| abstract |
BENZOPIRAN DERIVATIVES. Compounds of the formula wherein R 1 denotes hydrogen, halogen, trifluoromethyl, nitro, cyan, lower alkyl, lower alkoxycarbonyl, lower alkylthio, lower alkylsulfonyl, lower alkanoyl, aroyl, carbamoyl, mono (lower alkyl) carbamoyl or di (lower alkyl) denotes hydrogen, lower alkyl or phenyl, R3 denotes hydrogen or lower alkyl, R4 and R5 each independently denote hydrogen or R4 denotes hydroxy and R5 denotes hydrogen or R4 and R5 together denote a carbon-carbon bond and R6 denotes aryl- or N-heteroaryl- a group bearing a hydroxy group in position 2-, or, in the case of an N-heteroaryl group, also an N-oxide group in position 2-, and pharmaceutically acceptable acid addition salts of these compounds of formula I which are basic, have pronounced potassium channel activating action and can be used as drugs, especially in the suppression or prevention of hypertension, congestive heart defects, angina pectoris, peripheral and cerebral vascular diseases and smooth muscle disorders. išića. |