http://rdf.ncbi.nlm.nih.gov/pubchem/patent/YU-47212-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_571b8abacacea64d3f7089d0983b8b3b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 1989-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d256f049f85f016a6cf43a17eb17d79 |
| publicationDate | 1995-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | YU-47212-B |
| titleOfInvention | PROCEDURE FOR OBTAINING IMIDAZOPYRIDASINE DERIVATIVES |
| abstract | A process for the preparation of imidazopyridazine derivatives of the general formula (I) wherein R1 represents an optionally substituted carbocyclic aryl group having 6 or 10 ring members and containing at least one aromatic ring, optionally substituted heterocyclic aryl group, having 5 to 10 ring ring or an optionally substituted C1-10 alkyl, C2-10 alkenyl, C3-10 cycloalkyl or C3-10 cycloalkenyl group; R2 represents an optionally substituted C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 cycloalkyl, C3-10 cycloalkenyl, optionally substituted carbocyclic aryl group having 6 to 10 ring members and containing at least one aromatic ring, optionally a substituted heterocyclic group having 5 to 10 ring members or an optionally substituted aryl (C1-14) alkyl group wherein the aryl moiety is a carbocyclic or heterocyclic aryl group as defined herein; R3 represents a hydrogen atom or a C1-4 alkyl group; X represents an oxygen or sulfur atom, a group -CH 2 - or a NR 4 group wherein R 4 represents a hydrogen atom or a C 1-4 alkyl group; and Y represents a group -CH2 or -CH2CH2 or XY represents a group -CH = CH- and their pharmaceutically acceptable salts, comprising: a reaction preferably heating the compound of general formula (VI) to a temperature in the range of about 80 ° C to about 150 ° C, optionally in the presence of inert organic solvents such as benzene and toluene hydrocarbons with the corresponding alcohol R2OH wherein R1, R2, X and Y have the meanings given above, and, if desired, and / or if necessary, the compounds obtained formulas (I) can be converted to other compounds of formula (I) by: - separating the -CO2R2 group under acidic conditions, optionally in the presence of solvents, and then reacting with a reagent to introduce a different -CO2R2 group; - substituting the esterifying group R2 in the compound of formula (I) by treating said compound with a suitable alcoholic in the presence of a base at temperatures in the range of 50 to 180 ° C; or - alkylating a compound in which R 3 is hydrogen to provide a compound in which R 3 is an alkyl group; and / or salt formation. The application contains 6 more dependent requests. |
| priorityDate | 1987-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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