http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_3ba31e1394eeadb1a79081b52dfaf59c
Outgoing Links
| Predicate | Object |
|---|---|
| family-name | Yue Chen Chen |
| name | Yue Chen |
| given-name | Yue |
| organization-name | Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, China; Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, China; Institute of Nuclear Medicine, Southwest Medical University, Luzhou, China Department of Ultrasound, Huadong Hospital, Fudan University, Shanghai P.R. China Department of Nuclear Medicine (Y.C., Z.-k.P., J.W., H.-x.C., J.-m.L.), TEDA International Cardiovascular Hospital, China. Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, USA chenye614@sohu.com Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing People's Republic of China; Department of Basic Science of Stomatology Affiliated Hospital of Stomatology Nanjing Medical University Nanjing People's Republic of China The State Key Laboratory of Medicinal Chemical Biology, Collaborative Innovation Center of Chemical Science & Engineering (Tianjin), College of Pharmacy, & Tianjin Key Laboratory of Molecular Drug Research, College of Chemistry, Nankai University, Tianjin, 300353, PR China The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, People’s Republic of China Department of Orthopedic Surgery, Luoyang Orthopedic Hospital of Henan Province, Luoyang, China School of Clinical Medicine Anhui Medical University Hefei 230000 P. R. China Department of Plant Pathology College of Plant Protection Nanjing Agricultural University Nanjing 210095 China; Key Laboratory of Integrated Management of Crop Diseases and Pests Ministry of Education Nanjing 210095 China Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province Department of Nuclear Medicine The Affiliated Hospital of Southwest Medical University Luzhou 646000 China University of Ottawa. Center for Disease Control and Prevention of Guangzhou Military Command of the PLA, Guangzhou 510507, Guangdong Province, China; Guangdong Arbovirus Diseases Emergency Technology Research Center, Guangzhou 510507, Guangdong Province, China Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Twin Cities, Minneapolis, MN 55455, USA Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada. Department of Endodontics Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine Guangzhou China State Key Lab of Fluorinated Functional Membrane Materials Dongyue Polymer Material Company of Dongyue Federation Zibo Shandong 256401 P. R. China Pharmacy Department, PLA General Hospital Department of Pediatrics, The Center Hospital of Cangzhou, Cangzhou, China School of Life Science and Technology Harbin Institute of Technology Harbin China Department of Cardio‐Oncology Chongqing University Cancer Hospital Chongqing China Department of Fundamental and Community Nursing, School of Nursing Nanjing Medical University Nanjing China Department of Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China. Fujian Provincial Key Laboratory of Quantum Manipulation and New Energy Materials, College of Physics and Energy, Fujian Normal University, Fuzhou, 350117, China; Fujian Provincial Engineering Technical Research Centre of Solar-Energy Conversion and Stored Energy, Fuzhou, 350117, China Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261. Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350004, China School of Epidemiology and Public Health Faculty of Medicine University of Ottawa Ottawa Ontario Canada Department of Thoracic Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China School of Agriculture and Biology Shanghai Jiao Tong University Shanghai China Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota at Twin Cities, Minneapolis, Minnesota 55455, United States School of Epidemiology, Public Health, and Preventive Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H8M5, Canada School of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang 150080, China State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin Institute of Urology, Tianjin 300211, China Department of Nuclear Medicine, Affiliated Hospital of Southwest Medical University/Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou State Key Laboratory of Natural and Biomimetic Drugs; School of Pharmaceutical Sciences; Peking University; Beijing 100191; China Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, P. R. China School of Computer Science and Engineering, Nanyang Technological University, Singapore Institute of Plant Protection, Hunan Academy of Agricultural Sciences , 410125 Changsha, China Jiaxing City Jia Xin Cai Agricultural Development Group Co. Ltd., 314000 Jiaxing, Zhejiang, China Institute of Horticulture, Zhejiang Academy of Agricultural Sciences, Hangzhou, Zhejiang, China Ben May Department for Cancer Research, University of Chicago, Chicago, IL, USA. Yue Chen, Department of Radiology, Renji Hospital of Shanghai Jiaotong University School of Medicine, Shanghai 200001, China. Department of Nuclear Medicine the Affiliated Hospital of Luzhou Medical College Luzhou 646000 China State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China Department of Clinical Medicine, School of the First Clinical Medicine Anhui Medical University Hefei China Department of Nuclear Medicine, the Affiliated hospital of Southwest Medical University, Luzhou, China Department of Biology and Environment; Jiyang College of Zhejiang A&F University; Shaoxing 311800; China Beijing Advanced Innovation Center for Materials Genome Engineering, Key Laboratory for Renewable Energy, Beijing Key Laboratory for New Energy Materials and Devices, Institute of Physics, Chinese Academy of Sciences, Beijing 100049, P.R. China; University of Chinese Academy of Sciences, Beijing 100049, P.R. China Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Canada West China School of Stomatology and College of Mechanical and Electrical Engineering, Soochow University, Suzhou, 215000, China Agios Pharmaceuticals, Inc. Cambridge Massachusetts USA Department of Nuclear Medicine, The Affiliated Hospital of Southwest, Medical University; Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province; and Academician (Expert) Workstation of Sichuan Province, Luzhou, China Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois 60637, United States Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Affiliated Hospital of Southwest Medical University, Luzhou, China Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials Hubei Key Laboratory of Polymer Materials School of Materials Science and Engineering Hubei University Wuhan 430062 P. R. China Key Laboratory of Plant Secondary Metabolism and Regulation in Zhejiang Province, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China Guangdong Arbovirus Diseases Emergency Technology Research Center Center for Disease Prevention and Control of Southern Theatre Command of PLA Guangzhou China Division of Cardiothoracic and Vascular Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China; Key Laboratory of Organ Transplantation,Ministry of Education,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China; Key Laboratory of Organ Transplantation,Ministry of Health,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China Department of Ophthalmology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China University of Pittsburgh Department of Pathology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China Department of Cardiology Chongqing University Cancer Hospital Chongqing China Department of Nuclear Medicine Affiliated Hospital of Southwest Medical University Luzhou China; Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province Luzhou China Agios Pharmaceuticals, Inc., Cambridge, MA 02139; State Key Laboratory and Institute of Elemento‐Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering Nankai University Tianjin 300071 China; College of Pharmacy Nankai University Tianjin 300071 China Department of Cardiology,The First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou,China Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, China Department of Gastrointestinal Surgery/Department of Clinical Nutrition Beijing Shijitan Hospital, Capital Medical University Beijing China; Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition Beijing China; Key Laboratory of Cancer FSMP for State Market Regulation Beijing China National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, Jiangsu, China. Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota at Twin Cities, Minneapolis, MN, USA Chengdu Bio-HT Company Limited, Chengdu, China School of Computer Science and Engineering, Nanyang Technological University, Singapore, Singapore Department of Biomedical Engineering Georgia Institute of Technology Atlanta Georgia USA State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering Nanjing University Nanjing 210023 P. R. China Department of Radiology, Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, China Department of Physiological Sciences, Oklahoma State University, 264 McElroy Hall, Stillwater, OK 74078, USA Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Cooperative Innovation Center for Sustainable Pig Production, Wuhan, Hubei 430070, PR China; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China Department of Colorectal Surgery, Liaoning Province Cancer Hospital and Institute, Shenyang 110042, China. chunsong163@163.com. Epidemiology & Community Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, Canada K1H 8M5 Care Alliance Rehabilitation Hospital of Chengdu, P.R. China Department of Mechanical Engineering, University of Arkansas, Fayetteville, Arkansas, USA. Department of Integrated Chinese Medicine and Western Medicine, Fujian College of TCM, Fuzhou 350003, China. State Key Laboratory of Infrared Physics, Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 200083, China The Graduate School of Fujian Medical University, Fuzhou, Fujian, China Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA Department of Criminal Science and Technology, Shandong Police College, Jinan 250014, China State Key Laboratory of Materials-Oriented Chemical Engineering, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, P. R. China School of Epidemiology, Public Health and Preventive Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H8M5, Canada School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, China The Graduate School of Fujian Medical University, Fuzhou, Fujian 350001, China The Key Laboratory for Space Bioscience and Biotechnology; School of Life Sciences; Northwestern Polytechnical University; Xi'an; China Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Nanjing Tech University, Nanjing 211816, China Key Laboratory of Textile Science and Technology Ministry of Education Donghua University Shanghai 201620 China State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin 150001, China; Shandong Provincial Key Lab of Special Welding Technology, Harbin Institute of Technology at Weihai, Weihai 264209, China Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong SAR School of Material and Chemical, Ningbo University of Technology, Ningbo 315211, China Yunnan Herbal Laboratory, College of Ecology and Environmental Sciences, Yunnan University, Kunming 650504, China; The International Joint Research Center for Sustainable Utilization of Cordyceps Bioresources in China and Southeast Asia, Yunnan University, Kunming 650091, China College of Pharmacy, Xinjiang Medical University, Urumqi, P.R. China Department of Plant Pathology College of Plant Protection Nanjing Agricultural University, and Key Laboratory of Integrated Management of Crop Diseases and Pests, Ministry of Education Nanjing 210095 China Faculty of Medicine, School of Epidemiology, Public Health and Preventive Medicine University of Ottawa Ottawa Ontario Canada Department of Laboratory Medical Center, PLA North Military Command Region General Hospital, Shenyang 110000, China The State Key Laboratory of Medicinal Chemical Biology, Synergetic Innovation Center of Chemical Science and Engineering (Tianjin), College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, People’s Republic of China Department of Hematology, Nanjing Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing 210093, China Department of Mechanical Engineering The University of Hong Kong Pokfulam Road Hong Kong SAR China State Key Laboratory of Fluorinated Functional Membrane Materials; Zibo; China Key Laboratory of Cell Proliferation and Regulation of Ministry of Education, Beijing Normal University, Beijing 100875, China. National University of Singapore Department of Pathology, Kunming General Hospital/Kunming Medical College, Kunming, Yunnan 650032, China Department of Nuclear Medicine, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan, China Department of Pharmacy, School of Medicine, Women’s Hospital, Zhejiang University, Hangzhou, Zhejiang Province, People’s Republic of China; Key Lab Women’s Reproductive Health, School of Medicine, Women’s Hospital, Zhejiang University, Hangzhou, Zhejiang Province, People’s Republic of China Visual Psychophysiology Laboratory, McLean Hospital, MS stop 303, 115 Mill St, Belmont, MA 02478, USA State Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Science and Engineering Tianjin University of Science and Technology Tianjin 300457 China Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China Department of Urology, Second Hospital of TianJin Medical University, TianJin Institute of Urology, Tianjin, China (mainland) Key Laboratory of Industrial Biotechnology Ministry of Education and School of Biotechnology Jiangnan University 1800 Lihu Road Wuxi Jiangsu 214122 China Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, and Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, Peking University Health Science Center, Beijing 100191, China Department of Surgery, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania Xiangtan Medicine & Health Vocational College, Xiangtan, China. Department of Medical Microbiology and Immunology, Clinical Molecular Immunology Innovation Team, Dali University, Dali, 671000 Yunnan, China Department of Epidemiology and Biostatistics School of Public Health Anhui Medical University Hefei China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province Hefei China Central Laboratory, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China Department of Oncology, Heyuan People's Hospital, Affiliated Heyuan Hospital of Jinan University Heyuan Guangdong China Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9038, and Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, Texas 76019 Tianjin Institute for Women’s Health, Tianjin, China School of Epidemiology, Public Health and Preventive Medicine University of Ottawa Ottawa Canada Jilin Green Food Engineering Research Institute, Changchun, Jilin, China Department of Mechanical Engineering, The University of Hong Kong, Hong Kong SAR, China. Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Nanjing Tech University, 5 Xinmofan Road, Nanjing 210009, China Department of Physiological Sciences 264 McElroy Hall, Oklahoma State University Stillwater 74078 OK USA Department of Integrated Traditional Chinese and Western Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China School of Epidemiology, Pubic Health and Preventive Medicine, University of Ottawa, Ottawa, Canada Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania. School of Chemistry Engineering, Sichuan University of Science & Engineering, Zigong 643000, China State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, People’s Republic of China; School of Clinical Medicine, Anhui Medical University, Hefei, China The Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Xi’an Jiaotong University; The Center for Drug Safety and Policy Research, Xi’an Jiaotong University Department of Clinical Laboratory, The Second Clinical Medical College, Jinan University, Shenzhen, China. Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, People’s Republic of China Department of Nephrology, Tongji Hospital, Tongji University, Shanghai, China Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital Capital Medical University Beijing China; Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition Beijing China; Key Laboratory of Cancer FSMP for State Market Regulation Beijing China Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania. Jiangxi Key Laboratory of Surface Engineering, School of Materials and Mechanical & Electrical Engineering, Jiangxi Science and Technology Normal University, Nanchang 330013, P. R. China Department of Biochemistry, Molecular Biology and Biophysics, The University of Minnesota at Twin Cities, Minneapolis, MN, United States. Electronic address: yuechen@umn.edu. Department of Nuclear Medicine, Affiliated Hospital, Luzhou Medical College, Luzhou, Sichuan, China NSFC Center for Luminescence from Molecular Aggregates; SCUT-HKUST Joint Research Laboratory; State Key Laboratory of Luminescent Materials and Devices; South China University of Technology; Guangzhou 510640 Department of Radiation Oncology, Sun Yat‐sen University Cancer Center; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou Guangdong 510060 P. R. China Department of Hematology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada McLean Hospital, Harvard Medical School State Grid Tianjin Electric Power Company Economic and Technological Research Institute, Tianjin, China. School of Epidemiology and Public Health University of Ottawa Ottawa Canada Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China The Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy Xi'an Jiaotong University Xi'an Shaanxi China; The Center for Drug Safety and Policy Research Xi'an Jiaotong University Xi'an Shaanxi China The Institute of Cardiovascular Sciences, Institute of Systems Biomedicine, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Health Science Center, Xueyuan Road 38, Jiangxi Key Laboratory of Surface Engineering, School of Materials and Mechanical & Electrical Engineering, Jiangxi Science and Technology Normal University, Nanchang, Jiangxi, 330013, P. R. China School of Chemistry and Molecular Engineering; Nanjing Tech University; Nanjing 211816; P. R. China Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9038 College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, China; 1Department of Radiation Oncology, Sun Yat-sen University Cancer Center,; 2State Key Laboratory of Oncology in South China,; 3Collaborative Innovation Center of Cancer Medicine, and; 4Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, People’s Republic of China; and Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Science, Chengdu, Sichuan 610041, China; University of Chinese Academy of Sciences, Beijing 10049, P.R. China Center of Clinical Pharmacy, Chinese PLA General Hospital, Beijing, China; Department of Nutrition and Food Safety, School of Public Health Nanjing Medical University Nanjing China Department of Infectious Diseases and Microbiology, Graduate School of Public Health University of Pittsburgh Pittsburgh PA USA Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin Institute of Urology, Tianjin 300211, China Department of Psychology, Harvard University, 33 Kirkland Street, Cambridge, MA 02138; and McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478 Division of Biostatistics, Institute for Health and Equity, Medical College of Wisconsin, Milwaukee, WI; School of Pharmaceutical Sciences & Institute of Materia Medica, National Key Laboratory of Advanced Drug Delivery and Release Systems, Shandong First Medical University & Shandong Academy of Medical Sciences , Jinan 250117 , PR China Department of Infectious Diseases, Taihe Hospital, Shiyan, Hubei, 442008, China Department of Pediatrics, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. cwn2@sohu.com Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong. Department of Geriatrics, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9041 Department of Cardiology First Affiliated Hospital of Dalian Medical University Dalian China Department of Medical Service, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin’ s Clinical Research Center for Cancer, Tianjin, China Department of Mechanical Engineering, University of Arkansas, Fayetteville, Arkansas. Institute of Horticulture, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, Zhejiang, China. College of Chemistry, Beijing Normal University, Beijing 100875, People's Republic of China Nursing Department of Taian City Central hospital Taian China School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing; Ovation Health Science and Technology Co. Ltd, ENN Group, Langfang Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University , Nanjing , China Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Xi’an Jiaotong University, Xi’an, Shannxi, China; School of Public Health, Xi’an Jiaotong University, Xi’an, Shannxi, China Department of Chemistry, Nankai University, Tianjin 300071, P.R. China, and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9038 Department of Integrated Chinese and Western Medicine, Fujian College of TCM, Fuzhou 350003, China. Sports Nutrition Center, National Institute of Sports Medicine, Beijing 100029, China; Key Lab of Sports Nutrition, State General Administration of Sport of China, Beijing 100029, China; National Testing & Research Center for Sports Nutrition, Ministry of Science and Technology of the People’s Republic of China, Beijing 100029, China School of Nursing, Nanjing Medical University, Nanjing, Jiangsu, China School of Psychology, Sichuan Normal University, Chengdu, China Department of Neurosurgery, Fuzong Clinical Medical College, Fujian Medical University, Fuzhou, China.; Department of Neurosurgery, National Regional Medical Center, First Affiliated Hospital, Fuzong Clinical Medical College, Fujian Medical University, Fuzhou, China. Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0359, USA Department of Neurosurgery, the Affiliated Hospital of Southwest Medical University, Luzhou, China. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States Department of Clinical Medicine, School of the First Clinical Medicine, Anhui Medical University , Hefei, Anhui, China Department of Nuclear Medicine, Affiliated Hospital of Southwest Medical University, Luzhou 646000, China; Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou 646000, Sichuan, China State Key Laboratory of Luminescent Materials and Devices, Center for Aggregation-Induced Emission, South China University of Technology, Guangzhou 510640, China Department of Psychology University of Toronto Mississauga Mississauga Ontario Canada College of Plant Protection, Shandong Agricultural University, Tai’an, Shandong, People’s Republic of China Department of Hematology, Huai'an First People's Hospital, Nanjing Medical University Huai'an, P. R. China. Key Laboratory of Oral Biomedical Engineering Ministry of Education, Sichuan University, Chengdu 610041, China. Pittsburgh Retrovirus Laboratory, Department of Infectious Diseases and Microbiology, Graduate School of Public Health Graduate School, Guangxi University of Chinese Medicine, Nanning, Guangxi 530001, P.R. China Department of Nuclear Medicine & Sichuan Key Laboratory of Nuclear Medicine and Molecular Imaging, Affiliated Hospital of Southwest Medical University, Luzhou Sichuan, 646000, P.R.China. Liaoning Urban Construction Technical College, Shenyang 110122, China Medical College of Xiamen University Xiamen City 361005 China Department of Biomedical Engineering, University of Rochester, Rochester, New York 14627 Department of Nephrology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China Jiangxi Key Laboratory for Postharvest Technology and Nondestructive Testing of Fruits & Vegetables, Collaborative Innovation Center of Post-Harvest Key Technology and Quality Safety of Fruits and Vegetables, College of Agronomy, Jiangxi Agricultural University, Nanchang, Jiangxi 330045, China Nuclear Medicine Department, Tianjin Medical University Clinical Cardiovascular Institute, Teda International Cardiovascular Hospital, Tianjin, China Institute for Catalysis; Hokkaido University; Sapporo 001-0021; Japan; CREST State Key Laboratory of Respiratory Diseases Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Guangzhou P.R. China Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Strongly-Coupled Quantum Matter Physics Key Laboratory of Surface and Interface Chemistry and Energy Catalysis of Anhui Higher Education Institutes National Synchrotron Radiation Laboratory Department of Chemical Physics Department of Physics University of Science and Technology of China Hefei Anhui 230026 P. R. China From the Department of Cardiology, Daping Hospital, The Third Military Medical University, Chongqing, China (Y.C., S.Z., D.H., L.Z., C.Z.); Chongqing Institute of Cardiology, Chongqing, China (Y.C., S.Z., D.H., L.Z., C.Z.); and Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD (L.D.A., V.A.M.V., P.A.J.). Department of Cardiology, Daping Hospital, The Third Military Medical University , Chongqing 400042 , China Shandong Provincial Key Laboratory for Biology of Vegetable Diseases and Insect Pests, College of Plant Protection, Shandong Agricultural University, Tai’an, Shandong 271018, P.R. China Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital of Fujian Medical University, Fujian Provincial Key Laboratory of Precision Medicine for Cancer, Fuzhou, Fujian 350001, China Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Canada. Agios Pharmaceuticals Inc. 88 Sidney Street Cambridge MA 02139‐4169 USA School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China Department of Hematology, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an 223300, Jiangsu Province, China;Key Laboratory of Hematology of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China. Institute of Horticulture, Zhejiang Academy of Agricultural Science, Hangzhou, Zhejiang, China State Key Laboratory of Plant Physiology and Biochemistry College of Life Sciences Zhejiang University Hangzhou 310058 China Department of Anesthesiology, Zhejiang Province People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China High-Throughput Molecular Drug Discovery Center, Tianjin Joint Academy of Biotechnology and Medicine, Tianjin 300457, China State Key Laboratory of Materials Processing and Die & Mold Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan, Hubei 430074, PR China Department of Ocean Science The Hong Kong University of Science and Technology Clear Water Bay Hong Kong, China Department of Pharmacy, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China Department of Pharmacy, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China National Research and Development Center for Egg Processing, College of Food Science and Technology Huazhong Agricultural University Wuhan People's Republic of China Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, China; Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, The Affiliated Hospital of Southwest Medical University, Luzhou, China; Academician (Expert) Workstation of Sichuan Province, The Affiliated Hospital of Southwest Medical University, Luzhou, China; Institute of Nuclear Medicine, Southwest Medical University, Luzhou, China Department of Endocrinology, Baoshan Branch, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; Department of Endocrinology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Science, Nankai University, Tianjin, China NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Department of Physiological Sciences Center for Veterinary Health Sciences, Oklahoma State University Stillwater OK 74078 USA Jilin Provincial Key Laboratory of Animal Embryo Engineering, The Center for Animal Embryo Engineering of Jilin Province, College of Animal Science and Veterinary Medicine, Jilin University, Changchun, Jilin, China. Beijing Engineering Research Center of Process Pollution Control, Division of Environment Technology and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China Shandong Provincial Key Laboratory of Marine Environment and Geological Engineering (MEGE), College of Environmental Science and Engineering, Ocean University of China, Qingdao, People’s Republic of China Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota at Twin Cities, Minneapolis, MN 55455, USA Authors' Affiliations: 1Department of Pharmaceutical Sciences, College of Pharmacy, North Dakota State University, Fargo, North Dakota and 2Department of Pathology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota College of Geology and Environment, Xi’an University of Science and Technology, Xi’an 710054, China College of Physics and Energy, Fujian Normal University, Fujian Provincial Key Laboratory of Quantum Manipulation and New Energy Materials, Fuzhou 350117, China; Fujian Provincial Engineering Technical Research Centre of Solar-Energy Conversion and Stored