| abstract |
A PROCEDURE FOR THE PREPARATION OF TETRACYCLIC IMIDAZODIAZEPINS OF THE GENERAL FORMULA IN WHICH THEY DESIGN A together with both carbon atoms labeled with alpha and beta group B dimethylene, trimethylene or propenylene, R 1 hydrogen, halogen, trifluoromethyl, amino, nitro, cyanogen or lower R trifluoromethyl, amino, nitro cyan, lower alkyl, lower alkyloxy, lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl, and the gamma-labeled carbon atom has the (S) - or (R, S) -configuration, and their pharmaceutically acceptable acid addition salts, wherein the compound of general formula wherein A and B have the meaning given above and X represents a leaving group, is reacted in the presence of a base with an isocyanic acetic acid tert-butyl ester and, if desired, the compound of general formula I is converted into a pharmaceutically acceptable acid addition salt. The application contains another 19 patent claims. |