| abstract |
The present invention provides the use of a compound for the preparation of a medicament for minimizing bone damage wherein R is -CH2CON (CH3) -n-CH2CH2CH2CH3 or -SO (CH2) 3CF2CF3, or a pharmaceutically acceptable salt thereof of a compound II administered to a mammal in need of treatment in which each R 1 is independently -H, -Oh, -O (C 1 -C 4 alkyl), -OCOC 6 H 5, -OCO (C 1 -C 6 alkyl), or -OSO 2 (C 4 -C 6 alkyl); R 2 is 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, or 1-hexamethyleneimino; or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions of compounds I and II. |