Energy, Fuzhou 350117, China State Key Laboratory of Crop Stress Biology for Arid Areas, College of Agronomy, Northwest A&F University, Xianyang 712100, China Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Science, Chengdu, Sichuan 610041, China Department of Basic Science of Stomatology The Affiliated Stomatological Hospital of Nanjing Medical University Nanjing China; Jiangsu Province Key Laboratory of Oral Diseases Nanjing China; Jiangsu Province Engineering Research Center of Stomatological Translational Medicine Nanjing China Department of Nephrology, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, Jiangsu, China Key Laboratory of Drug-Targeting and Drug-Delivery Systems of the Ministry of Education, Department of Medicinal Chemistry,West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, 610041, P. R. China, and Department of Nuclear Medicine Affiliated Hospital, Luzhou Medical College, No. 25 Taiping Street, Luzhou, Sichuan, 646000, P. R. China Medical and Pharmaceutical Analysis Center, Beijing University, Beijing 100083. University of OttawaOttawa, Ontario, Canada From the State Key Laboratory of Oncology in Southern China, Guangzhou, China; Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, China; Department of Radiology, Sun Yat-sen University Cancer Center, Guangzhou, China College of Electronic and Information Engineering, Taizhou University, Taizhou, Zhejiang, China State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering Hunan University Changsha China Key Laboratory of Plant Secondary Metabolism and Regulation in Zhejiang Province, College of Life Sciences and Medicine Zhejiang Sci‐Tech University Hangzhou China Center for Rehabilitation Medicine, Department of Anesthesiology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, Zhejiang 310014, China Department of Immunology, Southern Medical University, Guangzhou 510515, China. chenyue@fimmu.com Department of Medicinal Chemistry, ‡Department of Discovery Biology, and §Department of Drug Metabolism and Pharmaceutical Sciences, Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States School of Life Sciences, Nanchang University, Nanchang, Jiangxi 330031, China Guangdong Pharmaceutical University, Hai Zhu District, Guangzhou City, Guang Dong Province, China Institute of Drug Clinical Trial, Department of Thoracic Oncology of Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China; Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan, China; Institute of Nuclear Medicine, Southwest Medical University, Luzhou, Sichuan, China Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA Science for Life Laboratory, Department of Applied Physics, KTH Royal Institute of Technology, SE-17121 Solna, Sweden The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing, Jiangsu, China School of Mechanical and Electrical Engineering, Xuzhou University of Technology, Xuzhou 221018, China Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital Capital Medical University Beijing China; National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital Capital Medical University Beijing China; Key Laboratory of Cancer FSMP for State Market Regulation Beijing China; Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition Beijing China Department of Hematology, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China National Engineering Research Center of Neuromodulation, Tsinghua University , Beijing 100084 , China Department of Anesthesiology, Zhejiang Provincial People?s Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China Key Laboratory of Applied Technology of Sophisticated Analytical Instruments; Shandong Academy of Sciences; Jinan Shandong China Department of Hematology, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huaian, People’s Republic of China; Key Laboratory of Hematology of Nanjing Medical University, Nanjing, People’s Republic of China Department of Nuclear Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan, People’s Republic of China Department of Nuclear Medicine, Affiliated Hospital, Luzhou Medical College, Luzhou, Sichuan 646000, China. Department of Fundamental and Community Nursing, School of Nursing, Nanjing Medical University, Nanjing 211166, China Department of Hematology, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huai’an, People’s Republic of China Division of Cardiothoracic and Vascular Surgery Sino‐Swiss Heart‐Lung Transplantation Institute, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China Jiangxi Key Laboratory of Surface Engineering, School of Materials and Energy, Jiangxi Science and Technology Normal University, Nanchang 330013, China Department of Medicine, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Agios Pharmaceuticals Inc. Cambridge MA USA Department of Nuclear Medicine, Affiliated Hospital, Luzhou Medical College, No. 25 Taiping Street, Luzhou, Sichuan, 646000, P. R. China Department of Psychiatry, Harvard Medical School/McLean Hospital, Belmont, MA 02478, USA. ychen@wjh.harvard.edu Department of Nutrition, School of Public Health Nanjing Medical University Nanjing Jiangsu China Chemistry Department, University of Saskatchewan, Saskatoon, SK, S7N 5C9 Canada, and J&W Scientific Inc., 91 Blue Ravine Road, Folsom, California 95630-4714 Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350001, China Department of Radiation Oncology, Sun Yat-sen University Cancer Centre, Guangzhou, Guangdong 510060, P.R. China Department of Medical Microbiology and Immunology, Clinical Molecular Immunology Innovation Team, Dali University, Dali 671000, China Institute of Crop Science, College of Agriculture and Biotechnology, Zhejiang University, Zijingang Campus, Hangzhou, China Department of Dermatology, Shanghai General Hospital of Nanjing Medical University, Shanghai, China; School of Geology and Environment, Xi’an University of Science and Technology, Xi’an710054, China Department of Materials Science and Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan Key Laboratory of Thin Film and Microfabrication (Ministry of Education), Department of Micro/Nano Electronics, School of Electronics, Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, PR China Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390–9038, USA. Laboratory of Animal Nutrition Physiology and Metabolism, The Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha 410125, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China; CAS Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Changsha 410125, China Department of Colorectal Cancer Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Dadong District, Shenyang 110042, Liaoning Province, P R China Xinjiang Key Laboratory of Oasis Ecology Xinjiang University Urumqi China College of Physics and Energy; Fujian Normal University; Fujian Provincial Key Laboratory of Quantum Manipulation and New Energy Materials; Fuzhou; China Department of Cardiothoracic Surgery, The First Affiliated Hospital, Chongqing Medical University, Yuzhong, Chongqing, China (mainland) College of Urban Construction, Wuhan University of Science and Technology, Wuhan, China Center of Clinical Pharmacy, Chinese PLA General Hospital, Beijing, China Department of Gynecology and Obstetrics The First Affiliated Hospital of Guangxi Medical University Nanning China School of Epidemiology Public Health and Preventive Medicine University of Ottawa Ontario Canada State Key Lab of Fluorinated Functional Membrane Materials, Shandong Dongyue Polymer Material Co., Ltd., Zibo 256401, P. R. China Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City, Biological Science Research Center Southwest University Chongqing China Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of Stomatology Xi’an Jiaotong University Xi’an China; Department of Periodontology College of Stomatology Xi’an Jiaotong University Xi’an China Department of Infectious Disease Xiamen Hospital of Traditional Chinese Medicine Xiamen China McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health, and Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada. Sliu@uottawa.ca Department of Hematology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai’an, China Department of Mechanical Engineering; The University of Hong Kong; Hong Kong SAR; China School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, P. R. China Department of Epidemiology and Community Medicine Faculty of Medicine University of Ottawa Ottawa Canada Departments of Cell Biology and Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, and A&G Pharmaceutical, Inc., 9130 Red Branch Road, Columbia, Maryland 21045 College of Pharmacy and The State Key Laboratory of Elemento-Organic Chemistry, Nankai University, and State Key Laboratory of Experimental Hematology, Institute of Hematology, Chinese Academy of Medical Sciences, Tianjin, People's Republic of China Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, K1H 8M5, Canada Department of Infectious Diseases and Microbiology,University of Pittsburgh,Pittsburgh,PA Department of Mechanical Engineering The University of Hong Kong Hong Kong China Department of Hepatology Unit, Xiamen Hospital of Traditional Chinese Medicine, Beijing University of Traditional Chinese Medicine, Xiamen, Fujian 361001, P.R. China Department of Epidemiology and Community Medicine, University of Ottawa, Canada. Department of Physiology, Dalian Medical University, Lvshun South Road No.9, Dalian, Liaoning, People's Republic of China School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China; Precision Pharmacy & Drug Development Center, Department of Pharmacy, Tangdu Hospital, Air Force Medical University, Xi'an, China Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 