Traditional Chinese Medicine , Jinan, People’s Republic of China Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Hebei Key Laboratory of Photoelectric Control on Surface and Interface, College of Science, Hebei University of Science and Technology, Shijiazhuang 050018, China Delaware Valley College 2 Department of Chemistry and Biochemistry, , Doylestown, Pennsylvania 18901, USA Department of Cardiothoracic Surgery The Third Affiliated Hospital of Sun Yat‐sen University Guangzhou China College of Agronomy, Guizhou University, Guiyang 550025, China. liyun1120@163.com Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan MOE Key Lab for Neuroinformation, High‐Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, Center for Psychiatry and Psychology, School of Life Science and Technology University of Electronic Science and Technology of China Chengdu China; School of Management Chengdu University of Traditional Chinese Medicine Chengdu China Center for Statistical Genetics and Biostatistics, University of Michigan, 48109, Ann Arbor, Michigan, USA Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor Department of Clinical Laboratory Anhui Provincial Hospital Anhui Medical University Hefei 23001 China Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques (CNRS UMR 8601), Université René Descartes, 45, rue des Saints-Pères, 75270 Paris Cedex 06, France Water Administration and Water Resources Management Office; Hali Barikun County 839200; PR China Departments of Biochemistry Department of Biostatistics, University of North Carolina, Chapel Hill, NC, 27599, USA; Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA; Department of Computer Science, University of North Carolina, Chapel Hill, NC, 27599, USA. Philadelphia VAMC, Philadelphia, Pennsylvania; University of Pennsylvania, Philadelphia, Pennsylvania Department of Dermatology 181st Hospital of the Chinese People's Liberation Army Guilin China Department of Radiology, Zhengzhou No. 7 People's Hospital, Zhengzhou, Henan 450016, P.R. China Departments of Biostatistics, Epidemiology, and Informatics; Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania; Center for Pediatric Clinical Effectiveness State Key Laboratory of Heavy Oil Processing, China University of Petroleum, Changping, Beijing 102249, P. R. China Department of Ophthalmology, Provincial Hospital Affiliated to Shandong University, Jinan, China. State Key Laboratory of Digital Manufacturing Equipment and Technology, School of Mechanical Science and Engineering, Huazhong University of Science and Technology 1 , 1037 Luoyu Road, Wuhan, Hubei 430074, People’s Republic of China Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, and Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing, China Sleep Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China Department of Sleep Medicine, Mental Health Center of Shanou University, Shantou, China;; Sleep Medicine Center, Shantou University Medical College, Shantou, China; College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, P. R. China Medicine Institute, Cleveland Clinic, Cleveland, OH, USA The College of Water Resources and Environmental Engineering; East China University of Technology; Nanchang; China Encephalopathy Department, Hubei Provincial Hospital of TCM, Hubei 430061, China University of North Carolina at Chapel Hill Department of Otolaryngology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China Sleep Medicine Center, Shantou University Medical College, Shantou, China (Y.L.) Department of Chemistry, University of Science and Technology of China, Hefei 230026, China, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 College Road, Beijing 100083, China, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China, and CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China 2 Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases (14DZ2260300), Shanghai, China; The authors contributed equally to this work. Department of Ophthalmology Kunming Maternity and Child Care Hospital Kunming city China Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China; Children's Hospital of Philadelphia Philadelphia Pennsylvania USA; Department of Biostatistics Epidemiology & Informatics, and Department of Pediatrics Perelman School of Medicine of the University of Pennsylvania Philadelphia Pennsylvania USA Division of Energy Storage; Dalian Institute of Chemical Physics; Chinese Academy of Sciences; Dalian 116023, China; University of Chinese Academy of Sciences Department of Hematology, West China Hospital, Sichuan University, Chengdu 610041, China. Department of Biostatistics University of Michigan School of Public Health Ann Arbor Michigan Department of Otorhinolaryngology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, P.R. China; Department of Biostatistics University of Michigan Ann Arbor MI USA; Cancer Surveillance and Outcomes Research Team University of Michigan Comprehensive Cancer Center Ann Arbor MI USA Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.; Genome Technology Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA.; Department of Mathematics and Statistics, Calvin College, Grand Rapids, MI 49546, USA.; Center for Inherited Disease Research (CIDR), Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA. 1 Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA, 2Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599, USA and 3Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA; 1 Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA, 2Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599, USA and 3Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA; 1 Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA, 2Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599, USA and 3Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA Institute of Biotechnology, Guizhou Academy of Agricultural Sciences, Guiyang, China Department of Critical Care Medicine, The First Medical Centre, Chinese PLA General Hospital, Beijing 100853, China Department of Nephrology, The Third People’s Hospital of Longgang District, Shenzhen, China Department of Biostatistics, School of Public Health University of Michigan Ann Arbor Michigan Laboratoire de Chimie des Processus Biologiques, UMR 8229 CNRS, Université Pierre et Marie Curie-Paris 6, Collège de France, 11 Place Marcelin Berthelot, 75231 Paris Cedex 05, France Laboratoire de Chimie des Processus Biologiques; UMR 8229 CNRS; Collège de France; Université Paris 6; 75231 Paris Cedex 05 Institute of Materia Medica, Dali University, Dali, Yunnan , China; Department of Neurology, The First Affiliated Hospital of Dali University, Dali, Yunnan, China Department of Biostatistics University of North Carolina Chapel Hill North Carolina; Department of Genetics University of North Carolina Chapel Hill North Carolina; Department of Computer Science University of North Carolina Chapel Hill North Carolina Nanjing Maternal and Child Health Institute, Women's Hospital of Nanjing Medical University (Nanjing Maternity and Child Health Care Hospital) Nanjing China Laboratoire de Chimie des Processus Biologiques UMR 8229 CNRS Collège de France Université Paris 6 11 Place Marcelin Berthelot 75231 Paris CEDEX 05 France MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage; School of Chemistry and Chemical Engineering; Harbin Institute of Technology; Harbin; China Department of Dermatology, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100059, China Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China. Department of Geography and GeoInformation Science George Mason University Fairfax VA USA; NSF Spatiotemporal Innovation Center George Mason University Fairfax VA USA Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan; Department of Neurology, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China Rice Research Institute, Sichuan Agricultural University, Chengdu 611130, China. Department of Anesthesiology The Second Hospital of Anhui Medical University Hefei Anhui Province 230601 PR China Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong, China; and Departments of Genetics and Biostatistics , University of North Carolina, Chapel Hill, North Carolina, 27599 Jiangsu Key Laboratory of Pesticide Science and Department of Chemistry, College of Sciences, Nanjing Agricultural University, Nanjing 210095, P. R. China State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engeneering, Lanzhou University, Lanzhou 730000, China; State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China Department of Otolaryngology, The First Affiliated Hospital of Sun Yat-Sen University, No.58 Zhongshan Er Road, 510080, Guangzhou, Guangdong, People's Republic of China Department of Thoracic Surgery Shandong Provincial Hospital Affiliated to Shandong University Jinan China Department of Biostatistics University of Michigan Ann Arbor Michigan Department of Genetics and Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USA. College of Chemical Engineering, Jiangsu Key Lab for the Chemistry & Utilization of Agricultural and Forest Biomass, Nanjing Forestry University, Nanjing, China; Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Laboratory for TCM Standardization Technology Shanghai Institute of Materia Medica Chinese Academy of Sciences Haike Road 501 Shanghai 201203 P. R. China School of Life Sciences and Food Technology, Hanshan Normal University, Chaozhou, Guangdong 521041, China. School of Chemistry and Chemical Engineering, Yangzhou University, 180 Siwangting Street, Yangzhou 225002, P. R. China Department of Cardiothoracic Surgery The Third Affiliated Hospital Sun Yat‐sen University Guangzhou 510080 P. R. China Fisheries College Huazhong Agricultural University Wuhan 430070 Hubei China; Donghu Experimental Station of Lake Ecosystems State Key Laboratory of Freshwater Ecology and Biotechnology Institute of Hydrobiology Chinese Academy of Sciences Wuhan 430072 Hubei China Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USA School of Life Sciences and Food Technology, Hanshan Normal University, Chaozhou, PR China From Nanjing Maternal and Child Health Medical Institute, Nanjing Medical University Affiliated Nanjing Maternal and Child Health Hospital The State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering Lanzhou University 222 Tianshui South Road Lanzhou 730000 China Medical School of Chinese PLA, Beijing 100853, P.R. China Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital; Southern Medical