http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_119f21d73beb9ccc54ab4cd573c077ae
Outgoing Links
Predicate | Object |
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family-name | Min Xu Xu |
name | Min Xu |
given-name | Min |
organization-name | State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Rui‐Jin Hospital, Shanghai Jiao‐Tong University School of Medicine Shanghai China; Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases Rui‐Jin Hospital, Shanghai Jiao‐Tong University School of Medicine Shanghai China * Ophthalmology, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, China; Zhejiang Provincial Key Laboratory for Genetic Improvement and Quality Control of Medicinal Plants, Hangzhou Normal University, Hangzhou, China Clinical Trial Center, Huzhou Central Hospital, Huzhou, Zhejiang, People’s Republic of China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Centre for Infectious Diseases Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital,Zhejiang University School of Medicine Hangzhou 310003 China Department of Pathology and Laboratory Medicine, Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio; Shanghai Jiao Tong University Shanghai National Clinical Research Center for Metabolic Diseases Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai Institute of Endocrine and Metabolic Diseases Shanghai China School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, 210023, China Quantitative Biosciences, Merck & Co., Inc., Kenilworth, New Jersey, USA State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China Department of Laboratories, Seattle Children’s Hospital, Seattle, Washington; Department of Laboratory Medicine, University of Washington, Seattle, Washington Department of Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China Children's Hospital Oakland Research Institute, Oakland, California Key Laboratory of Soil Environment and Pollution Remediation, Institute of Soil Science, Chinese Academy of Sciences, 71 East Beijing Road, Nanjing, Jiangsu 210008, People’s Republic of China Shanghai Clinical Center for Endocrine and Metabolic Diseases and Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 1 Program in Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA and 2European Molecular Biology Laboratory, Computational and Structural Biology Unit, Meyerhofstrasse 1, 69117 Heidelberg, Germany Department of Laboratories, Seattle Children’s Hospital, Seattle, WA; Department of Laboratory Medicine, University of Washington, Seattle Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China; Hubei Key Laboratory of Soil Environment and Pollution Remediation, Huazhong Agricultural University, Wuhan, China State Key Laboratory of Medical Genomics National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China; Shanghai Institute of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China Department of Oncology, Affiliated Nanhai Hospital of Southern Medical University Foshan, Oncology Section 2, Foshan, Guangdong, China (mainland). State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, CAS Research/Education Center for Excellence in Molecular Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China Institute of Nephrology, Zhongda Hospital, Southeast University School of Medicine, Nanjing, China Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui Lishui China State Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health National Clinical Research Center for Metabolic Diseases Collaborative Innovation Center of Systems Biomedicine Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Jiao Tong University School of Medicine Shanghai China; Shanghai Institute of Endocrine and Metabolic Diseases Department of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Faculty of Basic Medical Sciences, Guilin Medical University, Guilin 541004, PRChina Institute of Remote Sensing and Digital Earth, Chinese Academy of Sciences, Beijing, China College of Horticulture and Forestry, Xinjiang Agricultural University, Urumqi, China; Laboratory of Germplasm Resources and Efficient Production of Horticultural Crops in Xinjiang, Urumqi, China Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts Department of Gastroenterology, Shanghai First People's Hospital of Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China Cultivation Base of State Key Laboratory of Humid Subtropical Mountain Ecology, Fujian Normal University, Fuzhou 350007, China. School of Geographical Science, Fujian Normal University, Fuzhou 350007, China. Translational Immunology Department, Genentech Inc., South San Francisco, California, USA PegBio Co., Ltd. Suzhou Jiangsu China From the Department of Pathophysiology, Shanghai Institute of Hematology, Rui-Jin Hospital, Shanghai Second Medical University, Shanghai, China; the Health Science Center, Shanghai Institutes for Biological Sciences and Graduate School, Chinese Academy of Sciences, Shanghai, China; the Department of Hematology, Zhong-Shan Hospital, Fu-Dan University, Shanghai, China; and the Department of Medicine/Endocrinology, Weill Medical College of Cornell University, New York, NY. Department of Thoracic Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, China Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Rui-jin Hospital, Shanghai Jiao-Tong University School of Medicine; Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, China National Clinical Research Center for Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, E-Institute of Shanghai Universities Department of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, P. R. China Department of Endocrinology, the First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, 230022 PR China. Department of Surgery, Section of Abdominal Transplantation, Washington University School of Medicine, St. Louis, MO. School of Public Health, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China Department of Pediatric Intensive Care Unit, Nursing Department, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, China (mainland) Translational Immunology, Genentech , South San Francisco, California, USA Department of Pharmacy The Third People's Hospital of Chengdu The Affiliated Hospital of Southwest Jiaotong University The Second Chengdu Hospital Affiliated to Chongqing Medical University Chengdu China Department of Cardiology, Luhe Hospital, Capital Medical University, China Department of Otorhinolaryngology Head and Neck Surgery, Air Force Medical University, XiJing Hospital, Xian, Shanxi, China Department of Laboratories, Seattle, WA; Department of Laboratory Medicine, University of Washington, Seattle Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212000, P.R. China Department of General Medicine Jiangsu Province Official Hospital Nanjing China State Key Laboratory of Brain and Cognitive Sciences, Department of Linguistics, and Shenzhen Institute of Research and Innovation, University of Hong Kong, Hong Kong Key Laboratory of Cultivation and High-Value Utilization of Marine Organisms in Fujian Province, Fisheries Research Institute of Fujian, Xiamen 361013, China The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi) Zunyi China Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, China National Research Center for Metabolic Diseases, National Key Laboratory for Medical Genomes, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China Eskitis Institute for Drug Discovery, Griffith University, Brisbane, QLD 4111, Australia Fudan University 10Department of Pathology, Yale University, New Haven, CT Department of Nursing Tongren Hospital Hongqiao International Institute of Medicine Shanghai Jiao Tong University School of Medicine Shanghai China Center for Fusion Science of Southwestern Institute of Physics 3 , P. O. Box 432, Chengdu 610041, China Department of Echocardiography The Third Affiliated Hospital of Soochow University Changzhou City China Department of Neurology the Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou China; Department of Neurology the Second Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou China Laboratory of Clean Energy Chemistry and Materials, State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China; School of Physical Science and Technology, Lanzhou University, Lanzhou 730000, China Department of Pharmaceutical Science, Second Military Medical University School of Pharmacy, Shanghai 200433, China Department of Pediatric Surgery, Burns and Plastic Surgery, and Hemorrhoids Fistula Surgery, Yidu Central Hospital of Weifang, Shandong 262500, P.R. China Science and Technology on Vacuum Technology and Physical Laboratory, Lanzhou Institute of Physics, Lanzhou 730000, China Department of Nuclear Medicine, Cancer Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, China. nacya@sohu.com Department of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Air Force Millitary Medical University, Xi’an, Shaanxi Province, China National Clinical Research Center for Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China School of Pharmacy, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 211166, China Key Laboratory of Soil Environment and Pollution Remediation, Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008, China; University of Chinese Academy of Sciences, Beijing 100049, China Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China; Reproductive Medical Center, The Second Affiliated Hospital of Zhengzhou University, Henan Province, China Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commision of the PR China, Shanghai Institute of Endocrine and Metabolic Disease, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases Capital Medical University Beijing China Department of General Surgery Tianjin Union Medical Center Tianjin China Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences Kunming China; Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences Shanghai China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou City, China State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P. R. China Shanghai PerioImplant Innovation Center, Department of Oral and Maxillofacial Implantology Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China; College of Stomatology, Shanghai Jiao Tong University Shanghai China; National Center for Stomatology Shanghai China; National Clinical Research Center for Oral Diseases Shanghai China; Shanghai Key Laboratory of Stomatology Shanghai China Department of Pediatric Surgery Shanghai Children’s Medical Center Affiliated to Shanghai Jiaotong University School of Medicine Shanghai China Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research the Fifth Affiliated Hospital of Wenzhou Medical University /Affiliated Lishui Hospital of Zhejiang University/ The Central Hospital of Zhejiang Lishui Lishui China; Department of Radiology the Fifth Affiliated Hospital of Wenzhou Medical University /Affiliated Lishui Hospital of Zhejiang University/ The Central Hospital of Zhejiang Lishui Lishui China Hong Kong Baptist University Kowloon Tong Hong Kong Liaoning Key