http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_7754d5f64f6ddb8b065e0217ca72ac87
Outgoing Links
Predicate | Object |
---|---|
family-name | Xu Yan Xu |
name | Yan Xu Yan. Xu |
given-name | Yan. Yan |
organization-name | New England Biolabs 32 Tozer Road Beverly Massachusetts 01915 USA †Institute of Health Sciences, Shanghai Jiaotong University School of Medicine/Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; School of Food and Biological Engineering; Hefei University of Technology; Hefei; P. R. China Department of Chemistry, Graduate School of Science, Kyoto University Sakyo, Kyoto 606-8502, Japan. Division of Physical Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China; National Engineering Research Center for Nanotechnology, Shanghai 200241, China Department of Neurosurgery, First Affiliated Hospital of Anhui Medical University, Hefei, 230031, China 3Department of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China. National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Qingchun Rd, Hangzhou, China College of Chemistry and Chemical Engineering, State Key Laboratory of Materials-oriented Chemical Engineering, Nanjing Tech University, Nanjing, 210009, People’s Republic of China Department of Cancer BiologyThe Lerner Research InstituteCleveland Clinic Foundation 9500 Euclid Avenue Cleveland OHIO 44195; Department of Gynecology and ObstetricsThe Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland OHIO 44195 Department of Clinical Laboratories, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China. Institute of International Medical Science and Technology Sanda University Shanghai China Los Alamos National Laboratory, Joint Genome Institute, Biosciences Division Genome Science B6, Los Alamos, New Mexico, USA Department of Medical statistics and Epidemiology, School of Public Health; Sun Yat-sen University; Guangzhou China Institute of Sports Medicine, Peking University Third Hospital, Beijing 100191, China College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China New England Biolabs, 32 Tozertypeoad, Beverly, MA 01915 College of Electrical, Engineering and Automation; Shandong University of Science and Technology; Qingdao; China; College of Electronic and Information Engineering Department of Neurology , Zhongnan Hospital of Wuhan University , Wuhan 430071 , China; Teaching and research section of Neuropsychiatry , Zhongnan Hospital of Wuhan University , Wuhan 430071 , China Department of Ultrasound, Zhejiang Rongjun Hospital, The Third Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China (mainland) Marine College, Shandong University Henan Eye Hospital & Henan Eye Institute, Department of Ophthalmology, Henan Provincial People's Hospital, Zhengzhou, Henan, China Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Jiangsu China; Department of Periodontics Affiliated Hospital of Stomatology Nanjing Medical Nanjing Jiangsu China Department of Emergency, The First Affiliated Hospital of Baotou Medical College of Inner Mongolia University of Science and Technology, Baotou, China Department of Ultrasound Diagnosis the Second Xiangya Hospital Central South University Changsha Hunan 410011 China Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China; Department of Periodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China Nursing College, Zunyi Medical University School of Medicine and Technology, Zunyi, Guizhou Province, China. Division of Respiratory Medicine Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing China Jiangsu Provincial Center for Disease Control and Prevention, Jiangsu Road 172, Nanjing 210009, China Dorrance H. Hamilton Laboratories, Center for Human Virology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 grid.258151.a 0000000107081323 The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology Jiangnan University 1800 Lihu Avenue 214122 Wuxi Jiangsu China; grid.258151.a 0000000107081323 State Key Laboratory of Food Science and Technology Jiangnan University 1800 Lihu Avenue 214122 Wuxi Jiangsu China Key Laboratory of Industrial Biotechnology of Ministry of Education, State Key Laboratory of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China Zunyi Municipal Key Laboratory of Medicinal Biotechnology, Affiliated Hospital of Zunyi Medical University, Zunyi, China; Center for Translational Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China Zunyi Municipal Key Laboratory of Medicinal Biotechnology, Affiliated Hospital of Zunyi Medical University, Huichuan District, Zunyi 563003, China; Center for Translational Medicine, Affiliated Hospital of Zunyi Medical University, Huichuan District, Zunyi 563003, China Department of Chemistry, University of Chicago, Chicago, Illinois 60637, United States; Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States School of Life Science and Technology Xidian University Xi'an Shaanxi People's Republic of China; Engineering Research Center of Molecular and Neuro Imaging Ministry of Education Xi'an People's Republic of China Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, 3333 Burnet Avenue,Cincinnati, OH 45229-3039, USA. State Key Laboratory of Heavy Oil Processing, Center for Bioengineering and Biotechnology, College of Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, China; College of Electronic Engineering and Automation, Shandong University of Science and Technology, Qingdao 266590, China Department of Rheumatology and Immunology, The Affiliated Suqian First People’s Hospital of Nanjing Medical University , Suqian, China State Key Laboratory of Advanced Processing and Recycling of Non-Ferrous Metals and School of Materials Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, P. R. China Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technology, Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, School of Environmental Science and Engineering, Nanjing University of Information Science & Technology, Nanjing 210044, China. State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. Department of Internal Medicine–Cardiovascular, the People’s Hospital of Rizhao City, Rizhao 276800, Shandong, P.R. China.; Department of Internal Medicine–Cardiovascular, the People’s Hospital of Rizhao City, Rizhao 276800, Shandong, P.R. China. Institute of Hematology, Jinan University, Guangzhou 510632, China; Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou 510632, China Department of Mechanical Engineering & Mechanics, Lehigh University, Bethlehem, Pennsylvania; Institute of Hematology & Blood Diseases Hospital, CAMS & PUMC, Tianjin, China. Department of Respiratory Medicine, Lung Cancer Center, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730 P.R. China China-UK HUST-RRes Genetic Engineering and Genomics Joint Laboratory, International Science and Technology Cooperation Base (Genetic Engineering) of Chinese Ministry of Science and Technology, The key laboratory of Molecular Biophysics of Chinese Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology (HUST), Luoyu Road 1037, Wuhan 430074, China. Department of General Internal Medicine, The First Affiliated Hospital of Jiangxi Medical College Shangrao 334000, Jiangxi, China. Department of Respiratory Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100730, China. College of Food Science and Nutritional Engineering China Agricultural University Beijing P. R. China; School of Food Science and Pharmaceutics Zhejiang Ocean University Zhoushan P. R. China School of Life Sciences, Tsinghua University, Beijing, China; Nobel Institute of Biomedicine, Zhuhai, Guangdong, China Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China. Department of Cell Biology and of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA Department of Pathology, Cancer Hospital, Fudan University and Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. Center for Brewing Science and Enzyme Biotechnology, School of Biotechnology Jiangnan Univ Wuxi Jiangsu 214122 China Biochemistry Research Division, Shandong Medical College, Linyi 276002, China. Department of Neurology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China Research Center for Biochemistry and Molecular Biology, Jiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical University, Xuzhou, China. Department of Ophthalmology, First People's Hospital, Shanghai Jiao Tong University, Shanghai 200080, China. The University of Hong Kong Department of Physics, The Center of Theoretical and Computational Physics, , Pokfulam Road, Hong Kong, China Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China Division of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio Department of Pulmonary and Critical Care Medicine Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Beijing P.R. China Department of Medicine, Ottawa Hospital Research Institute at the University of Ottawa, Ottawa, Ontario, Canada Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China. Jiangsu Key Laboratory for Science and Applications of Molecular Ferroelectrics and School of Chemistry and Chemical Engineering, Southeast University, Nanjing211189, People’s Republic of China Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China Institute of Stomatology Nanjing Medical University Nanjing China Children’s Hospital of Fudan University, National Children’s Hospital of Fudan University,National Children’s Medical Center,Department of Neurology,Shanghai,China Department of Hematology The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan China Department of Anesthesiology University of Pittsburgh School of Medicine Pittsburgh PA USA School of Public Health, Peking Union Medical College, Beijing, China. Department of Chemistry, Cleveland State University, Cleveland, Ohio, USA State Key Laboratory of Food Science and Technology, The Key Laboratory of Industrial Biotechnology, Ministry of Education, Synergetic Innovation Center of Food Safety and Nutrition, and School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China 214122 Patent Examination Cooperation (Beijing) Center of The Patent Office, CNIPA, Beijing 100160, China Department of Lymphoma and Myeloma, Institute of Hematology and Blood Diseases Hospital, State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Sciences and Peking Union of Medical College, Tianjin, People's Republic of China School of Environmental Science and Engineering, Qingdao University, Qingdao 266071, China Department of Cancer Biology, Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA.; Department of Gynecology and Obstetrics, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education School of Chemistry and Chemical Engineering Shaanxi Normal University Xi'an 710119 China Department of Oral Medicine, College of Stomatology, Nanjing Medical University, Nanjing 210029, China. Xinhua Hospital Shanghai Jiaotong University School of Medicine Shanghai China; Shanghai Institute for Pediatric Research Shanghai China Key Laboratory of Chemical Biology (Ministry of Education) School of Pharmaceutical Sciences Cheeloo College of Medicine Shandong University Jinan Shandong 250012 China China-Japan Union Hospital of Jilin University, Changchun 130033, China. grid.258151.a 0000000107081323 The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology JiangNan University 1800# Lihu Road 214122 Wuxi JiangSu Province China Biotherapy Centre, The Third Affiliated Hospital Sun Yat‐Sen University Guangzhou China; Guangdong Provincial Key Laboratory of Liver Disease Research, The Third Affiliated Hospital Sun Yat‐Sen University Guangzhou China College of Chemistry and Molecular Engineering Zhengzhou University Zhengzhou 450001 People's Republic of China Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.; Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A. Department of Pediatrics Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital Nanjing China; Department of Pediatrics, The Affiliated Hospital of Xuzhou Medical University Xuzhou China Department of Expanded Program on Immunization, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China State Key Laboratory of Heavy Oil Processing and Center for Bioengineering and Biotechnology, China University of Petroleum (East China), Qingdao 266580, China 3 Department of Drug Abuse Control, Center for ADR monitoring of Guangdong, Guangzhou, People’s Republic of China Department of Andrology. Division of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States; Divisions of Pulmonary Biology and Biomedical Informatics, University of Cincinnati College of Medicine, Cincinnati, United States Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261; W-1358 Biomedical Science Tower, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261 State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjing 210023 China; Institute of Information Engineering Suqian College Suqian 223800 China Unit 36, Department of Neurology, Daqing Oilfield General Hospital, Daqing 163714, Heilongjiang, China Reproductive Medicine Center, The First Affiliated Hospital of Sun Yat-sen University , Guangzhou, Guangdong 510080 , China; The Key Laboratory for Reproductive Medicine of Guangdong Province , Guangzhou 510080 , China Perinatal Institute, Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio; and Department of Respiration, Peking Union Medical College Hospital, Chinese Academy of Medical Science No. 1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, China. State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China; Tianjin Institutes of Health Science, Tianjin 301600, China Department of Orthopaedic Surgery Nanjing First Hospital Nanjing Medical University Nanjing China; Cartilage Regeneration Center Nanjing First Hospital Nanjing Medical University Nanjing China; China‐Korea United Cell Therapy Center Nanjing First Hospital Nanjing Medical University Nanjing China Center for Neurodegenerative Disease Research (CNDR) Institute on Aging Department of Pathology and Laboratory Medicine University of Pennsylvania Perelman School of Medicine Philadelphia PA USA Digestive Department China‐Japan Union Hospital of Jilin University Changchun China The First School of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, China Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China Henan Eye Institute, Zhengzhou 450003, China. xuyan990301@yahoo.com.cn State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, China; International Joint Laboratory on Tea Chemistry and Health Effects of Ministry of Education, Hefei, China Department of Chemistry and Biochemistry, University of MarylandBaltimore County, Baltimore, Maryland 21228 Department of Electrical and Computer Engineering, University of Connecticut, Storrs, CT 06269 State Key Laboratory of Food Science and Technology, Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu 214122, China Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center and The University of Cincinnati College of Medicine, Cincinnati, Ohio Department of Nephrology, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnostics of Education Ministry of China, College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China Department of Orthopedic, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China BGI-Shenzhen, Shenzhen, Guangdong, China; BGI Education Center, University of Chinese Academy of Sciences, Beijing, China Authors' Affiliation: Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, P. R. China Nanjing Regenerative Medicine Engineering and Technology Research Center, Nanjing 210029, China Department of Oral Implantology Affiliated Stomatological Hospital of Nanjing Medical University Nanjing China; Jiangsu Province Key Laboratory of Oral Diseases Nanjing China; Jiangsu Province Engineering Research Center of Stomatological Translational Medicine Nanjing China Department of Respiratory and Critical Care Medicine Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing China Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, China State Key Laboratory of Food Science and Technology, Key Laboratory of Industrial Biotechnology of Ministry of Education, School of Biotechnology, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu, China 214122 State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei, P.R. China Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329. Northwest A&F University State Key Laboratory of Crop Stress Biology in Arid Areas, College of Horticulture, , 712100, Yangling, Shaanxi, China School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, 2 Xuelin Road, Qixia District, Nanjing 210023, People’s Republic of China College of Chemistry and Chemical Engineering, State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing University of Technology, Nanjing 210009, P. R. China; Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, P. R. China Clinical Pharmacology and Pharmacometrics Janssen Research & Development, LLC Spring House Pennsylvania USA; Simcere Pharmaceuticals Cambridge Massachusetts USA Jiangxi Center for Disease Control and Prevention Institute of Chronic Non-communicable Diseases, Jiangxi, China Water Conservancy and Civil Engineering College, Shandong Agricultural University, Daizong Road No.61, Tai'an, Shandong 271018, China Department of Orthopaedic Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.; Cartilage Regeneration Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.; China-Korea United Cell Therapy Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences Zhengzhou University No.100 Science Avenue Zhengzhou Henan 450001 China Department of Dentistry, No.2 People's Hospital of Jingdezhen. Jingdezhen 333000, Jiangxi Province, China. E-mail:846783850@qq.com. Department of Neurology, Guangdong 999 Brain Hospital, Guangzhou, China; Department of Chemistry Cleveland State University 2121 Euclid Ave Cleveland OH 44115 USA; Case Comprehensive Cancer Center Case Western Reserve University 2103 Cornell Road Cleveland OH 44106 USA Department of Municipal Engineering, School of Civil Engineering, Southeast University, Nanjing 210096, China Jiangsu Key Laboratory for Organic Waste Utilization, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, PR China Department of Immunology, Institute of Laboratory Medicine, Jiangsu University, Zhenjiang 212013, China Key Laboratory of Health Risk Factors for Seafood of Zhejiang Province, School of Food Science and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China Department of Nephrology, the Affiliated Hospital of Qingdao University, Shandong 266003, China Centre for Immunology and Cancer Research, Princess Alexandra Hospital, University of Queensland, Woolloongabba, Brisbane, Australia Department of Neurology Peking University People's Hospital Beijing 100044 China Department of Neurology, People’s Hospital of Peking University, Beijing, China Global Clinical Pharmacology Janssen Research & Development, LLC Spring House PA USA State Key Lab of Inorganic Synthesis and Preparative Chemistry; Jilin University; Changchun; China Department of Obstetrics and Gynecology, Indiana University School of Medicine, 1044 W. Walnut St. R4-W037, Indianapolis, IN 46202, USA Department of Respiratory and Critical Care Medicine Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Beijing China State Key Laboratory of Coordination Chemistry; School of Chemistry and Chemical Engineering; Collaborative Innovation Center of Advanced Microstructures; Nanjing University; Nanjing 210023 Changchun University of Chinese Medicine, Changchun 130117, China Department of Gastraintestinal Endoscopy Room, Jingmen Central Hospital, Jingmen, Hubei, P.R. China 1Department of Cancer Biology, Lerner Research Institute, and; 2Department of Obstetrics and Gynecology, Gynecological Oncology Section, Cleveland Clinic, Cleveland, Ohio;; 6Department of Obstetrics and Gynecology, Indiana University, Indianapolis, Indiana School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China State Key Laboratory of Agricultural Genomics BGI‐Shenzhen Shenzhen China; College of Life Sciences University of Chinese Academy of Sciences Beijing China College of Food Science and Nutritional Engineering China Agricultural University Beijing PR China Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai 200438, China Department of Chemistry, Northeast Normal University, Changchun 130024, P.R. China, and State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, P.R. China Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai 200011, China Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania Departments of Anesthesiology (L.M.S., P.T., Y.X.), Immunology (B.L.), Pharmacology and Chemical Biology (P.T., Y.X.), Computational and Systems Biology (P.T.), and Structural Biology (Y.X.