6-155 Jackson Hall, 321Church Street S.E.,, Minneapolis, MN, 55455, USA. YueChen@UMN.edu. State Key Laboratory of Crop Stress Biology for Arid Areas, College of Plant Protection Northwest A&F University Yangling Shaanxi China Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China; Department of Basic Science of Stomatology Affiliated Hospital of Stomatology Nanjing Medical University Nanjing China Department of Nephrology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, Jiangsu, China Department of Nutrition and Food Safety School of Public Health, Nanjing Medical University, Nanjing, China; National Engineering Research Center of Neuromodulation, School of Aerospace Engineering, Tsinghua University , China Institute of Biostatistics Fudan University Shanghai 200433 China Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui,China Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada. chen@zeus.med.uottawa.ca School of Engineering; China Pharmaceutical University; Nanjing 211198; People's Republic of China College of Plant Protection, Shenyang Agricultural University, Shenyang, Liaoning 110161, China Center for Molecular Discovery, Verna and Mars McLean Department of Biochemistry and Molecular Biology, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 Department of Ultrasound, Huadong Hospital, Fudan University, Shanghai, China. South Texas Center for Emerging Infectious Diseases (STCEID), Center of Excellence in Infection Genomics and Department of Biology, The University of Texas at San Antonio, San Antonio, Texas, USA Fujian Provincial Key Laboratory of Quantum Manipulation and New Energy Materials, College of Physics and Energy, Fujian Normal University, Fuzhou 350117, China Agios Pharmaceuticals, Inc., 88 Sidney Street, Cambridge, Massachusetts 02139, United States Departments of aBiochemistry and; Department of Chemistry and Biochemistry, University of Texas, Arlington, TX 76019 Tsinghua Institute of Genome Research, Department of Biological Sciences and Biotechnology and School of Medicine, Tsinghua University, Beijing 100084, People’s Republic of China Institute of Pharmaceutical Science, China Pharmaceutical University, Tong Jia Xiang, Nanjing, Jiangsu 210009, China Department of Dermatology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China (mainland) Department of Ultrasound, Huadong Hospital Fudan University Shanghai China; Shanghai Key Laboratory of Clinical Geriatric Medicine Shanghai China Departments of Physiology and Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 Department of Dermatology Dokkyo Medical University Koshigaya Hospital Koshigaya Saitama Japan; Department of Dermatology Tokyo Medical and Dental University Tokyo Japan The Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi, 710072, China Department of Cardiology, Daping Hospital, The Third Military Medical University, Chongqing, China; Chongqing Institute of Cardiology & Chongqing Cardiovascular Clinical Research Center, Chongqing, China Department of Mechanical Engineering; The University of Hong Kong; Hong Kong The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, People’s Republic of China Faculty of Medicine, University of Ottawa, Ottawa K1N6N5, Canada. State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing 210009, People’s Republic of China The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, 94 Weijin Road, Nankai District, Tianjin 300071, People’s Republic of China Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University Chongqing China; Chongqing Key Laboratory of Neurobiology Chongqing China Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China Department of TCM Tongren Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Orthopedic Surgery, Chinese PLA General Hospital, Beijing 100853, China School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada. State Key Laboratory of Electrical Insulation and Power Equipment, School of Electrical Engineering, Xi’an Jiaotong University, Xi’an 710049, P. R. China Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China Department of Ultrasound; and Laboratory of Immunobiology Centre for Infectious Diseases and Immunology State Key Laboratory of Respiratory Diseases Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Guangzhou China Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. National Natural Science Foundation of China School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa , Ottawa , Canada Department of Applied Physics, Science for Life Laboratory, KTH Royal Institute of Technology, Sweden Tomtebodavägen 23, 171 65 Solna, Sweden Department of Endocrinology, Changhai Hospital the Second Military Medical University Shanghai China State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin 300071, P. R. China; Accendatech Co., Ltd., Tianjin 300384, P. R. China Department of Hematology, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huai’an, P. R. China;; Key Laboratory of Hematology of Nanjing Medical University, Nanjing, China College of Pharmaceutical Science, Anhui Xinhua University, Hefei 230088, China Department of Ocean Science, The Hong Kong University of Science and Technology , Clear Water Bay, Hong Kong, China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) , Guangzhou, China 10Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas. Shanghai Jiaotong University 1 College of Life Sciences and Biotechnology, , 800 Dongchuan Road, Shanghai 200240, China Departments of Medicinal Chemistry, Discovery Biology, Drug Metabolism, and Pharmaceutical Sciences, Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, People’s Republic of China Department of Nuclear Medicine Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province The Affiliated Hospital of Southwest Medical University Luzhou Sichuan China Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing 102206, China. Department of Medicine, Center for International Blood and Marrow Transplant Research Medical College of Wisconsin Milwaukee Wisconsin USA Department of Ocean Science The Hong Kong University of Science and Technology, Clear Water Bay Hong Kong China School of Mechanical Engineering, Nanjing Forestry University of China, Nanjing 210037, China 5Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN Center for Clinical Laboratory, Zhujiang Hospital, Guangzhou, People's Republic of China; Key Laboratory of Prevention and Control of Emerging Infectious Diseases of Guangdong Higher Education Institutes, Guangzhou, People's Republic of China Department of Traditional Chinese Medicine, Tongren Hospital, Shanghai, China College of Life Science, Zhejiang University, Hangzhou 310021, People’s Republic of China (Y.L., Yue.C., Yun.C.); and State Key Laboratory of Oral Diseases and National Clinical Research Centre for Oral Diseases, Sichuan University, Chengdu, China; Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China School of Science, Beijing University of Chemical Technology, Beijing 100029, China. *Department of Surgery, University of Pittsburgh School of Medicine, and Children’s Hospital of Pittsburgh, Pittsburgh, PA 15213; and Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA Ben May Department of Cancer Research, The University of Chicago, Chicago, IL 60637; 1Tsinghua Institute of Genome Research, Department of Biological Sciences and Biotechnology and Institute of Biomedicine, Tsinghua University, and Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan, People's Republic of China. State Key Lab of Fluorinated Functional Membrane Materials, Shandong Dongyue Polymer Material Co, Ltd, Zibo, China Shenzhen University Yantai-Jingshi Institute of Material Genome Engineering, Yantai 265505, P. R. China Department of Hematology, The Affiliated Huai’an No.1 People’s Hospital of Nanjing Medical University, Huai’an, People’s Republic of China; Key Laboratory of Hematology of Nanjing Medical University, Nanjing, People’s Republic of China Department of Infectious Diseases, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China Nursing Department of Taian City Central Hospital Taian China State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China; Department of Obstetrics and Gynecology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210028, P.R. China Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139; Biotechnology and Germplasm Resources Institute, Yunnan Academy of Agricultural Sciences, Kunming, China; Department of Industrial Engineering, Tsinghua University, Beijing, P.R. China Agios Pharmaceuticals, Inc., Cambridge, Massachusetts 02139, United States Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China Department of Nuclear Medicine, the Affiliated Hospital of Southwest Medical University, Luzhou, China State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China Fukui Institute for Fundamental Chemistry; Kyoto University; Kyoto 606-8103, Japan Division of Thoracic Tumor Multimodality Treatment, Cancer Center, West China Hospital, Sichuan University; Clinical Trial Center, National Medical Products Administration Key Laboratory for Clinical Research and Evaluation of Innovative Drugs, West China Hospital, Sichuan University, Chengdu, Sichuan Department of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning 110042, P.R. China State Key Laboratory of Crop Stress Biology for Arid Areas, College of Plant Protection Northwest A&F University Yangling China Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina 27710; Departments of Medicine, Duke University Medical Center, Durham, North Carolina 27710 Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, P. R. China Department of TÇM Tongren Hospital Shanghai, Jiao