University; Guangzhou; China Institute of Clinical Pharmacology, The First Hospital, Peking University, Beijing, China. Department of Urology Roswell Park Cancer Institute Buffalo New York Department of Pharmaceutics Department of Biostatistics, University of Michigan, Ann Arbor, Michigan Department of Pulmonary and Critical Care Medicine, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, People’s Republic of China. eDivision of Immunology, Allergy, and Retrovirology; fPediatric IDEAS Research Group of the Center for Pediatric Clinical Effectiveness; gDepartment of Biostatistics, Epidemiology, and Informatics School of Computer Science and Engineering, University of New South Wales, Sydney, NSW, Australia Key Laboratory of Ministry of Education for Gastrointestinal Cancer Fujian Medical University Fuzhou China Department of Otolaryngology–Head and Neck Surgery, Ninth People's Hospital; Ear Institute, Shanghai Jiaotong University School of Medicine; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China The First Affiliated Hospital/School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou, China Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China; University of Chinese Academy of Sciences Beijing China Department of Chemistry, University of Science and Technology of China, Hefei 230026, China. Rice and Sorghum Research Institute, Sichuan Academy of Agricultural Sciences, Key Laboratory of Southwest Rice Biology and Genetic Breeding, Ministry of Agriculture, Deyang, Sichuan 618000, China College of Plant Protection South China Agricultural University Guangzhou China; Key Laboratory of Natural Pesticide & Chemical Biology, Ministry of Education South China Agricultural University Guangzhou China School of Pharmacy Nanjing University of Chinese Medicine Nanjing 210023 People's Republic of China Department of Pain Management, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan, Shandong 250021, China Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine , Philadelphia, Pennsylvania , USA; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine , Philadelphia, Pennsylvania , USA; Pediatric IDEAS Research Group of the Center for Pediatric Clinical Effectiveness , USA Institute of Biomedical & Pharmaceutical Technology, Fuzhou University, Fuzhou 350002, PR China Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, First Affiliated Hospital, Soochow University, 199 Ren Ai Road, Suzhou Industrial Park, Suzhou, Jiangsu 215123, China Gansu College of Traditional Chinese Medicine, Key Laboratory of Chemistry and Quality for Traditional Chinese Medicine of Gansu Province, Lanzhou 730000, China. liyunherb@163.com Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China;; Ear Institute, Shanghai Jiaotong University School of Medicine, Shanghai, China;; Department of Otolaryngology Head and Neck Surgery, Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China; Department of Pain, Wuchang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei, China Comprehensive Cancer Center, University of Michigan, Ann Arbor4Department of Biostatistics, University of Michigan, Ann Arbor Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA College of Teacher Education Dali University Dali China; College of Culture, Tourism, and Health Care Chongqing City Vocational College Chongqing China Department of Orthopedics, The First People's Hospital of Yichang, China Three Gorges University, Yichang, Hubei 443000, P.R. China Department of Thoracic Surgery; People's Hospital of Peking University; Beijing; China Department of Oral and Maxillofacial Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China; State Key Laboratory of Agricultural Microbiology, College of Food Science and Technology, College of Science, Huazhong Agricultural University, Wuhan 430070, People’s Republic of China Department of Rheumatology and Immunology, Peking University People’s Hospital and Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China; Center of Clinical Immunology, Peking University, Beijing 100044, China; Peking-Tsinghua Center for Life Sciences, Beijing, China Merck & Co., Inc., Kenilworth, NJ, USA Department of Genetics and Department of Biostatistics, University of North Carolina, Chapel Hill, N.C., U.S.A. Department of Anesthesiology and Surgery, Lanzhou University Second Hospital, Lanzhou University Second Clinical Medical College , Lanzhou 730030 , China Department of Pharmacy, Wannan Medical College Wuhu China Department of Pharmacy, The Second Xiangya Hospital Central South University Changsha Hunan China Department of Anesthesiology, Chifeng Municipal Hospital, Inner Mongolia, China Department of Gerontology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, China Thoracic Oncology Institute/Department of Thoracic Surgery Peking University People's Hospital Beijing China National Laboratory of Solid‐State Microstructures School of Electronic Science and Engineering Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjing 210093 P. R. China Allison W. Kurian, Stanford University, Stanford; Ann S. Hamilton, Keck School of Medicine, University of Southern California, Los Angeles, CA; Yun Li, M. Chandler McLeod, and Steven J. Katz, University of Michigan, School of Public Health; Sarah