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bibliographicCitation Gurney ME, Nugent RA, Mo X, Sindac JA, Hagen TJ, Fox D, O’Donnell JM, Zhang C, Xu Y, Zhang H, Groppi VE, Bailie M, White RE, Romero DL, Vellekoop AS, Walker JR, Surman MD, Zhu L, Campbell RF. Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders. J. Med. Chem. 2019 Apr 23;62(10):4884–901. doi: 10.1021/acs.jmedchem.9b00193.
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date 2019-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
identifier https://pubmed.ncbi.nlm.nih.gov/31013090
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language English
source https://pubmed.ncbi.nlm.nih.gov/
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title Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598256_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440186317_AID1598195_PMID31013090_VALUE20
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103594774_AID1598240_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598244_PMID31013090_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440214700_AID1598199_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440178336_AID1598236_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440185061_AID1598193_PMID31013090_VALUE19
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440125247_AID1598192_PMID31013090_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598242_PMID31013090_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598260_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598215_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440229827_AID1598193_PMID31013090_VALUE27
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440185061_AID1598195_PMID31013090_VALUE19
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440229827_AID1598241_PMID31013090_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440173831_AID1598196_PMID31013090_VALUE16
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440214700_AID1598223_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598280_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440214700_AID1598214_PMID31013090_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440125247_AID1598193_PMID31013090_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598247_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598193_PMID31013090_VALUE18
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440182176_AID1598195_PMID31013090_VALUE17
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440203632_AID1598193_PMID31013090_VALUE23
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440186317_AID1598196_PMID31013090_VALUE20
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440182176_AID1598194_PMID31013090_VALUE17
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598248_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598297_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440214700_AID1598221_PMID31013090_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440229827_AID1598198_PMID31013090_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598210_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598271_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID312349391_AID1598194_PMID31013090_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440161090_AID1598196_PMID31013090_VALUE15
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598294_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598275_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598196_PMID31013090_VALUE18
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103594774_AID1598255_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440186317_AID1598194_PMID31013090_VALUE20
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440186317_AID1598193_PMID31013090_VALUE20
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440214700_AID1598193_PMID31013090_VALUE26
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID312349391_AID1598193_PMID31013090_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440147947_AID1598192_PMID31013090_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440113113_AID1598194_PMID31013090_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440125247_AID1598195_PMID31013090_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440113113_AID1598192_PMID31013090_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440214700_AID1598224_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598254_PMID31013090_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440134094_AID1598195_PMID31013090_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID312349391_AID1598192_PMID31013090_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440125247_AID1598196_PMID31013090_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440212075_AID1598193_PMID31013090_VALUE25
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440214700_AID1598195_PMID31013090_VALUE26
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598296_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID312349392_AID1598195_PMID31013090_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440116209_AID1598194_PMID31013090_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440185061_AID1598196_PMID31013090_VALUE19
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440214700_AID1598230_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440214700_AID1598212_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440182176_AID1598196_PMID31013090_VALUE17
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440205929_AID1598195_PMID31013090_VALUE24
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440125247_AID1598194_PMID31013090_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103594774_AID1598193_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440229827_AID1598219_PMID31013090_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440194451_AID1598196_PMID31013090_VALUE21
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID312349392_AID1598194_PMID31013090_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440203632_AID1598196_PMID31013090_VALUE23
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440186317_AID1598192_PMID31013090_VALUE16
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440203632_AID1598194_PMID31013090_VALUE23
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440202238_AID1598193_PMID31013090_VALUE22
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598246_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440229827_AID1598244_PMID31013090_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440134094_AID1598194_PMID31013090_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598284_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID312349398_AID1598196_PMID31013090_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440234600_AID1598236_PMID31013090_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598249_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440229827_AID1598255_PMID31013090_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598239_PMID31013090_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598279_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103168167_AID1598202_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440214700_AID1598219_PMID31013090_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440212075_AID1598195_PMID31013090_VALUE25
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440214700_AID1598228_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440234600_AID1598237_PMID31013090_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598287_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598266_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598206_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598198_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598240_PMID31013090_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598200_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598192_PMID31013090_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598258_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID312349398_AID1598194_PMID31013090_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440214700_AID1598234_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440229827_AID1598196_PMID31013090_VALUE27
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440214700_AID1598207_PMID31013090_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440234834_AID1598236_PMID31013090_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440205929_AID1598192_PMID31013090_VALUE20
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440147947_AID1598196_PMID31013090_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440116209_AID1598195_PMID31013090_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440203632_AID1598195_PMID31013090_VALUE23
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598274_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440214700_AID1598206_PMID31013090_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440214700_AID1598220_PMID31013090_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440229827_AID1598201_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440202238_AID1598195_PMID31013090_VALUE22
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598263_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598298_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID312349398_AID1598195_PMID31013090_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440214700_AID1598192_PMID31013090_VALUE22
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440205929_AID1598194_PMID31013090_VALUE24
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440214700_AID1598215_PMID31013090_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440202238_AID1598194_PMID31013090_VALUE22
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440214700_AID1598213_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID312349391_AID1598195_PMID31013090_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440229827_AID1598214_PMID31013090_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440182176_AID1598193_PMID31013090_VALUE17
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103332718_AID1598192_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440214700_AID1598226_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440147947_AID1598193_PMID31013090_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103332718_AID1598194_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598194_PMID31013090_VALUE18
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440234533_AID1598236_PMID31013090_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440147947_AID1598194_PMID31013090_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598276_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440134001_AID1598194_PMID31013090_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440234950_AID1598237_PMID31013090_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440214700_AID1598245_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598278_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440214700_AID1598205_PMID31013090_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598218_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440116209_AID1598192_PMID31013090_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598289_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598262_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440159475_AID1598194_PMID31013090_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440131450_AID1598193_PMID31013090_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440134001_AID1598195_PMID31013090_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID312349392_AID1598192_PMID31013090_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440234505_AID1598237_PMID31013090_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103594774_AID1598244_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440184110_AID1598250_PMID31013090_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440202238_AID1598196_PMID31013090_VALUE22
isDiscussedBy http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID5139
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID5136
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID5137
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID1557
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID5152
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID5153
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID5150
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID5151
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID5141
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID5142
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID5140
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID5146
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID8654
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID5143
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID1576
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID5144
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID1565
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID1559
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID50940
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID385612211
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID10846
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID27115
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID3757
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID5138

Total number of triples: 386.