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bibliographicCitation Smith CR, Aranda R, Bobinski TP, Briere DM, Burns AC, Christensen JG, Clarine J, Engstrom LD, Gunn RJ, Ivetac A, Jean-Baptiste R, Ketcham JM, Kobayashi M, Kuehler J, Kulyk S, Lawson JD, Moya K, Olson P, Rahbaek L, Thomas NC, Wang X, Waters LM, Marx MA. Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP-Deleted Cancers. J Med Chem. 2022 Feb 10;65(3):1749–66. doi: 10.1021/acs.jmedchem.1c01900. PMID: 35041419.
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source https://pubmed.ncbi.nlm.nih.gov/
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title Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP-Deleted Cancers
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID476000283_AID1825245_PMID35041419_VALUE19
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475980667_AID1825248_PMID35041419_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475993185_AID1825248_PMID35041419_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475979569_AID1825237_PMID35041419_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475984721_AID1825247_PMID35041419_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475999185_AID1825239_PMID35041419_VALUE20
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475999997_AID1825238_PMID35041419_VALUE15
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID476000283_AID1825246_PMID35041419_VALUE23
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475980667_AID1825244_PMID35041419_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475980667_AID1825272_PMID35041419_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475979956_AID1825246_PMID35041419_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475995036_AID1825248_PMID35041419_VALUE17
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475995542_AID1825245_PMID35041419_VALUE17
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475980667_AID1825244_PMID35041419_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475991524_AID1825237_PMID35041419_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475983155_AID1825239_PMID35041419_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475999997_AID1825242_PMID35041419_VALUE35
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475979973_AID1825284_PMID35041419_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475992022_AID1825243_PMID35041419_VALUE21
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475983155_AID1825243_PMID35041419_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475999361_AID1825282_PMID35041419_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475992513_AID1825247_PMID35041419_VALUE15
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID476000283_AID1825257_PMID35041419_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475999997_AID1825237_PMID35041419_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475984343_AID1825280_PMID35041419_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475979194_AID1825279_PMID35041419_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475980667_AID1825256_PMID35041419_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475997488_AID1825239_PMID35041419_VALUE19
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475979973_AID1825242_PMID35041419_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475979194_AID1825238_PMID35041419_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475993185_AID1825244_PMID35041419_VALUE17
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475980667_AID1825259_PMID35041419_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475989053_AID1825245_PMID35041419_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475980667_AID1825277_PMID35041419_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475987576_AID1825242_PMID35041419_VALUE16
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475989053_AID1825248_PMID35041419_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475992022_AID1825261_PMID35041419_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475999997_AID1825239_PMID35041419_VALUE22
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475991524_AID1825239_PMID35041419_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID476000283_AID1825247_PMID35041419_VALUE22
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475981654_AID1825243_PMID35041419_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475993185_AID1825249_PMID35041419_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475980667_AID1825252_PMID35041419_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475980667_AID1825264_PMID35041419_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475981654_AID1825239_PMID35041419_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475995542_AID1825248_PMID35041419_VALUE18
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475995542_AID1825243_PMID35041419_VALUE28
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440141779_AID1825246_PMID35041419_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475994691_AID1825248_PMID35041419_VALUE16
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475997488_AID1825244_PMID35041419_VALUE22
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475980667_AID1825244_PMID35041419_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475987576_AID1825246_PMID35041419_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475981743_AID1825239_PMID35041419_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475999361_AID1825243_PMID35041419_VALUE33
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475979956_AID1825243_PMID35041419_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475979973_AID1825246_PMID35041419_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475980667_AID1825245_PMID35041419_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID381844004_AID1825279_PMID35041419_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475992513_AID1825239_PMID35041419_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475999361_AID1825254_PMID35041419_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475979973_AID1825249_PMID35041419_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475990497_AID1825238_PMID35041419_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475979956_AID1825247_PMID35041419_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475993741_AID1825247_PMID35041419_VALUE17
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475997041_AID1825242_PMID35041419_VALUE31
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475980667_AID1825250_PMID35041419_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475996084_AID1825238_PMID35041419_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475999361_AID1825237_PMID35041419_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475992022_AID1825257_PMID35041419_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475995036_AID1825242_PMID35041419_VALUE28
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440141779_AID1825247_PMID35041419_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475990497_AID1825237_PMID35041419_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475992022_AID1825269_PMID35041419_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475981743_AID1825244_PMID35041419_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID476000283_AID1825259_PMID35041419_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475992022_AID1825249_PMID35041419_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475980667_AID1825260_PMID35041419_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID476000283_AID1825244_PMID35041419_VALUE23
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475992022_AID1825265_PMID35041419_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475993185_AID1825245_PMID35041419_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475979569_AID1825243_PMID35041419_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475980667_AID1825254_PMID35041419_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475990259_AID1825237_PMID35041419_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475989053_AID1825243_PMID35041419_VALUE17