Tong University School of Medicine Shanghai China Department of Ultrasound, Huadong Hospital, Fudan University College of Life and Environmental Sciences Minzu University of China 27 South Zhongguancun Avenue Beijing 100081 P.R. China State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital Capital Medical University Beijing China; National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital Capital Medical University Beijing China; Key Laboratory of Cancer FSMP for State Market Regulation Beijing China From the *Department of Nuclear Medicine, Zigong First People's Hospital, Zigong; and †Department of Nuclear Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China. School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada School of Epidemiology and Public Health, Faculty of Medicine University of Ottawa Ottawa Canada Department of Pharmacology & Physiology, Georgetown University, Washington, DC; 1Agios Pharmaceuticals, Inc., Cambridge, Massachusetts. State Key Laboratory of Crop Stress Biology for Arid Areas College of Agronomy Northwest A&F University Yangling China Department of Cardiology, Daping Hospital, The Third Military Medical University, Chongqing 400042, P.R. China; Chongqing Institute of Cardiology, Chongqing 400042, P.R. China Department of Molecular Biology and Microbiology Tufts University School of Medicine Boston Massachusetts USA Key Laboratory for Biobased Materials and Energy of Ministry of Education and Department of Applied Chemistry, College of Materials and Energy, South China Agricultural University West China School of Public Health and West China Fourth Hospital Sichuan University Chengdu China NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China Key Laboratory of Psychiatric Disorders of Guangdong Province, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China chenyue614@sohu.com Department of Anesthesia, People's Hospital of Henan Province, People's Hospital of Zhengzhou University, Zhengzhou 450000, Henan, China. Institute for Clean Energy & Advanced Materials, Faculty of Materials & Energy, Southwest University, Chongqing 400715, China Key Laboratory of Quality Regulation of Tropical Horticultural Crop in Hainan Province, School of Horticulture, Hainan University, Haikou 570228, China; Hainan Yazhou Bay Seed Laboratory, Sanya Nanfan Research Institute of Hainan University, Sanya 572025, China Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9038, Department of Human Genetics, Emory University, Atlanta, Georgia 30322, and ThermoElectron Corporation, San Jose, California 95134 School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada; 5Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana. Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention Soochow University Suzhou China School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, Heilongjiang, China State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China Sichuan University Departments of Chemistry Agios Pharmaceuticals, Cambridge, MA 02139, USA. State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, People's Republic of China Department of Oncology, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, China Department of Neurosurgery, Neurosurgical Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China Biological Targeting Diagnosis and Therapy Research Centre, Guangxi Medical University, Nanning, Guangxi, China Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China; HKU Zhejiang Institute of Research and Innovation, 1623 Dayuan Road, Lin An 311305, China Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an, China Department of Ultrasound, Huadong Hospital Fudan University Shanghai China Department of Obstetrics and Gynecology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China; Department of Obstetrics and Gynecology, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China Central Laboratory, Fujian Key Laboratory of Precision Medicine for Cancer, Key Laboratory of Radiation Biology of Fujian Higher Education Institutions, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350005, China Protein Chemistry Technology Center, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-8816, Ben May Department for Cancer Research, The University of Chicago, Chicago, Illinois 60637, and Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305 NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China. Key Laboratory of Hubei Province for Coal Conversion and New Carbon Materials, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, China Department of Nuclear Medicine, Affiliated Hospital of Southwest Medical University, No. 25, Taiping St, Luzhou, Sichuan 646000, China Department of Breast and Thyroid Surgery, First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, No. 1295 Dingxi Road, Shanghai 200050, P. R. China 1Department of Cardiology, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing, China; 2Key Laboratory of Geriatric Cardiovascular and Cerebrovascular Disease Research, Ministry of Education of China, Chongqing Key Laboratory for Hypertension Research, Chongqing Cardiovascular Clinical Research Center, Chongqing Institute of Cardiology, Chongqing, China; 3State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University, Chongqing, China Visual Psychophysiology Laboratory, McLean Hospital, Belmont, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA Department of Ocean Science, The Hong Kong University of Science and Technology, Hong Kong, China Clinical Trial Center, National Medical Products Administration Key Laboratory for Clinical Research and Evaluation of Innovative Drugs, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Department of Thoracic Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China Department of Medical Imaging, Second Affiliated Hospital, Shantou University Medical College, Shantou515000, China Department of Oncology, The School of Clinical Medicine, Guizhou Medical University, Guiyang, P.R. China Departments of Nuclear Medicine, Affiliated Hospital of Southwest Medical University, Luzhou 646000, China Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China Ministry-of-Education Key Laboratory of Green Preparation and Application for Functional Materials, and School of Materials Science & Engineering, Hubei University, Wuhan430062, China Department of Urology, Ningbo First Hospital, Ningbo, People's Republic of China National Key Laboratory of Wheat and Maize Crop Science / CIMMYT‐China Wheat and Maize Joint Research Center /Agronomy College Henan Agricultural University Zhengzhou China State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, PR China The Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Xi’an Jiaotong University, Xi’an, Shannxi, China; The Center for Drug Safety and Policy Research, Xi’an Jiaotong University, Xi’an, Shannxi, China Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, 25 Taiping Street, Luzhou 646000, Sichuan, China State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin 300353, P. R. China Department of Chemistry Massachusetts Institute of Technology 77 Massachusetts Ave Cambridge MA 02139 USA Department of Clinical Laboratory, The Second Clinical Medical College (Shenzhen People's Hospital), Jinan University, Shenzhen, China. Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China; National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, China; Key Laboratory of Cancer FSMP for State Market Regulation, Beijing, China; Laboratory for Clinical Medicine Capital Medical University, Beijing, China Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA; School of Life Science and Technology, Harbin Institute of Technology, Harbin, China Agios Pharmaceuticals, Inc., Cambridge, MA; and Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education of China), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, China Department of Anesthesiology, Zhejiang Provincial People’s Hospital, Hangzhou, China;; People’s Hospital of Hangzhou Medical College, Hangzhou, China Zhejiang Institute for Food and Drug Control, Key Laboratory of Drug Contacting Materials Quality Control of Zhejiang Province, Hangzhou 310052, China Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada. Pharmacokinetics, Dynamics, and Metabolism Department, ‡Medicinal Chemistry Department and §Cardiovascular and Metabolic Diseases Department, Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States National Research and Development Center for Egg Processing, College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, P. R. China Department of Infectious Diseases and Microbiology; Graduate School of Public Health; University of Pittsburgh; Pittsburgh, PA USA Department of Nutrition and Food Safety, School of Public Health; Nanjing Medical University; Nanjing 211166 China Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario Silk Institute, College of Materials and Textile, Zhejiang Sci-Tech University, Hangzhou 310018, P. R. China College of Food Science and Technology, Huazhong Agricultural University, Wuhan, China; Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123, Jiangsu, China Agios Pharmaceuticals Inc., Cambridge, Massachusetts 02139, United States College of Materials Science and Engineering, Key Laboratory of Polymeric Composite Materials of Heilongjiang Province, Qiqihar University, Qiqihar 161006, P. R. China Chengdu Bio-HT Company Limited, Chengdu, China; School of Materials Science and Engineering; Shanghai Institute of Technology; Shanghai 201418; China National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu 214122, China; School of Biotechnology and Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu 214122, China; Jiangsu Provisional Research Center for Bioactive Product Processing Technology, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu 214122, China Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois 60637, Computation Institute, University of Chicago, Chicago, Illinois 60637, and Department of Pediatrics, Division of Neonatology, Northwestern University, Chicago, Illinois 60611 School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ontario, Canada 1Department of Biological Sciences and Biotechnology, State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Animal Science, Shanxi Agricultural University, Jinzhong 030801, China Department of Nuclear Medicine, Affiliated Hospital of Southwest Medical University Luzhou, People's Republic of China.; Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, People's Republic of China. Department of Mechanical and Aerospace Engineering University of California at Los Angeles (UCLA) 43–147 Eng. IV, 420 Westwood Plaza Los Angeles CA 90095–1597 USA Department of Cardiovascular Surgery, The First Affiliated Hospital, Harbin Medical University, Harbin, China Department of Nuclear Medicine Affiliated Hospital; Luzhou Medical College; Luzhou; P. R. China Department of Ultrasound, Huadong Hospital, Fudan University, Shanghai, China *Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710; School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, 600 Peter Morand Crescent, Ottawa, ON K1G 5Z3, Canada Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering Shenzhen University Shenzhen China Department of Urology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China Department of Clinical Medicine, School of the First Clinical Medicine, Anhui Medical University, China Center for International Blood and Marrow Transplant Research, Department of Medicine Medical College of Wisconsin Milwaukee Wisconsin USA The Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi, China Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China. Department of Nuclear Medicine Affiliated Hospital of Luzhou Medical College Luzhou Sichuan 646000 China Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. State Key Lab of Fluorinated Functional Membrane Materials, Dongyue Polymer Material Company of Dongyue Federation, Zibo, Shandong 256401, P. R. China Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin Institute of Urology, Tianjin 300211, P.R. China School of Epidemiology and Public Health University of Ottawa Ottawa ON Canada Department of Medical Laboratory Shenzhen People's Hospital (The Second Clinical Medical College Jinan University The First Affiliated Hospital Southern University of Science and Technology) Shenzhen 518020 P. R. China Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada The Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University School of Medicine Atlanta Georgia USA Shandong Academy of Pesticide Sciences, Jinan, Shandong 250033, China; College of Plant Protection, Shandong Agricultural University, Tai’an, Shandong 271018, China Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota at Twin Cities, Minneapolis, MN 55455, USA. Department of Epidemiology and Community Medicine,University of Ottawa, Canada. School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1G 5Z3, Canada South Texas Center for Emerging Infectious Diseases, Center of Excellence in Infection Genomics and Department of Biology, The University of Texas at San Antonio, San Antonio, Texas, USA Department of Infectious Diseases and Microbiology, Graduate School of Public Health Department of Chemistry & Biochemistry, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, Indiana 46556-5670 The State Key Laboratory of Medicinal Chemical Biology, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, People’s Republic of China Authors' Affiliation: Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency; School of Pharmaceutical Science and Technology; Tianjin University; Tianjin; P. R. China Ultrasound Department, Huadong Hospital, Fudan University, Shanghai, China Duke Human Vaccine Institute, Duke University, Durham, North Carolina; Medicine, Duke University, Durham, North Carolina Department of Nuclear Medicine the Affiliated Hospital of Southwest Medical University Luzhou 646000 China Faculty of Chinese Medicine, Macau University of Science and Technology; Department of Nuclear Medicine, The Affiliated Hospital, Southwest Medical University; Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province; Institute of Nuclear Medicine, Southwest Medical University; Academician (Expert) Workstation of Sichuan Province, Luzhou, China China National GeneBank BGI‐Shenzhen Shenzhen 518120 China; BGI‐Shenzhen Shenzhen 518083 China Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China Department of Biochemistry and Molecular Biology Baylor College of Medicine Houston TX USA School of Life Science and Technology, Harbin Institute of Technology, 150080 Harbin, China Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI; Center for International Blood and Marrow Transplant Research, Department of Medicine, Medical College of Wisconsin, Milwaukee The Second Clinical Medical College, Nanchang University, Nanchang 330006, China Department of Infectious Diseases and Microbiology Graduate School of Public Health University of Pittsburgh Pittsburgh USA Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China; NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, No. 25, Taiping Street, Jiangyang District, Luzhou, Sichuan 646000, People’s Republic of China; Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan 646000, People’s Republic of China; Academician (Expert) Workstation of Sichuan Province, Luzhou, Sichuan 646000, People’s Republic of China Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods; College of Food Science; South China Agricultural University; Guangzhou; China Department of Anesthesiology, Center for Rehabilitation Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital Hangzhou medical College Hangzhou China Department of Basic Science of Stomatology, Affiliated Hospital of Stomatology Nanjing Medical University Nanjing China; Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300353, P. R. China Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada K1H 8M5. ychen@uottawa.ca College of Chemistry, Beijing Normal University, Beijing 100875, People’s Republic of China Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University , Luzhou, Sichuan 646000, China; Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, The Affiliated Hospital of Southwest Medical University , Luzhou, Sichuan 646000, China; Institute of Nuclear Medicine, Southwest Medical University , Luzhou, Sichuan 646000, China Department of Cardiology, First Affiliated Hospital of Dalian Medical University Beijing University of Chinese Medicine, Beijing, China Department of Nutrition and Food Safety, School of Public Health Nanjing Medical University Nanjing Jiangsu China Lab of Experimental Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, P.R.China. Department of Medical Laboratory, The Second Clinical Medical College (Shenzhen People’s Hospital) of Jinan University, Shenzhen 518020, China School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada Department of Ultrasound, Huadong Hospital, Fudan University, Shanghai, China.; Shanghai Key Laboratory of Clinical Geriatric Medicine Shanghai, China. University of Ottawa, Ottawa, Canada Harvard University Institute of Horticulture, Zhejiang Academy of Agriculture Science, Hangzhou, Zhejiang, China; Key Laboratory of Creative Agriculture, Ministry of Agriculture, Hangzhou, China Laboratory of Animal Nutrition Physiology and Metabolism, The Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China Chemical Biology Research Center, School of Pharmaceutical Sciences Wenzhou Medical University Wenzhou China Crop Stress Molecular Biology Laboratory Heilongjiang Bayi Agricultural University Daqing 163319 China Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou 646099, China; Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan, Luzhou 646099, China; Academician (Expert) Workstation of Sichuan, Luzhou 646099, China Department of Dermatology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Wujin Road 85, Hongkou District, Shanghai 200080, China Department of Nephrology, Zigong First People's Hospital, Zigong, Sichuan 643000, P.R. China Department of Plastic Surgery, Zhejiang Hospital Affiliated to the Zhejiang University School of Medicine State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco‐Environmental Sciences Chinese Academy of Sciences Beijing 100085 China; Department of Urology The Second Hospital of Tianjin Medical University Tianjin Institute of Urology Tianjin 300211 China Oral and Maxillofacial Reconstruction and Regeneration Laboratory, Southwest Medical University. Luzhou 646000, China. E-mail: 2916067367@qq.com. Authors' Affiliations: 1Graduate and Postdoctoral Studies, 2McLaughlin Center for Population Health Risk Assessment, Institute of Population Health, and 3Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa; 4Risk Sciences International, Ottawa, Ontario, Canada; 5Department of Economics, Brigham Young University, Provo, Utah; and 6Epidemiology Research Program, American Cancer Society, Atlanta, Georgia Department of Gastrointestinal Surgery/Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China; National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, China; Key Laboratory of Cancer Food for Special Medical Purposes for State Market Regulation, Beijing, China; Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, China Department of Nuclear Medicine The Affiliated Hospital of Luzhou Medical College Luzhou 646000 China Department of Mechanical Engineering The University of Hong Kong Pokfulam Road Hong Kong SAR 999077 China Institute of Horticulture Zhejiang Academy of Agricultural Sciences Hangzhou China The Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Xi’an Jiaotong University Department of Cardiology, Daping Hospital, The Third Military Medical University, Chongqing, China (Y.C., G.W., C.Z.). Department of Radiology, Jingzhou Central Hospital Jingzhou, China. 