T. Hawley, University of Michigan, Veterans Administration Center for Clinical Management Research, Ann Arbor Veterans Affairs Health Care System; Reshma Jagsi, University of Michigan, Center for Bioethics and Social Science in Medicine, Ann Arbor, MI; Kevin C.... Department of Pharmacy, General Hospital, Tianjin Medical University, Tianjin, China Center for Pediatric Clinical Effectiveness, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia University of Michigan, Ann Arbor, MI, USA Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, Pennsylvania; Mental Health Center, Shantou University Medical College, China Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, China Department of Central Laboratory, Shenzhen Second People's Hospital Shenzhen University 1st Affiliated Hospital Shenzhen China Key Laboratory of the Ministry of Education for Gastrointestinal Cancer, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, People's Republic of China University of Macau Macao China Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China Tangjiazhuang Hospital of Kailuan, Tanshan 063100, Hebei, China. Engineering Research Center for Nanomaterials, Henan University, Kaifeng 475004, People’s Republic of China Department of Respiratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China. State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China Department of Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science; MOE; College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology; Qingdao 266042; China Department of Biostatistics , The University of North Carolina at Chapel Hill; Department of Genetics , The University of North Carolina at Chapel Hill; Department of Computer Science , The University of North Carolina at Chapel Hill Key Laboratory of Cluster Science of Ministry of Education, School of Chemistry and Chemical Engineering, Liangxiang Campus, Beijing Institute of Technology, Beijing102488, PR China Surgery Room, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, Chile Department of Biostatistics, University of Michigan, Center for Statistical Genetics, 1420 Washington Heights, Ann Arbor, Michigan 48109, USA. Department of Obstetrics and Gynecology, Perinatal Research Laboratories and *Cancer Immunology, Genentech, Inc., South San Francisco, CA 94080; School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Zhejiang, China Children's Mental Health Research Center The Affiliated Brain Hospital of Nanjing Medical University Nanjing China School of Public Health, Hebei United University, Tangshan, Hebei 063007, P. R. China. liyun8022@163.com Shanghai TCM-Integrated Hospital, Shanghai University of Chinese Medicine, Shanghai 200082, China Department of Gastrointestinal Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, P.R. China; Jiangxi Institute of Digestive surgery, Nanchang, Jiangxi 330006, P.R. China Department of Ophthalmology The Second Xiangya Hospital Central South University Changsha 410011 China School of Public Health North China University of Science and Technology Tangshan 063210 China Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA Department of Nephrology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, People’s Republic of China; Hebei Clinical Research Center for Chronic Kidney Disease, Hebei Key Laboratory of Vascular Calcification in Kidney Disease, Shijiazhuang, People’s Republic of China Department of Pharmacy, General Hospital Tianjin Medical University Tianjin China State Key Laboratory of Heavy Oil Processing China University of Petroleum Changping Beijing 102249 China International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, Institute of Microscale Optoelectronics, Shenzhen University, Shenzhen 518060, China Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China Department of Otorhinolaryngology-Head Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China Department of Civil and Environmental Engineering, University of Southern California, Los Angeles, California 90089, United States Department of Pharmacology and Therapeutics, and Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China From the Department of Preventive Medicine (Yun Li), School of Public Health, North China University of Science and Technology, Tangshan; Department of Nutritional Sciences (Yun Li, X.G.), Pennsylvania State University, State College; Department of Nutrition (Yanping Li), Harvard T.H. Chan School of Public Health; Department of Neurology (M.E.G.), Massachusetts General Hospital and Harvard Medical School, Boston; Departments of Neurology (Y. Liu) and Cardiology (J.S., S.W.), Kailuan General Hospital... Department of Otorhinolaryngology—Head and Neck Surgery Xinhua Hospital, Shanghai Jiaotong University School of Medicine Shanghai China; Ear Institute Shanghai Jiaotong University School of Medicine Shanghai China Department of Thoracic Surgery, Peking University People’s Hospital , Beijing, China; Thoracic Oncology Institute, Peking University People’s Hospital , Beijing, China Department of Respiratory Medicine, The 309th Hospital of PLA Arbor Research Collaborative for Health Ann Arbor Michigan USA; University of Michigan Ann Arbor Michigan USA School of Food Science, Henan Inst. of Science and Technology Xinxiang 453003 