http://rdf.ncbi.nlm.nih.gov/pubchem/patent/YU-46780-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-425 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D243-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D243-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 |
| filingDate | 1988-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dce87cbd0ff121f2b125a23b80f6fcd2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7919ee6f270dc6d2f6f1d9581e454ac6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1e11d37658054ef73e73d320053a470 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bbb5471c48498344a9cf575ea9030f38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_956ba2f4deff4cd5c86cb1ede519d2fe |
| publicationDate | 1994-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | YU-46780-B |
| titleOfInvention | PROCESS FOR PREPARATION OF TETRAHYDRONAFTHALINE DERIVATIVES |
| abstract | A PROCESS FOR THE PREPARATION OF TETRAHYDRONAFTHALINE DERIVATIVES OF GENERAL FORMULA: in which R denotes lower alkyl, R1 denotes halogen, R2 denotes C1-C12-alkyl, R3 denotes lower alkylcarbonyloxy or lower alkoxy-lower alkylcarbonyloxy, X denotes C1 or c1 case may be interrupted by 1,4-phenylene or interrupted or extended by 1,4-cyclohexylene, A denotes di- or tri-substituted 2-imidazo- or which is attached via an ethylene group or optionally substituted ben-zimidazolyl, benzimidazolonyl , imidazo [4,5-c] pyridinyl, imidazo [4,5-c] pyridinonyl, benzthiazolyl or benzodiazepine-2,5-dion-1-yl or pyrrolo [2,1-c] (1,4) benzodiazepine -5,11-dione-10.yl in represents the number 0 or 1, in the form of racemates and optical antipodes, as well as N-oxides and pharmaceutically acceptable acid addition salts of these compounds, characterized in that a) the compound of general formula in which R, R1, R2, A, X and have the meanings given above, with an acylating agent giving a lower alkylcar a bonyl or lower alkoxy-lower-alkylcarbonyl group, in particular with one activated acid derivative, such as an acid halide and an acid anhydride or a mixture of an acid anhydride, in one reaction-inert organic solvent, such as an aromatic hydrocarbon, such as benzene , toluene or xylene, a chlorinated hydrocarbon such as methylene chloride or chloroform, an ether such as diethyl ether, tetrahydrofuran or dioxam, or a mixture of solvents, at a temperature between about 0V ° and the reflux temperature, which b) the resulting compound is oxidized with an oxidant such as hydrogen peroxide or peracid, such as peracetic or perbenzoic acid, in a solvent such as alcohol, such as methanol or ethanol, at a temperature between about 0V ° and 50V ° C, preferably at ambient temperature, in the corresponding N-oxide, and / or c) the resulting racemate is separated into optical antipodes, and / or d) the resulting compound is converted into a pharmaceutically acceptable acid addition onu so. The application contains 4 independent and 5 dependent requests. |
| priorityDate | 1988-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 59.