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endingPage 5081
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bibliographicCitation Ding L, Pannecouque C, De Clercq E, Zhuang C, Chen FE. Hydrophobic Pocket Occupation Design of Difluoro-Biphenyl-Diarylpyrimidines as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: from N-Alkylation to Methyl Hopping on the Pyrimidine Ring. J Med Chem. 2021 Apr 22;64(8):5067–81. doi: 10.1021/acs.jmedchem.1c00128. PMID: 33851529.
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date 2021-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
identifier https://pubmed.ncbi.nlm.nih.gov/33851529
https://doi.org/10.1021/acs.jmedchem.1c00128
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language English
source https://pubmed.ncbi.nlm.nih.gov/
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title Hydrophobic Pocket Occupation Design of Difluoro-Biphenyl-Diarylpyrimidines as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: from N-Alkylation to Methyl Hopping on the Pyrimidine Ring
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469800301_AID1750720_PMID33851529_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469808962_AID1750714_PMID33851529_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469814773_AID1750719_PMID33851529_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469798980_AID1750714_PMID33851529_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469808962_AID1750725_PMID33851529_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103268452_AID1750722_PMID33851529_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469810501_AID1750716_PMID33851529_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469820948_AID1750717_PMID33851529_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469806477_AID1750720_PMID33851529_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469806477_AID1750724_PMID33851529_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103167682_AID1750723_PMID33851529_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469798980_AID1750676_PMID33851529_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469800301_AID1750727_PMID33851529_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469808962_AID1750719_PMID33851529_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469820948_AID1750719_PMID33851529_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469798980_AID1750692_PMID33851529_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469825452_AID1750717_PMID33851529_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469820603_AID1750715_PMID33851529_VALUE26
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469798980_AID1750693_PMID33851529_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818742_AID1750715_PMID33851529_VALUE24
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469820948_AID1750725_PMID33851529_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469810123_AID1750721_PMID33851529_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469814773_AID1750726_PMID33851529_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469808962_AID1750723_PMID33851529_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103268452_AID1750721_PMID33851529_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469826655_AID1750716_PMID33851529_VALUE31
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469825452_AID1750727_PMID33851529_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469808962_AID1750724_PMID33851529_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469825192_AID1750723_PMID33851529_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103167682_AID1750714_PMID33851529_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469813052_AID1750724_PMID33851529_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID104234240_AID1750727_PMID33851529_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103268452_AID1750725_PMID33851529_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469820948_AID1750716_PMID33851529_VALUE27
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469826655_AID1750726_PMID33851529_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469826655_AID1750717_PMID33851529_VALUE15
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID104234240_AID1750716_PMID33851529_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469798980_AID1750691_PMID33851529_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469798980_AID1750709_PMID33851529_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469826655_AID1750722_PMID33851529_VALUE15
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469798980_AID1750728_PMID33851529_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469798980_AID1750685_PMID33851529_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469825452_AID1750718_PMID33851529_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103167682_AID1750721_PMID33851529_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103167682_AID1750725_PMID33851529_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440195391_AID1750728_PMID33851529_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469798980_AID1750707_PMID33851529_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469798980_AID1750721_PMID33851529_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469808962_AID1750720_PMID33851529_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469820948_AID1750714_PMID33851529_VALUE27
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469806477_AID1750718_PMID33851529_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469809970_AID1750720_PMID33851529_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469798980_AID1750700_PMID33851529_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469798980_AID1750701_PMID33851529_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469810123_AID1750719_PMID33851529_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818715_AID1750716_PMID33851529_VALUE23
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469798980_AID1750687_PMID33851529_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469825452_AID1750719_PMID33851529_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103268452_AID1750717_PMID33851529_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404652390_AID1750728_PMID33851529_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469825192_AID1750716_PMID33851529_VALUE29
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469816028_AID1750715_PMID33851529_VALUE21
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103268452_AID1750727_PMID33851529_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469809970_AID1750715_PMID33851529_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469811865_AID1750716_PMID33851529_VALUE15