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (L.-J.J.); and Department of Biomedical Sciences, Texas Tech University Health Sciences Center, El Paso, Texas (H.D.) State Key Laboratory of Crop Stress Biology for Arid Areas College of Horticulture Northwest A&F University Yangling Shaanxi 712100 China; Key Laboratory of Horticultural Plant Biology and Germplasm Innovation in Northwest China Ministry of Agriculture Yangling Shaanxi 712100 China BioHelix Corporation, 32 Tozer Road, Beverly, MA 01915, USA. Department of Andrology, Jiangsu Province Hospital of Chinese Medicine / The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210029, China. Department of Emergency, Changzhou City No.1 People’s Hospital, Changzhou, Jiangsu Province, 213000, China State Key Laboratory of Heavy Oil Processing; China University of Petroleum (East China); Qingdao; China; Center for Bioengineering and Biotechnology Perinatal Institute Divisions of Neonatology Perinatal and Pulmonary Biology Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine Cincinnati OH USA Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan Province Changsha Hunan 410008 China; Department of Sports Medicine Xiangya Hospital Central South University Changsha Hunan 410008 China School of Biotechnology; Jiangsu University of Science and Technology; Zhenjiang 212018; PR China; Sericultural Research Institute Department of Chemistry, Cleveland State University, Cleveland, OH 44115, USA Microsoft Research, Redmond, WA, USA. Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China Department of Nephrology, The First People's Hospital of Wujiang, Wujiang Hospital Affiliated to Nantong University, Suzhou, Jiangsu 215200, P.R. China Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry, Chemical Engineering and Materials Science Soochow University 199 Ren-Ai Road, Suzhou Jiangsu 215123 China Los Alamos National Laboratory (LANL), Los Alamos, New Mexico, USA Department of Obstetrics and Gynecology the Affiliated Drum and Tower Hospital of Medical School of Nanjing University Nanjing Jiangsu China Department of Orthopedics, Xi’an Fifth Hospital, Xi’an, Shaanxi, PR China Department of Neurology, University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX 77030, USA Department of Anatomy Charité‐Universitätsmedizin Berlin Berlin Germany Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, China Division of Hematology, Department of Medicine University of Ottawa at the Ottawa Hospital Ottawa Ontario Canada Institute for Human Virology and Biodefense, Thomas Jefferson University, Jefferson Alumni Hall, Philadelphia, Pennsylvania 19107. College of Engineering, Shenyang Agricultural University, Shenyang 110866, China State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin China; Tianjin Institutes of Health Science Tianjin China *Institute of Molecular Cell Biology, Westfalian Wilhelms University-Münster, Münster 48149, Germany; and School of Management, Tianjin University of Technology, Tianjin 300384, China Department of Neurology, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, P.R. China Department of Clinical Laboratory Liyang People’s Hospital Liyang China College of Energy, Soochow Institute for Energy and Materials Innovations Light Industry Institute of Electrochemical Power Sources Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu Province Soochow University Suzhou Jiangsu 215006 China; Department of Applied Chemistry School of Chemistry and Materials Science Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of China Hefei Anhui 230026 China Laboratory of Brewing Microbiology and Applied Enzymology, School of Biotechnology, Jiangnan University, Wuxi 214122, China; Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China Department of Medical Ultrasound; Shanghai Tenth People's Hospital; Tongji University Cancer Center; Tongji University School of Medicine; Shanghai 200072 Department of Chemistry, University of Chicago, Chicago, Illinois 60637, United States State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. Department of Orthopedics, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China (mainland) Department of Health Management Center Xiangya Hospital, Central South University Changsha China College of Pediatrics, Henan University of Chinese Medicine, Zhengzhou, Henan 450000, China State Key Laboratory of Food Science and Technology, Key Laboratory of Industrial Biotechnology of Ministry of Education, Synergetic Innovation Center of Food Safety and Nutrition, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China State Key Laboratory of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China School of Psychology, Beijing Normal University School of Mathematics and Physics, University of Science and Technology Beijing, Beijing 100083, China. xuyan@ustb.edu.cn Key Laboratory of Industrial Biotechnology of Ministry of Education & School of Biotechnology, Jiangnan University , Wuxi, China State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China; Center for Infection & Immunity of Lille (CIIL), INSERM U1019, CNRS UMR 8204, Institut Pasteur de Lille, University of Lille Nord de France, Lille, France Institute of Stomatology, Nanjing Medical University, Nanjing, China.; Department of Periodontics, School of Stomatology, Nanjing Medical University, Nanjing, China. Department of Rehabilitation, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Huzhou Hospital of Zhejiang University, Huzhou 313000, P. R. China Department of Chemistry, College of Science Northeastern University Shenyang China JNU-WLY Collaborative Innovation Laboratory of Microbiome and Ecological Fermentation Technology, Jiangnan University, Wuxi 214122, PR China; Lab of Brewing Microbiology and Applied Enzymology, Key Laboratory of Industrial Biotechnology of Ministry of Education, Jiangnan University, Wuxi 214122, PR China Institute of Soil and Water Resources and Environmental Science, College of Environmental and Resource Sciences, Zhejiang University , Hangzhou, China; Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment, Zhejiang University , Hangzhou, China Department of Applied Chemistry School of Chemistry and Materials Science Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of China 230026 Hefei Anhui China International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, Institute of Microscale Optoelectronics, Shenzhen University, Shenzhen 518060, China; Department of Physics Chemistry and Biology (IFM), Linköping University, Linköping SE-58183, Sweden Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261;; Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261;; Department of Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261;; Department of Physics and Astronomy, University of Pittsburgh, Pittsburgh, PA 15261 Key Laboratory of Agricultural Microbiology of Heilongjiang Province, Northeast Agricultural University, Harbin 150030, PR China Key Laboratory of Industrial Biotechnology of the Ministry of Education & School of Biotechnology 214036 Wuxi P.R. China Department of Clinical Laboratory, Xijing Hospital, School of Preventive Medicine, Fourth Military Medical University, Xi'an 710032, China. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China Institute of Ultrasound Imaging and Department of Ultrasound, Second Affiliated Hospital of Chongqing Medical University; Chongqing Key Laboratory of Ultrasound Molecular Imaging, Chongqing, P.R. China. Shenyang National Laboratory for Materials Science, Northeastern University, Shenyang 110819, China; Electrobiomaterials Institute, Key Laboratory for Anisotropy and Texture of Materials (Ministry of Education), Northeastern University, Shenyang 110819, China From the Departments of Anesthesiology (M.N.K., Q.C., Y.X., P.T.), Pharmacology and Chemical Biology (Y.X., P.T.), Structural Biology (Y.X.), and Computational and Systems Biology (P.T.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania (W.B Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, Ministry of Education, Shandong Key Laboratory of Biochemical Analysis, Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, PR China Intervention Center, Jinan Infectious Disease Hospital, Medical College of Shandong University, Jinan, China. Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine Nanjing, Jiangsu, China. Global Clinical Pharmacology Janssen Research & Development LLC Spring House PA USA State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, People's Republic of China Division of Pulmonary Biology, and College of Chemistry and Chemical Engineering; State Key Laboratory of Materials-Oriented Chemical Engineering; Nanjing University of Technology; Nanjing 210009; PR China Department of Oral Medicine, School of Stomatology, Anhui Medical University, Hefei 230032, China. Department of Chemical Engineering and Material, Dalian Institute of Light Industry, China. Department of Pulmonary Medicine, Lung Cancer Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China Beijing Key Laboratory of Applied Experimental Psychology, National Demonstration Center for Experimental Psychology Education (Beijing Normal University), Faculty of Psychology Beijing Normal University Beijing China Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital Peking Union Medical College & Chinese Academy of Medical Science Beijing China Departments of Anesthesiology and Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261 Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana West China Biobanks, Department of Clinical Research Management, West China Hospital, Sichuan University, Chengdu 610041, China. 1The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210023, P. R. China The Dorrance H. Hamilton Laboratories, Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Jefferson Alumni Hall, Philadelphia, Pennsylvania 19107 National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research (Wuhan), Huazhong Agricultural University, Wuhan, 430070, P.R. China Department of Pharmacy at the Second Affiliated Hospital, and Department of Pharmacology (The Key Laboratory of Cardiovascular Research, Ministry of Education) at College of Pharmacy, Harbin Medical University, Harbin, China Key Lab of Biomaterial and Additive Manufacturing Research, Institute of Digital Medicine, Nanjing Medical University Nanjing China; Clinical Orthopaedic Medical Center of Nanjing Metro, Nanjing First Hospital Nanjing China State Key Laboratory of Food Science and Technology, The Key Laboratory of Industrial Biotechnology, Ministry of Education, Synergetic Innovation Center of Food Safety and Nutrition, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, China; and Department of Chemistry; College of Sciences; Northeastern University; Shenyang; China Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350004, China Division of Pulmonary BiologyCincinnati Children's Hospital Medical CenterCincinnatiOhioUSA Genome Science Programs, Bioenergy and Biome Science, Los Alamos National Laboratory, Los Alamos, New Mexico, USA Institute of Aviation Medicine, Air Force, Beijing 100142, China Invivotek, Hamilton, New Jersey, USA National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, the Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, the Ministry of Education, College of Life Sciences, Shaanxi Normal University , Xi’an, The People’s Republic of China Perinatal Institute, Division of Neonatology, Perinatal, and Pulmonary Biology, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio; and Yerkes Regional Primate Research Center, Division of Microbiology and Immunology, Emory University, Atlanta, Georgia 30329 Beijing Key Laboratory of Applied Experimental Psychology, National Demonstration Center for Experimental Psychology Education (Beijing Normal University), Faculty of Psychology, Beijing Normal University, Beijing, China Shenzhen Luohu People’s Hospital (The Third Affiliated Hospital of Shenzhen University), Shenzhen, China State Key Laboratory of Food Science and Technology, Key Laboratory of Industrial Biotechnology of Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, China Department of Neurology, Huashan Hospital Fudan University Shanghai China College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, People's Republic of China; School of Computer Science and Technology, Harbin Institute of Technology, Harbin 150001, People's Republic of China Reproductive Medicine Center The First Affiliated Hospital, Sun Yat‐sen University Guangzhou Guangdong China; Guangdong Provincial Key Laboratory of Reproductive Medicine Guangzhou Guangdong China Departments of Anesthesiology, Computational Biology, Pharmacology and Chemical Biology, and Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261 Department of Health Management Center, Xiangya Hospital, Central South University , Changsha, Hunan , People’s Republic of China State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, China Pharmaceutical University, Nanjing 211198; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China. 3Department of Chemistry, Cleveland State University, Cleveland, Ohio.; 7Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio. Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Division of Chemistry, Department of Medical Sciences, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan. xuyan@med.miyazaki-u.ac.jp. Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), School of Physical and Mathematical Sciences, Nanjing Tech University (NanjingTech), Nanjing 211816, China Perinatal Institute, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, Division of Neonatology, Perinatal and Pulmonary Biology, Cincinnati, Ohio Department of Gynecology, Shenyang Women and Children’s Hospital, Shenyang 110000, China. Department of Orthopaedic Surgery Nanjing First Hospital Nanjing Medical University Nanjing People's Republic of China; Cartilage Regeneration Center Nanjing First Hospital Nanjing Medical University Nanjing People's Republic of China Institute of Intelligence Science and Technology, Hohai University, Nanjing, Jiangsu 211100, China State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing, China School of Biotechnology Key Laboratory of Industrial Biotechnology State Key Laboratory of Food Science and Technology Ministry of Education Jiangnan University Wuxi China Clinical Pharmacology and Pharmacometrics Janssen Research & Development, LLC Spring House Pennsylvania USA Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo, Kyoto, 606-8502, Japan b Invivotek, Hamilton, New Jersey, USA Division of Pulmonary Biology, and; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio Department of Endocrinology, The Affiliated Hospital of Beihua University, Jilin City, Jilin Province, 132000, China Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China Department of Orthopaedic Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China (mainland) *Medical Innovation Center, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan; Case Comprehensive Cancer Center, Cleveland, Ohio, USA Department of Medical Genetics and Cell Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450052, P.R. China Nanoscience and Nanotechnology Research Center Research Organization for the 21st Century Osaka Prefecture University 1‐2, Gakuen‐cho Naka‐ku, Sakai Osaka 599‐8570 Japan Department of Orthopedics, Nanjing First Hospital, Nanjing Medical University, Nanjing Jiangsu, 210006, PR China. yanxu5427@yahoo.com.cn The Perinatal Institute, Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. yan.xu@cchmc.org. Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. yan.xu@cchmc.org. School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, People’s Republic of China Department of Pharmaceutical Analysis, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China Key Laboratory of Industrial Biotechnology of Ministry of Education and School of Biotechnology, Jiangnan University, Wuxi, P. R. China; Department of Pathology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, P.R. China Beidaihe Central Experimental Station, Chinese Academy of Fishery Sciences, Qinhuangdao 066100, China. Orthopaedic Laboratory of Nanjing First Hospital, Nanjing Medical University, Nanjing, China Key Laboratory of Food Nutrition and Safety (Tianjin University of Science & Technology); Ministry of Education; Tianjin 300457; China Department of Neurology and Epilepsy Center Children's Hospital of Fudan University Shanghai China State Key Laboratory of Software Development Environment Key Laboratory of Biomechanics and Mechanobiology of Ministry of Education Beihang University Beijing 100191 China Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China Janssen Research & Development, LLC Spring House Pennsylvania USA Division of Pulmonary Biology and Neonatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine,Cincinnati, OH 45229, USA. School of Life and Health Sciences Chinese University of Hong Kong Shenzhen China Learner Research Institute, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Department of Chemistry, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States Microsoft Research, Beijing, China Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, and The University of Cincinnati College of Medicine, Cincinnati, OH 45229 State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou City, China The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Qingchun Rd, Hangzhou, China Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. Department of Chemistry University of Texas at Austin 100 East 24th street Austin TX 78712 USA Center for Reproductive Medicine and Department of Gynecology & Obstetrics First Affiliated Hospital of Sun Yat‐sen University, Guangdong Provincial Key Laboratory of Reproductive Medicine Guangzhou China Division of Pulmonary Biology, Cincinnati Children’s Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. From the Departments of Neuroscience (V.R.V., R.V., L.M.O’K., Y.X., J.C., B.F., L.D.M.) and Neurology (L.D.M.), University of Connecticut, Farmington. Department of Ob/GYN; Indiana University School of Medicine; Indianapolis, IN USA Department of Gastroenterology Zhongnan Hospital of Wuhan University Wuhan China; Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases Wuhan China Center of Morphological Experiment, Yanbian University, Yanji 133002, Jilin, China College of Chemistry and Chemical Engineering; State Key Laboratory of Materials-Oriented Chemical Engineering; Nanjing Tech University; Nanjing 210009; PR China From the Department of Neuroscience (F.L., J.L., J.L., S.E.B., M.S., S.A., Y.X., L.D.M.), University of Connecticut Health Center, Farmington, CT; and The Stroke Center at Hartford Hospital (L.D.M.), Hartford, CT. Jiangsu Key Laboratory for Science and Applications of Molecular Ferroelectrics and School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, P. R. China Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital Chinese Academy of Medical Sciences, Peking Union Medical College Beijing People’s Republic of China Michael Smith Laboratories University of British Columbia Vancouver British Columbia V6T 1Z4 Canada; Department of Botany University of British Columbia Vancouver British Columbia V6T 1Z4 Canada Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA; Baltimore Veterans Affairs Medical Center, Baltimore, Maryland, USA Authors' Affiliations: 1Department of Molecular and Cellular Biology, Dan L. Duncan Cancer Center, Baylor College of Medicine; State Key Laboratory of Crop Stress Biology in Arid Areas, Northwest A&F University, Yangling , Shaanxi , China; College of Horticulture, Northwest A&F University , Yangling, Shaanxi , China; Key Laboratory of Horticultural Plant Biology and Germplasm Innovation in Northwest China, Ministry of Agriculture , Yangling, Shaanxi , China State Key Laboratory of Materials-oriented Chemical Engineering, Nanjing University of Technology, Nanjing 210009, People’s Republic of China; State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, People’s Republic of China Chinese Education Ministry’s Key Laboratory of Western Resources and Modern Biotechnology, Key Laboratory of Biotechnology Shaanxi Province, Shaanxi Key Laboratory for Carbon Neutral Technology, Shaanxi Academy of Basic Sciences, College of Life Sciences, Northwest University, Xi’an 710069, China Department of Laboratory Medicine, Hunan Aerospace Hospital, Changsha, Hunan, China Departments of Anesthesiology, Pharmacology & Chemical Biology, Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Nanjing Regenerative Medicine Engineering and Technology Research Center, Nanjing, China. State Key Lab of Inorganic Synthesis and Preparative Chemistry; Jilin University; Changchun 130012, China Departments of Anesthesiology, Pharmacology and Structural Biology, and Computational Biology, University of Pittsburgh School of Medicine, and Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260 Nanoscience and Nanotechnology Research Center, Research Organization for the 21st Century, Osaka Prefecture University, 1-2, Gakuen-cho, Naka-ku, Sakai, Osaka 599-8570, Japan Department of Applied Chemistry, China Agricultural University, Key Laboratory of Pesticide Chemistry and Application, Ministry of Agriculture, Beijing 100193, China. xuyanzsy@gmail.com State Key Laboratory of Experimental Hematology Institute of Hematology & Blood Diseases Hospital National Clinical Research Center for Blood Diseases Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, USA. Department of Chemistry, Wuhan University, Wuhan 430072, China College of Chemistry and Chemical Engineering State Key Laboratory of Materials-Oriented Engineering Nanjing Tech University Nanjing 210009 P.R. China School of Pharmacy Shanghai University of Traditional Chinese Medicine Shanghai China Department of Molecular Medicine of College of Biology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, China College of Chemistry and Chemical Engineering; Nanjing Tech University; Nanjing; P. R. China State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin 300020, China Biotherapy Centre & Cell‐Gene Therapy Translational Medicine Research Centre The Third Affiliated Hospital Sun Yat‐sen University Guangzhou 510630 China College of Chemistry and Chemical Engineering; State Key Laboratory of Materials-oriented Chemical Engineering; Nanjing Tech University; Nanjing 210009; P. R. China Department of Obstetrics and Gynecology, Dongtai Traditional Chinese Medicine Hospital, Dongtai City, Jiangsu Province, China Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education, Northwest Normal University, Lanzhou730070, China; College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou730070, China; Key Laboratory of Polymer Materials of Gansu Province, Northwest Normal University, Lanzhou730070, China The Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, People’s Republic of China; Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People’s Hospital Affiliated with Jinan University, Jinan University, Zhuhai, People’s Republic of China Laboratory of Brewing Microbiology and Applied Enzymology, Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China 214122 Department of Neurology, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston. Department of Surgical Oncology and General Surgery, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, The First Affiliated Hospital of China Medical University, Shenyang, China Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Gastroenterology Division, Department of Medicine, University of Maryland School of Medicine and Baltimore VA Hospital and Greenebaum Cancer Center, Baltimore, MD 21201. Institute of Aviation Medicine, Air Force, Beijing 100036, China. Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229-3039; Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232-2370; Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6145; and Division of Developmental Neurobiology, National Institute for Medical Research, London NW7 1AA, England Department of General Surgery, The Second Affiliated Hospital of The Air Force Medical University (formerly Tangdu Hospital of Fourth Military Medical University), Xi’an, Shaanxi, China (mainland) New Drug Pharmacology Center of Lunan Pharmaceutical Group Linyi 276006,China State Key Laboratory of Generic Technology of Traditional Chinese Medicine Linyi 276006,China. Medical Student, Queen's University, Kingston, Ontario ; Research Assistant, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia. Division of Pulmonary Biology, and; Division of Developmental Biology, Cincinnati Children’s Research Foundation, Cincinnati, Ohio Department of Information and Computer Science, University of Science and Technology Beijing, Beijing 100083, China Department of Nephrology, Affiliated Hospital of Qingdao University, Qingdao, China; From the Departments of Anesthesiology and Critical Care Medicine (S.L., P.T., Y.X.), Pathology (R.L.H.), and Pharmacology (Y.X.), University of Pittsburgh (Pa). Department of Statistics University of Science and Technology Beijing China School of Chemistry and Materials Science, Jiangsu Provincial Key Laboratory of Material Cycle Processes and Pollution Control, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Nanjing Normal University, Nanjing 210023, China Department of Medicine, University of Toronto, Toronto, Canada. Department of Chemistry, Jilin University Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China Dorrance H. Hamilton Laboratories, Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Thomas Jefferson University, 1020 Locust Street, Suite 329, Philadelphia, PA 19107; and Department of Biology, Chestnut Hill College, 9601 Germantown Avenue, Philadelphia, PA 19118 Department of Cardiology, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing People's Republic of China; Department of Periodontics Affiliated Hospital of Stomatology Nanjing Medical University Nanjing People's Republic of China Department of Orthopedic, Nanjing First Hospital, Nanjing, Jiangsu, China (mainland) Department of Applied Chemistry School of Chemistry and Materials Science Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of China Hefei Anhui 230026 China Respiratory Department, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, PR China Department of Gastroenterology, The First Affiliated Hospital of Chinese PLA General Hospital, Beijing - PR China Department of Clinical Laboratories, Xijing Hospital, Fourth Military Medical University Xi'an 710032, China. Department of Chemistry; College of Sciences; Northeastern University; Shenyang 110819; China Michael Smith Laboratories University of British Columbia Vancouver British Columbia Canada; Department of Botany University of British Columbia Vancouver British Columbia Canada Department of Gastroenterology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang, China Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland;; Baltimore Veterans Affairs Medical Center, Baltimore, Maryland State Key Laboratory of Heavy Oil Processing; Center for Bioengineering and Biotechnology; China University of Petroleum (East China); Qingdao; China Department of Interventional Therapy Tianjin Medical University Cancer Institute and Hospital Tianjin China School of Biotechnology; Key Laboratory of Industrial Biotechnology; Ministry of Education; Jiangnan University; Wuxi 214122 Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico, USA Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China. Department of Materials Engineering; School of Engineering and Center for NanoBio Integration; The University of Tokyo; Bunkyo-ku, Tokyo 113-8656; Japan Department of Neurology The University of Texas Health Science Center at Houston McGovern Medical School Houston TX 77030 USA College of Chemistry and Chemical Engineering, State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 210009, P. R. China; Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, P. R. China Department of Biology, College of Life Sciences, Shanghai Normal University, Shanghai, China. Henan Eye Institute, Henan Eye Hospital, Zhengzhou 450003, China. Email: xuyan990301@aliyun.com. Department of Ultrasound Diagnosis; The Second Xiangya Hospital; Central South University; Changsha; China Department of Neurology, National Children’s Medical Center, Children’s Hospital of Fudan University, Shanghai, China Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China Department of Cardiovascular Medicine, the Second Affiliated Hospital of Nanchang University, Nanchang, China Department of Information and Computer Science, University of Science and Technology Beijing, Beijing, China; Gordon Life Science Institute, Belmont, MA, USA Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing China Department of Neurology, Peking University People’s Hospital, Beijing, China Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China grid.258151.a 0000000107081323 The Key Laboratory of Industrial Biotechnology, School of Biotechnology Jiangnan University, Ministry of Education 214122 Wuxi China College of Bioinformatics Science and Technology Harbin Medical University China Department of Respiratory and Critical Care Medicine of Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China College of Chemistry and Chemical Engineering, State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 210009, P. R. China Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065; College of Bioinformatics Science & Technology, Harbin Medical University, Harbin 150081, PR China College of Chemistry and Chemical Engineering, State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing University of Technology, Nanjing 210009, People's Republic of China; Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, People's Republic of China 1Medicine, Division of Gastroenterology and Departments of Department of Thoracic Medical Oncology, Hunan Cancer Hospital/the Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Changsha China Department of ICU, Hangzhou Cancer Hospital, Hangzhou, 320001, Zhejiang, China State Key Laboratory of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, Key Laboratory of Industrial Biotechnology of Ministry of Education, School of Biotechnology, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu 214122, China 8Department of Chemistry, Cleveland State University, Cleveland, Ohio. Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing China Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University , Jinan 250012 , China; NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University , Jinan 250012 , China; Department of Pharmacology, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University , Jinan 250012 , China 1Medicine, Division of Gastroenterology, and Departments of Department of Nursing Platform for Bone and Joint and Sports Medicine, The First Hospital of Jilin University, Changchun, China; Department of Obstetrics and Gynecology, Reproductive Medicine Center, The First Affiliated Hospital of Sun Yat-sen University , Guangzhou, China; Guangdong Provincial Key Laboratory of Reproductive Medicine , Guangzhou, China Vaccine Research Center; Yerkes Regional Primate Research Center, Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8501, Japan. State Key Laboratory of Heavy Oil Processing, Center for Bioengineering and Biotechnology, College of Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, China Department of Periodontics, Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, Jiangsu, China; Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Shanghai road 1, Nanjing, Jiangsu, China; Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University, Nanjing, Jiangsu, China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, China Department of Geriatrics the Second Xiangya Hospital Central South University Changsha PR China Department of Respiratory Medicine, Lung Cancer Center, Peking Union Medical College Hospital, Peking Union Medical College Chinese Academy of Medical Sciences Beijing China Bioscience Division, Los Alamos National Laboratory , Los Alamos, NM 87545, USA Department of Food Science and Engineering, School of Agricultural Engineering and Food Sciences Shandong University of Technology Zibo China Reproductive Medicine Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Reproductive Medicine, Guangzhou, China Beijing National Laboratory of Molecular Sciences (BNLMS) Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education College of Chemistry Peking University Beijing 100871 China State Key Laboratory of Software Development Environment, Key Laboratory of Biomechanics and Mechanobiology of Ministry of Education; Beihang University; Beijing 100191 China; Microsoft Research; Beijing China Department of Neurology, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX 77030, USA Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan Jiangsu Key Laboratory for High-Tech Research and Development of Veterinary Biopharmaceuticals, Jiangsu Agri-Animal Husbandry Vocational College, Taizhou 225300, China Reproductive Medical Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Reproductive Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China Key Laboratory of Environment Correlative Dietology (Ministry of Education), College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210 Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, New York 13210, United States; Upstate Cancer Research Institute, Syracuse, New York 13210, United States Department of Neurology and Neuroscience, University of Connecticut Health Center, Farmington, Connecticut, USA Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) School of Physical and Mathematical Sciences Nanjing Tech University (NanjingTech) Nanjing 211816 China New Drug Pharmacological Center of Lunan Pharmaceutical Group Corporation Linyi 276006, China State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine Linyi 276006, China. From the Medical Informatics Center (H.L.) and Department of Epidemiology and Biostatistics, School of Public Health (Y.T.), Peking University, Beijing, China; and Department of Neurology, Peking University People’s Hospital, Beijing, China (Y.X., J.Z.). State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of Chemistry Jilin University 2699 Qianjin Street Changchun 130012 P. R. China From the Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, and Center for the Neural Basis of Cognition, Pittsburgh, Pennsylvania (A.R.S. and Y.X.); Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania (N.R.B., P.T., and Y.X.); Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pit Department of Applied Chemistry, School of Chemistry and Materials Science, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui 230026, People’s Republic of China Laboratory of Ocular Pharmacology, Henan Eye Institute; Henan Eye Hospital; Department of Ophthalmology, Henan Provincial People's Hospital, Zhengzhou, China. Department of Neurology Institute of Neurology Huashan Hospital Shanghai Medical College Fudan University Shanghai China Northwest A&F University State Key Laboratory of Crop Stress Biology in Arid Areas, College of Horticulture, , Yangling, Shaanxi 712100, China School of Pharmaceutical Science; Nanjing Tech University; Nanjing 211816; China Department of Pathogenic Biology and Immunology, Kunming Medical University, China Laboratory of Brewing Microbiology and Applied Enzymology, The Key Laboratory of Industrial Biotechnology, Ministry of Education, State Key Laboratory of Food Science and Technology, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China Hunan Key Laboratory of Super Microstructure and Ultrafast Process; School of Physics and Electronics; Central South University; Changsha 410083; China College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China Thoracic Medicine Department 2, Cancer Hospital Affiliated to Xiangya Medical College, Central South University, Changsha, Hunan 410013, P.R. China 4Ciechanover Institute of Precision and Regenerative Medicine, School of Medicine, Chinese University of Hong Kong, Shenzhen 518172, China State Key Laboratory of Crop Stress Biology for Arid Areas, Key Laboratory of Genetic Improvement of Horticultural Crops of Northwest China, College of Horticulture, Northwest A&F University, Yangling 712100, Shaanxi, P.R. China The First Afliated Hospital of University of South China University of South China Hengyang China School of Biotechnology, Jiangnan University, Wuxi 214122, China Department of Orthopedic Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China (mainland) Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio College of Chemistry and Chemical Engineering; State Key Laboratory of Materials-Oriented Chemical Engineering; Nanjing Tech University; Nanjing 210009; P.R. China Key Laboratory of Healthy Mariculture for the East China Sea, Ministry of Agriculture and Rural Affairs, Fisheries College Jimei University Xiamen China; National Demonstration Center for Experimental Aquatic Science and Technology Education Jimei University Xiamen China Department of Breast surgery Daping Hospital, Research Institute of Surgery, Third Military Medical University Chongqing 400038 China Heyuan Polytechnic, Heyuan, 517000, PR China; Department of Biology, College of Science, Shantou University, Shantou 515063, PR China Department of Molecular and Medical Genetics, University of Toronto, and Department of Genetics, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada Hoffman Institute of Advanced Materials, Shenzhen Polytechnic, Shenzhen, Guangdong 518000, China; Department of Applied Chemistry, School of Chemistry and Materials Science, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui 230026, China Electrical Engineering and Automation Shandong University of Science and Technology Tsingtao 266590 China School of Life Sciences and Technology, Tongji University, Shanghai, China Department of Neurology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China. 