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contentType Journal Article
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issueIdentifier 21
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publicationName Journal of Medicinal Chemistry
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bibliographicCitation Korff M, Imberg L, Will JM, Bückreiß N, Kalinina SA, Wenzel BM, Kastner GA, Daniliuc CG, Barth M, Ovsepyan RA, Butov KR, Humpf HU, Lehr M, Panteleev MA, Poso A, Karst U, Steinmetzer T, Bendas G, Kalinin DV. Acylated 1H-1,2,4-Triazol-5-amines Targeting Human Coagulation Factor XIIa and Thrombin: Conventional and Microscale Synthesis, Anticoagulant Properties, and Mechanism of Action. J Med Chem. 2020 Nov 12;63(21):13159–86. doi: 10.1021/acs.jmedchem.0c01635. PMID: 33089691.
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date 2020-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
identifier https://doi.org/10.1021/acs.jmedchem.0c01635
https://pubmed.ncbi.nlm.nih.gov/33089691
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title Acylated 1H-1,2,4-Triazol-5-amines Targeting Human Coagulation Factor XIIa and Thrombin: Conventional and Microscale Synthesis, Anticoagulant Properties, and Mechanism of Action
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103222421_AID1681854_PMID33089691_VALUE1
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461514556_AID1681813_PMID33089691_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461540431_AID1681851_PMID33089691_VALUE27
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461561113_AID1681850_PMID33089691_VALUE24
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461523301_AID1681850_PMID33089691_VALUE9
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461531590_AID1681832_PMID33089691_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103222421_AID1681853_PMID33089691_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461523684_AID1681854_PMID33089691_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461538973_AID1681839_PMID33089691_VALUE16
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461549450_AID1681838_PMID33089691_VALUE22
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103469795_AID1681826_PMID33089691_VALUE2
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461531590_AID1681823_PMID33089691_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461517103_AID1681854_PMID33089691_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461536428_AID1681839_PMID33089691_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103469795_AID1681849_PMID33089691_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461538973_AID1681850_PMID33089691_VALUE18
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461514556_AID1681849_PMID33089691_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461529602_AID1681854_PMID33089691_VALUE17
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461531590_AID1681853_PMID33089691_VALUE19
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103232921_AID1681851_PMID33089691_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461531590_AID1681821_PMID33089691_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461514556_AID1681852_PMID33089691_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461553587_AID1681852_PMID33089691_VALUE33
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461523684_AID1681842_PMID33089691_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461550482_AID1681839_PMID33089691_VALUE23
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461562230_AID1681853_PMID33089691_VALUE35
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461539138_AID1681854_PMID33089691_VALUE26
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461550482_AID1681846_PMID33089691_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103222421_AID1681850_PMID33089691_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461543575_AID1681851_PMID33089691_VALUE28
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461545807_AID1681839_PMID33089691_VALUE21
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461530813_AID1681851_PMID33089691_VALUE18
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461563576_AID1681853_PMID33089691_VALUE36
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461532712_AID1681850_PMID33089691_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461514556_AID1681811_PMID33089691_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461518386_AID1681839_PMID33089691_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461523684_AID1681844_PMID33089691_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461550482_AID1681852_PMID33089691_VALUE32
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103232921_AID1681807_PMID33089691_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461523053_AID1681850_PMID33089691_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461538973_AID1681836_PMID33089691_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461531590_AID1681837_PMID33089691_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461536428_AID1681850_PMID33089691_VALUE17
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103222421_AID1681849_PMID33089691_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461531590_AID1681815_PMID33089691_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461536428_AID1681849_PMID33089691_VALUE17
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461538612_AID1681854_PMID33089691_VALUE24
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461531590_AID1681854_PMID33089691_VALUE19
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461561113_AID1681851_PMID33089691_VALUE33
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461550482_AID1681849_PMID33089691_VALUE22
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461514302_AID1681849_PMID33089691_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461562230_AID1681838_PMID33089691_VALUE24
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461514302_AID1681854_PMID33089691_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461514302_AID1681844_PMID33089691_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461538612_AID1681853_PMID33089691_VALUE24
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461562230_AID1681854_PMID33089691_VALUE36
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461549450_AID1681851_PMID33089691_VALUE31
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461531590_AID1681845_PMID33089691_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461529602_AID1681853_PMID33089691_VALUE17
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461563576_AID1681854_PMID33089691_VALUE37
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461523301_AID1681851_PMID33089691_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461536295_AID1681853_PMID33089691_VALUE22
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461540431_AID1681852_PMID33089691_VALUE27
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461531590_AID1681822_PMID33089691_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461540099_AID1681853_PMID33089691_VALUE26
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461553587_AID1681853_PMID33089691_VALUE33
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242364125_AID1681851_PMID33089691_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461523053_AID1681854_PMID33089691_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461533094_AID1681850_PMID33089691_VALUE15
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461527873_AID1681853_PMID33089691_VALUE16
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103469795_AID1681851_PMID33089691_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461536295_AID1681854_PMID33089691_VALUE22
