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endingPage 9999
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0022-2623
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bibliographicCitation Zhang J, Murugan NA, Tian Y, Bertagnin C, Fang Z, Kang D, Kong X, Jia H, Sun Z, Jia R, Gao P, Poongavanam V, Loregian A, Xu W, Ma X, Ding X, Huang B, Zhan P, Liu X. Structure-Based Optimization of N-Substituted Oseltamivir Derivatives as Potent Anti-Influenza A Virus Agents with Significantly Improved Potency against Oseltamivir-Resistant N1-H274Y Variant. J Med Chem. 2018 Nov 21;61(22):9976–99. doi: 10.1021/acs.jmedchem.8b01065. PMID: 30365885.
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date 2018-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
identifier https://doi.org/10.1021/acs.jmedchem.8b01065
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language English
source https://pubmed.ncbi.nlm.nih.gov/
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title Structure-Based Optimization of N-Substituted Oseltamivir Derivatives as Potent Anti-Influenza A Virus Agents with Significantly Improved Potency against Oseltamivir-Resistant N1-H274Y Variant
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404704916_AID1409405_PMID30365885_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404707242_AID1409408_PMID30365885_VALUE15
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404711979_AID1409405_PMID30365885_VALUE22
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404714461_AID1409432_PMID30365885_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID104234237_AID1409410_PMID30365885_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404703893_AID1409410_PMID30365885_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404714461_AID1409455_PMID30365885_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404710384_AID1409407_PMID30365885_VALUE21
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID104234161_AID1409419_PMID30365885_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404714461_AID1409417_PMID30365885_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404706259_AID1409406_PMID30365885_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404714461_AID1409434_PMID30365885_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID104234161_AID1409405_PMID30365885_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID104234161_AID1409410_PMID30365885_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404709914_AID1409406_PMID30365885_VALUE19
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404697770_AID1409447_PMID30365885_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404714461_AID1409448_PMID30365885_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404710327_AID1409404_PMID30365885_VALUE20
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404697770_AID1409448_PMID30365885_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404713259_AID1409409_PMID30365885_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID104234161_AID1409424_PMID30365885_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404714461_AID1409437_PMID30365885_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404714461_AID1409438_PMID30365885_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404700199_AID1409404_PMID30365885_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404708805_AID1409405_PMID30365885_VALUE16
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404700562_AID1409405_PMID30365885_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404715388_AID1409410_PMID30365885_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404706938_AID1409407_PMID30365885_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103191369_AID1409434_PMID30365885_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404700199_AID1409417_PMID30365885_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404699381_AID1409413_PMID30365885_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404699381_AID1409406_PMID30365885_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404698704_AID1409405_PMID30365885_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID104234237_AID1409405_PMID30365885_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404714461_AID1409410_PMID30365885_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404709369_AID1409407_PMID30365885_VALUE17
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404714461_AID1409446_PMID30365885_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404715388_AID1409406_PMID30365885_VALUE26
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404709369_AID1409417_PMID30365885_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404714461_AID1409422_PMID30365885_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404714461_AID1409444_PMID30365885_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404699381_AID1409415_PMID30365885_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404700562_AID1409404_PMID30365885_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404713259_AID1409414_PMID30365885_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404710384_AID1409414_PMID30365885_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404698704_AID1409404_PMID30365885_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404717133_AID1409408_PMID30365885_VALUE28
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404714461_AID1409436_PMID30365885_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404710384_AID1409416_PMID30365885_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404698704_AID1409407_PMID30365885_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404698704_AID1409415_PMID30365885_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID104234161_AID1409409_PMID30365885_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404713259_AID1409411_PMID30365885_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404710384_AID1409406_PMID30365885_VALUE21
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID104234228_AID1409437_PMID30365885_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404703893_AID1409418_PMID30365885_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404711979_AID1409413_PMID30365885_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404703543_AID1409408_PMID30365885_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404710384_AID1409415_PMID30365885_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404710384_AID1409409_PMID30365885_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404714461_AID1409456_PMID30365885_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404706259_AID1409405_PMID30365885_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID104234237_AID1409415_PMID30365885_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103191369_AID1409437_PMID30365885_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404710384_AID1409410_PMID30365885_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404709474_AID1409408_PMID30365885_VALUE18
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404709914_AID1409408_PMID30365885_VALUE19
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404714461_AID1409449_PMID30365885_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404713259_AID1409412_PMID30365885_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404706938_AID1409404_PMID30365885_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID104234228_AID1409434_PMID30365885_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404714461_AID1409460_PMID30365885_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404713259_AID1409407_PMID30365885_VALUE23
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404716252_AID1409406_PMID30365885_VALUE27
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404699381_AID1409404_PMID30365885_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404700199_AID1409406_PMID30365885_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404709369_AID1409404_PMID30365885_VALUE17
