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bibliographicCitation Rodríguez Sarmiento RM, Bissantz C, Bylund J, Limberg A, Neidhart W, Jakob-Roetne R, Wang L, Baumann K. Stepwise Design of γ-Secretase Modulators with an Advanced Profile by Judicious Coordinated Structural Replacements and an Unconventional Phenyl Ring Bioisostere. J Med Chem. 2020 Aug 13;63(15):8534–53. doi: 10.1021/acs.jmedchem.0c00909. PMID: 32706964.
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date 2020-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
identifier https://pubmed.ncbi.nlm.nih.gov/32706964
https://doi.org/10.1021/acs.jmedchem.0c00909
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language English
source https://www.crossref.org/
https://pubmed.ncbi.nlm.nih.gov/
title Stepwise Design of γ-Secretase Modulators with an Advanced Profile by Judicious Coordinated Structural Replacements and an Unconventional Phenyl Ring Bioisostere
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442051682_AID1661510_PMID32706964_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442050473_AID1661509_PMID32706964_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442064109_AID1661525_PMID32706964_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442051682_AID1661507_PMID32706964_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442050473_AID1661516_PMID32706964_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442053842_AID1661515_PMID32706964_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442059140_AID1661510_PMID32706964_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442060927_AID1661515_PMID32706964_VALUE16
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442053842_AID1661506_PMID32706964_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442048946_AID1661514_PMID32706964_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442063951_AID1661513_PMID32706964_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442055624_AID1661509_PMID32706964_VALUE16
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442056751_AID1661524_PMID32706964_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442063951_AID1661510_PMID32706964_VALUE17
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442063951_AID1661537_PMID32706964_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442059140_AID1661509_PMID32706964_VALUE20
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442051524_AID1661521_PMID32706964_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442055624_AID1661510_PMID32706964_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442063951_AID1661541_PMID32706964_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442060927_AID1661509_PMID32706964_VALUE22
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442052016_AID1661514_PMID32706964_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442050473_AID1661506_PMID32706964_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442063951_AID1661519_PMID32706964_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442064109_AID1661547_PMID32706964_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442051682_AID1661550_PMID32706964_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442063103_AID1661515_PMID32706964_VALUE18
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442052718_AID1661519_PMID32706964_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442051524_AID1661546_PMID32706964_VALUE1
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442052718_AID1661518_PMID32706964_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442051524_AID1661516_PMID32706964_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442051682_AID1661538_PMID32706964_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442061530_AID1661509_PMID32706964_VALUE23
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442051682_AID1661514_PMID32706964_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442060755_AID1661514_PMID32706964_VALUE15
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442051798_AID1661515_PMID32706964_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442059140_AID1661507_PMID32706964_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442064109_AID1661514_PMID32706964_VALUE20
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442052016_AID1661507_PMID32706964_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442052718_AID1661516_PMID32706964_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442064109_AID1661543_PMID32706964_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442052718_AID1661545_PMID32706964_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442051682_AID1661516_PMID32706964_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442051682_AID1661535_PMID32706964_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442063951_AID1661516_PMID32706964_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442064109_AID1661519_PMID32706964_VALUE11
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442051524_AID1661519_PMID32706964_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442064109_AID1661540_PMID32706964_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442051682_AID1661549_PMID32706964_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442060755_AID1661516_PMID32706964_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442051682_AID1661520_PMID32706964_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442050182_AID1661517_PMID32706964_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442060755_AID1661509_PMID32706964_VALUE21
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442059140_AID1661515_PMID32706964_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442052718_AID1661509_PMID32706964_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442052016_AID1661509_PMID32706964_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442064109_AID1661515_PMID32706964_VALUE20
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442051682_AID1661525_PMID32706964_VALUE1
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442051682_AID1661548_PMID32706964_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442064109_AID1661524_PMID32706964_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442052718_AID1661513_PMID32706964_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442051682_AID1661521_PMID32706964_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442051682_AID1661530_PMID32706964_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442063951_AID1661549_PMID32706964_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442051682_AID1661536_PMID32706964_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442056751_AID1661507_PMID32706964_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442051682_AID1661529_PMID32706964_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442051682_AID1661518_PMID32706964_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442063103_AID1661516_PMID32706964_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442056751_AID1661521_PMID32706964_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442051682_AID1661519_PMID32706964_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442052718_AID1661510_PMID32706964_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442048946_AID1661509_PMID32706964_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442063951_AID1661546_PMID32706964_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442056751_AID1661541_PMID32706964_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442051131_AID1661515_PMID32706964_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442052718_AID1661541_PMID32706964_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442052016_AID1661506_PMID32706964_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442052718_AID1661510_PMID32706964_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442064109_AID1661539_PMID32706964_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442051524_AID1661507_PMID32706964_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442051798_AID1661507_PMID32706964_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442063951_AID1661544_PMID32706964_VALUE1
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442056751_AID1661509_PMID32706964_VALUE18
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442056751_AID1661510_PMID32706964_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442063951_AID1661515_PMID32706964_VALUE19
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442060927_AID1661517_PMID32706964_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442051524_AID1661510_PMID32706964_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442051798_AID1661516_PMID32706964_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442050182_AID1661514_PMID32706964_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442055624_AID1661513_PMID32706964_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442056751_AID1661548_PMID32706964_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442060755_AID1661510_PMID32706964_VALUE15
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442051524_AID1661519_PMID32706964_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442060927_AID1661549_PMID32706964_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442052718_AID1661511_PMID32706964_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442059140_AID1661514_PMID32706964_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442051682_AID1661531_PMID32706964_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442060755_AID1661521_PMID32706964_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442056751_AID1661540_PMID32706964_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442052718_AID1661546_PMID32706964_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442055632_AID1661509_PMID32706964_VALUE17
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442051682_AID1661547_PMID32706964_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442050473_AID1661507_PMID32706964_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442052718_AID1661514_PMID32706964_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442056751_AID1661520_PMID32706964_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID442052718_AID1661506_PMID32706964_VALUE7
isDiscussedBy http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID5243
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID3757
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID5664
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID5663
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID4851
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID51107
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID5298
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID83464
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID55851
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID23385

Total number of triples: 339.