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Schann S, Bruban V, Pompermayer K, Feldman J, Pfeiffer B, Renard P, Scalbert E, Bousquet P, Ehrhardt J. Synthesis and Biological Evaluation of Pyrrolinic Isosteres of Rilmenidine. Discovery ofcis-/trans-Dicyclopropylmethyl-(4,5-dimethyl-4,5-dihydro-3H- pyrrol-2-yl)-amine (LNP 509), an I1Imidazoline Receptor Selective Ligand with Hypotensive Activity. J. Med. Chem. 2001 Mar 24;44(10):1588–93. doi: 10.1021/jm001111b. |