| abstract |
A process is provided for the preparation of a quinoline derivative of general formula wherein R 1 is an H, methyl or ethyl group; R2 is H, a methyl or fluoromethyl group; R3 and R4 are either different and each is H or a methyl group and Y is H or a C1-5 alkyl group. The process comprises reacting a compound of general formula wherein X is a halogen atom and the other substituents have the meanings given above with ammonia and, if desired, further hydrolysis of the ether to give the carboxylic acid which is optionally converted into its pharmaceutically acceptable salt. |