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475994691_AID1825245_PMID35041419_VALUE16
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475992022_AID1825271_PMID35041419_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475992022_AID1825242_PMID35041419_VALUE22
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475994691_AID1825247_PMID35041419_VALUE18
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475979973_AID1825246_PMID35041419_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475979973_AID1825247_PMID35041419_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475980667_AID1825246_PMID35041419_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475994691_AID1825249_PMID35041419_VALUE16
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475989053_AID1825242_PMID35041419_VALUE18
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475992513_AID1825242_PMID35041419_VALUE24
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475999997_AID1825243_PMID35041419_VALUE34
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475990259_AID1825239_PMID35041419_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475983155_AID1825247_PMID35041419_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475992022_AID1825264_PMID35041419_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475999361_AID1825238_PMID35041419_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475979973_AID1825284_PMID35041419_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475981743_AID1825242_PMID35041419_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475980667_AID1825258_PMID35041419_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475979973_AID1825243_PMID35041419_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475989000_AID1825242_PMID35041419_VALUE17
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475997041_AID1825243_PMID35041419_VALUE30
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475981743_AID1825249_PMID35041419_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475995036_AID1825249_PMID35041419_VALUE17
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475980667_AID1825243_PMID35041419_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475992513_AID1825248_PMID35041419_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475992022_AID1825248_PMID35041419_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475990259_AID1825243_PMID35041419_VALUE18
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475980667_AID1825247_PMID35041419_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475996084_AID1825237_PMID35041419_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475979973_AID1825242_PMID35041419_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID476000283_AID1825239_PMID35041419_VALUE23
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475979973_AID1825247_PMID35041419_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475979973_AID1825249_PMID35041419_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475979194_AID1825242_PMID35041419_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475991524_AID1825238_PMID35041419_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475987576_AID1825243_PMID35041419_VALUE15
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475982165_AID1825239_PMID35041419_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475982165_AID1825238_PMID35041419_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475980667_AID1825284_PMID35041419_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475979956_AID1825248_PMID35041419_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475992513_AID1825245_PMID35041419_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475999361_AID1825242_PMID35041419_VALUE34
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475991524_AID1825242_PMID35041419_VALUE21
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475995542_AID1825246_PMID35041419_VALUE21
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475980667_AID1825286_PMID35041419_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475999361_AID1825253_PMID35041419_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID476000283_AID1825262_PMID35041419_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID381844004_AID1825239_PMID35041419_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475979569_AID1825242_PMID35041419_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475989053_AID1825247_PMID35041419_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475980667_AID1825287_PMID35041419_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475990259_AID1825242_PMID35041419_VALUE19
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475980667_AID1825268_PMID35041419_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475991524_AID1825243_PMID35041419_VALUE20
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475980667_AID1825261_PMID35041419_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475989053_AID1825246_PMID35041419_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475989053_AID1825244_PMID35041419_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475999185_AID1825242_PMID35041419_VALUE33
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475980667_AID1825249_PMID35041419_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475982165_AID1825242_PMID35041419_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475995036_AID1825243_PMID35041419_VALUE27
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID476000283_AID1825248_PMID35041419_VALUE20
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475992022_AID1825245_PMID35041419_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475980667_AID1825253_PMID35041419_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475979973_AID1825248_PMID35041419_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475980667_AID1825242_PMID35041419_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475987576_AID1825247_PMID35041419_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475999361_AID1825256_PMID35041419_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475979194_AID1825239_PMID35041419_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475980667_AID1825248_PMID35041419_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475992022_AID1825244_PMID35041419_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475997488_AID1825242_PMID35041419_VALUE32
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475984343_AID1825279_PMID35041419_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475980667_AID1825246_PMID35041419_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475980667_AID1825247_PMID35041419_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475981743_AID1825248_PMID35041419_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475997488_AID1825248_PMID35041419_VALUE19
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475981654_AID1825237_PMID35041419_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475992022_AID1825258_PMID35041419_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475990497_AID1825239_PMID35041419_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475982165_AID1825243_PMID35041419_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475992022_AID1825267_PMID35041419_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475989053_AID1825249_PMID35041419_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475994691_AID1825243_PMID35041419_VALUE26
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475987576_AID1825249_PMID35041419_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475984721_AID1825248_PMID35041419_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475999361_AID1825239_PMID35041419_VALUE21
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475987576_AID1825248_PMID35041419_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID475979569_AID1825239_PMID35041419_VALUE3
isDiscussedBy http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID10419
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID79084
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID472319238

Total number of triples: 391.