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bibliographicCitation Romagnoli R, Baraldi PG, Lopez-Cara C, Cruz-Lopez O, Moorman AR, Massink A, IJzerman AP, Vincenzi F, Borea PA, Varani K. Synthesis and biological evaluation of a new series of 2-amino-3-aroyl thiophene derivatives as agonist allosteric modulators of the A 1 adenosine receptor. A position-dependent effect study. European Journal of Medicinal Chemistry. 2015 Aug;101():185–204. doi: 10.1016/j.ejmech.2015.06.041.
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date 2015-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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https://doi.org/10.1016/j.ejmech.2015.06.041
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language English
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title Synthesis and biological evaluation of a new series of 2-amino-3-aroyl thiophene derivatives as agonist allosteric modulators of the A 1 adenosine receptor. A position-dependent effect study
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386768_AID1243872_PMID26141910_VALUE7
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386804_AID1243878_PMID26141910_VALUE43
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386790_AID1243874_PMID26141910_VALUE27
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386796_AID1243872_PMID26141910_VALUE35
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386782_AID1243873_PMID26141910_VALUE17
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386799_AID1243871_PMID26141910_VALUE38
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386798_AID1243878_PMID26141910_VALUE37
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386796_AID1243875_PMID26141910_VALUE33
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386779_AID1243872_PMID26141910_VALUE18
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386784_AID1243878_PMID26141910_VALUE23
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386776_AID1243873_PMID26141910_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386788_AID1243873_PMID26141910_VALUE23
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386783_AID1243873_PMID26141910_VALUE18
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386793_AID1243877_PMID26141910_VALUE32
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386792_AID1243878_PMID26141910_VALUE31
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386794_AID1243877_PMID26141910_VALUE33
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386772_AID1243871_PMID26141910_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386785_AID1243877_PMID26141910_VALUE24
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386804_AID1243871_PMID26141910_VALUE43
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386770_AID1243875_PMID26141910_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386805_AID1243876_PMID26141910_VALUE42
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386778_AID1243874_PMID26141910_VALUE15
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386803_AID1243872_PMID26141910_VALUE42
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386795_AID1243877_PMID26141910_VALUE34
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386777_AID1243872_PMID26141910_VALUE16
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386780_AID1243875_PMID26141910_VALUE17
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386802_AID1243876_PMID26141910_VALUE39
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386785_AID1243872_PMID26141910_VALUE24
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386787_AID1243872_PMID26141910_VALUE26
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386769_AID1243875_PMID26141910_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103241573_AID1243875_PMID26141910_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386770_AID1243878_PMID26141910_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386775_AID1243874_PMID26141910_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386779_AID1243875_PMID26141910_VALUE16
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386794_AID1243871_PMID26141910_VALUE33
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386804_AID1243877_PMID26141910_VALUE43
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386802_AID1243877_PMID26141910_VALUE41
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386775_AID1243871_PMID26141910_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386786_AID1243878_PMID26141910_VALUE25
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386777_AID1243876_PMID26141910_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386783_AID1243872_PMID26141910_VALUE22
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386770_AID1243872_PMID26141910_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386774_AID1243873_PMID26141910_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386769_AID1243876_PMID26141910_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386796_AID1243877_PMID26141910_VALUE35
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386769_AID1243871_PMID26141910_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386786_AID1243876_PMID26141910_VALUE23
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386781_AID1243871_PMID26141910_VALUE20
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386783_AID1243875_PMID26141910_VALUE20
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386804_AID1243872_PMID26141910_VALUE43
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386773_AID1243874_PMID26141910_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386791_AID1243872_PMID26141910_VALUE30
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386768_AID1243875_PMID26141910_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386791_AID1243871_PMID26141910_VALUE30
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386800_AID1243871_PMID26141910_VALUE39
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386791_AID1243877_PMID26141910_VALUE30
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386786_AID1243875_PMID26141910_VALUE23
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386793_AID1243875_PMID26141910_VALUE30
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103241573_AID1243878_PMID26141910_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386777_AID1243878_PMID26141910_VALUE16
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID163321236_AID1243872_PMID26141910_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386767_AID1243875_PMID26141910_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386799_AID1243877_PMID26141910_VALUE38
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386800_AID1243874_PMID26141910_VALUE37
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386796_AID1243878_PMID26141910_VALUE35
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386775_AID1243878_PMID26141910_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386772_AID1243874_PMID26141910_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386794_AID1243872_PMID26141910_VALUE33
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386793_AID1243871_PMID26141910_VALUE32
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386769_AID1243873_PMID26141910_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386773_AID1243876_PMID26141910_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386797_AID1243876_PMID26141910_VALUE34
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386766_AID1243873_PMID26141910_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386803_AID1243871_PMID26141910_VALUE42
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386773_AID1243877_PMID26141910_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386777_AID1243877_PMID26141910_VALUE16