3Department of Biochemistry, South Texas Center for Emerging Infectious Diseases, Department of Biology, The University of Texas at San Antonio, San Antonio, Texas, USA Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University/Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan, PR China, Luzhou, China Department of Medicine, University of Saskatchewan, Saskatoon, SK Canada; Centre for Agricultural Medicine, Royal University Hospital, Saskatoon, SK S7N OXO Canada. Division of Clinical Immunology and Department of Infectious Diseases, Tongji Hospital, Research Institute of Immunology, Tongji Medical College of Huanzhong University of Science and Technology, Wuhan 430030, China. Division of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Hematology, Huai’an First People’s Hospital, Nanjing Medical University, Huai’an 223300, Jiangsu, China 1Department of Medicine, Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA Division of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, PR China; Laboratory of Emerging Infectious Diseases, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, PR China Department of Medical Laboratory The Second Clinical Medical College (Shenzhen People's Hospital) of Jinan University Shenzhen 518020 P. R. China Department of Ophthalmology, Shijiazhuang Aier Eye Hospital, Shijiazhuang Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. Department of Epidemiology and Community Medicine; Faculty of Medicine; University of Ottawa; Ottawa Canada Key Lab of Industrial Fermentation Microbiology of the Ministry of Education School of Biotechnology Tianjin University of Science and Technology Tianjin China University of Ottawa School of Epidemiology Ottawa Ontario Canada NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China College of Polymer Science and Engineering; State Key Laboratory of Polymer Materials Engineering; Sichuan University; Chengdu 610065; China Department of Nutrition and Food Safety, School of Public Health, Nanjing Medical University, Nanjing 211166, People’s Republic of China The Affiliated Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou 310000, China State Key Laboratory of Infrared Physics Chinese Academy of Sciences Shanghai 200083 China; School of Electronic, Electrical and Communication Engineering University of Chinese Academy of Sciences Beijing 100049 China Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada KIN 6N5 School of Epidemiology, Public Health and Preventive Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada State Key Laboratory of Infrared Physics, Shanghai Institute of Technical Physics Chinese Academy of Sciences, 500 Yutian Road, Shanghai 200083, China Institute for Catalysis, Hokkaido University, N21W10, Kita-ku, Sapporo 001-0021, Japan College of Pharmacy, Nankai University, 300071, Tianjin, China; State Key Laboratory of Elemento-Organic Chemistry, Nankai University, 300071, Tianjin, China Georgia Institute of Technology Department of Biomedical Engineering, , Atlanta, GA 30332 State Key Lab of Fluorinated Functional Membrane Materials, Dongyue Polymer Material Company of Dongyue Federation, Zibo, Shandong 256401, P.R. China Key Laboratory of Flexible Electronics (KLOFE) & Institution of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing 211816, Jiangsu, P.R. China School of Engineering China Pharmaceutical University Nanjing China School of Epidemiology, Public Health and Preventive Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada Tianjin Key Laboratory for Modern Drug Delivery & High‐Efficiency, School of Pharmaceutical Science and Technology Tianjin University Tianjin 300072 P. R. China Department of Ocean Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China; Fukui Institute for Fundamental Chemistry, Kyoto University, Takano-Nishihiraki-cho 34-4, Sakyo-ku, Kyoto 606-8103, Japan College of Pharmacy, The State Key Laboratory of Elemento-Organic Chemistry, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Department of Radiation Oncology Sun Yat‐sen University Cancer Center Guangzhou China Department of Urology The Second Hospital of Tianjin Medical University, Tianjin Institute of Urology Tianjin China Department of Infectious Diseases and Microbiology Pittsburgh Pennsylvania Department of Gastrointestinal Surgery/Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China; Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, China; Key Laboratory of Cancer FSMP for State Market Regulation, Beijing, China; The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Science of Ministry of Education, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides of Ministry of Health, Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing 100191, China Institute of Horticulture Research, Zhejiang Academy of Agricultural Sciences, Hangzhou, China College of Optometry, University of Houston, Houston, TX 77204-6052, USA Department of Nuclear Medicine Affiliated Hospital, Luzhou Medical College, No. 25 Taiping Street, Luzhou, Sichuan, 646000, P. R. China Department of Dermatology Shanghai General Hospital of Nanjing Medical University Shanghai China NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China; Center for AIDS Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China Department of Periodontology and Oral Medicine Xi'an Jiaotong University College of Stomatology Xi'an China Department of Nuclear Medicine, TEDA International Cardiovascular Hospital Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Soochow University, Suzhou, China Laboratory of Surgery, The First Affiliated Hospital of Sun-Yat Sen University, Guangzhou 510080, China; Department of Thyroid Surgery, The First Affiliated Hospital of Sun-Yat Sen University, Guangzhou 510080, China Department of Nephrology, Tongji Hospital, Tongji University, Shanghai, China;; Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China Department of Pharmacy, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, China Department of Pathology, Kunming General Hospital, Kunming, Yunnan, China. Department of Thoracic Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China; Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China Authors' Affiliation: Division of Life Science and Center for Cancer Research, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China State Key laboratory of Bioactive Substances and Functions of Natural Medicines, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Key Laboratory of Oncology in Southern China, Guangzhou, China; Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, China; Department of Radiology, Sun Yat-sen University Cancer Center, Guangzhou, China Department of Nuclear Medicine, The First Affiliated Hospital, Sichuan Medical University, Luzhou, Sichuan 64600, China. Departments of Biochemistry and Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9038 Department of Nuclear Medicine, Affiliated Hospital of Southwest Medical University, Jiangyang District, Luzhou 646000, Sichuan, China; Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Jiangyang District, Luzhou 646000, Sichuan, China; Institute of Nuclear Medicine, Southwest Medical University, Jiangyang District, Luzhou 646000, Sichuan, China Hunan Academy of Agricultural Sciences, Institute of Plant Protection Changsha Hunan 410125 China; Department of Plant Pathology, College of Plant Protection Nanjing Agricultural University, and Key Laboratory of Integrated Management of Crop Diseases and Pests, Ministry of Education Nanjing 210095 China State Key Laboratory of Medicinal Chemical Biology, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin, China Department of Nuclear Medicine, Affiliated Hospital of Luzhou Medical College, Luzhou, China School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, P. R. China Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, People's Republic China College of Chemistry, Beijing Normal University, Beijing 100875, China School of Engineering and Technology, China University of Geosciences (Beijing), 100083, Beijing, P. R. China Department of Mechanical Engineering The University of Hong Kong Hong Kong SAR 999077 China Brain Institute, School of Pharmacy, Wenzhou Medical University , Wenzhou, Zhejiang Province , China Georgia Tech Institute for Robotics and Intelligent Machines (IRIM),Atlanta,GA,USA,30313 University of Texas at San Antonio, Department of Biology and South Texas Center for Emerging Infectious Diseases, San Antonio, Texas, USA Biotechnology and Germplasm Resources Institute, Yunnan Academy of Agricultural Sciences, Kunming 650205, Yunnan, China Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China; Key Laboratory of Agroecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China; Hunan Provincial Key Laboratory of the Traditional Chinese Medicine Agricultural Biogenomics, Changsha Medical University, Changsha 410219, China Institute of Plant Protection, Hunan Academy of Agricultural Sciences, Changsha 410125, China; Longping Branch, College of Biology, Hunan University, Changsha 410125, China |
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