People's Republic of China Center for Applied Genomics, The Children's Hospital of Philadelphia, 1014H, 3615 Civic Center Blvd, Abramson Building, Philadelphia, PA, 19104, USA. LiY7@email.chop.edu. State Key Laboratory of Nuclear Resources and Environment, East China University of Technology, Nanchang 330013, China. School of Water Resources and Environmental Engineering, East China University of Technology, Nanchang 330013, China. Key Laboratory of Marine Drugs, Ministry of Education and School of Medicine and Pharmacy, Ocean University of China, Qingdao, China School of Pharmacy, Anhui University of Chinese Medicine, Hefei, China. College of Information Science and Engineering; Hunan University; Changsha; China School of Basic Medical Sciences, Weifang Medical University, Weifang, China Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health Baltimore Maryland; Department of Zoology and Physiology, University of Wyoming College of Arts and Sciences Laramie Wyoming Department of Genetics,; Department of Biostatistics and Department of Respiration Jingjiang People’s Hospital Jingjiang China Jiangxi Provincial People's Hospital, Nanchang, China. Clinical Futures, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom; and Division of Endocrinology, Diabetes, and Metabolism, Departments of Medicine and Genetics, and The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry Sun Yat-Sen University Guangzhou 510275 China Department of Immunology, Genentech, Inc., South San Francisco, CA 94080 1 Key Laboratory of Marine Drugs (Ocean University of China), Chinese Ministry of Education, and School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, China; Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266003, China Department of Hematology, Aviation General Hospital, Beijing, 100012, China National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China; Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China; Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, China Sleep Medicine Center, Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, China MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical Engineering Harbin Institute of Technology Harbin 150001 P. R. China School of Public Health, University of Michigan, Ann Arbor, MI, USA Public Security Department, Tianjin Public Security Police Profession College, Tianjin, 300382, P. R. China Department of Respiratory Medicine, Chinese People's Liberation Army (PLA) General Hospital and Chinese PLA Medical School, Beijing 100853, P.R. China Sleep Medicine Center, Shantou University Medical College, Shantou, China From Duke University Medical Center and Duke Clinical Research Institute (M.T.R., A.Y.C., R.H.M., E.M.O., E.D.P.), Durham, NC; Department of Biostatistics, University of Michigan (Y.L.), Ann Arbor; Kaiser-Permanente Health System (R.G.B.), San Francisco Medical Center, San Francisco, Calif; University of North Carolina School of Medicine (S.C.S.), Chapel Hill, NC; Section of Cardiology (J.S.R.), Denver Veterans Affairs Medical Center/Division of Cardiology, University of Colorado Health Sciences... College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China. Department of Genetics, Department of Biostatistics University of North Carolina Chapel Hill NC 27599 USA; Department of Computer Science University of North Carolina Chapel Hill NC 27599 USA BGI Clinical Laboratories‐Shenzhen, BGI‐Shenzhen Shenzhen China School of Chemistry and Chemical Engineering Xi'an Shiyou University Xi'an China Shanghai Institute of Materia Medica, Chinese Academy of Sciences Shanghai China Chengdu Academy of Agriculture and Forestry Sciences Chengdu China Department of Biostatistics, Epidemiology & Informatics Perelman School of Medicine of the University of Pennsylvania Philadelphia Pennsylvania USA; Division of Pulmonary Medicine Children's Hospital of Philadelphia and University of Pennsylvania Philadelphia Pennsylvania USA Department of Genetics, University of North Carolina, Chapel Hill, NC 27599;; Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599;; Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599 Department of Marine Biology, Ocean University of China, Qingdao, China Department of hematology, Daqing oil-field general hospital, Daqing City, China College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, Jiangsu Province, China State Key Laboratory of Soil Erosion and Dryland Farming on Loess Plateau, Research Center of Water and Soil Conservation and Ecological Environment, Chinese Academy of Sciences, Yangling 712100, China. Minyoung Kwak and Brad J. Zebrack, University of Michigan School of Social Work; Yun Li, University of Michigan and University of Michigan Comprehensive Cancer Center, Ann Arbor; Melissa Butler, University of Michigan, Dearborn, MI; Kathleen A. Meeske, University of Southern California, Children's Hospital Los Angeles, Los Angeles; Steven Cole, HopeLab Foundation, Redwood City, CA; Leanne Embry and Christine Aguilar, University of Texas Health Science Center at San Antonio, San Antonio, TX; Rebecca Block... Lauren P. Wallner, Yun Li, Allison K.C. Furgal, Christopher R. Friese, Reshma Jagsi, Steven J. Katz, and Sarah T. Hawley, University of Michigan; Sarah T. Hawley, Ann Arbor VA