http://rdf.ncbi.nlm.nih.gov/pubchem/patent/YU-47200-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_571b8abacacea64d3f7089d0983b8b3b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 1988-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d11a0319dd28ac161fa64523bbaf0b9 |
| publicationDate | 1995-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | YU-47200-B |
| titleOfInvention | PROCEDURE FOR OBTAINING IMIDAZOPYRIDASINE DERIVATIVES |
| abstract | A process for the preparation of imidazopyridazine derivatives of the general formula: wherein R 1 represents an optionally substituted carbocyclic aryl group of 6 or 10 members in the ring and containing at least one aromatic ring, optionally substituted heterocyclic aryl group having 5 to 10 members of the optionally substituted C1 to 5 members 10 alkyl, C2-10 alkenyl, C3-10 cycloalkyl or C3-10 cycloalkenyl group; R2 represents an optionally substituted C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 cycloalkenyl group, an optionally substituted carbocyclic aryl group having 6 to 10 ring members and containing at least one aromatic ring, optionally substituted heterocyclic a group having from 5 to 10 ring members, or an optionally substituted aryl (C1-14) alkyl group wherein the aryl is part of a carbocyclic or heterocyclic group as defined herein; R3 represents a hydrogen atom, a C1-14 alkyl group: and / or X represents an oxygen or sulfur atom, a group -CH2- or a NR4 group where R4 represents a hydrogen atom or a C1-4 alkyl group; and Y represents the group -CH2- or -CH2CH2- or XY together represent the group -CH = CH- and their pharmaceutically acceptable salts, comprising: reaction in an aprotic solvent such as dimethylformamide, 1,3-dimethylimidazolinone or hexamethylphosphoramide to at a temperature of from about 50 ° C to about 120 ° C, a pyridisine derivative of the general formula (II) wherein R1 and X and Y are as defined for formula (I) with the compound of general formula (III) wherein R2 and R3 are as defined in of formula (I) a is a halogen atom, after which, if desired and / or if necessary, the resulting compounds of formula (I) can be converted to other compounds of formula (I) by: - separating the group -CO2R2 under acidic conditions, optionally in the presence of solvents, and then by reaction with a reagent to introduce a different -CO2R2 group; - substituting the esterifying group R2 in the compound of formula (I) by treating said compound with an appropriate alcohol in the presence of a base at a temperature in the range of 50 to 180 ° C; or - alkylating a compound in which R 3 is hydrogen so as to provide a compound in which R 3 is an alkyl group; and / or salt formation. The application contains 6 more dependent requests. |
| priorityDate | 1987-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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