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID104234161_AID1409415_PMID30365885_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404700199_AID1409414_PMID30365885_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404716252_AID1409415_PMID30365885_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404714461_AID1409459_PMID30365885_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404700199_AID1409407_PMID30365885_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404699381_AID1409417_PMID30365885_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404711979_AID1409415_PMID30365885_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404711979_AID1409417_PMID30365885_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404701855_AID1409405_PMID30365885_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404713259_AID1409410_PMID30365885_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404701855_AID1409406_PMID30365885_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID104234161_AID1409412_PMID30365885_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404703543_AID1409407_PMID30365885_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404703893_AID1409415_PMID30365885_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404710384_AID1409417_PMID30365885_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404703543_AID1409405_PMID30365885_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404710327_AID1409407_PMID30365885_VALUE20
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404697770_AID1409452_PMID30365885_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID104234237_AID1409411_PMID30365885_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404707242_AID1409405_PMID30365885_VALUE15
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404716252_AID1409414_PMID30365885_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404709369_AID1409411_PMID30365885_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404711979_AID1409416_PMID30365885_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404700081_AID1409408_PMID30365885_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404714461_AID1409426_PMID30365885_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404709474_AID1409407_PMID30365885_VALUE18
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404713259_AID1409416_PMID30365885_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404709369_AID1409410_PMID30365885_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID104234161_AID1409426_PMID30365885_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID104234228_AID1409435_PMID30365885_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103619997_AID1409405_PMID30365885_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404703893_AID1409417_PMID30365885_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404709369_AID1409416_PMID30365885_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404699381_AID1409407_PMID30365885_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404714461_AID1409411_PMID30365885_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404698704_AID1409406_PMID30365885_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404717133_AID1409405_PMID30365885_VALUE28
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404710384_AID1409412_PMID30365885_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404716252_AID1409405_PMID30365885_VALUE27
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404714461_AID1409405_PMID30365885_VALUE24
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404704916_AID1409408_PMID30365885_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404706938_AID1409405_PMID30365885_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404714461_AID1409407_PMID30365885_VALUE24
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404700562_AID1409407_PMID30365885_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404709914_AID1409407_PMID30365885_VALUE19
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103619997_AID1409406_PMID30365885_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404714461_AID1409427_PMID30365885_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404714461_AID1409445_PMID30365885_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404714461_AID1409413_PMID30365885_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID104234161_AID1409407_PMID30365885_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404709369_AID1409406_PMID30365885_VALUE17
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404715388_AID1409417_PMID30365885_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404710384_AID1409408_PMID30365885_VALUE21
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID104234161_AID1409420_PMID30365885_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404716252_AID1409407_PMID30365885_VALUE27
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404711979_AID1409406_PMID30365885_VALUE22
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID104234161_AID1409428_PMID30365885_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404703893_AID1409408_PMID30365885_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404707242_AID1409407_PMID30365885_VALUE15
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404716252_AID1409417_PMID30365885_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404703893_AID1409407_PMID30365885_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404714461_AID1409430_PMID30365885_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404716252_AID1409416_PMID30365885_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404710384_AID1409411_PMID30365885_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID104234161_AID1409423_PMID30365885_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404699381_AID1409408_PMID30365885_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID104234228_AID1409436_PMID30365885_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404698704_AID1409414_PMID30365885_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404709369_AID1409409_PMID30365885_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404711979_AID1409407_PMID30365885_VALUE22
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404713259_AID1409406_PMID30365885_VALUE23
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404700081_AID1409405_PMID30365885_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404714636_AID1409404_PMID30365885_VALUE25
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404710327_AID1409406_PMID30365885_VALUE20
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404710384_AID1409405_PMID30365885_VALUE21
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404706259_AID1409404_PMID30365885_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404715388_AID1409414_PMID30365885_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404709369_AID1409412_PMID30365885_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404703893_AID1409414_PMID30365885_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404708805_AID1409406_PMID30365885_VALUE16
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404709369_AID1409413_PMID30365885_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404707242_AID1409404_PMID30365885_VALUE15
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103619997_AID1409407_PMID30365885_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404714461_AID1409421_PMID30365885_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404704916_AID1409406_PMID30365885_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404714636_AID1409407_PMID30365885_VALUE25
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID104234228_AID1409435_PMID30365885_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID104234161_AID1409421_PMID30365885_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404715388_AID1409412_PMID30365885_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404714461_AID1409452_PMID30365885_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404704916_AID1409404_PMID30365885_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103378350_AID1409432_PMID30365885_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID104234161_AID1409418_PMID30365885_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404703893_AID1409413_PMID30365885_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404714461_AID1409431_PMID30365885_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404715388_AID1409411_PMID30365885_VALUE8

Total number of triples: 403.