Center of Excellence in Health Services Research and Development, Ann Arbor, MI; Ann S. Hamilton, University of Southern California Keck School of Medicine, Los Angeles, CA; and Kevin C. Ward, Emory University, Atlanta, GA. College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China. National Key Laboratory of Green Pesticide, South China Agricultural University, Guangzhou, Guangdong, China; Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou, China Department of Biostatistics, Department of Genetics, Department of Computer Science , The University of North Carolina at Chapel Hill , Chapel Hill 27599 , NC , USA Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, China Division of Chronic Non‐communicable Disease and Health Education Pinghu Municipal Center for Disease Control and Prevention Pinghu Zhejiang China Department of Marine Biology, College of Marine Life Sciences, Ocean University of China, Qingdao 266003, People's Republic of China School of Economics and Management, Anhui University of Science and Technology, Huainan, China. Department of Genetics and Biostatistics, University of North Carolina–Chapel Hill, Chapel Hill, NC 27599, USA. Genecast Biotechnology Co., Ltd Wuxi Jiangsu China Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China. From the Sleep Medicine Center, Department of Respiratory and Critical Care Medicine, Translational Neuroscience Center, Department of Otolaryngology, West China Hospital, Sichuan University, Chengdu, China (R.R., Y.L., J.Z., Y.S., L.T., T.L., X.T.); and Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR (J.Z., Y.-K.W.). Intensive Care Unit, Central Hospital Affliated to Shandong First Medical University, Jinan, China Department of Thoracic Surgery Peking University People’s Hospital No. 11 Xizhimen South Avenue, Xicheng District 100044 Beijing People’s Republic of China Department of Pharmacology and Therapeutics Roswell Park Comprehensive Cancer Center Buffalo New York; Department of Urology Roswell Park Comprehensive Cancer Center Buffalo New York Department of Computer Science University of North Carolina at Chapel Hill Chapel Hill North Carolina; Department of Genetics Department of Biostatistics University of North Carolina at Chapel Hill Chapel Hill North Carolina Department of Sleep Medicine, Shantou University Mental Health Center, Shantou University Medical College, Shantou, Guangdong, China; Sleep Medicine Center, Shantou University Medical College, Shantou, Guangdong, China Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, National Engineering Laboratory for Tree Breeding, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China Department of Biostatistics, Epidemiology, and Informatics, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania , Philadelphia, Pennsylvania , USA College of Architecture and Civil Engineering, Beijing University of Technology, Beijing, People’s Republic of China University of Michigan, Ann Arbor, MI 1 Department of Biostatistics, 2Department of Genetics, 3Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599 USA, 4Merck Research Laboratories, North Wales, PA, USA, 5School of Statistics, Renmin University of China, Beijing, People’s Republic of China, 6Department of Statistics, North Carolina State University, Raleigh, NC, 27607 USA, 7Department of Biostatistics, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA and 8Broad Institute of MIT and Harvard, Cambridge, MA 02141, USA; 1 Department of Biostatistics, 2Department of Genetics, 3Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599 USA, 4Merck Research Laboratories, North Wales, PA, USA, 5School of Statistics, Renmin University of China, Beijing, People’s Republic of China, 6Department of Statistics, North Carolina State University, Raleigh, NC, 27607 USA, 7Department of Biostatistics, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA and 8Broad Institute of MIT and Harvard, Cambridge, MA 02141, USA; 1 Department of Biostatistics, 2Department of Genetics, 3Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599 USA, 4Merck Research Laboratories, North Wales, PA, USA, 5School of Statistics, Renmin University of China, Beijing, People’s Republic of China, 6Department of Statistics, North Carolina State University, Raleigh, NC, 27607 USA, 7Department of Biostatistics, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA and 8Broad Institute of MIT and Harvard, Cambridge, MA 02141, USA State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, Fourth Military Medical University, Xi’an, China School for Environment and Sustainability, University of Michigan, Ann Arbor, Michigan 48109-1041, United States; School of Economics and Management, North China Electric Power University, Beijing 102206, People’s Republic of China Department of Critical Medicine, Jinan Central Hospital of Shandong University, Jinan, Shandong 250013, People’s Republic of China. Department of Genetics, University of North Carolina at Chapel Hill; Department of Biostatistics, University of North Carolina at Chapel Hill; Department of Computer Science, University of North Carolina at Chapel Hill Sleep Medicine Center Shantou University Medical College Shantou Guangdong China; Mental Health Center Shantou University Medical College