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461526472_AID1681829_PMID33089691_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461514556_AID1681854_PMID33089691_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461523301_AID1681853_PMID33089691_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461514302_AID1681814_PMID33089691_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461514556_AID1681840_PMID33089691_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461518386_AID1681838_PMID33089691_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461545807_AID1681851_PMID33089691_VALUE30
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461523684_AID1681838_PMID33089691_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461523301_AID1681852_PMID33089691_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461514556_AID1681838_PMID33089691_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461514556_AID1681843_PMID33089691_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461526472_AID1681853_PMID33089691_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103455066_AID1681845_PMID33089691_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID163326781_AID1681854_PMID33089691_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461530813_AID1681853_PMID33089691_VALUE18
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461518386_AID1681853_PMID33089691_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461538612_AID1681838_PMID33089691_VALUE15
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461543575_AID1681853_PMID33089691_VALUE28
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103232921_AID1681854_PMID33089691_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461543575_AID1681829_PMID33089691_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461531590_AID1681842_PMID33089691_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461517103_AID1681838_PMID33089691_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461518386_AID1681850_PMID33089691_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461536428_AID1681851_PMID33089691_VALUE23
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103222421_AID1681851_PMID33089691_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461523301_AID1681854_PMID33089691_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461545111_AID1681839_PMID33089691_VALUE20
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461517103_AID1681851_PMID33089691_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461540099_AID1681852_PMID33089691_VALUE26
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103232921_AID1681853_PMID33089691_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461545807_AID1681850_PMID33089691_VALUE20
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461514556_AID1681842_PMID33089691_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103232921_AID1681839_PMID33089691_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461545111_AID1681838_PMID33089691_VALUE20
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461536428_AID1681854_PMID33089691_VALUE23
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461514302_AID1681812_PMID33089691_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461533094_AID1681854_PMID33089691_VALUE21
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461527873_AID1681854_PMID33089691_VALUE16
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461550482_AID1681838_PMID33089691_VALUE23
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242364125_AID1681852_PMID33089691_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461523684_AID1681835_PMID33089691_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461523684_AID1681853_PMID33089691_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461531590_AID1681850_PMID33089691_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461523301_AID1681849_PMID33089691_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461550482_AID1681835_PMID33089691_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103227521_AID1681853_PMID33089691_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461538612_AID1681851_PMID33089691_VALUE24
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461536428_AID1681838_PMID33089691_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461530813_AID1681849_PMID33089691_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461540431_AID1681839_PMID33089691_VALUE19
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461545807_AID1681838_PMID33089691_VALUE21
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461531590_AID1681849_PMID33089691_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461532712_AID1681851_PMID33089691_VALUE20
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461514302_AID1681839_PMID33089691_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461539138_AID1681838_PMID33089691_VALUE17
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461545111_AID1681852_PMID33089691_VALUE29
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461531590_AID1681817_PMID33089691_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461540099_AID1681838_PMID33089691_VALUE18
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461531590_AID1681810_PMID33089691_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID163326781_AID1681849_PMID33089691_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461531590_AID1681814_PMID33089691_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461514302_AID1681843_PMID33089691_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461538973_AID1681829_PMID33089691_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103469795_AID1681833_PMID33089691_VALUE1
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461543575_AID1681852_PMID33089691_VALUE28
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461514302_AID1681847_PMID33089691_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461531590_AID1681816_PMID33089691_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461538973_AID1681838_PMID33089691_VALUE16
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461536295_AID1681846_PMID33089691_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461549450_AID1681852_PMID33089691_VALUE31
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461523053_AID1681853_PMID33089691_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103227521_AID1681852_PMID33089691_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461531590_AID1681811_PMID33089691_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461514302_AID1681829_PMID33089691_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461549450_AID1681849_PMID33089691_VALUE21
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461526472_AID1681854_PMID33089691_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461514302_AID1681842_PMID33089691_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461527873_AID1681851_PMID33089691_VALUE16
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461523684_AID1681849_PMID33089691_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID163326781_AID1681853_PMID33089691_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461526472_AID1681839_PMID33089691_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461545111_AID1681849_PMID33089691_VALUE19
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461538973_AID1681851_PMID33089691_VALUE25
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461523053_AID1681851_PMID33089691_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID461549450_AID1681839_PMID33089691_VALUE22
isDiscussedBy http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID11343
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID2147
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID5328
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID5327
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID5340
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID3818
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID100911581
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID2159
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID2161
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID2160

Total number of triples: 413.