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Auton M, Sowa KE, Smith SM, Sedlák E, Vijayan KV, Cruz MA. Destabilization of the A1 Domain in von Willebrand Factor Dissociates the A1A2A3 Tri-domain and Provokes Spontaneous Binding to Glycoprotein Ibα and Platelet Activation under Shear Stress. Journal of Biological Chemistry. 2010 Jul;285(30):22831–9. doi: 10.1074/jbc.m110.103358. |