Laboratory of Diabetic Cognitive and Perceptive Dysfunction, Jinzhou Medical University, Jinzhou, 121000, China Department of Surgery Shanghai Children's Medical Center Shanghai Jiaotong University School of Medicine Shanghai China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, China; Kunming College of Life Science, University of Chinese Academy of Sciences, China Department of Hematology and Oncology Wuhan Children's Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.; The Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois. Computational Biology Department, Carnegie Mellon University , Pittsburgh, PA 15213, USA Division of Pulmonary Medicine, The First Affiliated Hospital of Wenzhou Medical University, Key Laboratory of Heart and Lung, Wenzhou, Zhejiang 325000, P.R. China Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, Sichuan, China Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Materials Science, East China Normal University, Shanghai, China Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, China Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Clinical and Research Centre of Thrombosis and Hemostasis, Wuhan 430022, China Drug Clinical Trial Center, Huzhou Central Hospital Affiliated Central Hospital Huzhou University Huzhou Zhejiang China Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health Rui‐Jin Hospital, Shanghai Jiao‐Tong University School of Medicine, E‐Institute of Shanghai Universities Shanghai China; Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases Rui Jin Hospital Shanghai China Department of Rehabilitation, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China Southwestern Institute of Physics , Chengdu, Sichuan 610225, China State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China Department of Pharmacology, Southeast University, Nanjing 210009, China. the Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. Department of Pediatric General Surgery Shanghai Children’s Medical Center School of Medicine Shanghai Jiao Tong University Shanghai China National Key Laboratory for Medical Genomes, Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, China National Research Center for Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China Key Laboratory of Bio-based Material Science and Technology of the Ministry of Education of China, College of Material Science and Engineering, Northeast Forestry University, Harbin, China. National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China; Northwest Science Technology University of Agriculture and Forestry, Yangling, China; Northeast Agricultural University, Harbin, China Department of Neurosurgery, Kunshan Hospital of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Kunshan, China Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China Department of Radiation Oncology, Shandong Tumor Hospital, Jinan 250117, China. Key Laboratory for Endocrine and Metabolic Diseases (M.L., Y.X., M.X., L.M., T.W., Y.L., Y.C., J.Lu., J.Li., Y.B., G.N.), Shanghai 200025 China; Ministry of Health, and Shanghai Clinical Center for Endocrine and Metabolic Diseases (M.L., Y.X., M.X., T.W., M.D., Y.C., J.Lu., J.Li., Y.B., G.N.), Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, E-Institute of Shanghai Universities, Shanghai 200025 China Department of Ultrasonic Diagnosis, The Third People's Hospital of Chengdu, Chengdu, Sichuan, China Department of Pathology, Xijing Hospital; Department of Pathology and Pathophysiology, and Center for Transport Phenomena, Energy Research Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University , Chicago, IL, USA; Member of the Oncofertility Consortium, Michigan State University , East Lansing, MI, USA *Department of Immunology, Genentech, South San Francisco, CA 94080; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China, and Graduate School of the Chinese Academy of Sciences, Beijing 100039, People's Republic of China Department of Agronomy , Iowa State University, Ames, Iowa 50011 and Department of Pathology, Xijing Hospital, Fourth Military Medical University, Changle West Road 169, Xi'an 710032, China; Department of Pathology and Pathophysiology, Fourth Military Medical University, Xi'an 710032, China Department of Orthopedics, Central South University, Changsha, China. State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Shanghai Jiao‐Tong University School of Medicine, Shanghai, China; Shanghai Clinical Center for Endocrine and Metabolic Diseases, Rui‐Jin Hospital, Shanghai Jiao‐Tong University School of Medicine, Shanghai, China State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China Central Laboratory, Department of Liver Diseases, ShuGuang Hospital Affiliated to Shanghai University of Chinese Traditional Medicine, Shanghai, China Shanxi Unisdom Testing Technologies Co., Ltd. Taiyuan China Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu 212000, P.R. China Carnegie Mellon University Key Laboratory of Luminescence and Optical Information, Ministry of Education, Institute of Optoelectronic Technology, Beijing Jiaotong University, Beijing 100044, P. R. China Tianjin Normal University Immunobiology and Cancer Program, Oklahoma Medical Research Foundation School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, People’s Republic of China China Agricultural University National Maize Improvement Center, Department of Crop Genetics and Breeding, , Beijing, China Shanghai Clinical Center for Endocrine and Metabolic Diseases (J.X., X.-Y.L., M.X., J.H., Y.H., J.-R.T., X.L., M.D., G.N.), Shanghai Institute of Endocrinology and Metabolism and Shanghai Key Laboratory for Endocrine Tumors, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China Department of Translational Immunology, Genentech, South San Francisco, California, USA State Key Laboratory of Phytochemistry and Plant Resources in West China; Kunming Institute of Botany; Chinese Academy of Sciences; Kunming 650201, People's Republic of China Key Laboratory for Endocrine and Metabolic Diseases, Ministry of Health, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, E-Institute of Shanghai Universities, Shanghai 200025, China; Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China; . Guangdong Provincial Key Laboratory of Biotechnology for Plant Development School of Life Sciences South China Normal University Guangzhou 510631 China Department of Neurology, Xuanwu Hospital Capital Medical University Beijing China Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China. Key Laboratory of Integrated Management of Crop Diseases and Pests, Ministry of Education, Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Laboratory of Virology, Department of Plant Sciences, Wageningen University & Research, Droevendaalsesteeg 1, 6708PB Wageningen, The Netherlands Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China (Q.Y., R.Z., S.W., M.L., T.W., Z.Z., M.X., J.L., Y.C., G.N., W.W., Y.B., Y.X.).; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China (Q.Y., R.Z., S.W., M.L., T.W., Z.Z., M.X., J.L., Y.C., G.N., W.W., Y.B., Y.X.). School of Pharmacy Shanghai University of Traditional Chinese Medicine Shanghai People's Republic of China; Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery Shanghai Peopleʼs Republic of China Department of Pathology, Seattle Children’s Hospital, University of Washington, Seattle, WA; Molecular and Computational Biology, Department of Biological Sciences, and Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People’s Republic of China The Key Laboratory of Plant Immunity, Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, P. R. China State Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai China First Central Clinical College of Tianjin Medical University, Tianjin 300192, P.R. China College of Medicine, Yangzhou University, Yangzhou, Jiangsu 225001, China; The State Administration of Traditional Chinese Medicine Key Laboratory of Toxic Pathogens-Based Therapeutic Approaches of Gastric Cancer, Yangzhou University, Yangzhou, Jiangsu 225009, China Department of Radiation Oncology, Shandong Cancer Hospital and Institute (Shandong Cancer Hospital), Shandong First Medical University and Shandong Academy of Medical Sciences Department of Ultrasound Sun Yat‐Sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 China Department of Hematology, Zhangjiagang First People's Hospital, Suzhou, 215600, P. R. China. Department of Gastroenterology, Shanghai First People’s Hospital, Shanghai JiaoTong University, Shanghai, China Department of Chemistry, School of Pharmacy, The Air Force Medical University, Xi’an 710032, China Department of Paediatric Transplantation Tianjin First Central Hospital Tianjin China; Tianjin Key Laboratory for Organ Transplantation Tianjin China Departments of Surgery School of Medicine,Washington University,St. Louis,MO Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Center of Clinical Laboratory, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China National Key Laboratory of Plant Molecular Genetics Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Science 300 Fenglin Road Shanghai 200032 China Department of Radiology, Affiliated Lishui Hospital of Zhejiang University, The Fifth Affiliated Hospital of Wenzhou Medical University, The Central Hospital of Zhejiang, Zhejiang 323000, P. R. China College of Pharmacy, School of Modern Chinese Medicine Industry, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China Hefei University Chemistry department Jinxiudadao 99 Hefei CHINA Center for Fusion Science of Southwestern Institute of Physics 3 , P.O. Box 432, Chengdu 610041, China Computational Biology Department, School of Computer Science, Carnegie Mellon University , Pittsburgh, PA 15213, USA Department of Hematology, Zhangjiagang First Affiliated Hospital of Soochow University, Zhangjiagang, People’s Republic of China Department of Orthopedics, Second Xiangya Hospital, Central South University, Changsha 410011, China. xyeypd@163.com Department of Neurology, The second People’s Hospital of Deyang City, DeYang, Sichuan, China Shanghai Rui-Jin Hospital (M.Y., M.C., J.W., M.X., L.D., X.L., Q.M., Y.B., R.L., J.H., G.N.), Shanghai Jiao-Tong University School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases and Shanghai E-institute for Endocrinology, Shanghai 200025, China; Anhui Vocational College of Grain Engineering, Hefei, China Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania; and the Department of Immunology, College of Basic Medical Science ,Chongqing Medical University, Chongqing 400016, China. Changsha Municipal Hospital of Chinese Medicine, Changsha 410100, China. Department of Otolaryngology, Shaanxi Provincial People’s Hospital, Xi’an, China Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, PR China Fisheries Research Institute of Fujian, Key Laboratory of Cultivation and High-Value Utilization of Marine Organisms in Fujian Province, Xiamen 361013, China Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843-2128; and Department of Biological Sciences, State University of New York, 1400 Washington Avenue, Albany, NY 12222 Ningbo Cigarette Factory, China Tobacco Zhejiang Industry Co., Ltd., Ningbo 315040, China Department of Infectious Diseases Center, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China Department of Pathology and Laboratory Medicine; University of Cincinnati; Cincinnati Ohio 45237 Department of Radiology, The Affiliated Huai'an Hospital of Xuzhou Medical College and Huai'an Second People's Hospital Huaian 223002, China. Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China College of Materials & Environmental Engineering; Hangzhou Dianzi University; Hangzhou; P. R. China College of Science & Technology; Ningbo University; Ningbo 315300; P. R. China Department of Pediatrics, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China Department of Otorhinolaryngology Head and Neck Surgery, Xijing Hospital, Air Force Medical University, Xi’an, Shaanxi, China Department of Operating Theatre, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, E-Institute of Shanghai Universities, Shanghai, China; Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China Department of Otolaryngology Head and Neck Surgery, The Affiliated Changsha Central Hospital, Hengyang Medical School of University of South China, Changsha, Hunan 410000, China Department of Neurobiology, Nanjing Medical University, Nanjing, China; Key Laboratory of Human Functional Genomics of Jiangsu, Nanjing Medical University, Nanjing, China Department of Urology Jinhua Municipal Central Hospital Jinhua China Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China State Key Laboratory of Microbial Metabolism Shanghai-Islamabad-Belgrade Joint Innovation Center on Antibacterial Resistances Joint International Research Laboratory of Metabolic & Developmental Sciences School of Life Sciences and Biotechnology Shanghai Jiao Tong University Shanghai 200030 China Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory for Endocrine Tumors and E-Institute for Endocrinology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan School of Physical Science and Technology, Southwest Jiaotong University, Chengdu 610031, China Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China; Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, State Key Laboratory for Endocrine and Metabolic Diseases, State Key Laboratory for Endocrine Tumor, State Key Laboratory for Medical Genomics Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China Department of Oral Anatomy and Physiology, School and Hospital of Stomatology, Zunyi Medical University, Zunyi, China. Department of Biochemistry, University of Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland Department of Laboratory Medicine, National Institutes of Health, Bethesda, Maryland 20892-1508 Shanghai Engineering Research Center of Ultra-Precision Optical Manufacturing, Fudan University, Shanghai, China Department of Hematology, Longhua Hospital, Shanghai University of TCM. 6th floor, Building 1, No.725 Wanping South Rd., Shanghai, 200032, China. School of Food and Bio‐Engineering Xihua University Chengdu China Biology Science Institutes Chongqing Medical University Chongqing China Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China CT Scientific Collaboration, Siemens Healthcare Limited, Shanghai, PR China Department of Otorhinolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xian Jiaotong University, Xian, Shaanxi 710004, P.R. China Department of Radiology, the Affiliated Huai'an Hospital of Xuzhou Medical University. Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China Department of Operating Room, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, P. R. China Engineering Research Center of Nano-Geomaterials of Ministry of Education Faculty of Materials Science and Chemistry China University of Geosciences Wuhan 430074 China Department of Clinical Hematology, Key Laboratory of Laboratory Medical Diagnostics Designated by The Ministry of Education, Chongqing Medical University, Chongqing, People's Republic of China Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212008, China; Institute of Digestive Diseases, Jiangsu University, Zhenjiang, Jiangsu, 212013, China Department of Infectious Diseases, Guangzhou Eight People's Hospital Guangzhou Medical University Guangzhou China Department of Laboratories, Seattle Children's Hospital, Seattle, WA, USA; Department of Laboratory Medicine, University of Washington, Seattle, WA, USA Center for Plant Water-Use and Nutrition Regulation and College of Life Sciences, Joint International Research Laboratory of Water and Nutrient in Crop, Fujian Agriculture and Forestry University, Jinshan, Fuzhou 350002, China Fairfield University, Department of Physics, Fairfield, Connecticut, United States Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province Kunming Institute of Zoology Kunming Yunnan China; Kunming College of Life Science University of Chinese Academy of Sciences Kunming Yunnan China Chinese Education Ministry’s Key Laboratory of Western Resources and Modern Biotechnology, Key Laboratory of Biotechnology Shaanxi Province, Shaanxi Key Laboratory for Carbon Neutral Technology, Shaanxi Academy of Basic Sciences, College of Life Sciences, Northwest University, Xi’an 710069, China Department of Cardiology Beijing Luhe Hospital Capital Medical University Beijing China National Clinical Research Center for Metabolic Diseases Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai 200062, China Department of of Biochemistry, University of Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland Institute of Blood Transfusion, Peking Union Medical College, Chinese Academy of Medical Sciences Chengdu China Department of Physics, East China Normal University, Shanghai, 200062, China Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang 212000, China College of Pharmaceutical Science, Zhejiang University of Technology, 288 Liuhe Rd, Hangzhou 310014, P.R. China Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Department of Child Rehabilitation, Huanggang Pingan and Rehabilitation Hospital Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China Department of Cardiology, Beijing Anzhen Hospital, Beijing Institute of Heart Lung and Blood Vessel Diseases, Capital Medical University, Beijing 100029, China. Department of Pharmacology and Laboratory of Cerebrovascular Pharmacology College of Pharmaceutical Science Soochow University Suzhou 215123 China Research Centre of Characteristic Fruit Tree, College of Horticulture and Forestry, Xinjiang Agricultural University, Urumqi, Xinjiang 830052, China Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA. Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China (mainland) Research Center of Clinical Medicine Research Center of Gerontology and Longevity Key Laboratory of Immunology Research Center of Nursing Department of Rheumatology Affiliated Hospital of Nantong University Nantong University Nantong 226001 China Institute of Life Sciences Chongqing Medical University Chongqing People's Republic of China Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria, Australia Department of Hematology, Zhangjiagang Hospital of Soochow University, Zhangjiagang, China; Department of Horticulture, College of Agriculture and Biotechnology, Zhejiang University , Hangzhou 310058 , China Institute of Haematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China State Key Laboratory of Cryospheric Science, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou 730000, China Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China; Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China Shanghai National Center for Translational Medicine Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Laboratory Medicine, University of Washington, Seattle, WA, USA; Department of Laboratories, Seattle Children's Hospital, Seattle, WA, USA Xuanwu Hospital of Capital Medical University. Genentech Inc., Department of Microbial Pathogenesis, South San Francisco, California, USA Liver Center Gastrointestinal Division Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA School of Pharmacy Nanjing Medical University Nanjing Jiangsu China Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China 650201 Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China; Digestive Disease Research Institute, Jiangsu University, Zhenjiang, Jiangsu, China. School of Pharmacy Shanghai University of Traditional Chinese Medicine Shanghai China Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University, Affiliated Lishui Hospital of Zhejiang University, The Central Hospital of Zhejiang Lishui Lishui China Department of Otolaryngology Head and Neck Surgery, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China Department of Ophthalmology, Northern Jiangsu People's Hospital, Yangzhou, China State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, China State Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, the Chinese Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai China; Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai China Guangzhou Eighth Municipal People's Hospital, Guangzhou 510060, China. xumindoctor@163.net School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China College of Food and Bioengineering Xihua University Chengdu China Department of Pediatric Transplantation, Organ Transplantation Center, Tianjin First Central Hospital, Tianjin, China School of Chinese Medicine Hong Kong Baptist University Hong Kong SAR P. R. China Carnegie Mellon University,Computational Biology Department,United States National Clinical Research Center for Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Shanghai China; Department of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Organ Transplant Center Tianjin First Central Hospital Tianjin China; Tianjin Key Laboratory for Organ Transplantation Tianjin China; Tianjin Key Clinical Discipline (Organ Transplantation) Tianjin China Laboratory of Fruit Quality Biology/Zhejiang Provincial Key Laboratory of Horticultural Plant Integrative Biology Zhejiang University Zijingang Campus Hangzhou 310058 China State Key Laboratory of ASIC and System, Shanghai Institute of Intelligent Electronics & Systems, School of Microelectronics, Fudan University, Shanghai 200433, China; Shanghai Integrated Circuit Manufacturing Innovation Center Co., Ltd., Shanghai 200433, China Department of Radiology, The Xi’an Municipal Central Hospital, Affiliated Hospital of Xi’an Jiaotong University, Xi’an, PR China David Braley Center for Antibiotic Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada. Department of Intensive Care Unit, Second Xiangya Hospital, Central South University, Hunan, P. R. China. Departments of *Gastrointestinal Medical OncologyThe University of Texas MD Anderson Cancer CenterHoustonTexasUSA; School of Medical Science and Laboratory MedicineJiangsu UniversityZhenjiangJiangsuPeople's Republic of China Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111; Beth Israel Hospital and Department of Microbiology and Molecular Biology, , Harvard Medical School, Boston, Massachusetts 02115 Institute of Engineering Thermophysics; Chinese Academy of Sciences; Beijing 100190; China Department of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Endocrine and Metabolic E-Institutes of Shanghai Universities, and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Shanghai 200025, Chin Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.; Key Clinical Laboratory of Henan Province, Zhengzhou, People's Republic of China.; Department of Laboratory Medicine, Zhengzhou University, Zhengzhou, People's Republic of China. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, PR China Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China Research Center of Clinical Medicine Affiliated Hospital of Nantong University Nantong China Department of Endocrinology The First Hospital of An Hui Medical University Hefei China Guangzhou Eighth People's Hospital, Guangzhou, People's Republic of China Department of Otolaryngology‐Head and Neck Surgery The Second Affiliated Hospital of Xi’an Jiaotong University Xi'an China Shanghai National Clinical Research Center for Metabolic Diseases Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases Shanghai China 1Surgery, Departments of Canon Medical System (China) Company Limited,Beijing 100015,China. Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, E-Institute of Shanghai Universities; Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Magnetic Resonance, Department of Physics; East China Normal University; Shanghai China Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, 197 Rui-Jin 2nd Road, Shanghai 200025, China; Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, E-Institute of Shanghai Universities, Shanghai 200025, China Department of Radiation Oncology, Shandong Cancer Hospital & Institute, Jinan 250117, China. From the Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, E-Institute of Shanghai Universities, Shanghai, China (Y.H., Y.B., M.X., Y.X., T.W., M.L., J.L., Y.C., W.W., X.L., G.N.); and Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of... State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Chinese Clinical Research Center for Metabolic Diseases, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China; Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China State Key Laboratory of ASIC and System, Department of Microelectronics, Fudan University, Shanghai 200433, People's Republic of China Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China. College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China State Key Laboratory of ASIC and System, School of Microelectronics, Fudan University, Shanghai 200433, China; Shanghai Integrated Circuit Manufacturing Innovation Center Co., Ltd., Shanghai 201202, China; Zhangjiang Fudan International Innovation Center, Shanghai 200433, China Department of Radiology, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui, Zhejiang, P.R. China Departments of Medicinal & Biological Chemistry and Pharmacology, The University of Toledo, 2801 W. Bancroft St., Toledo, Ohio 43606 Department of General Surgery/Surgical Oncology Center Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine Shanghai China College of Chemistry and Materials Science, Hebei University, Baoding, Hebei Province 071002, P. R. China State Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health the National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai China Department of Ultrasound Medicine, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Key Laboratory of Pulsed Power Translational Medicine of Zhejiang Province, Hangzhou, Zhejiang 310003, China. National Clinical Research Center for Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Radiology, Weihai Municipal Hospital, Cheeloo College of Medicine Shandong University Weihai China State Key Laboratory of Pollution Control and Resource Reuse, School of Environment, Nanjing University, Nanjing 210023, P. R. China Department of Clinical Laboratory The First Affiliated Hospital of Zhengzhou University Zhengzhou China Nanjing Medical University 2 Department of Neurobiology, Key Laboratory of Human Functional Genomics of Jiangsu , , Nanjing, Jiangsu , China , 211166 Academy of Integrative Medicine, College of Pharmacy, Key Laboratory of Pharmacokinetic and Drug Transport of Liaoning Dalian Medical University Dalian China State Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Collaborative Innovation Center for Modern Crop Production co-sponsored by Jiangsu Province and Ministry of Education, Cotton Germplasm Enhancement and Application Engineering Research Center (Ministry of Education), Nanjing Agricultural University, Nanjing 210095, China Department of Biochemistry and ‡Department of Chemistry, University of Zürich, Winterthurerstrasse 190, Zürich CH-8057, Switzerland Shanghai Key Laboratory of Electrical Insulation and Thermal Aging School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai 200240 China Department of Radiation Oncology Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences Jinan China College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, 310036, China; Zhejiang Provincial Key Laboratory for Genetic Improvement and Quality Control of Medicinal Plants, Hangzhou Normal University, Hangzhou, 310036, China Department of Cardiology, The Second Affiliated Hospital Xi'an Jiaotong University Xi'an Shaanxi China Department of Cardiovascular Division of The Third Affiliated Hospital of Soochow University Chang Zhou City China; Department of Cardiovascular Division of The First Affiliated Hospital of Soochow University Su Zhou City China State Key Laboratory of Palaeobiology and Stratigraphy, Nanjing Institute of Geology & Palaeontology Chinese Academy of Sciences Nanjing China Department of Laboratories, Seattle Children's Hospital, Seattle, Washington; Department of Laboratory Medicine, University of Washington, Seattle, Washington Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of Chinese Health Ministry, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, China State Key Laboratory of ASIC and System, School of Microelectronics, Fudan University, Shanghai 200433, China Department of Hematology and Oncology, Wuhan Children's Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences Nanjing Normal University Nanjing PR China Department of Neurosurgery, Kunshan Hospital of Traditional Chinese Medicine, Kunshan Affiliated Hospital of Nanjing University of Chinese Medicine , No. 189 Chaoyang Road , Kunshan City , Jiangsu Province, 215300 , China Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, China; Shandong Academy of Medical Sciences, Jinan, China State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China; Department of Ultrasound, Sun Yat-Sen University Cancer Center, Guangzhou, China; Department of Ultrasound, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China Department of Radiation Oncology Shandong Cancer Hospital and Institute Jinan China State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, People’s Republic of China, National Center for Natural Products Research, School of Pharmacy, University of Mississippi, Mississippi 38677, and Weihe Biotech Laboratory, 653100, Yuxi, Yunnan, People’s Republic of China Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor 1National Engineering Laboratory for Anti-tumor Protein Therapeutics, Beijing, China.; 2Beijing Key Laboratory for Protein Therapeutics, Beijing, China.; 3Cancer Biology Laboratory, School of Life Sciences, Tsinghua University, Beijing, China. Eighth People’s Hospital, Guangzhou, China College of Electrical Engineering; Southwest Minzu University; Chengdu 610041; China Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China (S.W., M.L., J.L., R.Z., J.N., M.X., T.W., Z.Z., S.W., H.L., Y.C., G.N., Y.B., W.W., Y.X.).; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the People’s Republic of China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China (S.W., M.L., J.L., R.Z., J.N., M.X., T.W., Z.Z., S.W., H.L., Y.C., G.N., Y.B., W.W., Y.X.). Department of Nephrology, Wujin Hospital Affiliated with Jiangsu University, China; Department of Nephrology, The Wujin Clinical College of Xuzhou Medical University, China. State Key Laboratory of Microbial Metabolism and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, China State Key Laboratory of Lake Science and Environment Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences Nanjing China State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, and Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Computational Biology Department Carnegie Mellon University Pittsburgh PA 15213 USA Tianjin University Molecular and Cellular Technology, and Departments of Molecular Biology and Pharmacology and Psychiatry, Washington University School of Medicine, St. Louis, MO 63110; Department of Biological Chemistry, Merck Research Laboratories, West Point, PA 19486-0004; Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo Bunkyoku, Tokyo 113-0033, Japan; Department of Biochemistry and Molecular Biology, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre,... Tianjin Key Laboratory of Drug Delivery and High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China Shenzhen Jingtai Technology Co., Ltd. (XtalPi), Shenzhen 518000, China Department of Pediatric transplantation, Organ Transplantation Center Tianjin First Central Hospital Tianjin China College of Environmental Science and Engineering, Hunan University, Changsha 410082, China. ykxumin@21cn.com Department of Pharmacy The Third People's Hospital of Chengdu & College of Medicine, Southwest Jiaotong University Chengdu China State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People's Republic of China School of Microelectronics, Fudan University, Shanghai200433, China Department of Operating Theatre, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, P.R. China Department of Nephrology Xuhui District Central Hospital of Shanghai Shanghai China 1Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; 2National Clinical Research Center for Metabolic Diseases (Shanghai), Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, National Research Center for Translational Medicine, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, Iowa, USA Key Laboratory of Cultivation and High-Value Utilization of Marine Organisms in Fujian Province, Fisheries Research Institute of Fujian, National Research and Development Center for Marine Fish Processing (Xiamen), Xiamen 361013, China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China School of Chemical Engineering and Technology, Tianjin University, Tianjin, Puerto Rico 300350, United States Department of Oncology, RenMin Hospital of WuHan University, WuHan, Hubei, P.R. China Department of Gastroenterology, Jiangsu University Cancer Institute, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China Departments of Medicinal Chemistry, Structural Biology, Molecular Systems, and Alzheimer's Research, Merck Research Laboratories, P.O. Box 4, West Point, Pennsylvania 19486 Department of Gastroenterology, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, P.R. China 8th People's Hospital, Guangzhou, China. Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology Haiyang Center for Disease Control and Prevention, Haiyang, China. Southwestern Institute of Physics 1 , P.O. Box 432, Chengdu 610041, China Departments of Echocardiography, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213003, P.R. China Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China Department of Cardiology, The Second Affiliated Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, P.R. China Breast Surgery Affiliated Cancer Hospital, Institute of Guangzhou Medical University, Guangzhou 510000, China Department of Hematology and Oncology, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China The State Key Laboratory of Freshwater Ecology and Biotechnology Institute of Hydrobiology Chinese Academy of Sciences Wuhan Hubei China Department of Cardiology Renmin Hospital of Wuhan University Wuhan PR China; Cardiovascular Research Institute of Wuhan University Wuhan PR China; Hubei Key Laboratory of Cardiology Wuhan PR China China Light Industry Key Laboratory of Meat Microbial Control and Utilization, School of Food and Biological Engineering, Engineering Research Center of Bio-process, Ministry of Education, Hefei University of Technology, Hefei 230009, P. R. China 4Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA; 5Division of Reproductive Endocrinology and Infertility, University of Michigan, Ann Arbor, Michigan, USA Program in Computational Biology and Bioinformatics, Departments of Molecular Biophysics and Biochemistry, Computer Science, and Statistics & Data Science, Yale University, New Haven, CT 06520, USA. 1Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; 2Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the People’s Republic of China, Shanghai Jiao Tong University School of Medicine, Shanghai, China; 3Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) Nanjing Tech University (Nanjing Tech) 30 South Puzhu Road Nanjing 211816 China Key Laboratory of Functionalized Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-Based Materials, College of Chemistry and Materials Science, Anhui Normal University, 189 South Jiuhua Road, Wuhu, Anhui 241002, P. R. China Department of Nephrology, The 88th Hospital of People's Liberation Army, Taian, Shandong 271000, P.R. China Key Laboratory of Cultivation and High-Value Utilization of Marine Organisms in Fujian Province, National Research and Development Center for Marine Fish Processing (Xiamen), Fisheries Research Institute of Fujian, Xiamen 361013, China; College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China Department of Gastroenterology, Digestive Disease Institute of Jiangsu University, Affiliated Hospital of Jiangsu University, Zhenjiang, China USDA ARS CICGR, Department of Agronomy, Iowa State University, Ames, IA 50011-1010, USA.; Crop Research Institute, Anhui Academy of Agricultural Sciences, Hefei, Anhui, People’s Republic of China.; Department of Agronomy, Iowa State University, Ames, IA 50011-1010, USA. Institute for Stem Cell and Neural Regeneration, School of Pharmacy, Nanjing Medical University, Nanjing, China Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, Ministry of Education,China. jieyuan@stu.snnu.edu.cn Shangti Health Technology (Shanghai) Co., Ltd., Shanghai, China Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology; National Engineering Research Center for Process Development of Active Pharmaceutical Ingredients Institute of Nuclear and New Energy Technology, Tsinghua University, Beijing, 100084, China Department of General Surgery, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China Department of Agronomy and Interdepartmental Genetics Graduate Program, Iowa State University, Ames, IA 50011, USA. Chinese Education Ministry's Key Laboratory of Western Resources and Modern Biotechnology, Key Laboratory of Biotechnology Shaanxi Province, College of Life Sciences, Northwest University , Xi’an , China Department of Pharmacology and Laboratory of Cerebrovascular Pharmacology, College of Pharmaceutical Science, Soochow University, Suzhou 215123, China Egret Pharma (Shanghai) Co., Ltd, 4F, 1118 Halei Road, Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai 201203, P. R. China Departments of Medicinal Chemistry, Alzheimer's Research, and Drug Metabolism, Merck Research Laboratories, Post Office Box 4, West Point, Pennsylvania 19486 Key Laboratory of Specialty Agri‐product Quality and Hazard Controlling Technology of Zhejiang Province, College of Life Sciences China Jiliang University Hangzhou 310018 P.R. China Institute of Developmental Psychology, School of Psychology, Beijing Normal University, Beijing, China; Beijing Key Laboratory of Applied Experimental Psychology, School of Psychology, Beijing Normal University, Beijing, China Department of Translational Immunology, Genentech Inc., South San Francisco, CA 94080; Assisted Reproduction Laboratory, Center for Reproductive Medicine University of Michigan Ann Arbor MI USA Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Carcinogenesis and Intervention China Pharmaceutical University Department of Oral and Maxillofacial Implantology, National Clinical Research Center of Stomatology, Shanghai Perio‐Implant Innovation Center, School of Medicine Ninth People’ Hospital, Shanghai Jiao Tong University Shanghai China Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China; Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao‐Tong University School of Medicine Shanghai China Department of Pediatric Surgery Shanghai Children's Medical Center, School of Medicine Shanghai Jiaotong University Shanghai China Institute of Corpus Studies and Applications, Shanghai International Studies University, China From the Departments of Nutrition (M.X., Q.Q., F.B.H., F.M.S., L.Q) and Epidemiology (F.B.H.), Harvard School of Public Health, Boston, MA; Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China (M.X.); Department of Endocrinology, Central Hospital of Xuzhou, Affiliated Hospital of Southeast... 3Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China. Computational Biology and Computer Science Departments, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming, 650204, China Department of Biomedical Engineering School of Medicine, Shenzhen University Shenzhen China; Guangdong Key Laboratory of Biomedical Information Detection and Ultrasound Imaging Shenzhen China; School of Humanities, The University of Hong Kong Pokfulam Road Hong Kong Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington; Department of Laboratories, Seattle Children’s Hospital, Seattle, Washington Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China School of Electrical and Information Engineering of Jiangsu University Zhenjiang China Department of Biochemistry and Biophysics, Texas A&M University, 2128 TAMU, College Station, Texas 77843-2128 Institute of Engineering Thermophysics, Chinese Academy of Sciences, Beijing 100190, China; Nanjing Institute of Future Energy System, Nanjing 211135, China Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Drug Discovery & Innovation Center, College of Chemistry and Life Sciences, Zhejiang Normal University, China Department of Cardiology The Second Affiliated Hospital, Xi'an Jiaotong University Xi'an P.R. China Howard Hughes Medical Institute, Departments of Medicine and Microbiology/Immunology, University of California San Francisco, San Francisco, California Department of Anatomy, Liaoning Key Laboratory of Diabetic Cognitive and Perceptive Dysfunction Jinzhou Medical University Jinzhou Liaoning Province China Carnegie Mellon University,Computational Biology Department,Pittsburgh,PA,USA,15213 Department of Ophthalmology, Northern Jiangsu People's Hospital, Yangzhou, China. Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China; Shanghai National Clinical Research Center for metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China Shanghai National Center for Translational Medicine Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Merck & Co., Inc., Quantitative Biosciences, Kenilworth, New Jersey, USA Reproductive Health and Infertility Clinic, Huai’an First People's Hospital, Nanjing Medical University, Huai’an Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University /Affiliated Lishui Hospital of Zhejiang University/ The Central Hospital of Zhejiang Lishui, Lishui 323000, China; Department of Radiology, the Fifth Affiliated Hospital of Wenzhou Medical University /Affiliated Lishui Hospital of Zhejiang University/ The Central Hospital of Zhejiang Lishui, Lishui 323000, China 1Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Geriatrics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province Department of Endocrinology, Changzhou No. 2 People’s Hospital, Nanjing Medical University, Changzhou 213003, China Institute of Medical Biology, Chinese Academy of Medical Science & Peking Union Medical College, Kunming 650118, China Institute for Stem Cell and Neural Regeneration, State Key Laboratory of Reproductive Medicine School of Pharmacy Nanjing Medical University Nanjing China Department of Gynecology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou 215009, China Computational Biology Department, Carnegie Mellon University, Pittsburgh, PA, USA Department of Liver Surgery, Renji Hospital, School of Medicine,Shanghai Jiao Tong University,Shanghai,China State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China Institute of TCM-related Comorbid Depression, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, Jiangsu, China Department of Ophthalmology, Clinical Medical College, Yangzhou University, Yangzhou, China Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China (Y.W., C.Y., L.K., J.Z., M.X., Y.X., M.L., Z.Z., J.L., Y.C., W.W., G.N., Y.B., T.W.).; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China (Y.W., C.Y., L.K., J.Z., M.X., Y.X., M.L., Z.Z., J.L., Y.C., W.W., G.N., Y.B., T.W.). Department of Otorhinolaryngology - Head and Neck Surgery, Second Affiliated Hospital, Xi’an Jiaotong University School of Medicine, Xi’an, People’s Republic of China; Henan Provincial Tobacco Company, Zhengzhou 4510018, China Center for Pharmaceutical Sciences and Engineering, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases (R.Z., Y.X., M.L., J.L., Shujing Wu, J.N., Z.Z., M.X., T.W., S. Wang, H.L., Y.C., Y.B., G.N., W.W.); Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics (R.Z., Y.X., M.L., J.L., Shujing Wu, J.N., Z.Z., M.X., T.W., S. Wang, H.L., Y.C., Y.B., G.N., W.W.), Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China. School of Educational Science Ludong University Yantai China; Collaborative Innovation Center for the Mental Health of Youth from the Era of Conversion of New and Old Kinetic Energy along the Yellow River Basin, Ludong University Yantai China Department of Radiology and Medical Imaging, Huai’an Hospital Affiliated of Xuzhou Medical University, Huaian, China. Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Institute of Blood Transfusion Chinese Academy of Medical Sciences Chengdu China; Peking Union Medical College Chengdu China; Luoyang Blood Center Luoyang Henan China Department of Radiation Oncology, Shandong Cancer Hospital affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong province, China, 250117 School of Electrical and Information Engineering of Jiangsu University Zhenjiang China; School of Electronic Engineering, Changzhou College of Information Technology Changzhou Jiangsu China Departments of Medicinal Chemistry, Biological Chemistry, Molecular Systems, and Structural Biology, Merck Research Laboratories, P.O. Box 4, West Point, Pennsylvania 19486 School of Environmental and Chemical Engineering, Shanghai University, 333 Nanchen Road, Shanghai 200444, PR China Department of Otorhinolaryngology-HNS, Second Affiliated Hospital, Xi’an Jiaotong University School of Medicine, Xi’an, PR China; Department of Otolaryngology – Head & Neck Surgery, Second Affiliated Hospital of Xi’an Jiaotong University School of Medicine, Xi’an, China Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine E‐Institute of Shanghai Universities Shanghai China; Department of Endocrine and Metabolic Diseases Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui Jin Hospital Shanghai JiaoTong University School of Medicine Shanghai China Department of Translational Immunology, Genentech, South San Francisco, CA, USA. College of Biosystems Engineering and Food Science; Zhejiang University; Hangzhou; PR China; Key Laboratory of On Site Processing Equipment for Agricultural Products Department of Gastroenterology, Affiliated Hospital of Jiangsu University Jiangsu University Zhenjiang China Gyhnecology Department of Second Clinical Medical College of Guangzhou University of CM, Guangzhou 510120, Guangdong Province, China. Department of Laboratories, Seattle Children's Hospital, Seattle, WA; Department of Laboratory Medicine, University of Washington, Seattle, WA Key Laboratory of Beijing on Regional Air Pollution Control, College of Environmental and Energy Engineering, Beijing University of Technology, Beijing 100124, China. Department of Radiology, Maanshan People’s Hospital, Maanshan, Anhui, China Department of Pediatrics The Affiliated Hospital of Qingdao University Qingdao Shandong China School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong. South China Institute of Environmental Sciences, Ministry of Ecology and Environment, Guangzhou 510535, China. Institute of Stomatology Nanjing Medical University Nanjing China Key Laboratory of Luminescence and Optical Information; Ministry of Education; Institute of Optoelectronic Technology; Beijing Jiaotong University; Beijing 100044 Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine E‐Institute of Shanghai Universities Shanghai China; Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Department of Endocrinology and Metabolism Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai China Tianjin Key Laboratory of Drug Delivery & High-Efficiency; School of Pharmaceutical Science and Technology; Tianjin University; Tianjin; PR China Department of Otolaryngology‐Head and Neck Surgery The Second Hospital, Xi'an Jiaotong University Xi'an China Genentech, Inc., Translational Immunology, South San Francisco, California, USA Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health Ruijin Hospital Shanghai Jiaotong University School of Medicine E‐Institute of Shanghai Universities Shanghai China; Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Department of Endocrine and Metabolic Diseases Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China Department of Advanced Stroke Center, The Xinhua Hospital of Ili Kazak Autonomous Prefecture, Ili, Xinjiang, People’s Republic of China Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health The National Clinical Research Center for Metabolic Diseases of Ministry of Health Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine E‐Institute of Shanghai Universities Shanghai China; Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Department of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai China CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei 230026, China Vascular Surgery Division, Department of Surgery, Stony Brook University, Stony Brook, NY, USA Neuroimaging Laboratory, School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen 518060, China.; Center for Language and Brain, Shenzhen Institute of Neuroscience, Shenzhen 518057, China. Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai, 200062, P. R. China Department of Health Economics, Institute of Medical Information, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China. State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China Department of Medical, Midong Branch of People’s Hospital of Xinjiang Autonomous Region , Urumqi , Xinjiang , People's Republic of China Affiliated Hospital of Nantong University, Nantong 226001, PR China, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China, Changhai Hospital, Secondary Military Medical University, Shanghai 200433, PR China, Shanghai 9th People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, PR China, and Xiamen University, Xiamen 361005, PR China Liver Center,Gastrointestinal Division,Massachusetts General Hospital,Boston,Massachusetts,USA Department of Biological Chemistry, Merck Research Laboratories, West Point, PA 19486, USA Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China Key Laboratory of Materials Physics Centre for Environmental and Energy Nanomaterials Anhui Key Laboratory of Nanomaterials and Nanotechnology CAS Center for Excellence in Nanoscience Institute of Solid State Physics HFIPS Chinese Academy of Sciences Hefei 230031 China; University of Science and Technology of China Hefei 230026 China Institute of Haematology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China College of Pharmacy, Chengdu University of Traditional Chinese Medicine, No. 1166, Liutai Road, Wenjiang District, Chengdu 611137, China Northeast Institute of Geography and Agroecology, Key Laboratory of Soybean Molecular Design Breeding Chinese Academy of Sciences Harbin 150081 China; University of Chinese Academy of Sciences Beijing 100049 China Department of Biological Chemistry, Merck Research Laboratories, West Point, PA 19486 National Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Shanghai, China Program in Molecular and Computational Biology, University of Southern California 1 1 Los Angeles, USA †Department of Immunology, Liver Cancer Institute, Zhongshan Hospital Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education Shanghai 200032 People's Republic of China Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio The National Engineering Laboratory for Anti-Tumor Protein Therapeutics, School of Life Sciences, Tsinghua University, Beijing, China; Beijing Key Laboratory for Protein Therapeutics, School of Life Sciences, Tsinghua University, Beijing, China; Cancer Biology Laboratory, School of Life Sciences, Tsinghua University, Beijing, China 8th People's Hospital Guangzhou China Department of Translational Immunology, Genentech, Inc., South San Francisco, CA 94080; Department of Cardiac Ultrasound, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University Departments of Medicinal Chemistry, Molecular Systems, Structural Biology, Automated Biotechnology, and Alzheimer’s Research, Merck Research Laboratories, West Point, Pennsylvania 19486 Department of Orthopedics, Second Xiangya Hospital, Central South University, Changsha, China. Department of Gastroenterology Affiliated Hospital of Jiangsu University, Jiangsu University Zhenjiang China Department of Urology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China Department of Otolaryngology–Head and Neck Surgery The Second Hospital, Xi'an Jiao Tong University, Xi'an Department of Clinical Laboratory, Changzhou No. 2 People’s Hospital, Nanjing Medical University, Changzhou 213003, China Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, P. R. China, and University of Chinese Academy of Sciences, Beijing 100049, P. R. China *Harrison Department of Surgical Research and Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104; and Department of Pathology, Hunan Provincial Brain Hospital, 410007, P. R. China. Laboratory of Reproductive Medicine, Center of Human Functional Genomics, Nanjing Medical University, People's Republic of China. Department of Otolaryngology (M.X.) The Second Affiliated Hospital of Medical College of Xi'an Jiaotong University Xi'an China Department of Anesthesiology, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, Hubei 441000, P.R. China Carnegie Mellon University,Computational Biology,Pittsburgh,PA,USA,15213 Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Lishui Hospital of Zhejiang University, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China Department of Physics, Fairfield University, Fairfield, CT 06824 USA Department of Cardiology Cardiovascular Institute of Chengdu Chengdu Third People's Hospital The Affiliated Hospital of Southwest Jiaotong Chengdu China Department of Otorhinolaryngology-Head and Neck Surgery, 2nd Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China. Psychiatric Ward, Qingdao Mental Health Center, Qingdao University, No 299 Nanjing Road, Qingdao, 266034 Shandong, China David Braley Centre for Antibiotic Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8S 4K1, Canada; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, West 7th Avenue No. 32, 300308 Tianjin, China; Haihe Laboratory of Synthetic Biology, West 15th Avenue No. 21, 300308 Tianjin, China Department of Radiology the Fifth Affiliated Hospital of Wenzhou Medical University Lishui Hospital of Zhejiang University Lishui Central Hospital Lishui China Jiangsu Key Laboratory for Molecular and Medical Biotechnology College of Life Sciences Nanjing Normal University Nanjing Jiangsu PR China Natural Antibodies, Inc., Boston, MA 02115; and Departments of Pathology, Surgery, and Pediatrics, Harvard Medical School, CBR Institute for Biomedical Research, Brigham and Women's Hospital, and Massachusetts General Hospital, Boston, MA 02115 The National Engineering Laboratory for Anti‐Tumour Protein Therapeutics Tsinghua University Beijing PR China; Beijing Key Laboratory for Protein Therapeutics Tsinghua University Beijing PR China; Cancer Biology Laboratory, School of Life Sciences Tsinghua University Beijing PR China School of Microelectronics, Fudan University, Shanghai 200433, China; Shanghai Integrated Circuit Manufacturing Innovation Center Co., Ltd., Shanghai 201203, China State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200030, People’s Republic of China Department of Pathology, Xijing Hospital; Department of Pathology and Pathophysiology; the 88th Hospital of PLA, Taian, People's Republic of China Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Lishui Hospital, School of