1Department of Cancer Biology, Lerner Research Institute and; 2Department of Gynecology and Obstetrics, The Cleveland Clinic Foundation, Cleveland, Ohio; Physics and Electronic Engineering Department; Xinxiang University; Xinxiang 453003; P. R. China Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China Jiangsu Province Engineering Research Center of Stomatological Translational Medicine Nanjing Medical University Nanjing 210029 China Jiangsu Province Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu, China Medical Research Center, Zhoushan Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Zhoushan, 316000, China Department of Interventional Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China (mainland) College of Food Science, Northeast Agricultural University, Harbin, China Hoffmann Institute of Advanced Materials, Shenzhen Polytechnic, Shenzhen, Guangdong518000, China; Department of Applied Chemistry, School of Chemistry and Materials Science, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui230026, China Department of Analytical Chemistry, China Pharmaceutical University, Nanjing 210009, China; Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, Nanjing 210009, China The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST), Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology (KLOBME), Wuhan University, Wuhan, China Department of Clinical Biobank, Affiliated Hospital of Nantong University & Department of Pathology, Medical School of Nantong University, Nantong 226001, Jiangsu, China College of Horticulture Northwest A&F University Yangling People's Republic of China; Key Laboratory of Horticultural Plant Biology and Germplasm Innovation in Northwest China, Ministry of Agriculture Northwest A&F University Yangling People's Republic of China; State Key Laboratory of Crop Stress Biology in Arid Areas Northwest A&F University Yangling People's Republic of China Lab of Brewing Microbiology and Applied Enzymology, School of Biotechnology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China Department of Hepatobiliary and Pancreatic Surgery, Qunli Branch, the First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, P.R. China Department of Biology, College of Life and Environment Science, Shanghai Normal University, Shanghai, 200234, People's Republic of China State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University Department of Pathology, Jinling Hospital, Nanjing University School of Medicine Nanjing, P.R.China ; Department of Internal Medicine, Zhong Da Hospital Affiliated to Southeast University Nanjing, P.R.China. Department of Materials Engineering; School of Engineering and Center for NanoBio Integration; The University of Tokyo; Tokyo 113-8656; Japan College of Life Science, South-Central University for Nationalities, Wuhan 430074, China Janssen Research & Development LLC. Spring House Pennsylvania USA State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, P.R.China School of Life Sciences, Tsinghua University, 100084 Beijing, China; Department of Orthopaedics, Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Key Lab of Additive Manufacturing Technology, Institute of Digital Medicine, Nanjing Medical University, Nanjing, China; Cartilage Regeneration Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China College of Horticulture, Sichuan Agricultural University, 211 Huimin Road, Wenjiang District, Chengdu 611130, People’s Republic of China International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, Institute of Microscale Optoelectronics Shenzhen University Shenzhen 518060 China; Department of Physics, Chemistry, and Biology (IFM) Linköping University Linköping SE‐58183 Sweden Department of Respiratory Medicine Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Institute of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, Haidian District, Beijing, China. Jiangsu Provincial Key Laboratory for Organic Solid Waste Utilization Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, College of Resources and Environmental Sciences, Nanjing Agricultural University Nanjing 210095 China Office of Good Clinical Practice, The Affiliated Sir Run Run Hospital of Nanjing Medical University (the Third Affiliated Hospital of Nanjing Medical University), Nanjing 211166, Jiangsu Province, P.R.China Institute of Sports Medicine Peking University Third Hospital Beijing 100191 China Department of Anesthesiology and Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261 Department of Obstetrics and Gynecology, Indiana University, 975 W. Walnut St., IB355A, Indianapolis, IN 46202, USA. xu2@iupui.com Key Laboratory of 3D Micro/Nano Fabrication and Characterization of Zhejiang Province, School of Engineering, Westlake University, Hangzhou 310024, China; Institute of Advanced Technology, Westlake Institute for Advanced Study, Hangzhou 310024, China Jiangsu Key Laboratory for Advanced Metallic Materials, School of Materials Science and Engineering, Southeast University, Nanjing 211189, China School of Environmental Science and Engineering, Suzhou University of Science and Technology, Suzhou 215009, China. Division of Chemistry, Department of Medical Sciences, Faculty of Medicine University of Miyazaki 5200 Kihara Kiyotake Miyazaki Japan Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo-ku Kyoto 606-8502, Japan, Department of Materials Science and Chemistry, Faculty of Systems Engineering, Wakayama University, 930 Sakaedani Wakayama 640-8510, Japan, Department of Cellular and Molecular Biology, Hiroshima University, Hiroshima 734-8553, Japan, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba Meguro-ku Tokyo 153-8904, Japan, and Institute for Integrated Cell-Material... Department of Emergency, the First Hospital of Jiaxing, Jiaxing 314001, Zhejiang, China. Corresponding author: Xu Jun, Email: jiaxingxujun@qq.com. SUNY Upstate Cancer Research Institute, Department of Pharmacology, State University of New York, Syracuse, New York 13210, United States; School of Pharmaceutical Sciences, Jilin University, Changchun, China Department of Municipal Engineering, School of Civil Engineering, Southeast University, Nanjing, Jiangsu China, 210096; Department of Civil and Environmental Engineering, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, Pennsylvania 15213-3890, United States Department of Medicine, University of Toronto, Toronto, ON, Canada. The Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China Vaccine Research Center; Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia 30329 Division of Chemistry, Department of Medical Sciences, Faculty of Medicine, University of Miyazaki Synergetic Innovation Center of Food Safety and Nutrition , Key Laboratory of Industrial Biotechnology, Ministry of Education, and Laboratory of Brewing Microbiology and Applied Enzymology, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu 214122, China Department of Gastroenterology/Hepatology, Zhongnan Hospital of Wuhan University, Wuhan, China;; Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases, Wuhan, China; Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China New England Research Institutes, Watertown MA, USA Department of Thyroid and Breast Surgery Affiliated Kunshan Hospital of Jiangsu University China Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Yu Hang Tang Road 388, Hangzhou 310058, Peopleʼs Republic of China, Department of Biochemistry and Center of Novel Functional Molecules, The Chinese University of Hong Kong, Shatin, Hong Kong, Peopleʼs Republic of China, Max-Planck-Institut für Chemische Ökologie, D-07745 Jena, Germany, and Department of Physiology, The Chinese University of Hong Kong, Shatin, Hong Kong, Peopleʼs... Department of Cardiology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China; Department of Neurology, Peking Union Medical College Hospital, Beijing, China. Jiangsu Luhe High School Nanjing China Laboratory of Ocular Pharmacology, Henan Eye Institute & Henan Eye Hospital, and Department of Ophthalmology, Henan Provincial People's Hospital, Zhengzhou, China Institute of Hematology, Jinan University, Guangzhou, China.; Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, China. State Key Laboratory of Software Development Environment, Key Laboratory of Biomechanics and Mechanobiology of Ministry of Education, Beihang University, Beijing, China.; Microsoft Research Asia, Beijing, China. Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China Department of Cardiology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China. Email: anyi_xuyan@hotmail.com. Dept. of Oral Medicine, College of Stomatology, Nanjing Medical University, Nanjing 210029, China. Department of Cardiovascular Medicine, Second Affiliated Hospital of Nanchang University, Institute of Cardiovascular Disease, Nanchang, Jiangxi, People’s Republic of China Department of Chemistry; Cleveland State University; Cleveland Ohio College of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610068, People’s Republic of China The First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan, China From the Department of Neurology (S.L., H.R., Y.X., Y. Zhang, H.Y., Y. Zhu, B.P., L.C.), Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences; Department of Epidemiology and Biostatistics Institute of Basic Medical Sciences (T.X.), Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College; Department of Neurology (W.Z., J.L., X.R., F.F.), Beijing Children's Hospital, Capital Medical University, National... Department of Respiratory and Critical Care Medicine Peking Union Medical College Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing P.R. China Department of Chemistry Cleveland State University Cleveland OH USA; Case Comprehensive Cancer Center Case Western Reserve University Cleveland OH USA Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University, Nanjing 210029, China Department of Gastroenterology and Hepatology, China-Japan Union Hospital of Jilin University Department of Obstetrics and Gynecology The Affiliated Drum and Tower Hospital of Medical School of Nanjing University Nanjing Jiangsu China Faculty of Hepato-Pancreato-Biliary Surgery, Chinese People’s Liberation Army (PLA) General Hospital, Institute of Hepatobiliary Surgery of Chinese PLA, Key Laboratory of Digital Hepatobiliary Surgery, Beijing, China (mainland) Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi’an, Shanxi, China (mainland) Department of Pharmacy, General Hospital of Central Theater Command, Wuhan, 430010 Hubei, China Henan Institute of Ophthalmology, Zhengzhou 450003, China. xuyan990301@yahoo.com.cn Drug Product Science & Technology Department, Bristol-Myers Squibb Co., New Brunswick, New Jersey 08903, United States 1 Department of Bioinformatics and Computational Biology, UT MD Anderson Cancer Center, Houston, TX 77030, 2Stanford Genome Technology Center, Stanford University, Palo Alto, CA 94304, USA, 3Bioinformatics Division, Walter & Eliza Hall Institute, Parkville, VIC 3052, Australia and 4Department of Statistics, University of California, Berkeley, CA 94720, USA Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (mainland) Division of Chemistry, Department of Medical Sciences, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan Faculty of International Medical Technology, Sanda University , Shanghai , China Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN 46202 3 Southwest Jiaotong University College Of Medicine, No.111, North Section, Second Ring Road, Chengdu, Sichuan 610031, P.R. China grid.258151.a 0000000107081323 State Key Laboratory of Food Science and Technology; The Key Laboratory of Industrial Biotechnology, Ministry of Education; Synergetic Innovation Center of Food Safety and Nutrition; School of Biotechnology Jiangnan University 214122 Wuxi Jiangsu China Beijing Normal University Department of Gynaecology, Second People’s Hospital in Kashgar, Xinjiang Uyhur Autonomous Region, No.1, Health Road, Kashgar 844000, Xinjiang, China Department of Nephrology The Affiliated Hospital of Qingdao University Qingdao China Key Laboratory of Industrial Biotechnology of Ministry of Education, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu 214122, People’s Republic of China SUNY Upstate Cancer Research Institute, Department of Pharmacology, State University of New York, Syracuse, New York 13210, United States National Clinical Research Center for Blood Diseases, State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China; Tianjin Institutes of Health Science Tianjin China College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China State Key Laboratory of Tea Plant Biology and Utilization, Hefei, Anhui, China;; College of Tea & Food Science and Technology, Anhui Agricultural University, Hefei, Anhui, China Department of Periodontology, School and Hospital of Stomatology, Anhui Medical University, Hefei 230032, China. yanxu09@yahoo.com.cn School of Chemistry and Environmental Engineering, Changchun University of Science and Technology, Changchun, 130022, China Institute of Soil and Water Resources and Environmental Science, Zhejiang Provincial Key Laboratory of Subtropical Soil and Plant Nutrition, Zhejiang University, Hangzhou 310058, China Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, P.R. China School of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun, Jilin 130107, P.R. China Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, China Department of Radiation Oncology, Zhejiang Cancer Hospital/Zhejiang Key Laboratory, Hangzhou, China Department of Pediatric Endocrinology and Genetic Metabolism, Xinhua Hospital, Shanghai Institute of Pediatric Research, School of Medicine Shanghai Jiao Tong University Shanghai China; Center for Prenatal Diagnosis, Xinhua Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China Department of Gynaecology and Obstetrics, The Seventh People's Hospital of Shanghai University of TCM, The New Pudong District, Shanghai 200137, China Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China Department of Obstetrics and Gynecology Indiana University School of Medicine 975 W. Walnut St. IB355A Indianapolis IN 46202 USA UCLA Olympic Analytical Laboratory, David Geffen School of Medicine University of California Los Angeles CA USA Jiangsu Key Laboratory of Chinese Medicine Processing, Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing Nanjing University of Chinese Medicine Nanjing China Institute of Integrative Cell Biology and Physiology, University of Muenster Muenster Germany Hefei Jingchuang Technology Co., Ltd, Hefei, 231500, P. R. China Zunyi Municipal Key Laboratory of Medicinal Biotechnology, Institute of Medicinal Biotechnology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China Division of Chemistry, Department of Medical Sciences, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, Japan. xuyan@med.miyazaki-u.ac.jp. The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; Key Laboratory of Pediatric Hematology and OncologyMinistry of HealthShanghai Jiao Tong University School of Medicine Shanghai China; Pediatric Translational Medicine InstituteShanghai Children's Medical CenterShanghai Jiao Tong University School of Medicine Shanghai China Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine (TCM), Shanghai, China State Key Laboratory of Materials-Oriented Chemical Engineering; College of Chemistry and Chemical Engineering; Nanjing Tech University; Nanjing, China Department of Medicinal Chemistry, School of Pharmacy, Jilin University, Changchun 130021, China. Department of Cardiology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China. Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China Department of Pharmacy; School of chemistry; Chemical Engineering and Life Sciences; Wuhan University of Technology; Wuhan 430070 Chronic Disease Prevention and Control Institute, Jiangxi Province Center for Disease Control and Prevention, Nanchang, Jiangxi 330006, China 1Department of Medicine, Division of Gastroenterology, and Departments of Anesthesiology and Pharmacology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15260 Department of Cardiology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, PR China.; Department of Pharmacology, Anhui Medical University, Hefei, PR China. Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, The Ministry of Education; National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China; College of Life Sciences, Shaanxi Normal University Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050 State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology& Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China; Tianjin Institutes of Health Science, Tianjin, China State Key Laboratory of Lead Compound Research, WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210023, China; Institute of Information Engineering, Suqian College, Suqian, 223800, China State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan; Ministry of Education Key Laboratory of Agricultural Biodiversity for Plant Disease Management, Yunnan Agricultural University, 650201 Kunming, China Department of Neurology, Zhongnan Hospital of Wuhan University, No. 169 East Lake Road Wuchang District, Wuhan, 430071, Hubei, China National Engineering Laboratory for AIDS Vaccine, School of Life Sciences Jilin University Changchun, Jilin China Institute for Human Virology and Biodefense, Thomas Jefferson University, Philadelphia, Pennsylvania 19107. Department of Intensive Medicine, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China. Corresponding author: Chen Dechang, Email: 13916602257@163.com. First Affiliated Hospital, Kunming Medical College, Kunming 650032, China. Department of Gastroenterology Guangzhou Cadre Health Management Center Guangzhou Guangdong Province China Soochow Institute of Energy and Material Innovations Key Laboratory for Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu Province College of Energy Soochow University Suzhou 215006 P. R. China; Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Soochow University Suzhou 215006 P. R. China Key Laboratory of Industrial Biotechnology of Ministry of Education and School of Biotechnology, Jiangnan University, Wuxi 214122, People's Republic of China; State Key Laboratory for Food Science and Technology, Jiangnan University, Wuxi 214122, People's Republic of China School of Physical and Mathematical Sciences, Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing 211816, China Department of Pediatric Intensive Care Unit Beijing Children’s Hospital Capital Medical University National Center for Children’s Health China Jiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical University, Xuzhou, Jiangsu, China; Research Center for Biochemistry and Molecular Biology, Xuzhou Medical University, Xuzhou, Jiangsu, China Department of Pharmaceutical Analysis, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning 110016, People’s Republic of China Department of Sport Medicine, Xiangya Hospital, Central South University, Changsha, China Changchun University of Chinese Medicine, Changchun, Jilin 130117, China School of Cyber Science and Engineering, Zhengzhou University Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Department of Botany, University of British Columbia, Vancouver, BC V6T 1Z4, Canada Key Laboratory of Forensic Evidence and Science Technology, Ministry of Public Security, Institute of Forensic Science, Shanghai Public Security Bureau, Shanghai 200083, China. xxnnxy@hotmail.com National Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Collaborative Innovation Center of Hematology Peking University People's Hospital Peking University Institute of Hematology Beijing China State Key Laboratory of Software Development Environment, Key Laboratory of Biomechanics and Mechanobiology of Ministry of Education, Beihang University, China. Department of Medical Ultrasound Shanghai Tenth People's Hospital Tongji University Cancer Center The Institute for Biomedical Engineering and Nano Science School of Medicine Tongji University Shanghai 200072 China College of Chemistry and Chemical Engineering; State Key Laboratory of Materials-Oriented Chemical Engineering; Nanjing Tech University; Nanjing 210009; China Department of Cancer BiologyThe Lerner Research Institute The Cleveland Clinic Foundation Cleveland Ohio 44115; Department of Chemistry Cleveland State University Cleveland Ohio 44115; Department of Gynecology and Obstetrics The Cleveland Clinic Foundation Cleveland Ohio 44195 Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, United States Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 300020, China Department of Gastroenterology Linyi Central Hospital Linyi China Shanghai Key Laboratory of Crime Science Evidence, Key Laboratory of Forensic Evidence and Science Technology, Ministry of Public Security, Institute of Forensic Science, Shanghai Public Security Bureau, Shanghai 200083, China. xxnnxy@hotmail.com Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. Vaccine Research Center and Yerkes Regional Primate Research Center, Emory University, Atlanta, GA 30329, USA. Department of Chemistry, College of Chemistry and Chemical Engineering, Ministry of Education (MOE) Key Laboratory of Spectrochemical Analysis and Instrumentation, and Collaborative Innovation Center of Chemistry for Energy Materials, Xiamen University, Xiamen 361005, China Division of Neonatology, Perinatal and Pulmonary Biology Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States; Department of Structural Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States; Department of Physics and Astronomy, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States School of Mechanical and Aerospace Engineering Jilin University Changchun 130025 China Department of Pharmacology, SUNY Upstate Cancer Research Institute, State University of New York, 750 East Adams Street, Syracuse, New York 13210, United States Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Energy Genetics, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, PR China Department of Medicine, University of Toronto, Toronto, Ontario, Canada Operating Room, The Affiliated Hospital of Yangzhou University, No. 368 Hanjiang Middle Road, Yangzhou, Jiangsu, China Department of Respiratory Medicine Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing China Department of Nephrology, Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, China. Corresponding author: Cheng Hai, Email: chenghai2019@126.com. Henan Eye Institute, Department of Ophthalmology, Henan Provincial People's Hospital, Zhengzhou, China Key Laboratory for Green Chemical Technology of Ministry of Education; Collaborative Innovation Center of Chemical Science and Engineering; School of Chemical Engineering and Technology; Tianjin University; Tianjin 300072 Key Laboratory of Cancer Proteomics of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha 410008, China State Key Laboratory of Heavy Oil Processing; Center for Bioengineering and Biotechnology; College of Chemical Engineering; China University of Petroleum (East China); Qingdao 266580 State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjing 210023 P. R. China Laboratory of Animal Cell and Molecular Biology, College of Bioscience and Biotechnology, Shenyang Agricultural University, Shenyang, Liaoning, China College of Bioscience and Biotechnology, Shenyang Agricultural University, Shenyang, China Department of General Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an, China Department of Neurosurgery, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou 310014, China Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ‡RNA Discovery Biology, ∥Laboratory Animal Resources, and #Pharmaceutical Sciences, Merck Research Laboratories, Merck & Co., Inc., 770 Sumneytown Pike, West Point, Pennsylvania 19446, United States Research Center for Advanced Science and Technology, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan College of Chemistry and Chemical Engineering, State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing University of Technology, Nanjing 210009, People’s Republic of China; Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, People’s Republic of China Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA; Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA Department of Sports Medicine Peking University Third Hospital Beijing China Department of Occupational and Environmental Health Sciences, Peking University School of Public Health, Beijing, China. Department of Chemistry, Department of Anesthesiology, Department of Pharmacology and Chemical Biology, Department of Computational Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261 Department of Nephrology, Affiliated Hospital of Qingdao University, Qingdao, China. School of Computer and Cyber Sciences Communication University of China Beijing China Henan Institute of Ophthalmology, Department of Ophthalmology, Henan Provincial People's Hospital, Zhengzhou, China Perinatal Institute, Division of Neonatology, Perinatal and Pulmonary Biology, and Institute for Molecular Design and Synthesis, School of Pharmaceutical Science and Technology Tianjin University 92 Weijin Road Nankai District Tianjin 300072 P.R. China Genentech Research and Early Development South San Francisco CA USA Ultrasound, Nanjing Drum Tower Hospital, Nanjing, China Department of Cancer Center, Integrated Hospital of Traditional Chinese Medicine Southern Medical University Guangzhou Guangdong China; Department of Cancer Center Southern Medical University Guangzhou Guangdong China Department of Expanded Programme on Immunization, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China Division of Bone and Joint Surgery, Center of Orthopaedics First Hospital of Jilin University Changchun People's Republic of China ImClone Systems Incorporated, New York, New York Chongqing Engineering Research Center of Specialty Crop Resources and the College of Life Science Chongqing Normal University Chongqing China School of Chemistry and Chemical Engineering Southeast University Nanjing 211189 P. R. China Department of Biochemistry and Molecular Biology School of Basic Medical Sciences Zhengzhou University Zhengzhou China State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 300020, China; Tianjin Institutes of Health Science, Tianjin 301600, China Department of Chemistry, College of Science, Northeastern University, Liaoning 110819, People’s Republic of China State Key Laboratory of Food Science and Technology, Key Laboratory of Industrial Biotechnology, Ministry of Education, Wuxi, Jiangsu, China; Synergetic Innovation Center of Food Safety and Nutrition, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China Email: cdcxy@vip.sina.com. College of Chemistry and Chemical Engineering; State Key Laboratory of Materials-oriented Chemical Engineering; Nanjing Tech University; Nanjing 210009; P.R. China Department of Breast and Thyroid Surgery, Daping Hospital, Third Military Medical University, Chongqing, China; Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing, China Department of Breast and Thyroid Surgery, Daping Hospital, Army Medical University, Chongqing, P.R. China. Department of Neurosurgery Zhejiang Provincial People's Hospital Hangzhou Zhejiang China Department of Dermatology, First Affiliated Hospital of Kunming College, Kunming 650032, China. xuyanfirst@163.com College of Bioengineering, Chongqing University, Chongqing 400044, P. R. China Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry, Chemical Engineering and Materials Science Soochow University 199 Ren-Ai Road Suzhou Jiangsu 215123 China Department of Colorectal and Anal Surgery, Xiangyang No.1 People’s Hospital, Hubei University of Medicine, Xiangyang, P.R, China The Second Xiangya Hospital of Central South University, Changsha, Hunan, China Beijing Key Laboratory of Applied Experimental Psychology National Demonstration Center for Experimental Psychology Education (Beijing Normal University) Faculty of Psychology Beijing Normal University Beijing 100875 China Department of Respiratory Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China. State Key Laboratory of Food Science and Technology, Key Laboratory of Industrial Biotechnology of Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China 214122 Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China. Anhui Provincial Joint Key Laboratory for Innovative Drug Research and Industry Integration, School of Chemistry and Materials Engineering, Fuyang Normal University, Fuyang 236037, P. R. China State Key Laboratory of Experimental Hematology Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College Tianjin China WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China School of Nursing, Medicine & Technology, College of Zunyi Medical University, Zunyi 563003, Guizhou Province, China School of Materials Science and Engineering Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan Province Central South University Changsha Hunan 410083 P. R. China Department of Chemical Engineering Graduate School of Engineering Osaka Prefecture University 1‐2, Gakuen‐cho, Naka‐ku Sakai Osaka 599‐8570 Japan Department of Medical Genetics & Cell Biology, School of Basic Medical Sciences Zhengzhou University Zhengzhou China Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing 100730, China. School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China Institute of Sports Medicine, Third Hospital, Peking University, Beijing 100083, China. fingerprints@bj1860.net Stony Brook University Shandong Provincial Key Laboratory of Oral Tissue Regeneration, School of Stomatology, Shandong University, Jinan, Shandong, China (mainland) Key Laboratory of Industrial Biotechnology of Ministry of Education, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu, P. R. China; State Key Laboratory of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu, P. R. China Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States; Department of Structural Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States; Department of Physics and Astronomy, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States Department of Anatomy, Charité-Universitätsmedizin Berlin, Berlin, Germany Department of Endocrine, Affiliated Hospital of Beihua University, Chuanying, Jilin 132011, P.R. China Division of Chemistry, Department of Medical Sciences, University of Miyazaki Miyazaki Japan Key Laboratory of Industrial Biotechnology of Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, PR China Department of Mineralized Tissue Biology, The Forsyth Institute, Cambridge, MA 02142, U.S.A Department of Psychology, Peking University, Institute of Mental Health, Peking University, Beijing 100083, China. Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China; New Drug Research and Development Center, North China Pharmaceutical Group Corporation, National Microbial Medicine Engineering and Research Center, Hebei Industry Microbial Metabolic Engineering & Technology Research Center, Key Laboratory New Drug Screening Technology of Shijiazhuang City, Shijiazhuang 050015, People’s Republic of China Department of Pathology, Dalian Jinzhou First People's Hospital, Dalian, China. Department of Chemistry; Northeastern University; Shenyang 110819; China State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, China; Tianjin Institutes of Health Science, Tianjin, China i‐Lab Suzhou Institute of Nano‐Tech and Nano‐Bionics Chinese Academy of Sciences Suzhou Jiangsu 215123 China Y. Xuis a medical student, School of Medicine, Faculty of Health Sciences, Queen’s University, Kingston, Ontario, Canada. Southwest Jiaotong University College of Medicine Chengdu China 77103rd troops, PLA, Chongqing 400038, P.R. China State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, China; Institute of Molecular Cell Biology, Westfalian Wilhelms University Münster, 48149 Münster, Germany Laboratory of Molecular Immunology, State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China Department of Orthopedics Affiliated Hospital of Nanjing Medical University (Nanjing First Hospital) Nanjing China Shanghai Jiao Tong University Department of Plant Science, School of Agriculture and Biology, , Shanghai, 200240, P. R. China The First Department of Radiotherapy, Fushun Fourth Hospital Department of Interventional Therapy, Tianjin Medical University Cancer Institute & Hospital, National Clinical Cancer Research Center, Key Laboratory of Cancer Prevention and Therapy Department of Endocrinology, Fuyang First People's Hospital, Hangzhou, Zhejiang 311400, P.R. China Department of Applied Mathematics, University of Science and Technology Beijing, Beijing 100083, China Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, People's Republic of China Department of Interventional Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China. Department of Critical Care Medicine, Guangdong Second Provincial General Hospital, Guangzhou, People’s Republic of China State Key Laboratory of Food Science and Technology, Key Laboratory of Industrial Biotechnology, Ministry of Education, Synergetic Innovation Center of Food Safety and Nutrition, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu 214122, China College of Horticulture Northwest A&F University Yangling 712100 Shaanxi China; Key Laboratory of Biology and Genetic Improvement of Horticultural Crops (Northwest Region) Ministry of Agriculture Yangling Shaanxi 712100 China; State Key Laboratory of Crop Stress Biology in Arid Areas Northwest A&F University Yangling 712100 Shaanxi China Department of Pathology, University of Medicine and Dentistry of New Jersey–Robert Wood Johnson Medical School, Piscataway, New Jersey 08854-5635; Department of Biological Sciences, University of Wisconsin, Milwaukee, Wisconsin 53201 School of Biomedical Science, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Surugadai, Kanda, Chiyoda, Tokyo 101-0062, Japan, and Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo, Kyoto, 606-8502, Japan Department of Immunology, Institute of Laboratory Medicine, Jiangsu University, Xuefu Road 301, Zhenjiang 212013, China Department of Expanded Program on Immunization, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu, China grid.258151.a 0000000107081323 State Key Laboratory of Food Science and Technology, The Key Laboratory of Industrial Biotechnology of Ministry of Education School of Biotechnology, Jiangnan University 1800 Lihu Ave Wuxi 214122 Jiangsu People’s Republic of China Department of Andrology Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing China Departments of Anesthesiology, Pharmacology, and Computational Biology, University of Pittsburgh School of Medicine, and Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15261 Department of Chemistry, Cleveland State University, Cleveland, Ohio 44115 Department of Neurology, PUMC Hospital, CAMS, PUMC, Beijing 100730, China. xuyan6246@sina.com School of Mechanical Engineering, XinJiang University, Ürümqi, China Department of Chemistry; College of Chemistry and Chemical Engineering; the MOE Key Laboratory of Spectrochemical Analysis and Instrumentation and iChEM; Xiamen University; Xiamen 361005 College of Chemistry and Chemical Engineering, Nanjing University of Technology, Nanjing, 210009, P. R. China School of Biological and Medical Engineering; Hefei University of Technology; Hefei; P. R. China State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China Department of Chemistry Cleveland State University Cleveland Ohio 44115 USA Synergetic Innovation Center of Food Safety and Nutrition, State Key Laboratory of Food Science and Technology, Key Laboratory of Industrial Biotechnology of Ministry of Education, School of Biotechnology, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu 214122, People’s Republic of China Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing210029, China; Jiangsu Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University, Nanjing210029, China; Department of Periodontology, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing210029, China Key Laboratory of Health Risk Factors for Seafood of Zhejiang Province, School of Food Science and Pharmacy Zhejiang Ocean University Zhoushan China Infection Control Administration Department, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China Department of Neurology, Peking University People's Hospital, Beijing 100044,China. State Key Laboratory of Food Science, Technology Key Laboratory of Industrial Biotechnology of Ministry of Education, Synergetic Innovation Center of Food Safety and Nutrition, and School of Biotechnology, Jiangnan University Wuxi, Jiangsu, China 214122 State Key Laboratory of Food Science and Technology Jiangnan Univ 1800 Lihu Ave, Wuxi 214122 Jiangsu PR China; Centre for Brewing Science and Enzyme Biotechnology School of Biotechnology Jiangnan Univ 1800 Lihu Ave, Wuxi 214122 Jiangsu PR China Jiangsu Key Laboratory of Brain Disease Bioinformation Research Center for Biochemistry and Molecular Biology Xuzhou Medical College Jiangsu China Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030; Department of Respiratory Disease Peking Union Medical College Hospital Chinese Academy of Medical Science & Peking Union Medical