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bibliographicCitation Li D, Tu Y, Jin K, Duan L, Hong Y, Xu J, Chen N, Zhang Z, Zuo H, Gong W, Zhang J, Wang Q, Qian H, Wang X, Ke Y, Xia G. Discovery of SPH5030, a Selective, Potent, and Irreversible Tyrosine Kinase Inhibitor for HER2-Amplified and HER2-Mutant Cancer Treatment. J Med Chem. 2022 Apr 14;65(7):5334–54. doi: 10.1021/acs.jmedchem.1c00710. PMID: 35319895.
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date 2022-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
identifier https://pubmed.ncbi.nlm.nih.gov/35319895
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language English
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title Discovery of SPH5030, a Selective, Potent, and Irreversible Tyrosine Kinase Inhibitor for HER2-Amplified and HER2-Mutant Cancer Treatment
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482079993_AID1905730_PMID35319895_VALUE20
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905782_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905756_PMID35319895_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056533_AID1905727_PMID35319895_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905777_PMID35319895_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482063465_AID1905756_PMID35319895_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482070557_AID1905735_PMID35319895_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905792_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905781_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103441767_AID1905728_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905755_PMID35319895_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905767_PMID35319895_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103441767_AID1905726_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482051251_AID1905727_PMID35319895_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318405845_AID1905750_PMID35319895_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318405845_AID1905771_PMID35319895_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905764_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103441767_AID1905768_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482087914_AID1905729_PMID35319895_VALUE22
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056533_AID1905726_PMID35319895_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482062866_AID1905729_PMID35319895_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103441767_AID1905765_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482067535_AID1905726_PMID35319895_VALUE15
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482057295_AID1905735_PMID35319895_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905734_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482070557_AID1905727_PMID35319895_VALUE16
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103441767_AID1905750_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482049765_AID1905739_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482076065_AID1905735_PMID35319895_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905790_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482062866_AID1905736_PMID35319895_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482063465_AID1905746_PMID35319895_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482050668_AID1905730_PMID35319895_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905796_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482063465_AID1905795_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482079077_AID1905735_PMID35319895_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482087914_AID1905730_PMID35319895_VALUE22
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482052398_AID1905754_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103441767_AID1905729_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905798_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905728_PMID35319895_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318405845_AID1905775_PMID35319895_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482079077_AID1905730_PMID35319895_VALUE19
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905730_PMID35319895_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905727_PMID35319895_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482063465_AID1905740_PMID35319895_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905771_PMID35319895_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103441767_AID1905767_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103441767_AID1905771_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482062866_AID1905738_PMID35319895_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482079993_AID1905728_PMID35319895_VALUE19
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482052977_AID1905728_PMID35319895_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318405845_AID1905726_PMID35319895_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482079077_AID1905728_PMID35319895_VALUE18
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056533_AID1905728_PMID35319895_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482063465_AID1905735_PMID35319895_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482052398_AID1905747_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056533_AID1905729_PMID35319895_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318405845_AID1905767_PMID35319895_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318405845_AID1905770_PMID35319895_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056533_AID1905735_PMID35319895_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318405845_AID1905727_PMID35319895_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482052977_AID1905730_PMID35319895_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103441767_AID1905784_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482049765_AID1905736_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905729_PMID35319895_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905749_PMID35319895_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905802_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482050668_AID1905728_PMID35319895_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482050668_AID1905735_PMID35319895_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905780_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318405845_AID1905777_PMID35319895_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482080846_AID1905730_PMID35319895_VALUE21
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482052398_AID1905755_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482076065_AID1905736_PMID35319895_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318405845_AID1905772_PMID35319895_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482076065_AID1905795_PMID35319895_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482052977_AID1905736_PMID35319895_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905765_PMID35319895_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905739_PMID35319895_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905748_PMID35319895_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103441767_AID1905778_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482052977_AID1905726_PMID35319895_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482063465_AID1905747_PMID35319895_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905741_PMID35319895_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056533_AID1905730_PMID35319895_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482052398_AID1905728_PMID35319895_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905772_PMID35319895_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905732_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482067535_AID1905736_PMID35319895_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905751_PMID35319895_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905766_PMID35319895_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482079077_AID1905729_PMID35319895_VALUE19
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482087914_AID1905728_PMID35319895_VALUE21
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482070557_AID1905736_PMID35319895_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482051251_AID1905730_PMID35319895_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482079993_AID1905729_PMID35319895_VALUE20
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482052398_AID1905746_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482063465_AID1905754_PMID35319895_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482052398_AID1905745_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103441767_AID1905730_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482050969_AID1905726_PMID35319895_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905803_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318405845_AID1905769_PMID35319895_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482057295_AID1905736_PMID35319895_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482087914_AID1905726_PMID35319895_VALUE21
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482050969_AID1905727_PMID35319895_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905733_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482063465_AID1905729_PMID35319895_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482049765_AID1905738_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482050969_AID1905730_PMID35319895_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905747_PMID35319895_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905762_PMID35319895_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482063465_AID1905728_PMID35319895_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482063465_AID1905736_PMID35319895_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482057379_AID1905729_PMID35319895_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482070557_AID1905730_PMID35319895_VALUE16
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482056461_AID1905776_PMID35319895_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482049765_AID1905730_PMID35319895_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID482080846_AID1905727_PMID35319895_VALUE21
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103441767_AID1905794_PMID35319895_VALUE1
isDiscussedBy http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID2064
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID1565
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID1956

Total number of triples: 341.