| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ca2e4410855da087e11bf3eea8933fa |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-08 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-28 |
| filingDate |
1995-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7c965dbb3b23f8470e8ced8b2571655
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3185bd6b5574173107def3ad55eb517 |
| publicationDate |
1998-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
YU-71395-A |
| titleOfInvention |
ACILLATED INSULIN ANALYSIS |
| abstract |
The present invention relates to acylated insulin analogs with extended duration of action. These insulin analogs or their pharmaceutically acceptable salts have the formula SEQ ID NO: 1 Xaa He Val Glu Gin Cys Cys Thr Ser He Cys Ser 1 5 10 Leu Tyr Gin Leu Glu Asn Tyr Cys Asn 15 20 and SEQ ID NO: 2 Xaa Val Asn Gin His Leu Cys Gly Ser His Leu Val 1 5 10 Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Prh 15 20 Phe Tyr Thr Xaa Xaa Thr 25 30 and are properly cross-linked to each other, where Xaa at position 28 SEQ ID NO : 2 represents acylated Lys, and at position 29 of SEQ ID NO: 2, Xaa represents Pro. The acylating group is C6 - C17 fatty acid. The invention further provides a pharmaceutical composition comprising an effective amount of an acylated insulin analog of the present invention in combination with one or more pharmaceutically acceptable excipients and a process for preparing the composition. |
| priorityDate |
1994-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |