abstract |
The present invention relates to certain compounds containing benzoamide-piperidine and related compounds which show activity as NK-1 receptor antagonists (e.g. substance P antagonists), to pharmaceutical compositions containing them and to their use in the treatment and prevention of central nervous system disorders , inflammatory disorders, cardiovascular disorders, ophthalmic disorders, gastrointestinal disorders, disorders caused by Helicobacter pylori, immune system disorders, urinary incontinence, pain, migraines, vomiting, angiogenesis and other disorders. related compounds that exhibit activity as NK-1 receptor antagonists, (eg, substance P receptor antagonists), to pharmaceutical compositions containing them, and to their use in the treatment and prevention of central nervous system disorders, inflammatory disorders, cardiovascular disorders, ophthalmic disorders , gastroin testinal disorders, disorders caused by helicobacter pylori, disorders of the immune system, urinary incontinence, pain, migraine, emesis, angiogenesis and other disorders. (I) |