College Beijing China National Engineering Research Center for Nanotechnology, Shanghai 200241, PR China Bio-nanomaterials and Regenerative Medicine Research Division, Zhejiang-California International Nanosystems Institute, Zhejiang University, Hangzhou 310058, China Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University; Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors (China Medical University) , Ministry of Education, Shenyang , China Department of Chemistry College of Sciences Northeastern University Shenyang Liaoning 110819 China Department of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. Intensive Care Unit, Zhoushan Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Zhoushan, China Department of Chemistry, Cleveland State University, Cleveland Ohio 44115, United States Department of Obstetrics and GynecologyIndiana University Indianapolis Indiana USA Department of Biochemistry & Molecular Biology School of Basic Medical Sciences Zhengzhou University China National Engineering Laboratory for AIDS Vaccine, School of Life Sciences Jilin University Changchun Jilin China Nanoscience and Nanotechnology Research Center; Research Organization for the 21st Century; Osaka Prefecture University; Osaka 599-8570; Japan Department of Basic Medical Education, Zunyi Medical University Zunyi, Guizhou, People's Republic of China. Contribution from the Division of Chemistry, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan, Japan Biological Information Research Center (JBIRC), Japan Biological Informatics Consortium (JBIC), 2-41-6 Aomi, Koto-ku, Tokyo 135-0064, Japan, and Biomolecular Engineering Research Institute, 6-2-3 Furuedai, Suita, Osaka 565-0874, Japan, Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo... State Key Laboratory of Food Science and TechnologySchool of BiotechnologyJiangnan UniversityWuxiChina Department of Geosciences, Princeton University, Princeton, NJ 08544, USA. Department of Pediatrics, Peking Union Medical College (PUMC) Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China. The Arnold and Mabel Beckman Laboratory of Chemical Synthesis Division of Chemistry and Chemical Engineering California Institute of Technology Pasadena CA 91125 USA Department of Obstetrics Jingjiang People's Hospital Taizhou China Department of Biology, College of Life and Environment Science, Shanghai Normal University, Shanghai, People's Republic of China Department of Medical Genetics, University of Toronto, and Department of Genetics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada Contribution from the Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda, Tokyo 101-0062, Japan, and Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8501, Japan College of Chemistry, University of California, Berkeley, California 94720-1460, The Molecular Foundry, E.O. Lawrence Berkeley National Laboratory, Berkeley, California 94720-8139, and Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, P. R. China Department of Obstetrics and Gynecology, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China Prenatal Diagnosis Center Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China; Department of Genetics Shanghai Institute of Pediatric Research Shanghai China Institute of Hematology & Hospital of Blood Diseases, State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Sciences & Peking Union of Medical College, Tianjin, People's Republic of China. Key Laboratory of Cultivation and Protection for Non-Wood Forest Trees, Ministry of Education, Changsha 410004, China; Academy of Camellia Oil Tree, Central South University of Forestry and Technology, Changsha 410000, China Department of Neurology, Zhongnan Hospital of Wuhan University, Wuhan 430071, P. R. China The Center for Disease Control and Prevention of Luoyang City, Henan Province, China. Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, Maryland 21228, and Department of Biology and Biocalorimetry Center, The Johns Hopkins University, Baltimore, Maryland 21218 Changchun University of Chinese Medicine School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China The University of Tokyo 1 Department of Applied Chemistry, Graduate School of Engineering, , 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan; Japan Science and Technology Agency (JST) 2 CREST, , 7-3-1 Sanbacho, Chiyoda-ku, Tokyo 102-0075, Japan Department of Hematology The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an Shanxi Province China Department of Systems Science, Business School, University of Shanghai for Science and Technology 1 , Shanghai 200093, China From the Department of Neurology (M.F., H.Y., J.C., P. Zheng., C. Zhang, F.-D.S.), Tianjin Medical University General Hospital; China National Clinical Research Center for Neurological Diseases (X. Zhang, F.-D-.S.), Jing-Jin Center for Neuroinfalmmation Beijing Tiantan Hospital, Capital Medical University; Department of Neurology (W.Q.), the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou; Department of Neurology (B.B.), Tongji Hospital Affiliated to Tongji Medical College, Huazhong... Department of Orthopaedics, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China Department of Gastroenterology, China-Japan Union Hospital of Jilin University, Changchun, China Clinical Pharmacology and Pharmacometrics Janssen Research and Development, LLC. Spring House Pennsylvania USA; Current address: Clinical Pharmacology Simcere Pharmaceuticals Cambridge Massachusetts USA Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229 From the Department of Anesthesiology and Critical Care Medicine (Y.X., S.L., P.T.) and Department of Pharmacology (Y.X., P.T.), University of Pittsburgh School of Medicine (Pa). Department of Hematology, The Second Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China. School of Food and Biological Engineering, Hefei University of Technology, Hefei, People’s Republic of China; Hangzhou Red Cross Hospital, Hangzhou. Lab of Brewing Microbiology and Applied Enzymology, School of Biotechnology and Key Laboratory of Industrial Biotechnology of Ministry of Education, Jiangnan University, Wuxi 214122, China; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China College of Pharmacy Nanjing University of Chinese Medicine Nanjing P. R. China Department of Orthopaedic Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. Department of Breast and Thyroid Surgery, Research Institute of Surgery of Daping Hospital, Army Military Medical University, Chongqing 400042, China Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.; Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A. Department of Internal Medicine, Hubei Rongjun Hospital,Wuhan430079,China. Department of Biochemistry and Molecular Biology School of Basic Medical Sciences, Zhengzhou University Zhengzhou China Institute of Pathogen Biology and Immunology of the College of Biology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, China Department of Medicine, Division of Gastroenterology, Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore VA Hospital, 21201, USA. Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China. Center for Bioengineering and Biotechnology; College of Chemical Engineering; China University of Petroleum (East China); Qingdao 266580; China Beijing National Laboratory of Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China School of Life Science Beijing Institute of Technology Beijing China State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, P.R. China, and Analysis Center, Chengdu Branch of the Chinese Academy of Sciences, Chengdu 610041, P.R. China grid.258151.a 0000 0001 0708 1323 Key Laboratory of Industrial Biotechnology of Ministry of Education, School of Biotechnology Jiangnan University 214122 Wuxi Jiangsu China Institut für Molekulare Zellbiologie, and Department of Obstetrics and Gynecology, Indiana University School of Medicine Indianapolis, IN, USA. The Second Department of Thoracic Oncology Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University Changsha China *Division of Pulmonary Biology and Chemical Engineering Zhejiang University of Technology Hangzhou Zhejiang 310021 China Quantitative Clinical Pharmacology AstraZeneca South San Francisco California USA DMPK/Clinical Pharmacology Acerta Pharma South San Francisco California USA Departments of Anesthesiology, Pharmacology, and Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260 Department of Nephrology, Cangzhou Central Hospital, Cangzhou, Hebei Province, China School of Biological Science and Medical Engineering, Beihang University, Beijing, China Obstetrics Department of the First People’s Hospital of Lianyungang City, Lianyungang 222001, Jiangsu Province, China Department of Gynaecology, Taizhou University Affiliated Municipal Hospital, Taizhou, Zhejiang, China Ciechanover Institute of Precision and Regenerative Medicine, School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemistry and Chemical Engineering, Nanjing University of Technology, Nanjing 210009, P. R. China Ciechanover Institute of Precision and Regenerative Medicine, School of Medicine, Chinese University of Hong Kong, Shenzhen 518172, China Clinical Pharmacology and Pharmacometrics Janssen Research & Development, LLC, Spring House Pennsylvania USA Department of Cytokine Biology, The Forsyth Institute, Boston, Massachusetts. Department of Oncology Xiangya Hospital, Central South University Changsha People's Republic of China Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN 46202, USA grid.258151.a 0000000107081323 State Key Laboratory of Food Science and Technology, the Key Laboratory of Industrial Biotechnology of Ministry of Education, School of Biotechnology Jiangnan University 1800 Lihu Ave 214122 Wuxi Jiangsu People’s Republic of China Center of Oral Implantology, Stomatological Hospital, Southern Medical University, Guangzhou, China Department of Orthopaedics Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430074 China School of Pharmaceutical Science, Nanjing Tech University, Nanjing 211816, China Health Management Center, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215001, P.R. China From the Departments of Neurology (L.D.M.) and Neuroscience (L.D.M., S.T., L.L., S.B., Y.X., J.L.), University of Connecticut Health Center, Farmington, CT; and Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC (T.R., A.M.). Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University Guangzhou, China. Department of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, China (B.L., X.F., Z.C., X.L.,Y.X., L.Z., Q.H.).; Key Laboratory of Pulmonary Diseases of Ministry of Health, Tongji Medical College, HUST, Wuhan, China (B.X., X.F., X.H., Z.C., X.L., Y.X., L.W., T.W., L.Z., Q.H.). The Biomedical Translational Research Institute Faculty of Medical Science Jinan University Guangzhou Guangdong China Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA Department of Oncology, Beijing Hospital, National Center of Gerontology, Beijing, China College of Medicine Science and Laboratory Medicine, Jiangsu University, Zhenjiang, China. yanxu63@sina.com Department of Pulmonary Medicine, Lung Cancer Center, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, PR China 0000 0001 0708 1323 grid.258151.a The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology Jiangnan University 214122 Wuxi People’s Republic of China; 0000 0001 0708 1323 grid.258151.a State Key Laboratory of Food Science and Technology Jiangnan University 214122 Wuxi People’s Republic of China School of Food and Pharmacy, Zhejiang Ocean University, Zhejiang 316022, China Center for Supramolecular Chemistry and Catalysis and Department of Chemistry, College of Science, Shanghai University, Shanghai 200444, P. R. China State Key Laboratory of Food Science and Technology, Key Laboratory of Industrial Biotechnology, Ministry of Education, Synergetic Innovation Center of Food Safety and Nutrition, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China College of Chemistry and Chemical Engineering State Key Laboratory of Materials-Oriented Chemical Engineering Nanjing Tech University Nanjing 210009 P. R. China The Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology; Department of Pediatrics; Department of Biomedical Informatics, University of Cincinnati School of Medicine, Cincinnati, Ohio College of Pharmacy, Jiangsu Key Laboratory of Chinese Medicine Processing, Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing, China. Department of Psychiatry, Nanfang Hospital, Southern Medical University, Guangzhou 510515, P. R. China. Department of Neurology, Peking Union Medical College Hospital, Beijing 100730, China Shaanxi Provincial Land Engineering Construction Group Co., Ltd./Shaanxi Key Laboratory of Land Consolidation, Xi’an, Shaanxi, China; Institute of Land Engineering and Technology, Shaanxi Provincial Land Engineering Construction Group Co., Ltd., Xi’an, Shaanxi, China Multiple Sclerosis Center, Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People's Republic of China Department of Geriatrics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China (mainland) Departments of †Anesthesiology, ‡Computational and Systems Biology, §Structural Biology, and ∥Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States School of Optical and Electronic Information & Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074 China Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China National Engineering Laboratory for AIDS Vaccine; School of Life Sciences; Jilin University; Changchun; China From the Department of Surgery, Division of Plastic and Reconstructive Surgery, Stony Brook University Hospital; the Department of Materials Science and Chemical Engineering, Stony Brook University; and the Department of Surgery, Division of Plastic and Reconstructive Surgery, Nassau University Medical Center. Department of Chemistry, Cleveland State University, 2121 Euclid Avenue, Cleveland, OH 44115, USA Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China. Departments of Neurology (MFV, JLC, KSD, RW-M, LBG, MB-O) and Statistics (CK, YX), University of Kentucky, Lexington; Department of Neurology (MFV), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; and UK HealthCare Pharmacy Services (AMC), Lexington, KY. Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854-8020 Department of Radiology, Beijing Friendship Hospital, Capital Medical University, 95 Yong-an Road, Xicheng District, Beijing, China Southeast University, Nanjing, China Department of Gastroenterology, China-Japan Union Hospital of Jilin University, Changchun 130033, China. Department of Oncology, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China Department of Cardiology Second affiliated hospital Nanchang University Nanchang 330006 China Institute of Chemistry for Functionalized Materials, College of Chemistry and Chemical Engineering, Liaoning Normal University, No. 850 Huanghe Road, Dalian 116029, P. R. China Department of Mechanical and Electrical Engineering, Changsha University, Changsha, China West China School of Medicine West China Hospital Sichuan University Chengdu China State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan/Ministry of Education, Key Laboratory of Agricultural Biodiversity for Plant Disease Management, Yunnan Agricultural University, 650201, Kunming, China; College of Bioengineering, Jingchu University of Technology, 448000, Jingmen, China Faculty of Agronomy, Jilin Agricultural University, Changchun 130000, China College of Food Science and Nutritional Engineering, China Agricultural University, 17 Qinghuadonglu Road, Beijing 100083, P. R. China Department of Oncology The Second People's Hospital of Yibin City Yibin Sichuan China State Key Laboratory of Food Science & Technology, Key Laboratory of Industrial Biotechnology of Ministry of Education & School of Biotechnology Jiangnan Univ. Wuxi Jiangsu China 214122 HuiBo Heat Energy Engineering Technology Center, Shenyang Academy of Instrumentation Science Co., Ltd., Shenyang 110043, China College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, Hunan, P. R. China State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China Department of Surgical Oncology, China Medical University, Shenyang, China. Department of Pulmonary and Critical Care Medicine Peking Union Medical Hospital, Chinese Academy of Medical Science & Peking Union Medical College Beijing China Academy of Medical Sciences School of Basic Medical Sciences Zhengzhou University Zhengzhou China Department of Digestive China‐Japan Union Hospital affiliated to Jilin University Changchun China Division of Pulmonary Biology, Cincinnati Children’s Research Foundation, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio Nanjing Regenerative Medicine Engineering and Technology Research Center, Nanjing 210046, China; Regenerative Medicine Center, The Second Military Medical University, Shanghai 200433, China National Key Laboratory of Frigid Zone Cardiovascular Diseases, Department of Cardiovascular Diseases, General Hospital of Northern Theater Command, Shenyang, China Department of Medical Ultrasound Shanghai Tenth People's Hospital School of Medicine Tongji University Shanghai 200072 China; The Institute for Biomedical Engineering & Nano Science School of Medicine Tongji University 1239 Siping Road Shanghai 200092 China; Shanghai Frontiers Science Center of Nanocatalytic Medicine Tongji University 1239 Siping Road Shanghai 200092 China Department of Respiratory and Critical Care Medicine Peking Union Medical College Hospital Chinese Academy of Medical Science & Peking Union Medical College Beijing 100730 P. R. China Department of Internal Medicine, Jiangxi Medical College Shangrao, Jiangxi, China. Department of General Internal Medicine, The First Affiliated Hospital of Jiangxi Medical College Shangrao, Jiangxi, China. The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, P. R. China; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, P. R. China Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA 15261, U.S.A.; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, U.S.A.; Department of Structural Biology, University of Pittsburgh, Pittsburgh, PA 15261, U.S.A. Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853 i-Lab, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, Jiangsu 215123, China; School of Nano-Tech and Nano-Bionics, University of Science and Technology of China, Hefei, Anhui 230026, China Department of Neurology, 101st Hospital of Chinese People's Liberation Army, Wuxi, Jiangsu 214044, P.R. China Admedus Vaccines Pty Ltd (formerly Coridon Pty Ltd), Translational Research Institute, Woolloongabba, QLD, Australia; University of Queensland, Diamantina Institute, Translational Research Institute, Woolloongabba, QLD, Australia From the Department of Cancer Biology, Lerner Research Institute; Departments of Colorectal Surgery and Gastroenterology, Taussig Cancer Center, Cleveland Clinic; Department of Family Medicine-Research Division, Case Western Reserve University, Cleveland, OH; and the Department of Obstetrics and Gynecology, Indiana University Cancer Center, Indiana University School of Medicine, Indianapolis, IN School of Civil Engineering, Architecture and Environment, Hubei University of Technology, 430068 Wuhan, China Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Expanded Programme on Immunization, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu Province, China Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Indiana University Cancer Center, Indiana University School of Medicine , Indianapolis, Indiana , USA Department of Gastrointestinal Medical Oncology The University of Texas MD Anderson Cancer Center Houston TX USA Department of Cancer Biology Lerner Research Institute and the Department of Gynecology and Obstetrics Cleveland Clinic Foundation; Department of Chemistry, Cleveland State University, Cleveland, Ohio; Department of Cancer Biology, Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH 44195 Department of Hematology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an Shaanxi, 710004, P. R. China. Department of Prenatal Diagnosis Center, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shanghai Institute for Pediatric Research, Shanghai, China. International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai 200030 , China; Shanghai Key Laboratory of Embryo Original Diseases , Shanghai 200030 , China; Institute of Birth Defects and Rare Diseases, School of Medicine, Shanghai Jiao Tong University , Shanghai 200030 , China Laboratory of Brewing Microbiology and Applied Enzymology School of Biotechnology, Jiangnan University Wuxi Jiangsu P.R. China; State Key Laboratory of Food Science and Technology Jiangnan University Wuxi Jiangsu P.R. China Center of Multiple Sclerosis and Related Disorders, Peking Union Medical College Hospital , Beijing, 100730 , PR China; Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing, 100730 , PR China Zhejiang Provincial People's Hospital, Department of Neurosurgery, Hangzhou, China. Spatial Sciences Institute, University of Southern California , Los Angeles, CA , USA Department of Pathology, Clinical School of Nanjing University Medical College, Nanjing General Hospital of Nanjing Command, Nanjing 210002, China. Cancer Pharmacology Core Facility, Case Western Reserve University, Cleveland, OH 44106, USA.; Department of Chemistry, Cleveland State University, Cleveland, OH 44115, USA. Institute of Sports Medicine, the Third Hospital, Peking University, Beijing 100083, China. The Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics and University of Cincinnati College of Medicine, Cincinnati, Ohio; Key Laboratory of Infectious Disease & Biosafety, Provincial Department of Education, Zunyi Medical University, Zunyi, Guizhou, China; Institute of Life Sciences, Zunyi Medical University, Zunyi, Guizhou, China Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha, 410000, China Department of Gastroenterology, China-Japan Union Hospital of Jilin University, Changchun, China. Department of Ultrasound, Zhejiang Rongjun Hospital, Jiaxing, Zhejiang, China (mainland) Key Laboratory of Eco-Functional Polymer Materials of the Ministry of Education, Northwest Normal University, Lanzhou 730070, China; College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China; Key Laboratory of Eco-Environmental Polymer Materials of Gansu Province, Northwest Normal University, Lanzhou 730070, China Department of Nephrology, Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China Department of Cardiovascular, Institute of Cardiovascular Disease Department of Orthopaedics Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Pediatric Endocrinology/Genetics Xinhua Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai China; Molecular Genetics Group Shanghai Institute for Pediatric Research Shanghai China Department of Pediatric Respiratory Medicine, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, Gansu Province, China Heilongjiang Provincial Key Laboratory of CO2 Resource Utilization and Energy Catalytic Materials, School of Materials Science and Chemical Engineering, Harbin University of Science and Technology, Harbin 150040, P. R. China Institute of Polyoxometalate Chemistry, Department of Chemistry, Northeast Normal University, Changchun 130024, P. R. China, and Institute of Chemistry for Functionalized Materials, Liaoning Normal University, Dalian 116029, P. R. China Key Laboratory of Industrial Biotechnology of Ministry of Education, State Key Laboratory of Food Science and Technology, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China 4Cleveland Clinic Foundation, Cleveland, Ohio; Department of Breast and Thyroid Surgery, Daping Hospital Department of Cardiology, Shenzhen Sun Yat-sen Cardiovascular Hospital, No. 12 Langshan Road, Shenzhen, Guangdong Province, China grid.258151.a 0000000107081323 State Key Laboratory of Food Science and Technology, The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology Jiangnan University 1800 lihu Avenue 214122 Wuxi Jiangsu China Center for Viral Oncology, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA Henan Eye Institute, Department of Ophthalmology, Henan Provincial People's Hospital, Zhengzhou, China. xuyan990301@yahoo.com.cn School of Pharmacy, Nantong University, Nantong, China Department of Orthopaedic Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Cartilage Regeneration Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China; China-Korea United Cell Therapy Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China Department of Pharmaceutical Analysis, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, People’s Republic of China Institute of Sports Medicine, Peking University Third Hospital, Beijing, China Institute of Pathogen Biology and Immunology of College of Biology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, China Department of Hematology and Oncology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA; Department of Chemistry, Cleveland State University, Cleveland, OH, USA Laboratory of Brewing Microbiology and Applied Enzymology, School of Biotechnology and Key Laboratory of Industrial Biotechnology of Ministry of Education, Jiangnan University, Wuxi 214122, China; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China College of Life Sciences Nanjing Agricultural University Nanjing China The Hong Kong Polytechnic University Department of Industrial and Systems Engineering, , Hung Hom, Kowloon, Hong Kong SAR, People’s Republic of China School of Materials and Chemical Engineering, Xuzhou University of Technology, Xuzhou 221018, China Fisheries College, Jimei University, Xiamen 361021, China; Fujian Engineering Research Center of Aquatic Breeding and Healthy Aquaculture, Xiamen 361021, China; Key Laboratory of Healthy Mariculture for the East China Sea, Ministry of Agriculture, Xiamen 361021, China Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China School of Life Sciences, Shanghai University, Shanghai 200444, China Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. Department of Nephrology The Affiliated Hospital of Qingdao University Qingdao 266003 China State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China Department of Respiratory and Critical Care Medicine. i‐Lab Suzhou Institute of Nano‐Tech and Nano‐Bionics (SINANO) Chinese Academy of Sciences (CAS) 398 Ruoshui Road Suzhou 215123 P. R. China School of Physical Science and Technology, Lanzhou University, Lanzhou 730000, China Key Laboratory of Industrial Biotechnology, Ministry of Education, Synergetic Innovation Center of Food Safety and Nutrition, Laboratory of Brewing Microbiology and Applied Enzymology, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu 214122, China Institute for Biomedical Sciences of Pain, Capital Medical University, Beijing, China. Department of Pathology, University of Texas Southwestern Medical Center , Dallas, TX , USA Department of Chronic Non-Communicable Disease Control, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu 210009, China Key Laboratory of Industrial Biotechnology of Ministry of Education, Synergetic Innovation Center of Food Safety and Nutrition, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China College of Traditional Chinese Medicine, Ningxia Medical University, Yinchuan 750000, Ningxia, China Lab of Brewing Microbiology and Applied Enzymology, Key Laboratory of Industrial Biotechnology of Ministry of Education, State Key Laboratory of Food Science & Technology, School of Biotechnology, Jiangnan University, Wuxi 214122, China Department of Pharmacy, Fifth Affiliated Hospital of Zhengzhou University, Henan, 450052 China Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan Department of Clinical Laboratory, Liyang People's Hospital, Liyang, Jiangsu 213300, P.R. China College of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610066, People’s Republic of China Health Management Center Affiliated Hospital of Yangzhou University Yangzhou China; Department of Ultrasound, Medical Imaging Center Affiliated Hospital of Yangzhou University Yangzhou China for the China Patient-Centered Evaluative Assessment of Cardiac Events Million Persons Project Collaborative Group Department of Mechanical Engineering and Mechanics, Bioengineering Program, Lehigh University, Bethlehem, PA; Lab. of Brewing Science and Enzyme Technology, School of Biotechnology, Jiangnan University, Wuxi, China. State Key Laboratory of Experimental Hematology Institute of Hematology and Blood Disease Hospital National Clinical Research Center for Hematological Disorders Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin China Shanghai Normal University, Shanghai, China Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China. Biotechnology Research Institute (BRI), National Research Council (NRC), 6100 Royalmount Avenue, Montreal, PQ, Canada H4P 2R2 Department of Interventional Therapy Tianjin Cancer Hospital Tianjin Medical University Tianjin China Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing 100730, China. From the Third Hospital of Sun Yat-Sen University, Guangzhou, P. R. China Departments of Pharmaceutical Chemistry, University of California, San Francisco, California, U.S.A. Nanjing SCF Nanotech Ltd., Nanjing 211800, P. R. China Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China Yan Xu, Yong-Gui Zhang, Xu Wang, Wen-Qian Qi, Shao-You Qin, Zhen-Hua Liu, Jian Jiao, Jiang-Bin Wang, Department of Gastroenterology, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China. Department of Emergency, Huai’an Second People’s Hospital and The Affiliated Huai’an Hospital of Xuzhou Medical University, Huai’an, Jiangsu 223002, China Postdoctoral Innovation Practice Base of Hoffman Institute of Advanced Materials, Shenzhen Polytechnic, Shenzhen 518055, China Department of Chemistry; Cleveland State University; Cleveland; USA Jilin Tuohua Biotechnology Co., Ltd. Changchun Jilin China Department of Anesthesiology 3 , 4 , and 5; Department of Pharmacology & Chemical Biology 3 , 4 , and 5; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 3 , 4 , and 5; Department of Anesthesiology 3 , 4 , and 5; Department of Pharmacology & Chemical Biology 3 , 4 , and 5; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 3 , 4 , and 5; Department of Anesthesiology 3 , 4 , and 5; Department of Pharmacology & Chemical Biology 3 , 4 , and 5; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 3 , 4 , and 5 Key Laboratory of Dairy Science, Ministry of Education, College of Food Science, Northeast Agricultural University, Harbin 150030, P. R. China Departments of Anesthesiology, Pharmacology, Structural Biology, and Computational Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260 Maternal-fetal Medical Center, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210029, China. Department of Reproductive Genetics, International Peace Maternity and Child Health Care Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200030, China. xuchenm@163.com. Department of Medical Microbiology, Harbin Medical University, Pathogenic Biology Key Laboratory of Heilongjiang Province, 194 Xue Fu Road, Harbin 150086, China Department of Infectious Disease, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine Zhejiang University Hangzhou Zhejiang China Chongqing University Affiliated Tumor Hospital/Chongqing Cancer Institute, Chongqing 400030, China State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China Key Laboratory of Industrial Biotechnology, Ministry of Education, State Key Laboratory of Food Science and Technology, School of Biotechnology, Jiangnan University, Wuxi, China University of Connecticut, Electrical and Computer Engineering Department, 371 Fairfield Road, Unit 4157, Storrs, Connecticut 06269-4157, United States UCLA Olympic Analytical Laboratory, Los Angeles, California, United States State Key Laboratory of Food Science and Technology Jiangnan University 1800 Lihu Ave Wuxi 214122 Jiangsu P.R. China; Centre for Brewing Science and Enzyme Biotechnology, School of Biotechnology Jiangnan University 1800 Lihu Ave Wuxi 214122 Jiangsu P.R. China Fisheries College, Jimei University, Xiamen, Fujian, China; Key Laboratory of Healthy Mariculture for the East China Sea, Ministry of Agriculture, Xiamen, Fujian, China Changchun University of Chinese Medicine, Changchun, 130117, China Institute of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, Beijing, China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, International School of Materials Science and Engineering, Wuhan University of Technology, Wuhan, Hubei, China R&D Department, Nanjing Regenerative Medicine Engineering and Technology Research Center, Nanjing, Jiangsu 210046, P.R. China Department of Mechanical Engineering Xinjiang University Xinjiang China The Dorrance H. Hamilton Laboratories, Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Beijing 100730, China. State Key Laboratory of Materials-Oriented Chemical Engineering Nanjing Tech University Nanjing 210009 P.R. China Department of Respiratory Medicine, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China Departments of Anesthesiology, Pharmacology and Chemical Biology, Structural Biology, and Computational Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261 From the Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania (N.G.B., Y.X.); Saint Luke’s Mid America Heart Institute, Kansas City, Missouri (P.S.C.); and the University of Missouri, Kansas City, Missouri (P.S.C.). Department of Obstetrics and Gynecology Pan Yu Central Hospital Guangzhou China Department of Orthopedic Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.; Cartilage Regeneration Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.; China-Korea United Cell Therapy Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. Department of Prenatal Diagnosis Center Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China; Shanghai Institute for Pediatric Research Shanghai China State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China Department of Oncology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China College of Food Science and Nutritional Engineering, China Agricultural, University, Beijing, PR, China Research and Development, GlaxoSmithKline, No. 3 Building, 898 Halei Road, Pudong, Shanghai 201203, P. R. China Department of Medical Genetics & Cell Biology School of Basic Medical Sciences Zhengzhou University Zhengzhou China Department of Nephrology, Affiliated Hospital of Qingdao University , Qingdao , China Institute of Preventative Medicine and Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology; School of Medicine; Ningbo University; Ningbo; China Department of Economics, Liaoning University, Liaoning, China Institute of Chemistry for Functionalized Materials, College of Chemistry and Chemical Engineering, Liaoning Normal University, No. 850, Huanghe Road, Dalian 116029, People's Republic of China, and Department of Chemistry, College of Chemistry and Chemical Engineering, Nanjing University of Technology, No. 5, New Model Road, Nanjing 210009, People's Republic of China Laboratory of Integrative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.; CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.; Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China. Department of Andrology, The Affiliated Hospital of Nanjing University of Chinese Medicine / Jiangsu Provincial Hospital of Chinese Medicine, Nanjing, Jiangsu 210029, China. Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana; and Biomechanical Engineering Laboratory of Sichuan University, 610065, China. Division of Genetics and Mutagenesis, National Institute of Health Sciences, Tokyo, Japan, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan, Graduate School of Frontier Biosciences, Osaka University and SORST, JST, Osaka, Japan, Institute of Biomedical and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan, and Division of Medical Nutrition, Tokyo Healthcare University, Tokyo, Japan Department of Orthopaedics, Nanjing First Hospital Nanjing Medical University Nanjing China Department of Chemistry, Cleveland State University, 2121 Euclid Ave., Cleveland, Ohio 44115, United States Institute of Sports Medicine, Peking University Third Hospital, Beijing 100083, China. Department of Sports Medicine Peking University Third Hospital, Institute of Sports Medicine of Peking University, Beijing Key Laboratory of Sports Injuries Beijing China Department of Urinary Surgery, Laiyang Central Hospital of Yantai, Yantai, Shandong 265200, P.R. China School of Nano‐Tech and Nano‐Bionics University of Science and Technology of China Hefei Anhui 230026 China; i‐lab Suzhou Institute of Nano‐Tech and Nano‐Bionics Chinese Academy of Science Suzhou Jiangsu 215123 China Department of Urology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine/Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu 210046, China. Department of Interventional Therapy, Tianjin Medical University Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China LeBow Institute for Myeloma Therapeutics and Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; Department of Neurology Peking University People's Hospital Beijing China Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA; Department of Chemistry, Cleveland State University, Cleveland, OH 44115, USA Department of Breast Surgery, Daping Hospital, Research Institute of Surgery, Third Military Medical University, Chongqing 400038, P.R. China. Department of Geosciences, Princeton University, Princeton, NJ 08544, USA. yanxu12@stanford.edu University of Southern California Institute of Medicine, Tsinghua University, Beijing 100084, China. Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China Department of Urology, Chengdu, China. Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda, Tokyo 101-0062, Japan, Jin Zhou Medical College, China, Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8501, Japan, and Department of Materials Science and Chemistry, Faculty of Systems Engineering, Wakayama University, Sakaedani 930 Wakayama 640-8510, Japan Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030;; Daping Hospital, Third Military Medical University, Chongqing 400042, China; Lianyungang Academy of Agricultural Sciences, Lianyungang, P. R. China Department of Orthopedics, Nanjing Hospital Affiliated to Nanjing Medical University (Nanjing First Hospital), Nanjing Jiangsu, 210006, P.R.China. Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, P.R. China Department of Pathology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China. Department of Hematology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shanxi, China (mainland) State Key Laboratory of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, Key Laboratory of Industrial Biotechnology of Ministry of Education School of Biotechnology Jiangnan Univ 1800 Lihu Ave Wuxi Jiangsu 214122 China Biorepository, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan, P.R. China. Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China School of Food and Biological Engineering, Hefei University of Technology, Hefei, PR China Jiangsu Key Laboratory of Brain Disease Bioinformation, Research Center for Biochemistry and Molecular Biology, National Demonstration Center for Experimental Basic Medical Science Education, Xuzhou Medical University, Xuzhou, Jiangsu, China Global Clinical Pharmacology Janssen Research & Development LLC. Spring House PA USA b Key Laboratory of Industrial Biotechnology, Ministry of Education , Jiangnan University , Wuxi 214122 , China; c School of Biotechnology , Jiangnan University , Wuxi 214122 , China School of Information Science and Engineering, Linyi University, Linyi 276000, China 1Department of Obstetrics and Gynecology, Indiana University, Indianapolis, Indiana and 22nd Hospital of Jilin University, Jilin University, Changchun, Jilin, People's Republic of China National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research (Wuhan) Huazhong Agricultural University Wuhan 430070 China Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, United States Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha, China; Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China; Hunan Engineering Research Center of Sports and Health, Central South University, Changsha, China; Xiangya Hospital–International Chinese Musculoskeletal Research Society Sports Medicine Research Centre, Changsha, China Structural Biology Program, Memorial Sloan–Kettering Cancer Center, New York, NY 10065; and Clinical Laboratory, Affiliated Hospital of Jinggangshan University, Ji'an, Jiangxi 343100, P.R. China State Key Laboratory of Food Science and Technology, Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China 214122 New England Research Institutes, Watertown, Massachusetts College of Chemistry and Chemical Engineering; Central South University; Changsha 41083; PR China College of Bioengineering, Chongqing University, Chongqing 400044, P.R.China. Key Laboratory of Antibody Technique, Ministry of Health, Nanjing Medical University, Nanjing, China Department of Pharmaceutics, School of Pharmacy, Nantong University, Nantong, 226001, PR China Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, New Jersey 08854, USA. University of Pittsburgh, Pittsburgh, Pennsylvania; Institute of Sports Medicine, Peking University Third Hospital, Beijing, China College of Electronic Engineering and Automation, Shandong University of Science and Technology, Qingdao 266590, P. R. China Institute of Medicinal Biotechnology Affiliated Hospital of Zunyi Medical University Zunyi China; Zunyi Municiptal Key Laboratory of Medicinal Biotechnology and Guizhou Provincial Research Center for Translational Medicine Affiliated Hospital of Zunyi Medical University Zunyi China Department of Neurology Zhongnan Hospital of Wuhan University Wuhan China Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, Jilin, China Department of Periodontics, the Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China; Jiangsu Province Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China; Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing, China Department of research and Development, Zhejiang Shaoxing Topgen Biomedical Technology Co., Ltd. Shanghai China Departments of Department of Department of Nephrology The Affiliated Hospital of Qingdao University Qingdao China State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, People’s Republic of China Center for Supramolecular Chemistry and Catalysis, Department of Chemistry, College of Science, Shanghai University, Shanghai 200444, P.R. China Key Laboratory of Industrial Biotechnology of Ministry of Education and School of Biotechnology, Southern Yangtze University, Wuxi 214122, People's Republic of China 4Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China. State Key Laboratory of Software Development Environment and the Key Laboratory of Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Research Institute of Beihang University, Beihang University, Beijing, China Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing China Department of Materials Engineering, School of Engineering, and Center for NanoBio Integration, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8656, Japan Department of Oncology, Rizhao City Hospital of Traditional Chinese Medicine, Rizhao, Shandong 276800, P.R. China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, China Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China Institute of Mathematics and Physics, University of Science and Technology Beijing, Beijing 100083, P. R. China Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University; Department of Periodontology, Affiliated Stomatological Hospital of Nanjing Medical University Beijing National Laboratory of Molecular Sciences (BNLMS) Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education College of Chemistry Peking University 100871 Beijing China Department of Expanded Program on Immunization, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu Province, China Department of Neurology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province, China Department of Radiology Capital Medical University Affiliated Beijing Friendship Hospital Beijing China Key Laboratory of Medical Molecular Virology, Institute of Medical Microbiology, Shanghai Medical College, Fudan University, Shanghai 200032, China College of Energy, Soochow Institute for Energy and Materials Innovations, Light Industry Institute of Electrochemical Power Sources, Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu Province, Soochow University, Suzhou 215006, Jiangsu, China; Department of Chemistry, School of Chemistry and Materials Science, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, Anhui, China; Key Laboratory of Core Technology of High Specific Energy Battery and Key Materials for Petroleum and Chemical Industry, Soochow University, Suzhou 215006, Jiangsu, China Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio Key Laboratory of Industrial Biotechnology of Ministry of Education, State Key Laboratory of Food Science and Technology, School of Biotechnology, Jiangnan University, Wuxi, China Department of Urology Affiliated Hospital of Nanjing University of Traditional Chinese Medicine Jiangsu Province Hospital of Traditional Chinese Medicine Nanjing Jiangsu 210046 China Department of Geosciences, Princeton University, Princeton, New Jersey 08540, United States College of TCM, Changchun University of CM, Changchun 130117, Jilin Province, China. State Key Laboratory of Crop Stress Biology for Arid Areas, Yangling 712100, Shaanxi, China; College of Horticulture, Northwest A&F University, Yangling 712100, Shaanxi, China 1Department of Obstetrics and Gynecology, Indiana University, Indianapolis, Indiana; School of Psychology Beijing Normal University Beijing China Department of Orthopaedics, Nanjing Hospital Affiliated to Nanjing Medical University (Nanjing First Hospital), Nanjing Jiangsu, 210006, P.R.China.yanxu5427@aliyun.com. Division of Pulmonary Biology, The Perinatal Institute, and; Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, Ohio; Department of Orthopaedic Surgery; Nanjing First Hospital, Nanjing Medical University; Nanjing 210006 People's Republic of China; Cartilage Regeneration Center, Nanjing First Hospital, Nanjing Medical University; Nanjing 210006 People's Republic of China; China-Korea United Cell Therapy Center, Nanjing First Hospital, Nanjing Medical University; Nanjing 210006 People's Republic of China Department of Pulmonary and Critical Care Medicine Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China Departments of aAnesthesiology,; Pharmacology and Chemical Biology,; Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260; State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin University 2699 Qianjin Street Changchun 130012 China Department of Food Science and Technology, Oregon State University, Corvallis, Oregon 97331, and Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Southern Yangtze University, Wuxi, Jiangsu, China 214036 Division of Physical Biology and Bioimaging Centre, Shanghai Synchrotron Radiation Facility, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China Key Laboratory of Industrial Biotechnology of Ministry of Education & School of Biotechnology Jiangnan University Wuxi P. R. China; National Key Laboratory for Food Science Jiangnan University Wuxi P. R. China *Section of Neonatology, Perinatal and Pulmonary Biology, Perinatal Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229; Department of Cancer Biology, The Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, OH 44195, USA. xuy@ccf.org Department of Sports Medicine, Peking University Third Hospital, Institute of Sports Medicine of Peking University, Beijing Key Laboratory of Sports Injuries, Beijing, China. *Institute of Health Sciences, Shanghai Jiaotong University School of Medicine/Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Email: xuyanpumch@hotmail.com. Department of Cancer BiologyThe Lerner Research InstituteThe Cleveland Clinic Foundation Cleveland Ohio 44195; Center for Drug Development & DiscoveryTaussig Cancer Center Cleveland Ohio 44195; Department of Gynecology and ObstetricsThe Cleveland Clinic Foundation Cleveland Ohio 44195 Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China. Jiangsu Provincial Key Lab for Organic Solid Waste Utilization, Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China Department of Orthopaedics Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China Health Management Center, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215123, China; Suzhou Cancer Center Core Laboratory, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu 215001, China College of Biological Engineering Chongqing University Chong Qing China Department of Plant Biology and Pathology, Rutgers University, New Brunswick, NJ 08901, USA; Department of Biology, Ramapo College of New Jersey, NJ 07430, USA Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China; Department of Periodontology The Affiliated Stomatological Hospital of Nanjing Medical University Nanjing China Janssen Research & Development, LLC Spring House PA USA Shanghai Key Laboratory of Ocular Fundus Diseases, Department of Ophthalmology, Shanghai First People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai, PR China. The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Qingchun Rd, Hangzhou, China Department of Ultrasound, Affiliated Hospital of Yangzhou University, Medical Imaging Center Yangzhou University Yangzhou China Key Laboratory of Pediatric Hematology and Oncology Ministry of Health Pediatric Translational Medicine Institute Shanghai Children's Medical Center School of Medicine Shanghai Jiao Tong University China College of Chemical Engineering and Technology, Supercomputing Center, Tianshui Normal University, Tianshui 741001, China Department of Rheumatology and Immunology, The Suqian Clinical College of Xuzhou Medical University, Suqian, Jiangsu 223800, P.R. China Institute of Pathogen Biology and Immunology of College of Biology, Hunan Provincial Key Laboratory of Medical Virology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, China Key Laboratory of Industrial Biotechnology of Ministry of Education and School of Biotechnology Jiangnan University Wuxi 214122 P. R. China Breast and Thyroid Surgery Department, Daping Hospital, Army Medical University, Third Military Medical University, Chongqing, China Clinical Pharmacology and Pharmacometrics Janssen Research & Development, LLC Springhouse Pennsylvania USA Department of Oncology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, People's, Republic of China. Department of Mechanical Engineering & Mechanics and Bioengineering Program Lehigh University Bethlehem PA USA Beijing Key Laboratory of Applied Psychology, School of Psychology, Beijing Normal University College of Animal Science and TechnologySichuan Agricultural UniversityChengduChina School of Biotechnology and Key Laboratory of Industrial Biotechnology Ministry of Education Jiangnan University Wuxi China; State Key Laboratory of Food Science and Technology Jiangnan University Wuxi China 1Division of Pulmonary Biology Key Laboratory of Ecosystem Network Observation and Modeling, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China; College of Resource and Environment, University of Chinese Academy of Sciences, Beijing 100049, China School of Physics and Technology, Wuhan University, Wuhan 430072, China Research and Development, GlaxoSmithKline, No. 3 Building, 898 Halei Road, Pudong, Shanghai 201203, China School of Biotechnology and Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi, China;; International Joint Research Laboratory for Brewing Microbiology, Applied Enzymology at Jiangnan University, Wuxi, China;; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China Department of R&D, Neusoft Medical Systems Co. Ltd, Beijing, China Jiangsu Key Laboratory for Science and Applications of Molecular Ferroelectrics, Southeast University, Nanjing, 211189, P. R. China School of Mathematical Sciences, University of Science and Technology of China, Hefei, China From the Departments of Anesthesiology (Y.X., S.M.L., P.T.), Pharmacology and Chemical Biology (Y.X., P.T.), Structural Biology (Y.X.), and Computational Biology (P.T.), University of Pittsburgh School of Medicine, Pa; and the Departments of Neurosurgery (P.H.C.) and Neurology and Neurological Sciences (P.H.C.), Stanford University School of Medicine, Stanford, Calif. Divisions of Pulmonary Biology & Biomedical Informatics, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center , Cincinnati, OH 45229 , USA College of Life Sciences, Shaoxing University, Shaoxing, P.R.China Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, PR China; Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, PR China State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, China Department of Obstetrics and GynecologyIndiana University School of Medicine Indianapolis Indiana USA i-Lab, Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Science, Suzhou Industrial Park Suzhou Jiangsu 215123 P.R. China Department of Respiratory, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; Department of Respiratory, Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, China Reproductive Medical Center, Department of Obstetrics and Gynecology, Sun Yat-Sen University First Affiliated Hospital, Guangzhou, Guangdong, China Geriatrics Department, The Second Xiang Ya Hospital of Central South University, Changsha, China College of Life Science, China West Normal University, Nanchong 637002, China Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, PR China Sir Run Run Shaw Hospital, Zhejiang University Medical School, Hangzhou 310016, China. Department of Rheumatology and Immunology The Affiliated Suqian First People's Hospital of Nanjing Medical University Suqian Jiangsu China Department of Radiology Tongji Hospital Shanghai Frontiers Science Center of Nanocatalytic Medicine The Institute for Biomedical Engineering & Nano Science School of Medicine Tongji University Shanghai 200065 China Division of Physical Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China; University of Chinese Academy of Sciences, Beijing 100049, China School of Biotechnology, Jiangnan University, Jiangsu, People’s Republic of China Department of Respiratory Medicine, Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, China (mainland) Department of Biology, College of Science, Shantou University, Shantou 515063, PR China Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Energy Genetics, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, PR China Department of Trauma and Orthopedics, Institute of Chinese People’s Liberation Army, General Hospital of Jinan Military Command, Jinan, China Department of Sports Medicine, Peking University Third Hospital, Institute of Sports Medicine of Peking University, Beijing Key Laboratory of Sports Injuries, Beijing, China Admedus Vaccines Pty Ltd; Diamantina Institute, University of Queensland, Brisbane, Qld, Australia Departments of Anesthesiology, Pharmacology and Chemical Biology, and Computational Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261 Key Laboratory of Pediatric Hematology and Oncology Ministry of Health Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine Shanghai China; Pediatric Translational Medicine Institute Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine Shanghai China Laboratory of Brewing Microbiology and Applied Enzymology, School of Biotechnology, Jiangnan University, Wuxi 214100, China; Key Laboratory of Baijiu Supervision Technology for State Market Regulation, Chengdu 610097, China College of Life Sciences, Shaoxing University, Shaoxing, PR China Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, People’s Republic of China3Center for ADR Monitoring of Guangdong, Guangzhou 510080, People’s Republic of China School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China; Division of Physical Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China; National Engineering Research Center for Nanotechnology, Shanghai 200241, China Department of Chemistry, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States Department of Nephrology Lianyungang Hospital of Traditional Chinese Medicine Lianyungang China Nanoscience and Nanotechnology Research Center Research Organization for the 21st Century Osaka Prefecture University 1‐2 Gakuen‐cho, Naka‐ku, Sakai Osaka 599‐8570 Japan Department of Radiology, Tongji Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai 200065, China 1State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, China. College of Bioinformatics Science and Technology; Harbin Medical University; Harbin 150081; China Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education; College of Chemistry; Peking University; Beijing 100871, China Department of Chemistry University of Texas at Austin Austin TX 78712 USA Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA; Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA Department of Clinical Pharmacology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China National Engineering Research Center for Nanotechnology, Shanghai, 200241, China College of Sports and Human Sciences, Harbin Sport University, Harbin, 150008, China Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu, China. xuyannjmu@aliyun.com. |
Incoming Links
Total number of triples: 5483.