| abstract |
The invention relates to compounds of formula (I) wherein R 1, R 2, R 3 and R 4 are as defined and their pharmaceutically acceptable salts. The compounds of formula (1) show an inhibition of cdk2 and GSK-3. Pharmaceutical preparations and methods comprising the compounds of formula (1) for the treatment and prevention of diseases and conditions associated with abnormal cell growth, such as cancer, and neurodegenerative diseases and conditions associated with dopamine neurotransmission. Also disclosed are pharmaceutical preparations and methods of the compounds of formula (1) for the treatment of male infertility and sperm motility; diabetes mellitus, glucose resistance disorder, metabolic syndrome or syndrome X; polycystic ovary syndrome; adipogenesis and obesity; myogenesis and intolerance; for example, a decrease in physical endurance associated with aging; acute sarcopenia, for example, muscular atrophy and / or cachexia associated with burns; the consequences of lying in bed, limb immobilization or major surgery of the thorax, abdomen and / or orthopedic surgery; sepsis, spinal cord injury, hair loss, hair thinning and wholeness and immunodeficiency. |