http://rdf.ncbi.nlm.nih.gov/pubchem/patent/YU-59593-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ca2e4410855da087e11bf3eea8933fa |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B65H2511-512 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-426 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-425 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-426 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-425 |
| filingDate | 1993-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59be03ebfc4f1b37b1dfc19d08fa52a2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9138fc35629786391f0e27707246d970 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_310c92069d56811c74cf8934882ea767 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab0872bfecc452e322322d6c22cc00eb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b621a935e0370b1e3995396035d91388 |
| publicationDate | 1997-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | YU-59593-A |
| titleOfInvention | DERIVATIVES, THE PROCESS FOR THEIR OBTAINING, AND THE PHARMACEUTICAL FORMULATIONS CONTAINING THEM |
| abstract | RODANINE DERIVATIVES, A PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM, The compounds of the formula of this invention wherein Ar (i) is phenyl, (ii) phenyl substituted with one to three substituents independently selected from C1-C8 alkyl, C1-C8 alkyl, C1-C8 alkyl, C1-C8 alkyl C1-C8 alkylthio, trifluoromethyl. C1-C4 alkylphenyl, phenyl, NO3, F, Cl, hydroxy, phenoxy, C1-C4 alkyloxyphenyl, thiophenyl, C1-C4 alcythiophenyl, -COOR7, -N (R7) SO2R7 or -N (R7) 2, where R7 is hydrogen or C1-C6 alkyl, (iii) 1- or 2-naphthyl, (iv) 2- or 3-benzofuranyl, (v) 2-or 3-benzothiophenyl, (vi) 2- or 3-thienyl, (vii) 2- , 3- or 4-pyridyl, (viii) 2- III 3-furanyl, (ix) 1,3-benzodioxanyl, (x) substituted 1,3-benzodioxanyl, (xi) quinolinyl, (xii) 2- or 3- indolyl or (xiii) N-substituted 2- or 3-indolyl: R1 is C1-C6 alkyl, C1-C4 alkylphenyl, hydrogen phenyl or phenyl substituted with one or two substituents independently selected from Cl, Br, F, I, c1- C4 alkyl, C1-C4 alkoxy, hydroxy, trifluoromethyl, -NH2, -NH (C1-C4 alkyl), -N (C1-C4) or C1-C4 alkylthio; R2 and R3 are hydrogen or if they are together then they form a bond; R4 and R3 are hydrogen or when together = S, or when one of them is hydrogen, the other is -SCH3; R6 is hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, C2-C6 alkenyl, -SO2CH3, or - (CH2) p- Y where p is 0,1,2 or 3 and Y is cyano, -OR8, 4C = O) R 9, tetrazolyl, -NR 10 R, -SH, C 1 -C 4 alkylthio or wherein R 8 is hydrogen, C 1 -C 4 alkyl or - (C = CO) -C 1 -C 4 alkyl; R 9 is hydrogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, hydroxy or NH 2; R10 and Rn are independent hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, phenyl, C1-C4 alkiphenyl, (CH2) qOH, - (CH2) qN (C1-C4alkyl) 2 or - (CH2) (C 1 -C 4 alkyl), wherein q is a number from 1 to 6, or R 10 III R 11 taken together with the nitrogen atom to which they are attached form a morpholinyl, piperidinyl, piperizole, or N-methylpiperazinyl ring; and m is 0, 1 or 2; provided that Ar is not phenyl substituted with only one chlorine at position 4 on the ring: Ar is not phenyl substituted with the COOH group at position 2 on the phenyl ring; wherein Ar is phenyl substituted by two epoxy groups at the 3- and 4- positions on the phenyl ring. R1 must be hydrogen; Ar is not phenyl substituted with only two hydroxy groups: and when R4 and R5 are hydrogen, R6 is not C1-C4 |
| priorityDate | 1992-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 59.