| abstract |
PROCESS FOR OBTAINING NEW INSULIN ANALOGS, characterized in that they have the general formula I in which X is marked with amino acid residues of human insulin or the same or different residues of substituted amino acids, pure useful functions, which give the molecule the same charge or higher negative charge at a neutral pH than human insulin, provided that at least one X differs from the amino acid residues of human insulin at the appropriate site in the insulin molecule and that when X is at position A (8) His or Phe, X at position A ( 21) Asp, X in place B (5) Ala, X in place B (9) Leu, X in place B (10) Asn or Leu, X in place B (12) Asn or S in place B (26) Ala , at least one of the remaining X differs from the amino acid residues of human insulin at the appropriate site in the insulin molecule, and also provided that one or more amino acid residues can be removed from the N- and / or C-termini A- and / or B-chain. The application contains 9 more dependent requests. |