http://rdf.ncbi.nlm.nih.gov/pubchem/patent/YU-20097-A

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filingDate 1997-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_058b77962cd5fe7d56206352dfa0ecae
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publicationDate 1999-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber YU-20097-A
titleOfInvention FLUATED ANALYSIS OF VITAMIN D3, INTERMEDIATES FOR THEIR OBTAINING, A PROCEDURE FOR OBTAINING SUCH FLAMORATED ANALYSIS OF VITAMIN D3, A PHARMACEUTICAL MIXTURE CONTAINING ANALOGUE OF FLUORATED VITAMIN D3 AND
abstract Mine fluorinated analogues of Vitamin D3 of the formula in which X (H, H) or = CH2, R1 and R2 are independently hydrogen, (C1-C4) -alkyl or -fluoroalkyl, or R1 and R2 together with C-20 form (C3-C6) -cycloalkyl or -cyclofluoroalkyl, or R1 and R2 together form = CH2, R3 and R4 independently of one another, (C1-C4) -alkyl or fluoroalkyl, or R3 and R4 together with C-25 form (C3-C9) -cycloalkyl or -cyclofluoroalkyl, A simple or double bond, and B double or triple bond, except (i) when X is = CH2, R3 and R4 are each CF3, A is a double bond and one of R1 or R2 is hydrogen, then the other of R1 or R2 cannot be CH3, (ii) when X is = CH2, R3 and R4 are each (C1-C2) -alkyl, A is a double bond and R2 is hydrogen, then R1 cannot be CH3, (iii) when X is = CH2, R3 and R4 are each (C1-C4) -alkyl, A is a double bond and R1 is hydrogen, then R2 cannot be CH3, (iv) when X is = CH2. one of R3 or R4 is CF3, A is a double bond, R1 is CH3 and R2 is hydrogen, then the other of R3 or R4 cannot be CH3, and (v) when X is hydrogen, R3 and R4 are each CF3, A is a double bond, B is a triple bond and R2 is hydrogen, then R1 cannot be CH3, and the compounds of Formula I above in which X is (H, H) or = CH2, R1 and R2 are, independently of one another, hydrogen, (C1-C4) -alkyl or -fluoroalkyl, or R1 and R2 together with C-20 form (C3-C6 ) -cycloalkyl or -cyclofluoroalkyl, or R1 and R2 together form = CH2, R3 and R4 are, independently of one another, (C1-C4) -alkyl or -fluoroalkyl, or R3 and R4 together with C-25 form (C3- C9) -cycloalkyl or -cyclofluoroalkyl, A is a simple or double bond, and B is a double or triple bond, except when R3 and R4 are each CF3 and A is a double bond and B is a triple bond and R2 is hydrogen, then R1 cannot be CH3, are used in the treatment of osteoporosis.
priorityDate 1996-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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Total number of triples: 29.