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469798980_AID1750677_PMID33851529_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469813052_AID1750718_PMID33851529_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103268452_AID1750715_PMID33851529_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469802064_AID1750716_PMID33851529_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440195391_AID1750679_PMID33851529_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469813052_AID1750720_PMID33851529_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469798980_AID1750722_PMID33851529_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469809970_AID1750717_PMID33851529_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469800301_AID1750714_PMID33851529_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469798980_AID1750682_PMID33851529_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469817913_AID1750716_PMID33851529_VALUE22
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469798980_AID1750694_PMID33851529_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469801287_AID1750715_PMID33851529_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103439143_AID1750714_PMID33851529_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469800301_AID1750726_PMID33851529_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469825452_AID1750721_PMID33851529_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469826655_AID1750724_PMID33851529_VALUE15
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID104234240_AID1750724_PMID33851529_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469810123_AID1750722_PMID33851529_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469822980_AID1750716_PMID33851529_VALUE28
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469825192_AID1750721_PMID33851529_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469825452_AID1750722_PMID33851529_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID104234240_AID1750714_PMID33851529_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469814773_AID1750720_PMID33851529_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469810123_AID1750714_PMID33851529_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469820948_AID1750721_PMID33851529_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469820948_AID1750726_PMID33851529_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103439143_AID1750715_PMID33851529_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469826655_AID1750714_PMID33851529_VALUE31
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469800301_AID1750724_PMID33851529_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103167682_AID1750727_PMID33851529_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469798980_AID1750689_PMID33851529_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469820948_AID1750724_PMID33851529_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469798980_AID1750717_PMID33851529_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469814773_AID1750727_PMID33851529_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469825192_AID1750727_PMID33851529_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469813052_AID1750722_PMID33851529_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469806477_AID1750721_PMID33851529_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469820948_AID1750720_PMID33851529_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469814773_AID1750718_PMID33851529_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469798980_AID1750730_PMID33851529_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID104234240_AID1750723_PMID33851529_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469810123_AID1750724_PMID33851529_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404652390_AID1750729_PMID33851529_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469819854_AID1750715_PMID33851529_VALUE25
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469816028_AID1750714_PMID33851529_VALUE21
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103268452_AID1750726_PMID33851529_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469825192_AID1750722_PMID33851529_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469826655_AID1750720_PMID33851529_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID404652390_AID1750677_PMID33851529_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469801287_AID1750714_PMID33851529_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469826655_AID1750715_PMID33851529_VALUE31
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469808962_AID1750726_PMID33851529_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469826655_AID1750725_PMID33851529_VALUE15
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469822980_AID1750714_PMID33851529_VALUE28
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469814228_AID1750714_PMID33851529_VALUE18
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469814773_AID1750716_PMID33851529_VALUE20
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469825192_AID1750714_PMID33851529_VALUE29
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469810123_AID1750723_PMID33851529_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469811865_AID1750714_PMID33851529_VALUE15
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469813052_AID1750721_PMID33851529_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469811865_AID1750715_PMID33851529_VALUE15
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469810123_AID1750725_PMID33851529_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469813291_AID1750716_PMID33851529_VALUE17
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469814773_AID1750721_PMID33851529_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469825452_AID1750716_PMID33851529_VALUE30
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469817913_AID1750714_PMID33851529_VALUE22
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469798980_AID1750698_PMID33851529_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469816028_AID1750716_PMID33851529_VALUE21
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469822980_AID1750715_PMID33851529_VALUE28
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469808962_AID1750722_PMID33851529_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469813052_AID1750714_PMID33851529_VALUE16
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469809970_AID1750721_PMID33851529_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469802064_AID1750714_PMID33851529_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID104234240_AID1750721_PMID33851529_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469798980_AID1750719_PMID33851529_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID440195391_AID1750729_PMID33851529_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469798980_AID1750695_PMID33851529_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID469818715_AID1750714_PMID33851529_VALUE23

Total number of triples: 370.