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386766_AID1243872_PMID26141910_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386788_AID1243876_PMID26141910_VALUE25
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386782_AID1243872_PMID26141910_VALUE21
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386805_AID1243877_PMID26141910_VALUE44
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386801_AID1243875_PMID26141910_VALUE38
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386802_AID1243874_PMID26141910_VALUE39
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103241573_AID1243884_PMID26141910_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386780_AID1243873_PMID26141910_VALUE15
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386782_AID1243878_PMID26141910_VALUE21
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID163321236_AID1243871_PMID26141910_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386765_AID1243874_PMID26141910_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386770_AID1243871_PMID26141910_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386782_AID1243876_PMID26141910_VALUE19
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386793_AID1243876_PMID26141910_VALUE30
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386791_AID1243876_PMID26141910_VALUE28
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386788_AID1243878_PMID26141910_VALUE27
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386801_AID1243872_PMID26141910_VALUE40
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386783_AID1243878_PMID26141910_VALUE22
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386785_AID1243878_PMID26141910_VALUE24
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386783_AID1243876_PMID26141910_VALUE20
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386768_AID1243874_PMID26141910_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103241573_AID1243877_PMID26141910_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386796_AID1243876_PMID26141910_VALUE33
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386776_AID1243876_PMID26141910_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386788_AID1243871_PMID26141910_VALUE27
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386782_AID1243874_PMID26141910_VALUE19
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103241573_AID1243879_PMID26141910_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386798_AID1243872_PMID26141910_VALUE37
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386778_AID1243875_PMID26141910_VALUE15
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386802_AID1243871_PMID26141910_VALUE41
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386787_AID1243878_PMID26141910_VALUE26
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386784_AID1243875_PMID26141910_VALUE21
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386792_AID1243876_PMID26141910_VALUE29
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386785_AID1243874_PMID26141910_VALUE22
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386779_AID1243873_PMID26141910_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386803_AID1243878_PMID26141910_VALUE42
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386789_AID1243880_PMID26141910_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386799_AID1243876_PMID26141910_VALUE36
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386791_AID1243878_PMID26141910_VALUE30
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386801_AID1243877_PMID26141910_VALUE40
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386774_AID1243875_PMID26141910_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386775_AID1243877_PMID26141910_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386776_AID1243872_PMID26141910_VALUE15
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386772_AID1243875_PMID26141910_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386793_AID1243878_PMID26141910_VALUE32
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386805_AID1243871_PMID26141910_VALUE44
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386796_AID1243874_PMID26141910_VALUE33
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386781_AID1243875_PMID26141910_VALUE18
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386771_AID1243877_PMID26141910_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103241573_AID1243876_PMID26141910_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386772_AID1243877_PMID26141910_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386797_AID1243875_PMID26141910_VALUE34
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386794_AID1243874_PMID26141910_VALUE31
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386776_AID1243874_PMID26141910_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386802_AID1243878_PMID26141910_VALUE41
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID163321236_AID1243878_PMID26141910_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386789_AID1243873_PMID26141910_VALUE24
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386792_AID1243874_PMID26141910_VALUE29
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386779_AID1243878_PMID26141910_VALUE18
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386786_AID1243871_PMID26141910_VALUE25
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386772_AID1243873_PMID26141910_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386804_AID1243875_PMID26141910_VALUE41
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386765_AID1243872_PMID26141910_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386784_AID1243877_PMID26141910_VALUE23
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386795_AID1243878_PMID26141910_VALUE34
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386803_AID1243877_PMID26141910_VALUE42
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103241573_AID1243871_PMID26141910_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386767_AID1243876_PMID26141910_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386792_AID1243872_PMID26141910_VALUE31
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386782_AID1243877_PMID26141910_VALUE21
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386805_AID1243872_PMID26141910_VALUE44
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386766_AID1243874_PMID26141910_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386794_AID1243875_PMID26141910_VALUE31
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386801_AID1243876_PMID26141910_VALUE38
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103241573_AID1243874_PMID26141910_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386805_AID1243878_PMID26141910_VALUE44
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386791_AID1243873_PMID26141910_VALUE26
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386773_AID1243873_PMID26141910_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID163321236_AID1243877_PMID26141910_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386786_AID1243872_PMID26141910_VALUE25
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386787_AID1243871_PMID26141910_VALUE26
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386766_AID1243876_PMID26141910_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318386768_AID1243876_PMID26141910_VALUE5
isDiscussedBy http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID134
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID29290
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID140

Total number of triples: 390.