Shantou Guangdong China Department of Chemistry and Biochemistry, Delaware Valley College, Doylestown, Pennsylvania 18901, United States School of Food Science and Engineering Jiangxi Agricultural University Nanchang China Rice Research Institute, Sichuan Agricultural University, Wenjiang, Sichuan 611130, P.R. China.; Key Laboratory of Bio-resources and Eco-environment (Ministry of Education), College of Life Science, Sichuan University, Chengdu, Sichuan 610064, P.R. China.; Key Laboratory of Southwest Crop Genetic Resources and Improvement (Ministry of Education), Sichuan Agricultural University, Yaan, Sichuan 625014, P.R. China. Department of Dermatovenereology West China Hospital Sichuan University Chengdu China Department of Otolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200092, China. School of Public Health, West China University of Medical Sciences, Chengdu 610041, China. School of Chemistry & Chemical Engineering, South China University of Technology, Guangzhou 510640, China School of Pharmacy, Yancheng Teachers University, Yancheng 224007, China Grünberg Research Centre, Nanjing University of Posts and Telecommunications, Nanjing 210003, China Institute of Clinical Pharmacology, Peking University , Beijing , China Department of Social Work, School of Philosophy and Social Development, Shandong University, Jinan 250100, China Department of Genetics University of North Carolina Chapel Hill North Carolina; Department of Biostatistics University of North Carolina Chapel Hill North Carolina Chemistry & Chemical Engineering of College Yantai University, Yantai 264005, China ARC Centre of Excellence in Exciton Science, School of Chemistry, The University of Sydney, Sydney, New South Wales 2006, Australia Child Mental Health Research Center Nanjing Brain Hospital, Nanjing Medical University Nanjing China Hanzhong Wildlife Protection and Management Station, Hanzhong, Shaanxi, China Department of Pediatrics, Hunan People's Hospital, Changsha, China. liyunpd@21.cn.com Department of Statistics and Operations Research, University of North Carolina, Chapel Hill Center for Drug Safety Evaluation and Research, Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming 650118, China; Yunnan Key Laboratory of Vaccine Research Development on Severe Infectious Diseases, Kunming 650118, China Department of Dermatology, The First Affiliated Hospital of The Army Medical University Chongqing 400038, P.R. China. Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, China GMU‐GIBH Joint School of Life Sciences Guangzhou Medical University Guangzhou PR China; Department of Immunobiology Jinan University Guangzhou PR China College of Food Science and Engineering Tianjin University of Science and Technology Tianjin 300457 China Department of Thoracic Surgery People's Hospital of Peking University Beijing China Department of Clinical Oncology,University of Hong Kong,Hong Kong; Center for Cancer Research,University of Hong Kong,Hong Kong; State Key Laboratory for Liver Research,University of Hong Kong,Hong Kong Division of Neuropathology, Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 CAS Key Laboratory of Genome Sciences and Information Beijing Institute of Genomics, and China National Center for Bioinformation Chinese Academy of Sciences No. 1 Beichen West Road, Chaoyang District Beijing 100101 China Lab of Light and Physio‐psychological Health School of Psychology South China Normal University Guangzhou China; National Center for International Research on Green Optoelectronics South China Normal University Guangzhou China Department of Sleep Medicine, Mental Health Center of Shantou University, Shantou, China; Sleep Medicine Center, Shantou University Medical College, Shantou, China Department of Otolaryngology, Head and Neck Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine; Ear Institute, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Translational Medicine on Ear and Nose diseases Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Computer Science University of North Carolina, Chapel Hill, NC 27599, USA From the State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China. School of Biological and Food Processing Engineering, Center for Faculty Development, Personnel Department Huanghuai University Zhumadian China Whitehead Institute for Biomedical Research, Cambridge, MA 02142;; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada;; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. yun_li@med.unc.edu. Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. yun_li@med.unc.edu. School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China Department of Cardiovascular Medicine, Chengdu Sixth People's Hospital, Chengdu, China. Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Research Center for Geriatric Medicine, Beijing 100053, China The State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engeneering, Lanzhou University, Lanzhou 730000, China Institute of Clinical Pharmacology, Peking University First Hospital, Beijing 100034, China Tianjin Medical University, General Hospital, Tianjin, 300052, China Laboratoire de Chimie des Processus Biologiques, UMR CNRS 8229, Collège de France-CNRS-Sorbonne Université, PSL Research University, 11 Place Marcelin Berthelot, 75231 Paris Cedex 05, France University of Washington, School of Medicine, Department of Pharmacology, 1959 NE Pacific Street, Health Sciences Center, Box 357280, Seattle, Washington 98195-7280 Department of Thoracic Surgery, Peking University People's Hospital, Beijing, China Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin Research Institute of Anesthesiology, Tianjin, China. Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Research Center of Medicine, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Shenzhen, P. R. China State Key Laboratory of Agricultural Microbiology; College of Science; Huazhong Agricultural University; Wuhan 430070; People's Republic of China VA Ann Arbor Center for Clinical Management Research, Ann Arbor, Michigan (KAM, STH); University of Michigan School of Public Health, Department of Biostatistics, Ann Arbor, Michigan (YL); University of Michigan School of Public Health, Department of Health Behavior and Health Education, Ann Arbor, Michigan (KR); Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey (JJG); Keck School of Medicine, University of Southern California, Los Angeles, California (ASH) School of Public Health, University of Michigan, Ann Arbor Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Laboratory for TCM Standardization Technology Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai P. R. China State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Drug Discovery, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing 211198, P. R. China 1Department of Microbiology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China.; 2Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Chinese Ministry of Education, Guangzhou, Guangdong, China. Department of Nutrition and Food Hygiene and Toxicology; West China School of Public Health; Sichuan University; Chengdu; P.R. China School of Life Sciences, Guangxi Normal University, Guilin 541004, China; Guangxi Universities Key Laboratory of Stem Cell and Biopharmaceutical Technology, Guangxi Normal University, Guilin 541004, China; Research Center for Biomedical Sciences, Guangxi Normal University, Guilin 541004, China The First Affiliated Hospital of Wenzhou Medical University, China School of Psychology, South China Normal University, Guangzhou, China; Center for Studies of Psychological Application, South China Normal University, Guangzhou, China; Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, China Department of Traditional Chinese Medicine Department, QiLu Hospital of Shandong University Dezhou Hospital, Dezhou, Shandong, China. Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9148, USA. Nanjing University of Chinese Medicine, Jiangsu 210000, China. liyun3648@163.com College of Resources and Environment, Northwest A & F University, Yangling 712100, Shaanxi, China. wya313@yahoo.com.cn Department of Rehabilitation Medicine, The Third Affiliated Hospital of Nanchang University, Nanchang Department of Anesthesiology and Perioperative Medicine, The Second Hospital of Anhui Medical University, Hefei, China; Department of Anesthesiology and Pain Medicine, University of California Davis Health, Sacramento, California, USA Department of Thoracic Surgery Peking University People's Hospital Beijing People's Republic of China; Peking University People's Hospital Thoracic Oncology Institute Beijing People's Republic of China The State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. State Key Laboratory of Heavy Oil Processing, China University of Petroleum, Changping, 102249 Beijing, China 1Department of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, P.R. China Centre for Lipid Research & Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education) Institute for Viral Hepatitis Department of Infectious Diseases the Second Affiliated Hospital Chongqing Medical University Chongqing 400016 P. R. China Department of Ophthalmology and Visual Sciences, the 2nd Xiangya Hospital, Central South University, 410011, Changsha, Hunan, China. Department of Materials Science and Engineering, and ARC Centre of Excellence in Future Low-Energy Electronics Technologies (FLEET), Monash University, Clayton, Victoria 3800, Australia National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology Suzhou China; NHC Key Laboratory of Thrombosis and Hemostasis The First Affiliated Hospital of Soochow University Suzhou China; Collaborative Innovation Center of Hematology Soochow University Suzhou China Department of Thoracic Surgery, People's Hospital, Peking University, Beijing 100044, China. Infinitus (China) Company Ltd; Guangzhou; China School of Pharmacy, Nanjing Medical University, Nanjing City 210029, P.R. China State Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing 210095, China Center for Molecular Virology CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences Beijing 100101 China Key Laboratory of Mariculture; Ocean University of China; Ministry of Education; Qingdao 266003; China 1Department of Genetics, University of North Carolina, Chapel Hill, North Carolina.; 2Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina. Nursing Department Second Hospital of Hebei Medical University Shijiazhuang China |
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