Medicine, Zhejiang University, Lishui 323000, China; Department of Radiology, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Institute of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University , Lishui 323000, China; School of Medicine, Clinical College of The Affiliated Central Hospital, Lishui University , Lishui 323000, China; Department of Radiology, School of Medicine, Lishui Hospital of Zhejiang University , Lishui 323000, China Department of Endocrinology and Metabolism, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, China State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200030, China Department of Neurology, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, China. drhguo@163.com. Institute of Blood Transfusion, Chinese Academy of Medical Sciences and the Sichuan Blood Safety and Blood Substitute International Science and Technology Cooperation Base Chengdu China Department of Oncology, Affiliated Nanhai Hospital of Southern Medical University Foshan, Oncology Section 2, Foshan, Guangdong, China (mainland) School of Chemical Engineering and Technology Tianjin University 135 Yaguan Road Tianjin 300350 China Department of Surgery, Washington University School of Medicine, St. Louis, MO. Genentech, Inc., South San Francisco, CA 94080 Department of Pathology and Pathophysiology Fourth Military Medical University Xi'an China Institute of Organic Chemistry; School of Chemistry and Chemical Engineering; Shandong University; Jinan 250100; P.R. China School of Physics and Electronic Science & Shanghai Key Laboratory of Magnetic Resonance East China Normal University Shanghai 200062 P. R. China Translational Immunology, Genentech, Inc. South San Francisco California USA Imaging Center, Wuxi People's Hospital Nanjing Medical University Wuxi China Department of Gastroenterology Affiliated Hospital of Jiangsu University Jiangsu University Zhenjiang China College of Water Science, Beijing Normal University, Beijing 100875, China. Research Center of Water Pollution Control Technology, Chinese Research Academy of Environmental Sciences, Beijing 100012, China. State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200030, China; Department of Pharmacy, The Third People's Hospital of Chengdu, College of Medicine, Southwest Jiaotong University, Chengdu, China Department of Neurosurgery & Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow University Suzhou China State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People’s Republic of China Radiology Department and Interventional Radiology Center, The Fifth Affiliated Hospital of Wenzhou Medical University, Affiliated Lishui Hospital of Zhejiang University, The Central Hospital of Zhejiang Lishui, Lishui, P.R. China Beijing National Laboratory for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China Department of Echocardiography, The Third Affiliated Hospital of Soochow University, Chang Zhou City, Jiangsu Province, China. Department of Anesthesiology, Xiangyang No. 1 People's Hospital Hubei University of Medicine Xiangyang Hubei China Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R. China Guangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Sciences South China Normal University (SCNU) Guangzhou 510631 China Department of Ultrasonography, East Hospital, Tongji University, Shanghai, China. Department of Surgery, Shanghai Children’s Medical Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, China Center for Pharmaceutical Sciences Faculty of Life Science and Technology Kunming University of Science and Technology Kunming China Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China Institute of TCM‐Related Comorbid Depression Nanjing P. R. China Guangzhou No.8 People's Hospital Guangzhou Center for Brain Disorders and Cognitive Science, Shenzhen University, Shenzhen 518060, China; Center for Language and Brain, Shenzhen Institute of Neuroscience, Shenzhen 518060, China State Key Laboratory of Phytochemistry & Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People’s Republic of China Tianjin Key Laboratory of Drug Delivery & High‐Efficiency School of Pharmaceutical Science and Technology Tianjin University Tianjin 300072 P. R. China Shenzhen Yuanwei Medical Equipment Co. Ltd., Shenzhen 518116, China. Center for Sickle Cell Disease, Department of Medicine, Howard University, Washington, DC, USA Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health (T.W., M.L., M.X., Y.X., Y.H., J.L., Y.C., W.W., X.L., Y.L., Y.B., S.L., G.N.), Shanghai 200025, China; Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism (T.W., M.L., M.X., Y.X., Y.H., J.L., Y.C., W.W., X.L., Y.L., Y.B., G.N.), Shanghai 200025, China Department of Physics, Wenzhou University, Wenzhou 325035, China Department of Otolaryngology and Head and Neck Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, China Department of Pathology and Pathophysiology, Fourth Military Medical University, P.R. China Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, Shandong Province, China Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research School of Medicine Lishui Hospital of Zhejiang University Lishui China; Department of Radiology the Fifth Affiliated Hospital of Wenzhou Medical University Affiliated Lishui Hospital of Zhejiang University The Central Hospital of Zhejiang Lishui Lishui China Department of Medicine, University of Western Australia, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia; Guangzhou University of Chinese Medicine, Guangzhou, P.R. China Department of Pharmacy, School of Pharmaceutical Sciences, Sun Yat-sen University, University Town, Guangzhou 510006, People's Republic of China College of Chemistry, Key Laboratory for Radiation Physics and Technology of Ministry of Education, Institute of Nuclear Science and Technology, Key State Laboratory of Biotherapy, Sichuan University, Chengdu 610064, China Hongqiao International Institute of Medicine, China; Obstetrics and Gynecology Department, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, No. 1111, XianXia Road, Shanghai 200336, China Department of Neurology, Xuanwu Hospital, Capital Medical University , Beijing, China School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong Quantitative Biosciences, Merck & Co., Inc., Rahway, New Jersey 07065, United States Department of Dermatology Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou China Institute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu, China Department of Cardiovascular Division The Third Affiliated Hospital of Soochow University Chang Zhou China Department of Gastroenterology Affiliated Hospital of Jiangsu University Zhenjiang China Department of Obstetrics and Gynecology, Yancheng First City Hospital of Jiangsu Province, Yancheng, China. Department of Pediatrics, The People's Hospital of Yucheng City, Dezhou, China Cardiovascular Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China Laboratory of Virology, Department of Plant Sciences, Wageningen University and Research, Droevendaalsesteeg 1, 6708PB Wageningen, The Netherlands Departments of Surgery,Washington University School of Medicine,St. Louis,MO 8th People's Hospital; Guangzhou China Department of Pharmacology, School of Medicine, Southeast University, Nanjing, China Genomics and Genetic Engineering Laboratory of Ornamental Plants College of Agriculture and Biotechnology, Zhejiang University Hangzhou China Department of Ultrasound Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 31000, P. R. China Computational Biology Department Carnegie Mellon University Pittsburgh, PA, United States. Department of Cardiovascular medicine, The Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi, Guizhou, 563002, P.R. China Eskitis Institute, Griffith University, Brisbane, QLD 4111, Australia School of Physics and Materials Science; Shanghai Key Laboratory of Magnetic Resonance; East China Normal University; Shanghai 200062; P R China Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; and Department of Hepatology, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou Guangdong China From the Comprehensive Sickle Cell Center, Section of Hematology/Oncology (X.Z., S.S., V.R.G.), Section of Cardiology (A.A.D.), and Section of Pulmonary, Critical Care, and Sleep Medicine (J.G.N.G., R.F.M.), Department of Medicine, Institute of Human Genetics (W.Z., R.K.), Department of Pediatrics (W.Z.), and Institute for Personalized Respiratory Medicine (A.A.D., T.A., N.G.C., J.G.N.G., R.F.M.), University of Illinois at Chicago, Chicago, IL; Section of Pulmonary/Critical Care, Department of... Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences West 7th Avenue No. 32 300308 Tianjin China Department of Medical laboratory Zhumadian Central Hospital Zhumadian China Department of Neurology the First Affiliated Hospital of Soochow University Suzhou Jiangsu China Department of Pharmacy, School of Animal Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, P.R. China Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720 Department of Pediatrics Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China; China Hospital Development Institute Shanghai Jiao Tong University Shanghai China College of Food Science and Engineering Ocean University of China Qingdao China School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. Merck & Co., Inc., P.O. Box 4, 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States Department of Anatomy, College of basic medicine Jinzhou Medical University Jinzhou China Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States Department of Physics, Zhejiang Cancer Hospital, Zhejiang Hangzhou, People’s Republic of China Key Laboratory of Materials Physics, Centre for Environmental and Energy Nanomaterials, Anhui Key Laboratory of Nanomaterials and Nanotechnology, Institute of Solid State Physics, HFIPS Chinese Academy of Sciences Hefei 230031 China; University of Science and Technology of China Hefei 230026 China Center for Disease Control and Prevention, Chengdu Military Region, Chengdu 610021, China Department of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, No. 22, Shuangyong Road, Nanning 530021, China Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, PRC Xi’an Aerospace Propulsion Test Technology Institute, Xi’an 710100, China Department of Emergency Medicine, Northern Jiangsu People’s Hospital, Yangzhou University College of Clinical Medicine, China State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Peopleʼs Republic of China Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou, China State Key Laboratory of ASIC and System, School of Microelectronics, Fudan University, Shanghai 200433, China; Shanghai Integrated Circuit Manufacturing Innovation Center Co., Ltd., Shanghai 200433, China Department of Gastroenterology Affiliated Hospital of Jiangsu University Jiangsu Province China Department of Laboratory Medicine and Pathology Seattle Children's Hospital Seattle Washington; Department of Laboratory Medicine University of Washington Seattle Washington College of Water Science, Beijing Normal