| abstract |
New 3-substituted 2-oxindole derivatives of formula (I) are described in which R 1 represents H, R 2 is COR 6 where R 6 is (C 1 -C 6) alkyl or phenyl, X and Y are H, F, Cl or Br, Q is W wherein W is oxygen or Sulfur, an is 0, 1 or 2. The compounds of the present invention are used as inhibitors of prostaglandin H2 synthesis and interleukin-1-synthesis, per se, and as analgesic, anti-inflammatory and anti-arthritic agents for the treatment of chronic inflammatory diseases. . The present invention also relates to pharmaceutical compositions containing said 3-substituted-2-oxindole derivatives; to methods for inhibiting prostaglandin H2 synthesis and interleukin-1 biosynthesis; and for the treatment of chronic inflammatory diseases in mammals with said compounds. Furthermore, the present invention relates to certain novel carboxylic acids used as intermediates in the preparation of 3-substituted-2-oxindole derivatives according to the invention and to a process for the preparation of 3-substituted-2-oxindole derivatives. |