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Pirotte B, Florence X, Goffin E, Medeiros MB, de Tullio P, Lebrun P. 4-Phenylureido/thioureido-substituted 2,2-dimethylchroman analogs of cromakalim bearing a bulky ‘carbamate’ moiety at the 6-position as potent inhibitors of glucose-sensitive insulin secretion. European Journal of Medicinal Chemistry. 2016 Oct;121():338–51. doi: 10.1016/j.ejmech.2016.05.042. |