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McGowan KM, Nance KD, Cho HP, Bridges TM, Conn PJ, Jones CK, Lindsley CW. Continued optimization of the M 5 NAM ML375: Discovery of VU6008667, an M 5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. Bioorganic & Medicinal Chemistry Letters. 2017 Mar;27(6):1356–9. doi: 10.1016/j.bmcl.2017.02.020. |