http://rdf.ncbi.nlm.nih.gov/pubchem/patent/YU-46698-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0d269c8e41f178194d858c230c9f85e3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-455 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4406 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4418 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-522 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 |
| filingDate | 1988-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d22b9c3c88cf650dcf5bee14f54ba840 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9acbabcd161fe6c283c744071e4c596 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d756857a1f96c150937744c5d34c67ab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d2cc3bd111e9f0d0869aa45046a5b8eb |
| publicationDate | 1994-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | YU-46698-B |
| titleOfInvention | PROCESS FOR PREPARATION OF DERIVATIVES OF 4-Aryl-5-CARBAMOYL-1,4-DIHYDROPYRIDINE |
| abstract | A process for the preparation of 4-Aryl-5-carbamoyl-1,4-dihydropyridine derivatives of the formula: wherein R is phenyl or phenyl substituted with one or more substituents independently selected from nitro, halo, C1-C4alkyl, C1-C4alkoxy, aryl ( C1-C4) alkoxy, fluoro (C1-C4) alkoxy, C1-C4alkylthio, C1-C4alkylsulfonyl, hydroxy, trifluoromethyl and cyano, or phenyl fused to a dioxolane ring; R 1 and R 2 are each independently H or C 1 -C 6 alkyl, or R 1 and R 2 together form pyrrolidinyl, piperidino, morpholino, piperazinyl, N- (C 1 -C 4 alkyl) piperazinyl or N- (C 2 -C 4 alkanoyl) -piperazinyl group; R 2 is H or C 1 -C 4 alkyl and R 1 is a CN, C 3 -C 7 cycloalkyl, aryl, heteroaryl or C 1 -C 4 alkyl group, which may be substituted with one or more substituents each independently selected from C 3 -C 7 cycloalkyl, C 1 -C 4 alkoxycarbonyl, aryl or heteroaryl; Z is selected from OH, C1-C6 alkoxy and aryl (C1-C6) alkoxy, Y is 1,4 phenylene or pyridine-2,5-diyl, and X is a 5- or 6-membered group containing one or more nitrogen atoms in its ring; which ring may be fused to a benzene ring or further to a 5 or 6 membered aromatic heterocyclic ring containing one or two nitrogen atoms, at least one of said heterocyclic rings optionally also containing an oxygen or sulfur atom, and optionally substituted with one or more substituents independently selected from C1-C4alkyl, halo, CF3 and CN; and pharmaceutically acceptable salts thereof, wherein aryl means phenyl or phenyl substituted with one or two substituents selected from halo, tri-fluoromethyl, C1-C4alkyl, hydroxy, C1-C4 alkoxy, (C1-C4alkoxy) carbonyl, sulfamoyl and CN, heteroaryl in by definition R1 means a 5- or 6-membered aromatic heterocyclic group containing one or two heteroatoms independently selected from N, O and S and which may be optionally fused to a benzene ring and which may be optionally substituted in at least one of the heterocyclic and fused benzene rings with one or two substituents selected from C1-C4 alkoxy and halo, wherein halo means fluoro, chloro, bromo or iodo, wherein the compound of formula XN is reacted with p-haloacetophenone in the presence of potassium carbonate in anhydrous solution. the compound XY -COCH3 would be obtained where X and Y are as previously defined, which then reacts with the compound of formula (Z2) CO in the presence of sodium hydride, wherein Z is as defined above, to give a compound of formula (III) wherein Y and X are as defined above, R 3 is C 1 -C 6 alkyl or aryl (C 1 -C 4 alkyl), which then reacts with the compound thus obtained with RCHO, where R is as previously defined, in the presence of isopropyl alcohol and piperidine at room temperature to give a compound of formula (IV) in which R, R3 X and Y are as defined above, |
| priorityDate | 1987-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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