University, Beijing 100875, China; Research Center of Water Pollution Control Technology, Chinese Research Academy of Environmental Sciences, Beijing 100012, China Key Laboratory of Imaging Diagnosis and Minimally Invasive Interventional Research of Zhejiang Province, Lishui Hospital, School of Medicine, Zhejiaing University, Lishui 323000, Zhejiang, China State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Chinese Clinical Research Center for Metabolic Diseases Rui‐Jin Hospital, Shanghai Jiao‐Tong University School of Medicine Shanghai China; Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China Department of Otorhinolaryngology, Head and Neck Surgery, Second Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an 710004, China. Email: ent551205@163.com. Departments of Medicinal Chemistry, Biological Chemistry, Structural Biology and Molecular Systems, Merck Research Laboratories, West Point, Pennsylvania 19486-0004, and Department of Chemistry, NeoGenesis Pharmaceuticals, 840 Memorial Drive, Cambridge, Massachusetts 02139 Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650204, China 1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. State Key Laboratory of Crop Genetics and Germplasm Enhancement Cotton Hybrid R& D Engineering Center (the Ministry of Education) College of Agriculture Nanjing Agricultural University Nanjing China Southwestern Institute of Physics, Chengdu 610041, China Department of Neurosurgery, Kunshan Hospital of Traditional Chinese Medicine, Kunshan Affiliated Hospital of Nanjing University of Chinese Medicine, Suzhou, China Department of Cardiology The Second Affiliated Hospital Xi’an Jiaotong University Xi’an Shaanxi People’s Republic of China Department of Information Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. Institute of Blood Transfusion Chinese Academy of Medical Sciences Chengdu Sichuan China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China Women’s Hospital School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People’s Republic of China Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio; and Department of Ultrasound Shengjing Hospital of China Medical University Shenyang 110004 China Department of Radiology, The Fifth Affiliated Hospital of Wenzhou Medical University, Affiliated Lishui Hospital of Zhejiang University, The Central Hospital of Zhejiang Lishui, Lishui, Zhejiang, P.R. China Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China Department of Plant Pathology, and MOA Key Laboratory of Plant Pathology China Agricultural University Beijing China Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843–2128, USA. Department of Plant and Microbial Biology, University of California, Berkeley CA 94720;; Department of Biology, Northwest University, 710069 Xi’an, China Department of Surgery, University of Pennsylvania School of Medicine , Philadelphia, Pennsylvania , USA Guangdong Key Laboratory of Genome Instability and Human Disease Prevention Department of Biochemistry and Molecular Biology Shenzhen University School of Medicine Shenzhen China School of Information Science and Technology, Fudan University From the Department of Nutrition (Y.Z., M.X., Y.L., A.H., E.B.R., F.B.H., L.Q.) and Department of Epidemiology (E.B.R., F.B.H., J.E.M.), Harvard T.H. Chan School of Public Health, Boston, MA; Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (M.X.); Department of Epidemiology, German Institute of Human... Canon Medical Systems, Beijing, China. School of Biomedical Engineering Health Science Center, Shenzhen University Shenzhen 518060 China; Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging Shenzhen University Shenzhen 518060 China; Center for Neuroimaging Shenzhen Institute of Neuroscience Shenzhen 518057 China Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, E-Institute of Shanghai Universities, Shanghai, China, and the Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Rui-jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 354 Fenglin Road, Shanghai 200032, P. R. China Institute for Stem Cell and Neural Regeneration, Key Laboratory of Targeted Intervention of Cardiovascular Disease, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China Department of Translational Immunology Genentech, Inc. South San Francisco CA USA Department of Translational Immunology, Genentech, Inc., South San Francisco, California, USA Guangzhou Eighth People's Hospital Guangzhou China Genomics and Genetic Engineering Laboratory of Ornamental Plants, College of Agriculture and Biotechnology, Zhejiang University , Hangzhou 310058 , China Department of Radiology & Medical Imaging, The Affiliated Huai’an Hospital of Xuzhou Medical University, Huaian, China School of Chemistry University of St Andrews St Andrews KY16 9ST UK Sino-Medic, Hefei, Anhui Department of Hepatobiliary Surgery, Yueyang Central Hospital, Yueyang, China Department of Physics, Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai 200062, People’s Republic of China Department of Pathology and Laboratory Medicine University of Cincinnati College of Medicine 2180 E. Galbraith Road Cincinnati OH 45215 USA Department of Infectious Disease, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine Zhejiang University Hangzhou Zhejiang China School of Pharmacy, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, China Department of Cardiovascular Division of The Third Affiliated Hospital of Soochow University Chang Zhou City Jiangsu Province China; Department of Cardiovascular Division of The First Affiliated Hospital of Soochow University Su Zhou City Jiangsu Province China Global Health Drug Discovery Institute, Haidian, Beijing 100192, China State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China; College of Resources and Environment, Huazhong Agricultural University, Wuhan 430070, China Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an, Shaanxi, China Department of Environmental Engineering, College of Resources and Environmental Science, Nanjing Agricultural University, Nanjing 210095, P. R. China Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China. Department of Hospital Administration, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China Genentech, Inc., South San Francisco, California Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, People’s Republic of China. Dongfeug Peugeot Citroen Automobile Company LTD, Wuhan 430056, China. Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 0000 0004 1936 8227 grid.25073.33 M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences DeGroote School of Medicine, McMaster University 1280 Main Street West L8S 4K1 Hamilton ON Canada Research Center of Clinical Medicine, Research Center of Clinical Immunology Affiliated Hospital of Nantong University Nantong China Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China. College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China Clinical Laboratory and Department of Periodontology Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials Beijing China Guangzhou Eighth Municipal People's Hospital Guangzhou China Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission, National Clinical Research Center for Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Institute of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu 610041, China. Department of Gynecology; Guangdong Provincial Hospital of TCM; Guangzhou China Department of Radiology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Key Laboratory of Environment Correlative Dietology, Ministry of Education College of Food Science and Technology, Huazhong Agricultural University Wuhan 430070 China Department of Otorhinolaryngology-Head and Neck Surgery and Ear Institute, The Second Affiliated Hospital, Sweden Department of Translational Immunology, Genentech, South San Francisco, United States Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China 1 Program in Molecular and Computational Biology, University of Southern California, Los Angeles, CA, USA, 2 Academy of Mathematics and Systems Science, CAS, Beijing 100190, China and 3 Institute of Structural and Molecular Biology, Crystallography, Department of Biological Sciences, Birkbeck College, University of London, London, UK Yancheng First People's Hospital Yancheng 224006, Jiangsu Province, P. R. China. Zhejiang Provincial Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Lishui Hospital of Zhejiang University, Lishui, China.; Department of Radiology, Lishui Hospital of Zhejiang University, Lishui, China. Center for Higher Brain Functions, Department of Neurobiology, Capital Medical University, Beijing, China School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, P. R. China Department of Laboratory Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892-1508 Department of Pharmacology, Merck Research Laboratories, West Point, Pennsylvania, USA Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA. Department of Cardiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. Dalian marine diesel CO., Ltd, Dalian 116083, China Department of Microbial and Biochemical Pharmacy, School of Pharmacy, China Medical University, Shenyang, Liaoning Province, China Department of Nephrology, Wujin Hospital Affiliated with Jiangsu University, Changzhou, Jiangsu, China; Department of Nephrology, The Wujin Clinical College of Xuzhou Medical University Changzhou, Jiangsu, China. Department of Pediatrics, Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China. Department of Endocrinology, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China Department of Plant Pathology, the Key Laboratory of Plant Immunity Nanjing Agricultural University Nanjing China Northwestern University, USA. From the Department of Noninvasive Cardiac Function, Heart Center (F.M., M.C., M.X.), and Department of Radiology (N.X.), East Hospital, Tongji University School of Medicine, Shanghai, China; and Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong (J.P.S., A.P.L., X.S.Y., C.Y.). School of Life Sciences, Central China Normal University Wuhan China Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research The Fifth Affiliated Hospital of Wenzhou Medical University, Affiliated Lishui Hospital of Zhejiang University, The Central Hospital of Zhejiang Lishui Lishui China National Clinical Research Center for Oral Diseases, China (X.-N.S., L.-J.D., Yuan Liu, Yan Liu, J.-Y.S., Z.T., M.X., B.F., S.-Z.D.); Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, China (X.-N.S., L.-J.D., Yuan Liu, Yan Liu, J.-Y.S., Z.T., M.X., B.F., S.-Z.D.); Department of Orthodontics (M.X., B.F.), Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, China. Department of Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China Department of Otolaryngology Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi’an, China State Key Laboratory of Medical Genomics, and National Clinical Research Center for Metabolic Diseases Rui‐Jin Hospital affiliated with Shanghai Jiao‐Tong University School of Medicine Shanghai China |
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