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Zhang D, Li P, Gao Y, Song Y, Zhu Y, Su H, Yang B, Li L, Li G, Gong N, Lu Y, Shao H, Yu C, Huang H. Discovery of a Candidate Containing an (S)-3,3-Difluoro-1-(4-methylpiperazin-1-yl)-2,3-dihydro-1H-inden Scaffold as a Highly Potent Pan-Inhibitor of the BCR-ABL Kinase Including the T315I-Resistant Mutant for the Treatment of Chronic Myeloid Leukemia. J. Med. Chem. 2021 May 20;64(11):7434–52. doi: 10.1021/acs.jmedchem.1c00082. |