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endingPage 4904
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issueIdentifier 12
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publicationName Journal of Medicinal Chemistry
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bibliographicCitation Lai A, Kahraman M, Govek S, Nagasawa J, Bonnefous C, Julien J, Douglas K, Sensintaffar J, Lu N, Lee KJ, Aparicio A, Kaufman J, Qian J, Shao G, Prudente R, Moon MJ, Joseph JD, Darimont B, Brigham D, Grillot K, Heyman R, Rix PJ, Hager JH, Smith ND. Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts. J Med Chem. 2015 Jun 25;58(12):4888–904. doi: 10.1021/acs.jmedchem.5b00054. PMID: 25879485.
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language English
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title Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373568_AID1228233_PMID25879485_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103211976_AID1228211_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228288_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373570_AID1228208_PMID25879485_VALUE28
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228237_PMID25879485_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373518_AID1228205_PMID25879485_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373572_AID1228208_PMID25879485_VALUE30
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373529_AID1228205_PMID25879485_VALUE17
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373525_AID1228231_PMID25879485_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103517317_AID1228235_PMID25879485_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228252_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373531_AID1228208_PMID25879485_VALUE17
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103447197_AID1228305_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228270_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373580_AID1228272_PMID25879485_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228282_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103211976_AID1228212_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228287_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373577_AID1228238_PMID25879485_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373564_AID1228208_PMID25879485_VALUE22
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228231_PMID25879485_VALUE38
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373532_AID1228208_PMID25879485_VALUE18
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103211976_AID1228222_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373569_AID1228205_PMID25879485_VALUE29
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228246_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373567_AID1228208_PMID25879485_VALUE25
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228301_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228266_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373567_AID1228205_PMID25879485_VALUE27
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373565_AID1228205_PMID25879485_VALUE25
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373566_AID1228233_PMID25879485_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228293_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373571_AID1228208_PMID25879485_VALUE29
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373577_AID1228232_PMID25879485_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228258_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373521_AID1228205_PMID25879485_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103465810_AID1228239_PMID25879485_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373527_AID1228205_PMID25879485_VALUE15
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228310_PMID25879485_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373523_AID1228232_PMID25879485_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373573_AID1228231_PMID25879485_VALUE32
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373574_AID1228232_PMID25879485_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373566_AID1228238_PMID25879485_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373529_AID1228208_PMID25879485_VALUE15
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228278_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103465810_AID1228235_PMID25879485_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103224021_AID1228231_PMID25879485_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373564_AID1228205_PMID25879485_VALUE24
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103517317_AID1228239_PMID25879485_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373569_AID1228232_PMID25879485_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103465810_AID1228208_PMID25879485_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103517317_AID1228208_PMID25879485_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103517317_AID1228237_PMID25879485_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373528_AID1228231_PMID25879485_VALUE15
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373519_AID1228205_PMID25879485_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228243_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228260_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103447197_AID1228236_PMID25879485_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373523_AID1228238_PMID25879485_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373562_AID1228208_PMID25879485_VALUE20
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103211976_AID1228225_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373576_AID1228205_PMID25879485_VALUE36
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103211976_AID1228224_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373523_AID1228231_PMID25879485_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373563_AID1228231_PMID25879485_VALUE22
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228291_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373561_AID1228208_PMID25879485_VALUE19
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373569_AID1228208_PMID25879485_VALUE27
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228279_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103447197_AID1228309_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373522_AID1228231_PMID25879485_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373532_AID1228231_PMID25879485_VALUE19
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373571_AID1228205_PMID25879485_VALUE31
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373564_AID1228238_PMID25879485_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373565_AID1228208_PMID25879485_VALUE23
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373561_AID1228231_PMID25879485_VALUE20
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228233_PMID25879485_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103465810_AID1228236_PMID25879485_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228244_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373519_AID1228208_PMID25879485_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228247_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373572_AID1228205_PMID25879485_VALUE32
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228306_PMID25879485_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242556586_AID1228241_PMID25879485_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228285_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103465810_AID1228230_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103211976_AID1228205_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103517317_AID1228310_PMID25879485_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103447197_AID1228205_PMID25879485_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373563_AID1228205_PMID25879485_VALUE23
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228283_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373526_AID1228229_PMID25879485_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103224021_AID1228208_PMID25879485_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373578_AID1228234_PMID25879485_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373523_AID1228205_PMID25879485_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103465810_AID1228206_PMID25879485_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373569_AID1228233_PMID25879485_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228232_PMID25879485_VALUE15
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373570_AID1228205_PMID25879485_VALUE30
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373529_AID1228231_PMID25879485_VALUE16
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228299_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103211976_AID1228228_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373578_AID1228205_PMID25879485_VALUE38
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373526_AID1228231_PMID25879485_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103465810_AID1228205_PMID25879485_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373562_AID1228231_PMID25879485_VALUE21
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373567_AID1228232_PMID25879485_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373578_AID1228208_PMID25879485_VALUE36
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103517317_AID1228206_PMID25879485_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373570_AID1228231_PMID25879485_VALUE29
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228289_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373527_AID1228238_PMID25879485_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373526_AID1228208_PMID25879485_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103211976_AID1228210_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103211976_AID1228218_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373564_AID1228233_PMID25879485_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373530_AID1228205_PMID25879485_VALUE18
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373575_AID1228231_PMID25879485_VALUE34
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103465810_AID1228231_PMID25879485_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103211976_AID1228231_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373574_AID1228208_PMID25879485_VALUE32
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373527_AID1228233_PMID25879485_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373577_AID1228231_PMID25879485_VALUE36
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228205_PMID25879485_VALUE39
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228264_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373576_AID1228231_PMID25879485_VALUE35
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103224021_AID1228310_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373564_AID1228232_PMID25879485_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373568_AID1228205_PMID25879485_VALUE28
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228255_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103517317_AID1228231_PMID25879485_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373567_AID1228238_PMID25879485_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103224021_AID1228237_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373524_AID1228231_PMID25879485_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103211976_AID1228215_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373525_AID1228232_PMID25879485_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228208_PMID25879485_VALUE37
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228295_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373572_AID1228231_PMID25879485_VALUE31
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373528_AID1228208_PMID25879485_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228245_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228275_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID103224021_AID1228239_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373521_AID1228208_PMID25879485_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373578_AID1228231_PMID25879485_VALUE37
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373531_AID1228231_PMID25879485_VALUE18
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228251_PMID25879485_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID318373579_AID1228261_PMID25879485_VALUE1
isDiscussedBy http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID1576
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID1565
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID2100
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID1559
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID2099
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID5241
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID3757
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID4306
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID2908
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID367
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID6531
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID1558
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID1557
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID1544

Total number of triples: 387.